Quantitative Nanofriction Characterization of Corrugated Surfaces by Atomic Force Microscopy

Atomic Force Microscopy (AFM) is a suitable tool to perform tribological characterization of materials down to the nanometer scale. An important aspect in nanofriction measurements of corrugated samples is the local tilt of the surface, which affects the lateral force maps acquired with the AFM. This is one of the most important problems of state-of-the-art nanotribology, making difficult a reliable and quantitative characterization of real corrugated surfaces. A correction of topographic spurious contributions to lateral force maps is thus needed for corrugated samples. In this paper we present a general approach to the topographic correction of AFM lateral force maps and we apply it in the case of multi-asperity adhesive contact. We describe a complete protocol for the quantitative characterization of the frictional properties of corrugated systems in the presence of surface adhesion using the AFM.Comment: 33 pages, 9 figures, RevTex 4, submitted to Journal of Applied Physic

A robust method for measurement of fluctuation parallel wavenumber in laboratory plasmas

Measuring the parallel wavenumber is fundamental for the experimental characterization of electrostatic instabilities. It becomes particularly important in toroidal geometry, where spatial inhomogeneities and curvature can excite both drift instabilities, whose wavenumber parallel to the magnetic field is finite, and interchange instabilities, which typically have vanishing parallel wavenumber. We demonstrate that multipoint measurements can provide a robust method for the discrimination between the two cases

Reduced Physics Model of the Tokamak Scrape-off-Layer for Pulse Design

The dynamic interplay between the core and the edge plasma has important consequences in the confinement and heating of fusion plasma. The transport of the Scrape-Off-Layer (SOL) plasma imposes boundary conditions on the core plasma, and neutral transport through the SOL influences the core plasma sourcing. In order to better study these effects in a self-consistent, time-dependent fashion with reasonable turn-around time, a reduced model is needed. In this paper we introduce the SOL Box Model, a reduced SOL model that calculates the plasma temperature and density in the SOL given the core-to-edge particle and power fluxes and recycling coefficients. The analytic nature of the Box Model allows one to readily incorporate SOL physics in time-dependent transport solvers for pulse design applications in the control room. Here we demonstrate such a coupling with the core transport solver TRANSP and compare the results with density and temperature measurements, obtained through Thomson scattering and Langmuir probes, of an NSTX discharge. Implications for future interpretive and predictive simulations are discussed.Comment: 8 pages, 10 figure

Haploidentical α/β T-cell and B-cell Depleted Stem Cell Transplantation in Severe Mevalonate Kinase Deficiency

Objective: Mevalonic aciduria represents the most severe form of mevalonate kinase deficiency (MKD). Patients with mevalonic aciduria have an incomplete response even to high doses of anti-cytokine drugs such as anakinra or canakinumab and stem cell transplantation (SCT) represents a possible therapy for this severe disease. Methods: We report the first two children affected by severe MKD who received haploidentical α/β T-cell and B-cell depleted SCT. Both patients received a treosulfan-based conditioning regimen and one received a second haploidentical-SCT for secondary rejection of the first. Results: Both patients obtained a stable full donor engraftment with a complete regression of clinical and biochemical inflammatory signs, without acute organ toxicity or acute and chronic GvHD. In both, the urinary excretion of mevalonic acid remained high post-transplant in the absence of any inflammatory signs. Conclusion: Haploidentical α/β T-cell and B-cell depleted SCT represents a potential curative strategy in patients affected by MKD. The persistence of urinary excretion of mevalonic acid after SCT, probably related to the ubiquitous expression of MVK enzyme, suggests that these patients should be carefully monitored after SCT to exclude MKD clinical recurrence. Prophylaxis with anakinra in the acute phase after transplant could represent a safe and effective approach. Further biological studies are required to clarify the pathophysiology of inflammatory attacks in MKD in order to better define the therapeutic role of SCT.info:eu-repo/semantics/publishedVersio

Effetti di amplificazione topografica osservati sul patrimonio monumentale

La ricerca ha avuto l’obiettivo di indagare gli effetti di amplificazione sismica, per cause topografiche, che possono aver interessato le chiese danneggiate da alcuni terremoti storici italiani. La novità di questo studio consiste nell’aver messo a punto una metodologia di analisi che, partendo dall’osservazione degli effetti del terremoto sull’edificio, confronta il danno osservato ed il danno atteso, calcolato attraverso modelli basati su dati statisticamente affidabili, prevede una fase di rilevo delle caratteristiche geologiche, geomorfologiche, geotecniche e geofisiche dei siti di ubicazione delle chiese, arriva a quantificare, anche attraverso modellazioni numeriche della risposta sismica locale, l’influenza che la morfologia di questi siti può aver avuto nel determinare l’incremento dell’input sismico e conseguentemente del danno osservato

Correlation between local amplification effects and damage mechanism for monumental buildings

The damage and vulnerability survey of the monumental buildings, damaged by the 2002 earthquake in the Molise Region, has allowed singling out of a correlation between the observed damage of the churches and their morphological site conditions. The vulnerability model connected to the survey methodology provides an evaluation of the expected mean damage. Comparison with the observed damage determined the introduction of a local morphological behaviour modifier, able to take into account the vulnerability increase due to the site effects. In order to validate the previous results, a numerical 2-D analysis of the seismic local response has been performed. In particular, a numerical code, working with boundary elements, has been applied to the analyzed situations. The results, in terms of pseudo-acceleration response spectra and amplification factors, allow one to compare the numerical and the observed analyses. This comparison shows good agreement and allows one to find some correlations between the geometric characteristics of the sites, the values of the amplification coefficients and the damage mechanism activated

Correlation between local amplification effects and damage mechanisms for monumental buildings

The damage and vulnerability survey of the monumental buildings, damaged by the 2002 earthquake in the Molise Region, has allowed singling out of a correlation between the observed damage of the churches and their morphological site conditions. The vulnerability model connected to the survey methodology provides an evaluation of the expected mean damage. Comparison with the observed damage determined the introduction of a local morphological behaviour modifier, able to take into account the vulnerability increase due to the site effects. In order to validate the previous results, a numerical 2-D analysis of the seismic local response has been performed. In particular, a numerical code, working with boundary elements, has been applied to the analyzed situations. The results, in terms of pseudo-acceleration response spectra and amplification factors, allow one to compare the numerical and the observed analyses. This comparison shows good agreement and allows one to find some correlations between the geometric characteristics of the sites, the values of the amplification coefficients and the damage mechanism activated

Nothing is as it seems: genetic analyses on stranded fin whales unveil the presence of a fin-blue whale hybrid in the Mediterranean Sea (Balaenopteridae)

The fin whale Balaenoptera physalus is a large rorqual species occurring worldwide, mainly in temperate and subpolar zones. In contrast to many baleen whales, not all the fin whale populations show the same model of migration. In fact, migratory behaviours of this latter species range from long seasonal migration between high and low latitudes to a complete nonmigratory behaviour. A resident fin whale population was described in the Mediterranean Sea, which is also frequented by North Atlantic individuals entering through the Strait of Gibraltar in winter to feed. Between 2020 and 2021 three individuals initially identified as fin whales died along the Tyrrhenian coasts (Mediterranean Sea, Italy). Their mitochondrial DNA control region (mtDNA CR) was analysed and compared to fin whale haplotypes previously described in North Atlantic Ocean and Mediterranean Sea to identify their geographical origin. Our results show that two individuals most likely belong to the Mediterranean fin whale population, while an individual was recognised as a putative fin-blue whale hybrid (Balaenoptera physalus x Balaenoptera musculus) with a North Atlantic origin. The discovery of the first fin-blue whale hybrid in the Mediterranean Sea was confirmed by the analysis of a biparentally inherited marker, the α-lactalbumin (α-lac) nuclear gene, demonstrating that the morphological analysis alone does not allow to correctly identify hybrids, especially if intermediate characters of both parental species are not clearly distinguishable

Progress in the Theory of Singular Riemannian Foliations

A singular foliation is called a singular Riemannian foliation (SRF) if every geodesic that is perpendicular to one leaf is perpendicular to every leaf it meets. A typical example is the partition of a complete Riemannian manifold into orbits of an isometric action. In this survey, we provide an introduction to the theory of SRFs, leading from the foundations to recent developments in research on this subject. Sketches of proofs are included and useful techniques are emphasized. We study the local structure of SRFs in general and under curvature conditions. We review the solution of the Palais-Terng problem on integrability of the horizontal distribution. Important special classes of SRFs, like polar and variationally complete foliations and their connections, are treated. A characterisation of SRFs whose leaf space is an orbifold is given. Moreover, desingularizations of SRFs are studied and applications, e.g., to Molino's conjecture, are presented