Efficacy of Elaborated Semantic Features Analysis in Aphasia: a quasi-randomised controlled trial

Background: Word finding difficulty is one of the most common features of aphasia. Semantic Features Analysis (SFA) directly aims to improve word finding in people with aphasia. Evidence from systematic reviews suggests that SFA leads to positive outcomes, yet the evidence comprises single case studies and case series. There is a need to evaluate the efficacy of SFA in controlled group studies/trials. Aims: To evaluate the efficacy of Elaborated Semantic Feature Analysis (ESFA) for word finding in people with aphasia. We investigated: (a) the efficacy of ESFA versus a delayed therapy/control, (b) the efficacy of two therapy approaches– individual versus a combination of individual and group therapy. Methods and procedures: We ran a multi-centre, quasi-randomised controlled trial, nested in a larger study (Thales-Aphasia). Participants were recruited from community settings. They had to be people with aphasia due to stroke at least four months post-onset. Participants were randomized to individual vs combination vs delayed therapy/control groups. Both therapy groups had three hours of ESFA per week for 12 weeks. Delayed therapy/control group had no intervention for 12 weeks and were then randomized to either individual or combination therapy. The primary outcome was confrontation naming. Secondary outcomes were the Boston Naming Test, Discourse, the Functional Assessment of Communication Skills for adults (ASHA–FACS), the Stroke and Aphasia Quality of Life scale (SAQOL-39g), the General Health Questionnaire-12 item, and the EQ-5D. Outcomes and Results: Of the 72 participants of the Thales-Aphasia project, 58 met eligibility criteria for speech-language therapy and 39 were allocated to ESFA. The critical p-value was adjusted for multiple comparisons (.005). For the therapy versus control comparison, there was a significant main effect of time on the primary outcome (p<.001, η2p=.42) and a significant interaction effect (p=.003, η2p=.21). An interaction effect for the SAQOL-39g (p=.015, η2p=.11) and its psychosocial domain (p=.013, η2p=.12) did not remain significant after Bonferroni adjustment. For the individual versus combination ESFA comparison, there were significant main effects of time on the primary outcome (p<.001, η2p=.49), the BNT (p<.001, η2p=.29) and the ASHA-FACS (p=.001, η2p=.18). Interaction and group effects were not significant. Conclusion: Though underpowered, this study provides evidence on the efficacy of ESFA to improve word finding in aphasia, with gains similar in the two therapy approaches. Trial registration: ISRCTN71455409, https://doi.org/10.1186/ISRCTN7145540

Optimization of Patterned Surfaces for Improved Superhydrophobicity Through Cost-Effective Large-Scale Computations

The growing need for creating surfaces with specific wetting properties, such as superhyrdophobic behavior, asks for novel methods for their efficient design. In this work, a fast computational method for the evaluation of patterned superhyrdophobic surfaces is introduced. The hydrophobicity of a surface is quantified in energy terms through an objective function. The increased computational cost led to the parallelization of the method with the Message Passing Interface (MPI) communication protocol that enables calculations on distributed memory systems allowing for parametric investigations at acceptable time frames. The method is demonstrated for a surface consisting of an array of pillars with inverted conical (frustum) geometry. The parallel speedup achieved allows for low cost parametric investigations on the effect of the fine features (curvature and slopes) of the pillars on the superhydophobicity of the surface and consequently for the optimization of superhyrdophobic surfaces.Comment: 18 pages, 18 figure

Microstructure Clustering in Multiphase Materials: The role of dimensionless temperature and surface fraction

The significant development and intensified use of composite materials (reinforced plastics, extruded materials and mechanically blended thermoplastics) over the last 30 years has provided the impetus for intense research on their processability as well as on the durability and properties of the final products. In disperse multiphase systems, the dispersion/distribution of particles (microstructure) is regarded as a key factor, both affected by processing and in its turn determining performance

A digital platform for the design of patient-centric supply chains

Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a unique therapeutic to manufacture and distribute. In this work, we focus on the development of a computer modelling tool to assist the design and assessment of supply chain structures that can reliably and cost-efficiently deliver autologous CAR T cell therapies. We focus on four demand scales (200, 500, 1000 and 2000 patients annually) and we assess the tool’s capabilities with respect to the design of responsive supply chain candidate solutions while minimising cost

Isokinetic Evaluation of the Elbow Joint at 45° and 80° of Shoulder Abduction

Since Hislop and Thistle published the first reports on isokinetic exercise, a lot of progress has been made towards the use of isokinetic exercise and isokinetic evaluation of muscle and joint performance in sports and orthopedic physical therapy. Cybex II+ with the Cybex Data Reduction Computer is one of the most widely used isokinetic systems for research and rehabilitation purposes. There are more than 500 published works describing the use of Cybex in various applications, Many investigations have used the Cybex isokinetic system to develop normative data on torque and work measurements of various muscle groups. Normative data are valuable to clinicians in the evaluation of the severity of an injury in terms of muscle performance deficits. In addition, such data provide physical therapists with objective data in setting rehabilitation goals, and enabling sports medicine experts to identify functional deficiencies during screening of athletes. There is a limited number of published works that have developed normative data for elbow flexor and extensor muscle groups. While there is some information about peak torque and agonist-antagonist ratios, minimal information is available about torque acceleration energy, work endurance ratios, average power and flexion-extension total work ratios. The purpose of this study was to examine the effects of 450 and 800 of shoulder abduction on torque and work measurements of the elbow joint. In addition, normative data for elbow flexion and extension at both arm positions (testing positions suggested by Cybex) were developed

Propagation of acoustic-gravity waves in inhomogeneous ocean environment based on modal expansions and HP-FEM

A coupled mode model is presented for the propagation of acoustic-gravity waves in layered ocean waveguides. The analysis extends previous work for acoustic waves in inhomogeneous environment. The coupled mode system is derived by means of a variational principle in conjunction with local mode series expansion, obtained by utilizing eigenfunction systems defined in the vertical section. These are obtained through the solution of vertical eigenvalue problems formulated along the waveguide. A crucial factor is the inclusion of additional modes accounting for the effects of spatialy varying boundaries and interfaces. This enhancement provides an implicit summation for the slowly convergent part of the localmode series, rendering the series rapidly convergent, increasing substantialy the efficiency of the method. Particular aspects of the method include high order Lagrange Finite Element Methods for the solution of local vertical eigenvalue problems in the case of multilayered waveguides, and Gauss-type quadrature for the computation of the coupled-mode system coefficients. The above aspects make the present method quite efficient for long range propagation in extended waveguides, such as the ones found in geophysical applications, e.g. ocean basins, as only few modes are needed for the accurate representation of the wave field

Hydroelastic analysis of ice shelves under long wave excitation

Abstract. The transient hydroelastic response of an ice shelf under long wave excitation is analysed by means of the finite element method. The simple model, presented in this work, is used for the simulation of the generated kinematic and stress fields in an ice shelf, when the latter interacts with a tsunami wave. The ice shelf, being of large length compared to its thickness, is modelled as an elastic Euler-Bernoulli beam, constrained at the grounding line. The hydrodynamic field is represented by the linearised shallow water equations. The numerical solution is based on the development of a special hydroelastic finite element for the system of governing of equations. Motivated by the 2011 Sulzberger Ice Shelf (SIS) calving event and its correlation with the Honshu Tsunami, the SIS stable configuration is studied. The extreme values of the bending moment distribution in both space and time are examined. Finally, the location of these extrema is investigated for different values of ice shelf thickness and tsunami wave length