Impaired immunogenicity to COVID-19 vaccines in autoimmune systemic diseases. High prevalence of non-response in different patients’ subgroups

Autoimmune systemic diseases (ASD) may show impaired immunogenicity to COVID-19 vaccines. Our prospective observational multicenter study aimed to evaluate the seroconversion after the vaccination cycle and at 6-12-month follow-up, as well the safety and efficacy of vaccines in preventing COVID-19. The study included 478 unselected ASD patients (mean age 59 ± 15 years), namely 101 rheumatoid arthritis (RA), 38 systemic lupus erythematosus (SLE), 265 systemic sclerosis (SSc), 61 cryoglobulinemic vasculitis (CV), and a miscellanea of 13 systemic vasculitis. The control group included 502 individuals from the general population (mean age 59 ± 14SD years). The immunogenicity of mRNA COVID-19 vaccines (BNT162b2 and mRNA-1273) was evaluated by measuring serum IgG-neutralizing antibody (NAb) (SARS-CoV-2 IgG II Quant antibody test kit; Abbott Laboratories, Chicago, IL) on samples obtained within 3 weeks after vaccination cycle. The short-term results of our prospective study revealed significantly lower NAb levels in ASD series compared to controls [286 (53–1203) vs 825 (451–1542) BAU/mL, p < 0.0001], as well as between single ASD subgroups and controls. More interestingly, higher percentage of non-responders to vaccine was recorded in ASD patients compared to controls [13.2% (63/478), vs 2.8% (14/502); p < 0.0001]. Increased prevalence of non-response to vaccine was also observed in different ASD subgroups, in patients with ASD-related interstitial lung disease (p = 0.009), and in those treated with glucocorticoids (p = 0.002), mycophenolate-mofetil (p < 0.0001), or rituximab (p < 0.0001). Comparable percentages of vaccine-related adverse effects were recorded among responder and non-responder ASD patients. Patients with weak/absent seroconversion, believed to be immune to SARS-CoV-2 infection, are at high risk to develop COVID-19. Early determination of serum NAb after vaccination cycle may allow to identify three main groups of ASD patients: responders, subjects with suboptimal response, non-responders. Patients with suboptimal response should be prioritized for a booster-dose of vaccine, while a different type of vaccine could be administered to non-responder individuals

POS1246 COVID-19 IN ITALIAN PATIENTS WITH RHEUMATIC AUTOIMMUNE SYSTEMIC DISEASES: RESULTS OF A NATIONWIDE SURVEY STUDY

Background: SARS-CoV-2 infection poses a serious challenge for patients with rheumatic autoimmune systemic diseases (ASD), characterized by marked immune-system dysregulation and frequent visceral organ involvement. Objectives: To evaluate the impact of Covid-19 pandemic in a large series of Italian patients with ASD. Methods: Our multicenter telephone survey (8-week period, March-April 2020) included a large series of 2,994 patients (584 M, 2,410 F, mean age 58.9±13.4SD years) with ASD followed at 34 tertiary referral centers of 14 regions of northern, central, and southern Italian macro areas, characterized by different prevalence of SARS-CoV-2 infection. According to currently used criteria, Covid-19 was classified as definite Covid-19 (signs or symptoms of Covid-19 confirmed by positive oral/nasopharyngeal swabs at PCR testing) or highly suspected Covid-19 (signs or symptoms highly

Delivering a Timely and Just Energy Transition: Which Policy Research Priorities?

In recent years, the concept of“energy justice”has attracted much attention andresearch effort. Although all policy issues related to energy justice are worthy of furtherstudy, the time constraints posed by the looming threat of climate change suggests theneed for coordinated policy research efforts. At the current stage of development ofEuropean societies, we consider that four policy research strands might be most impor-tant in the light of specific evolving trendsof European energy systems. Therefore, wepropose these priorities as a shared researchagenda for academic and policy researchers.In this article, we develop and discuss thefollowing four research priority strands:(a) intergenerational justice and energy justice, (b) justice and energy vulnerability,(c) transformation of the social imaginary and energy infrastructure, and (d) damage, com-pensation, and energy infrastructure. For each topic, we highlight their critical issues andresearch opportunities. We conclude that these priorities are necessary not only to accel-erate the energy transition but also to avoid negative impacts that climate change andthe transition phase could produce on already established patterns of inequality

Suspected venous air embolism in three horses

Venous air embolism was suspected in 3 hospitalised horses on the basis of an inadvertently open jugular venous line. Subsequently the 3 horses developed clinical signs including cardiovascular collapse, cardiac dysrhythmia, pulmonary oedema, behavioural abnormalities and neurological signs consistent with central nervous system injury. Treatment included intranasal oxygen therapy, i.v. fluid administration and anti-inflammatory therapy. Specific therapy aimed at treating air embolism in man is reviewed, with pertinent therapy potentially applicable to horses emphasised

Developing a Theoretical Framework to Explain the Social Acceptability of Wind Energy

The social acceptability of wind farms has been researched for several decades now, with the first research tracing back to the 1980s. This paper aims to deliver a literature review within the structural framework proposed by the paper of variables influencing the acceptability of wind farms. The large amount of research published on the social acceptability of wind farms requires an effort to identify and categorise variables to deliver a holistic understanding of opposition and support to wind energy. We classify the variables into three main categories: first, ‘psychological variables’, including perceived benefits and costs, emotions, and attitudes; second, ‘contextual variables’, including community energy schemes and media influence; and finally, third, ‘personal resources’, including income or wealth, place of residence, and relevant knowledge in relation to the wind farm. In agreement with other scholars, we argue that NIMBYism (not in my backyard) is an outdated and simplistic explanation for opposition to wind farms. Instead, we provide a theoretical framework to explain the acceptability of wind energy and show how these variables might influence both acceptance and opposition