ANALISIS UPAYA SEKOLAH UNTUK PENGAMALAN PROFIL PELAJAR PANCASILA "FOKUS RELIGIUS" DI KELAS 4 SD MUHAMMADIYAH 4 BATU

Based on the results of observations on February 9 2023 at SD Muhammadiyah 4 Batu, is a school that has implemented an independent curriculum program by making religious moral character education one of the programs implemented in the school. This research aims to (1). Describe the school's readiness in implementing the Pancasila student profile. Elements of religious morals in Class 4 of Muhammadiyah 4 Batu Elementary School (2). Describe the school's obstacles in implementing the Pancasila student profile. Elements of religious morals at Muhammadiyah 4 Batu Elementary School (3). This research uses qualitative research methods with an ethnographic approach. The school principal, deputy head of student affairs and class 4 teacher were chosen as data sources. Data collection methods in this research were observation, interviews and documentation. From the results of research that has been carried out by the school in an effort to implement the profile of Pancasila students (religious focus) in class 4 at Muhammadiyah 4 Batu Elementary School, it has been good by implementing several activities including the habit of reading short surahs before entering class, implementing obligatory prayers and sunnah at school, cultivating noble qualities. . Even though there are still obstacles in its implementation, the author appreciates this activity. The distribution of breakfast after morning prayers in congregation was good and conducive, but the researchers found that there were several students who did not finish their food, therefore the researchers felt the need for additional education for students regarding the prohibition of throwing away food (wasteful)

Двигательная активность студентов

В статье рассмотрены теоретические аспекты двигательной активности студентов, возможности увеличения ее объема. The article considers theoretical aspects of physical activity of students, the possibility of increasing its volume

Polarity-dependent reversible resistance switching in Ge–Sb–Te phase-change thin films

In this paper, we demonstrate reversible resistance switching in a capacitorlike cell using a Ge–Sb–Te film that does not rely on amorphous-crystalline phase change. The polarity of the applied electric field switches the cell resistance between lower- and higher-resistance states, as was observed in current-voltage characteristics. Moreover, voltage pulses less than 1.25 V showed this switching within time scales of microseconds with more than 40% contrast between the resistance states. The latter are found to be nonvolatile for months. The switching could also be achieved at nanoscales with atomic force microscopy with a better resistance contrast of three orders of magnitude.

Role of the Fas/FasL pathway in HIV or SIV disease

Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Both depletion in immune cell numbers as well as defects in their effector functions are responsible for this immunodeficiency The broad impact of HIV reflects a similarly broad pattern of cell depletion including subsets that do not express viral receptors or support viral replication. Indirect cell killing, the destruction of uninfected cells, is due partly to activation of the Fas/FasL system for cell death. This death-signaling pathway is induced during HIV disease and contributes significantly to viral pathogenesis and disease

Repertoire Development and the Control of Cytotoxic/Effector Function in Human γδ T Cells

T cells develop into two major populations distinguished by their T cell receptor (TCR) chains. Cells with the αβ TCR generally express CD4 or CD8 lineage markers and mostly fall into helper or cytotoxic/effector subsets. Cells expressing the alternate γδ TCR in humans generally do not express lineage markers, do not require MHC for antigen presentation, and recognize nonpeptidic antigens. We are interested in the dominant Vγ2Vδ2+ T cell subset in human peripheral blood and the control of effector function in this population. We review the literature on γδ T cell generation and repertoire selection, along with recent work on CD56 expression and defining a cytotoxic/effector lineage within the phosphoantigen-reactive Vγ2Vδ2 cells. A unique mechanism for MHC-independent repertoire selection is linked to the control of effector function that is vital to the role for γδ T cells in tumor surveillance. Better understanding of these mechanisms will improve our ability to exploit this population for tumor immunotherapy

Sensitization and translocation of TRPV1 by insulin and IGF-I

Insulin and insulin-like growth factors (IGFs) maintain vital neuronal functions. Absolute or functional deficiencies of insulin or IGF-I may contribute to neuronal and vascular complications associated with diabetes. Vanilloid receptor 1 (also called TRPV1) is an ion channel that mediates inflammatory thermal nociception and is present on sensory neurons. Here we demonstrate that both insulin and IGF-I enhance TRPV1-mediated membrane currents in heterologous expression systems and cultured dorsal root ganglion neurons. Enhancement of membrane current results from both increased sensitivity of the receptor and translocation of TRPV1 from cytosol to plasma membrane. Receptor tyrosine kinases trigger a signaling cascade leading to activation of phosphatidylinositol 3-kinase (PI(3)K) and protein kinase C (PKC)-mediated phosphorylation of TRPV1, which is found to be essential for the potentiation. These findings establish a link between the insulin family of trophic factors and vanilloid receptors

Ultra high density scanning electrical probe phase-change memory for archival storage

The potential for using probe-based phase-change memories for the future archival storage at densities of around 1 Tbit/in.² is investigated using a recording medium comprising a Si/TiN/DLC/GeSbTe/diamond-like carbon (DLC) stack together with a conductive PtSi tip for writing and reading. Both experimental and computational simulation results are presented. The simulations include a physically-realistic threshold switching model, as well as the effects of thermal boundary resistance and electrical contact resistance. The simulated bit size and shape correspond closely to that written experimentally

Ultra-high density scanning electrical probe phase-change memory for archival storage.

In our work, we investigate the recording and readout performance of such phase-change memories and demonstrate experimental and simulation results which are based on a particular medium stack (Si/TiN/DLC/GST/DLC). The recording is achieved by injecting electrical current from a conductive tip to the storage medium to cause phase transformation through Joule heating, while readout is realised by sensing the current variation due to the significant differences in the electrical resistivity between the amorphous and crystalline phases. The experimental results clearly show that a crystalline bit with approximately 30nm diameter can be produced and readback, in good agreement with the corresponding simulations of the write/read processes

Complexity of the frog intracardiac neurons. Intracellular injection study

The goal of this study was to determine the structure of intracardiac neurons in the frog Rana temporaria. Fifty-six intracardiac neurons from 8 animals were labelled ionophoretically by the intracellular markers AlexaFluor 586 and Lucifer Yellow CH. Among the labelled neurons, we found the cells of unipolar, bipolar, multipolar and pseudounipolar types. Multiple neuronal processes originated from the soma, the axon hillock and the initial segment of axon. With respect to the soma, the neuron contained (Mean ± SE) 3.5 ± 0.3 long and 5.5 ± 0.6 short processes. Most neurons had the spine, the bubble or the flake like extensions on their soma surface and were classified as Golgi I typeneurons. Few Golgi II type neurons, the presumptive interneurons, were also found. Our findings contradict to a general view that the frog intracardiac ganglia contain only the adendritic neurons of the unipolar type. Our findings demonstrate that the frog intracardiac neurons are structurally complex and diverse. This diversity may account for the complicated integrative functions of the frog intrinsic cardiac ganglia