Monitorização biológica de exposição a agentes químicos em estabelecimentos de saúde

Os produtos químicos são essenciais no nosso quotidiano e os seus benefícios são comuns e reconhecidos. Contudo, da exposição profissional a estes produtos podem resultar efeitos adversos para a saúde humana, pelo que a mesma deve ser monitorizada e controlada. Os estabelecimentos de saúde incluem muitas atividades profissionais, que envolvem o manuseamento e aplicação de diversos produtos químicos. Destacam-se os agentes desinfetantes e esterilizantes, os gases anestésicos voláteis, os compostos citostáticos e os solventes laboratoriais. A monitorização biológica da exposição profissional consiste na quantificação e avaliação do agente químico em meios biológicos tais como o sangue, a urina ou o ar expirado. Podem ser quantificados o próprio agente químico, metabolitos ou agentes que resultam da interação dos agentes químicos com o organismo. A monitorização ambiental pode e deve ser complementada com a monitorização biológica para alguns dos agentes químicos. A implementação da monitorização biológica pode permitir melhorar as práticas de trabalho nas atividades de maior risco

Occupational Exposure to formaldehyde in pathology laboratories

Occupational exposure to formaldehyde by inhalation causes irritation of the mucous membranes of the eye and upper respiratory tract (nose and throat), leading to tingling, redness or burns to the nose and throat, nasal discharge and watery eyes. At concentrations below 1 ppm symptoms are usually negligible, but they become disturbing when concentrations exceed 2 to 3 ppm. According to IARC, continuous occupational exposure to formaldehyde causes cancer of the nasopharynx and leukemia. IARC classified formaldehyde in group 1 (carcinogenic to humans) in 2004. Formaldehyde is used worldwide, mainly in the production of resins and adhesives used in wood, paper, plastic and textile industry. It is also used in aqueous solutions as a disinfectant and preservative in embalming activities and pathology laboratories. Pathology laboratories receive organ, tissue, or cell specimens collected from humans to study their structural alterations and to serve as support in the diagnosis and prognosis. The main steps are the preparation of formaldehyde solutions, macroscopy, placing the samples in cassettes and microscopic observation. Supporting tasks, necessary to laboratory operation, are emptying and maintenance of the parts prepared, elimination of specimens, recycling or elimination of the waste formaldehyde solutions. Based on results obtained in routine exposure evaluations, formaldehyde concentrations in Portuguese pathology laboratories are not always negligible, so it is important to share them in order to raise awareness to the problem.N/

contributo para proposta de valores-limite biológicos

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Assessment of indoor air quality in elderly care centers, 2013-2014: GERIA project

O risco da população idosa desenvolver efeitos adversos em virtude da exposição a contaminantes químicos e microbiológicos do ar interior é mais elevado tanto pelo facto do seu sistema imunitário ser mais débil, como por este grupo etário permanecer no interior de edifícios por períodos mais longos. O objetivo deste estudo foi a caraterização da qualidade do ar interior numa amostra representativa de lares de idosos de modo a estudar a sua relação com a ventilação dos locais e a saúde/qualidade de vida dos utentes. O estudo apresentado incidiu sobre a avaliação da qualidade do ar interior em 18 lares de idosos situados em Lisboa (116 locais avaliados), em duas campanhas, uma no inverno e outra na primavera/verão e incluiu a avaliação de contaminação do ar por agentes químicos - dióxido de carbono (CO2 ), monóxido de carbono (CO), formaldeído (HCHO), compostos orgânicos voláteis totais (COVT), PM10 e PM2,5; por agentes microbiológicos – bactérias e fungos. Os resultados indicam que, de um modo geral a contaminação do ar por compostos orgânicos voláteis totais e formaldeído é baixa. Contudo, os valores de referência são excedidos para o dióxido de carbono, microrganismos e as partículas em 20%, 35% e 25-30% dos locais estudados respetivamente. Assim, há que identificar as fontes de contaminação do ar por partículas por forma e reduzir os efeitos adversos associados à exposição e melhorar a ventilação dos lares, particularmente no inverno, por forma a conseguir ambientes interiores mais saudáveis.Elderly people are at a greater risk for adverse health effects from exposure to indoor air pollutants because their immune system become less effective with age and they stay more than 80% of their time indoors. The aim of this study was to characterize indoor air quality in a representative sample of Elderly Care Centers (ECC) in order to associate it with ventilation, health and comfort. Indoor air quality was performed twice, during winter and summer/spring in 18 ECC located in Lisbon and included the monitoring of chemical agents - carbon dioxide, carbon monoxide, formaldehyde, Total Volatile Organic Compounds (TVOC) and Particulate matter (PM10 and PM2,5) and biological agents – bacteria and fungi. The results obtained for TVOC and formaldehyde indicate a low air contamination. However, reference concentrations of dioxide of carbon, particulate matter and microorganisms were exceeded in 20%, 25-30% and 35% of the rooms respectively. Consequently it is necessary to identify particulate matter contamination sources to reduce related adverse effects and to improve ventilation in ECC, particularly in the Winter, in order to achieve healthier indoor environments.Este projeto foi financiado pela Fundação para a Ciência e Tecnologia (FTC), PTDC/SAU-SAP/116563/2010

usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposure

Funding Information: This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means. Publisher Copyright: © 2022 The AuthorsOccupational exposures to hexavalent Chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful when more specific information on systemic and intracellular bioavailability is necessary. To this aim, concentrations of Cr in red blood cells (RBC-Cr) and in plasma (P–Cr) were analyzed in 345 Cr(VI) exposed workers and 175 controls to understand how these biomarkers may be affected by variable levels of exposure and job procedures. Compared to controls, significantly higher RBC-Cr levels were observed in bath plating and paint application workers, but not in welders, while all the 3 groups had significantly greater P–Cr concentrations. RBC-Cr and P–Cr in chrome platers showed a high correlation with Cr(VI) in inhalable dust, outside respiratory protective equipment (RPE), while such correlation could not be determined in welders. In platers, the use of RPE had a significant impact on the relationship between blood biomarkers and Cr(VI) in inhalable and respirable dust. Low correlations between P–Cr and RBC-Cr may reflect a difference in kinetics. This study showed that Cr-blood-based biomarkers can provide information on how workplace exposure translates into systemic availability of Cr(III) (extracellular, P–Cr) and Cr(VI) (intracellular, RBC-Cr). Further studies are needed to fully appreciate their use in an occupational health and safety context.publishersversionpublishe

HBM4EU chromates study - Usefulness of measurement of blood chromium levels in the assessment of occupational Cr(VI) exposure

Occupational exposures to hexavalent Chromium (Cr(VI)) can occur in welding, hot working stainless steel processing, chrome plating, spray painting and coating activities. Recently, within the human biomonitoring for Europe initiative (HBM4EU), a study was performed to assess the suitability of different biomarkers to assess the exposure to Cr(VI) in various job tasks. Blood-based biomarkers may prove useful when more specific information on systemic and intracellular bioavailability is necessary. To this aim, concentrations of Cr in red blood cells (RBC-Cr) and in plasma (P-Cr) were analyzed in 345 Cr(VI) exposed workers and 175 controls to understand how these biomarkers may be affected by variable levels of exposure and job procedures. Compared to controls, significantly higher RBC-Cr levels were observed in bath plating and paint application workers, but not in welders, while all the 3 groups had significantly greater P-Cr concentrations. RBC-Cr and P-Cr in chrome platers showed a high correlation with Cr(VI) in inhalable dust, outside respiratory protective equipment (RPE), while such correlation could not be determined in welders. In platers, the use of RPE had a significant impact on the relationship between blood biomarkers and Cr(VI) in inhalable and respirable dust. Low correlations between P-Cr and RBC-Cr may reflect a difference in kinetics. This study showed that Cr-blood-based biomarkers can provide information on how workplace exposure translates into systemic availability of Cr(III) (extracellular, P-Cr) and Cr(VI) (intracellular, RBC-Cr). Further studies are needed to fully appreciate their use in an occupational health and safety context.Highlights: - Suitability of blood biomarkers was evaluated to assess occupational Cr(VI)exposure; - Bath platers and painters had higher Red Blood Cells-Cr levels compared to controls; - Bath platers, painters and welders had higher plasma-Cr levels compared to controls; Red Blood Cells- and Plasma-Cr were highly correlated with inhalable Cr(VI) in platers; Blood-Cr biomarkers can provide information on systemic and intracellular availability.This work has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means.info:eu-repo/semantics/publishedVersio

HERA - Environmental Risk Assessment of a contaminated estuarine environment: a case study

Sado River estuary is located in the west coast of Portugal. Previous environmental studies identified industrial contamination, non-point anthropogenic sources and contamination coming from the river, all promoting accumulation of polluted sediments with known impacts on the ecological system. Surrounding human populations have intense economic fishery activities. Together with agriculture, estuary fishing products are available to local residents. Food usage previously characterized through ethnographic studies suggests exposure to estuarine products, farming products, and water in daily activities, as potential routes of contamination. It is well established that long term exposure to heavy metals are associated with renal and neurological diseases, most heavy metals are classified as carcinogenic and teratogenic.Instituição Financiadora: FCT; Instituições participantes: IMAR -Instituto do Mar (coord.)e PRÓ-INSA, Associação para a Promoção da Investigação em Saúde, Instituto Nacional de Saúde Doutor Ricardo Jorg

HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.This work has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 733032 and received co-funding from the author's organizations and/or Ministries. Luxembourg entered the study at a later stage and thus financed the study at its own means.S