Manual control of unstable systems

Under certain operational regimes and failure modes, air and ground vehicles can present the human operator with a dynamically unstable or divergent control task. Research conducted over the last two decades has explored the ability of the human operator to control unstable systems under a variety of circumstances. Past research is reviewed and human operator control capabilities are summarized. A current example of automobile directional control under rear brake lockup conditions is also reviewed. A control system model analysis of the driver's steering control task is summarized, based on a generic driver/vehicle model presented at last year's Annual Manual. Results from closed course braking tests are presented that confirm the difficulty the average driver has in controlling the unstable directional dynamics arising from rear wheel lockup

Overhead Guide Sign Visibility Factors, Volume I: Final Report

DTFH61-83-C-00151The project discussed in this report concerned the night use of overhead guide signs, including button and reflectorized copy and all practical combinations of reflectorized and opaque backgrounds. This project was a follow-up effort to the literature review by Gordon. Gordon's review found areas requiring further investigation, including the comparison of nonilluminated-nonretroreflectorized signs with both illuminated-nonretroreflectorized and retroreflectorized signs. The current project included the investigation of current signing practices throughout the country, development of a set of in-use luminance values for current overhead guide sign materials, development of life cycle costs for current signing materials and practices, and determination of driver response characteristics for these overhead guide sign systems. These goals were met through review of the literature, field testing, and static and dynamic laboratory testing. While the results of the tests are presented, no attempt has been made to draw conclusions from these data

Porphyromonas gingivalis Participates in Pathogenesis of Human Abdominal Aortic Aneurysm by Neutrophil Activation. Proof of Concept in Rats

International audienceBACKGROUND: Abdominal Aortic Aneurysms (AAAs) represent a particular form of atherothrombosis where neutrophil proteolytic activity plays a major role. We postulated that neutrophil recruitment and activation participating in AAA growth may originate in part from repeated episodes of periodontal bacteremia. METHODS AND FINDINGS: Our results show that neutrophil activation in human AAA was associated with Neutrophil Extracellular Trap (NET) formation in the IntraLuminal Thrombus, leading to the release of cell-free DNA. Human AAA samples were shown to contain bacterial DNA with high frequency (11/16), and in particular that of Porphyromonas gingivalis (Pg), the most prevalent pathogen involved in chronic periodontitis, a common form of periodontal disease. Both DNA reflecting the presence of NETs and antibodies to Pg were found to be increased in plasma of patients with AAA. Using a rat model of AAA, we demonstrated that repeated injection of Pg fostered aneurysm development, associated with pathological characteristics similar to those observed in humans, such as the persistence of a neutrophil-rich luminal thrombus, not observed in saline-injected rats in which a healing process was observed. CONCLUSIONS: Thus, the control of periodontal disease may represent a therapeutic target to limit human AAA progression