3,546 research outputs found
Visual slant misperception and the Black-Hole landing situation
A theory which explains the tendency for dangerously low approaches during night landing situations is presented. The two dimensional information at the pilot's eye contains sufficient information for the visual system to extract the angle of slant of the runway relative to the approach path. The analysis is depends upon perspective information which is available at a certain distance out from the aimpoint, to either side of the runway edgelights. Under black hole landing conditions, however, this information is not available, and it is proposed that the visual system use instead the only available information, the perspective gradient of the runway edgelights. An equation is developed which predicts the perceived approach angle when this incorrect parameter is used. The predictions are in close agreement with existing experimental data
Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects
The advanced glycation end products (AGEs) are organic molecules formed in any living organisms with a great variety of structural and functional properties. They are considered organic markers of the glycation process. Due to their great heterogeneity, there is no specific test for their operational measurement. In this review, we have updated the most common chromatographic, colorimetric, spectroscopic, mass spectrometric, and serological methods, typically used for the determination of AGEs in biological samples. We have described their signaling and signal transduction mechanisms and cell epigenetic effects. Although mass spectrometric analysis is not widespread in the detection of AGEs at the clinical level, this technique is highly promising for the early diagnosis and therapeutics of diseases caused by AGEs. Protocols are available for high-resolution mass spectrometry of glycated proteins although they are characterized by complex machine management. Simpler procedures are available although much less precise than mass spectrometry. Among them, immunochemical tests are very common since they are able to detect AGEs in a simple and immediate way. In these years, new methodologies have been developed using an in vivo novel and noninvasive spectroscopic methods. These methods are based on the measurement of autofluorescence of AGEs. Another method consists of detecting AGEs in the human skin to detect chronic exposure, without the inconvenience of invasive methods. The aim of this review is to compare the different approaches of measuring AGEs at a clinical perspective due to their strict association with oxidative stress and inflammation
Fluorescence and Hybrid Detection Aperture of the Pierre Auger Observatory
The aperture of the Fluorescence Detector (FD) of the Pierre Auger
Observatory is evaluated from simulated events using different detector
configurations: mono, stereo, 3-FD and 4-FD. The trigger efficiency has been
modeled using shower profiles with ground impacts in the field of view of a
single telescope and studying the trigger response (at the different levels) by
that telescope and by its neighbours. In addition, analysis cuts imposed by
event reconstruction have been applied. The hybrid aperture is then derived for
the Auger final extension. Taking into account the actual Surface Detector (SD)
array configuration and its trigger response, the aperture is also calculated
for a typical configuration of the present phase.Comment: contribution to the 29th International Cosmic Ray Conference, Pune,
India, 3-10 August 200
Self-Organized Criticality model for Brain Plasticity
Networks of living neurons exhibit an avalanche mode of activity,
experimentally found in organotypic cultures. Here we present a model based on
self-organized criticality and taking into account brain plasticity, which is
able to reproduce the spectrum of electroencephalograms (EEG). The model
consists in an electrical network with threshold firing and activity-dependent
synapse strenghts. The system exhibits an avalanche activity power law
distributed. The analysis of the power spectra of the electrical signal
reproduces very robustly the power law behaviour with the exponent 0.8,
experimentally measured in EEG spectra. The same value of the exponent is found
on small-world lattices and for leaky neurons, indicating that universality
holds for a wide class of brain models.Comment: 4 pages, 3 figure
Collaboration between two COST actions. Ionosphere and space weather
In this paper, we describe the collaboration between two COST action: COST 724 devoted
to space weather and COST 296 devoted to the study of the ionosphere and its impact on communication
and positionning. Several colleagues work in the two actions. This resulted in an important input on
ionospheric models provided by the COST 296 action to COST 724
Undamped electrostatic plasma waves
Electrostatic waves in a collision-free unmagnetized plasma of electrons with
fixed ions are investigated for electron equilibrium velocity distribution
functions that deviate slightly from Maxwellian. Of interest are undamped waves
that are the small amplitude limit of nonlinear excitations, such as electron
acoustic waves (EAWs). A deviation consisting of a small plateau, a region with
zero velocity derivative over a width that is a very small fraction of the
electron thermal speed, is shown to give rise to new undamped modes, which here
are named {\it corner modes}. The presence of the plateau turns off Landau
damping and allows oscillations with phase speeds within the plateau. These
undamped waves are obtained in a wide region of the plane
( being the real part of the wave frequency and the
wavenumber), away from the well-known `thumb curve' for Langmuir waves and EAWs
based on the Maxwellian. Results of nonlinear Vlasov-Poisson simulations that
corroborate the existence of these modes are described. It is also shown that
deviations caused by fattening the tail of the distribution shift roots off of
the thumb curve toward lower -values and chopping the tail shifts them
toward higher -values. In addition, a rule of thumb is obtained for
assessing how the existence of a plateau shifts roots off of the thumb curve.
Suggestions are made for interpreting experimental observations of
electrostatic waves, such as recent ones in nonneutral plasmas.Comment: 11 pages, 10 figure
Análise histolĂłgica e imuno-histoquĂmica de neoplasias melanocĂticas cutâneas caninas
O artigo nĂŁo apresenta resumo
Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter. Folding of HIV-1 LTR G4s inhibits viral transcription; stabilization by G4 ligands intensifies this effect. Cellular proteins modulate viral transcription by inducing/unfolding LTR G4s. We here expanded our investigation on the presence of LTR G4s to all lentiviruses. G4s in the 5'-LTR U3 region were completely conserved in primate lentiviruses. A G4 was also present in a cattle-infecting lentivirus. All other non-primate lentiviruses displayed hints of less stable G4s. In primate lentiviruses, the possibility to fold into G4s was highly conserved among strains. LTR G4 sequences were very similar among phylogenetically related primate viruses, while they increasingly differed in viruses that diverged early from a common ancestor. A strong correlation between primate lentivirus LTR G4s and Sp1/NF\u3baB binding sites was found. All LTR G4s folded: their complexity was assessed by polymerase stop assay. Our data support a role of the lentiviruses 5'-LTR G4 region as control centre of viral transcription, where folding/unfolding of G4s and multiple recruitment of factors based on both sequence and structure may take place
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