153 research outputs found
The Black Ranger
In lieu of an abstract, below is the essay\u27s first paragraph.
The kid just doesn\u27t seem to understand that turning on a light switch won\u27t hurt him! Little Bobby used to love to run around the house playing swords with his older brother. Bobby and his brother used to take the cardboard cylinder tubes out of the paper towel rolls to bash each other on their heads. However, as Bobby\u27s older brother reached his adolescent years, Bobby was left to play alone, for Bobby\u27s older brother was no longer interested in Bobby\u27s level of play. But Bobby always loved playing with objects that could resemble a sword! A pencil, a twig, a butter knife
Symmetries, Cluster Synchronization, and Isolated Desynchronization in Complex Networks
Synchronization is of central importance in power distribution,
telecommunication, neuronal, and biological networks. Many networks are
observed to produce patterns of synchronized clusters, but it has been
difficult to predict these clusters or understand the conditions under which
they form, except for in the simplest of networks. In this article, we shed
light on the intimate connection between network symmetry and cluster
synchronization. We introduce general techniques that use network symmetries to
reveal the patterns of synchronized clusters and determine the conditions under
which they persist. The connection between symmetry and cluster synchronization
is experimentally explored using an electro-optic network. We experimentally
observe and theoretically predict a surprising phenomenon in which some
clusters lose synchrony while leaving others synchronized. The results could
guide the design of new power grid systems or lead to new understanding of the
dynamical behavior of networks ranging from neural to social
Complete Characterization of Stability of Cluster Synchronization in Complex Dynamical Networks
Synchronization is an important and prevalent phenomenon in natural and
engineered systems. In many dynamical networks, the coupling is balanced or
adjusted in order to admit global synchronization, a condition called Laplacian
coupling. Many networks exhibit incomplete synchronization, where two or more
clusters of synchronization persist, and computational group theory has
recently proved to be valuable in discovering these cluster states based upon
the topology of the network. In the important case of Laplacian coupling,
additional synchronization patterns can exist that would not be predicted from
the group theory analysis alone. The understanding of how and when clusters
form, merge, and persist is essential for understanding collective dynamics,
synchronization, and failure mechanisms of complex networks such as electric
power grids, distributed control networks, and autonomous swarming vehicles. We
describe here a method to find and analyze all of the possible cluster
synchronization patterns in a Laplacian-coupled network, by applying methods of
computational group theory to dynamically-equivalent networks. We present a
general technique to evaluate the stability of each of the dynamically valid
cluster synchronization patterns. Our results are validated in an electro-optic
experiment on a 5 node network that confirms the synchronization patterns
predicted by the theory.Comment: 6 figure
A Unified Approach to Attractor Reconstruction
In the analysis of complex, nonlinear time series, scientists in a variety of
disciplines have relied on a time delayed embedding of their data, i.e.
attractor reconstruction. The process has focused primarily on heuristic and
empirical arguments for selection of the key embedding parameters, delay and
embedding dimension. This approach has left several long-standing, but common
problems unresolved in which the standard approaches produce inferior results
or give no guidance at all. We view the current reconstruction process as
unnecessarily broken into separate problems. We propose an alternative approach
that views the problem of choosing all embedding parameters as being one and
the same problem addressable using a single statistical test formulated
directly from the reconstruction theorems. This allows for varying time delays
appropriate to the data and simultaneously helps decide on embedding dimension.
A second new statistic, undersampling, acts as a check against overly long time
delays and overly large embedding dimension. Our approach is more flexible than
those currently used, but is more directly connected with the mathematical
requirements of embedding. In addition, the statistics developed guide the user
by allowing optimization and warning when embedding parameters are chosen
beyond what the data can support. We demonstrate our approach on uni- and
multivariate data, data possessing multiple time scales, and chaotic data. This
unified approach resolves all the main issues in attractor reconstruction.Comment: 22 pages, revised version as submitted to CHAOS. Manuscript is
currently under review. 4 Figures, 31 reference
On the Mechanism of Time--Delayed Feedback Control
The Pyragas method for controlling chaos is investigated in detail from the
experimental as well as theoretical point of view. We show by an analytical
stability analysis that the revolution around an unstable periodic orbit
governs the success of the control scheme. Our predictions concerning the
transient behaviour of the control signal are confirmed by numerical
simulations and an electronic circuit experiment.Comment: 4 pages, REVTeX, 4 eps-figures included Phys. Rev. Lett., in press
also available at
http://athene.fkp.physik.th-darmstadt.de/public/wolfram.htm
Testing Whether Two Chaotic One Dimensional Processes Are Dynamically Identical
Consider the situation where two individuals observe the same chaotic physical process but through time series of different measured variables (e.g., one individual measures a temperature and the other measures a voltage). If the two individuals now use their data to reconstruct (e.g., via delay coordinates) a map, the maps they obtain may appear quite different. In the case where the resulting maps appear one dimensional, we introduce a method to test consistency with the hypothesis that they represent the same physical process. We illustrate this method using experimental data from an electric circuit
Some elements for a history of the dynamical systems theory
Leon Glass would like to thank the Natural Sciences and Engineering Research Council (Canada) for its continuous support of curiosity-driven research for over 40 years starting with the events recounted here. He also thanks his colleagues and collaborators including Stuart Kauffman, Rafael Perez, Ronald Shymko, Michael Mackey for their wonderful insights and collaborations during the times recounted here. R.G. is endebted to the following friends and colleagues, listed in the order encountered on the road described: F. T. Arecchi, L. M. Narducci, J. R. Tredicce, H. G. Solari, E. Eschenazi, G. B. Mindlin, J. L. Birman, J. S. Birman, P. Glorieux, M. Lefranc, C. Letellier, V. Messager, O. E. Rössler, R. Williams. U.P. would like to thank the following friends and colleagues who accompanied his first steps into the world of nonlinear phenomena: U. Dressler, I. Eick, V. Englisch, K. Geist, J. Holzfuss, T. Klinker, W. Knop, A. Kramer, T. Kurz, W. Lauterborn, W. Meyer-Ilse, C. Scheffczyk, E. Suchla and M. Wisenfeldt. The work by L. Pecora and T. Carroll was supported directly by the Office of Naval Research (ONR) and by ONR through the Naval Research Laboratoryâs Basic Research Program. C.L. would like to thank JĂŒrgen Kurths for his support to this project.Peer reviewedPostprintPublisher PD
LUMINOS-102: Lerapolturev with and without α-PD- 1 in unresectable α-PD- 1 refractory melanoma
Lerapolturev (lera, formerly PVSRIPO) is a novel poliovirus based intratumoral immunotherapy that infects both cancer cells and antigen-presenting cells (APCs) via CD155, the poliovirus receptor. Lera has direct anticancer effects while also generating type I/III interferon-dominated inflammation and anti-tumor T-cell priming and activation via infection of local APCs. LUMINOS-102 (NCT04577807) is a multi-center, open-label, two-arm randomized Phase 2 study investigating the efficacy and safety of lera ± α-PD- 1 in patients with unresectable melanoma who failed prior α-PD- 1 therapy. Cross-over to the α-PD- 1 arm is permitted after progression, PR for â„6 mo or 6 mo on treatment with SD. The maximum initial lera dose was 6x108 TCID50 /visit every 3 or 4 weeks (Q3/4 W). As of March 2022, the maximum lera dose was increased to 1.6 x 109 TCID50/visit, every week (QW) for 7 weeks (induction), followed by Q3/4 W dosing (maintenance). As of 20-Jun- 2022, 21 participants (10 male, 11 female, median 64 yrs) received lera (n = 14 at initial dose, Q3/4 W; n = 4 at increased dose, Q3/4 W; n = 3 at increased dose, QW) ± αPD-1. Five patients are currently on treatment. With the initial regimen, no objective responses and a CBR of 7% were observed. However, with the higher dose regimen, 1 complete response and a CBR of 71% (5/7) has been observed. Two of 4 participants with stable disease have evidence of response (1 with resolution of uninjected lung metastasis, 1 with decreased PET signal in injected and uninjected lesions receiving combination therapy). The only treatment related AE in \u3e1 pt was fatigue (19%, all grade 1 or 2). No dose-limiting toxicities or treatment-related SAEs were reported. Multiplex-IF analysis of on-treatment tumor biopsies will be presented. Lera ± αPD-1 is well tolerated, with early signs of efficacy at the higher dose level. Enrollment and randomization are ongoing
The Vehicle, Spring 2010
Table of Contents
ForgettingRashelle McNairpage 34
MuseMary Lieskepage 35
My CompulsionAshton Tembypage 38
MemoryKate Vandermeerpage 41
Killmercialize MeGreg Petersonpage 42
PenJake Smithpage 46
GrassKate Vandermeerpage 48
Character CreationMary Lieskepage 52
Ring Around TheKim Hunter-Perkinspage 54
The Great Cursive ScareJake Smithpage 55
OpiateDoug Urbanskipage 61
What Happens to Little Girls...Jennifer O\u27Neilpage 63
Poetry
Sunny DaysRyan Poolpage 2
AtlantisDoug Urbanskipage 4
Garbage CityKate Vandermeerpage 6
Fat Girl ThongsKim Hunter-Perkinspage 7
MercilessRosalia Pecorapage 19
ChemistryMary Lieskepage 20
He-Who-Stopped-TalkingJustin Sudkamppage 22
In Which Iris Contemplates a Barren EarthSean Slatterypage 24
At the Bottom of the WorldNick Canadaypage 27
Dogma: Mush!Scott Maypage 28
ThiefMary Lieskepage 29
Prose
Coming HomeDoug Urbanskipage 8
DodoDan Davispage 31
The Poet in the PedestrianScott Maypage 37
Toxic RainJacob Swansonpage 40
What\u27s Your Greatest Fear?Justine Fittonpage 43
Soul VoiceHolly Thomaspage 49
Conversations with a SniperKim Hunter-Perkinspage 56
LettersDaniel Paquinpage 65
Art
San Marcos, MexicoKate Vandermeercover
Contemplation of the World\u27s EndNicholas Giffordpage 18
Little Lady SitsSarah Hadwigerpage 26
MoodAlycia Rockeypage 30
Four Ducks in a RowMegan Mathypage 36
The Daily EasternBen Tillerypage 39
BirdsAlycia Rockeypage 45
March of the BugsMegan Mathypage 47
Mexico Work ExperienceKate Vandermeerpage 53
Feather and JewelsAlycia Rockeypage 60
The ForgottenMegan Mathypage 64
Special Features
Fall 2009-Spring 2010 Vehicle Award Winnerspage 1
James K. Johnson Creative Writing Awardpage 74
Kim Hunter-PerkinsWinning Entries (Poetry)page 75
Clint WalkerWinning Entry (Fiction)page 86
Faculty Spotlight: Professor Jason Brownpage 99
About the Contributorspage 106
About the Editorspage 110https://thekeep.eiu.edu/vehicle/1093/thumbnail.jp
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