899 research outputs found
Melt block copolymerization of ε-caprolactone and L-lactide
AB block copolymers of ε-caprolactone and (L)-lactide could be prepared by ring-opening polymerization in the melt at 110°C using stannous octoate as a catalyst and ethanol as an initiator provided ε-caprolactone was polymerized first. Ethanol initiated the polymerization of ε-caprolactone producing a polymer with ε-caprolactone derived hydroxyl end groups which after addition of L-lactide in the second step of the polymerization initiated the ring-opening copolymerization of L-lactide. The number-average molecular weights of the poly(ε-caprolactone) blocks varied from 1.5 to 5.2 × 103, while those of the poly(L-lactide) blocks ranged from 17.4 to 49.7 × 103. The polydispersities of the block copolymers varied from 1.16 to 1.27. The number-average molecular weights of the polymers were controlled by the monomer/hydroxyl group ratio, and were independent on the monomer/stannous octoate ratio within the range of experimental conditions studied. When L-lactide was polymerized first, followed by copolymerization of ε-caprolactone, random copolymers were obtained. The formation of random copolymers was attributed to the occurrence of transesterification reactions. These side reactions were caused by the ε-caprolactone derived hydroxyl end groups generated during the copolymerization of ε-caprolactone with pre-polymers of L-lactide. The polymerization proceeds through an ester alcoholysis reaction mechanism, in which the stannous octoate activated ester groups of the monomers react with hydroxyl groups
Laser-induced periodic surface structures:Fingerprints of light localization
The finite-difference time-domain (FDTD) method is used to study the inhomogeneous absorption of linearly polarized laser radiation below a rough surface. The results are first analyzed in the frequency domain and compared to the efficacy factor theory of Sipe and coworkers. Both approaches show that the absorbed energy shows a periodic nature, not only in the direction orthogonal to the laser polarization, but also in the direction parallel to it. It is shown that the periodicity is not always close to the laser wavelength for the perpendicular direction. In the parallel direction, the periodicity is about lambda/Re((n) over tilde), with (n) over tilde being the complex refractive index of the medium. The space-domain FDTD results show a periodicity in the inhomogeneous energy absorption similar to the periodicity of the low-and high-spatial-frequency laser-induced periodic surface structures depending on the material's excitation
Parity transitions in the superconducting ground state of hybrid InSb-Al Coulomb islands
The number of electrons in small metallic or semiconducting islands is
quantized. When tunnelling is enabled via opaque barriers this number can
change by an integer. In superconductors the addition is in units of two
electron charges (2e), reflecting that the Cooper pair condensate must have an
even parity. This ground state (GS) is foundational for all superconducting
qubit devices. Here, we study a hybrid superconducting-semiconducting island
and find three typical GS evolutions in a parallel magnetic field: a robust
2e-periodic even-parity GS, a transition to a 2e-periodic odd-parity GS,and a
transition from a 2e- to a 1e-periodic GS. The 2e-periodic odd-parity GS
persistent in gate-voltage occurs when a spin-resolved subgap state crosses
zero energy. For our 1e-periodic GSs we explicitly show the origin being a
single zero-energy state gapped from the continuum, i.e. compatible with an
Andreev bound states stabilized at zero energy or the presence of Majorana zero
modes
Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on Platelet Activating Factor and Eicosanoid Production By nasal Mucosa in Patients with A house Dust Mite Allergy
The relationship between the release of platelet activating factor
(PAF), leukotriene C4/D4/EE
(LTC4/D4/E4) and prostaglandin D2 (PGD2)
from nasal mucosa in vivo was examined in 24 rhinitis patients
allergic to the house dust mite (HDM). During a double blind placebo
controlled cross-over study 200 μg fluticasone propionate aqueous
nasal spray (FPANS) was administered twice daily for two weeks. In
response to allergen provocation (100, 1 000, 10 000 Bu/ml) and
during the 9.5 h after this challenge the nasal fluid was obtained
by washing the nose with saline and the levels of PAF, LTC4/D4/E4 and
PGD2, as indicators of mediator release, were measured at the
following time-points: baseline (t = − 1/2), allergen provocation with
10 000 Bu/ml (t = 0), 3.5 and 7.5 h (late phase). After allergen
provocation the levels of the mediators increased in the nasal
fluids of placebo treated patients (x-fold increase to baseline:
PAF, 15; LTC4/D4/E4, 12; PGD2, 1.5). In fluids of patients treated
with FPANS these levels tended to decrease. At the time of
provocation the levels of PAF, LTC4/D4/E4 and PGD2 showed a significant
correlation. The results indicate that these mediators can be used
as markers of allergic reactions against house dust mites and that
fluticasone propionate aqueous nasal spray tended to reduce the
release of mediators of inflammation correlated with beneficial
effects on clinical symptoms in this type of allergic reactions
Neural correlates of object identity and reward outcome in the sensory cortical-hippocampal hierarchy:coding of motivational information in perirhinal cortex
Neural circuits support behavioral adaptations by integrating sensory and motor information with reward and error-driven learning signals, but it remains poorly understood how these signals are distributed across different levels of the corticohippocampal hierarchy. We trained rats on a multisensory object-recognition task and compared visual and tactile responses of simultaneously recorded neuronal ensembles in somatosensory cortex, secondary visual cortex, perirhinal cortex, and hippocampus. The sensory regions primarily represented unisensory information, whereas hippocampus was modulated by both vision and touch. Surprisingly, the sensory cortices and the hippocampus coded object-specific information, whereas the perirhinal cortex did not. Instead, perirhinal cortical neurons signaled trial outcome upon reward-based feedback. A majority of outcome-related perirhinal cells responded to a negative outcome (reward omission), whereas a minority of other cells coded positive outcome (reward delivery). Our results highlight a distributed neural coding of multisensory variables in the cortico-hippocampal hierarchy. Notably, the perirhinal cortex emerges as a crucial region for conveying motivational outcomes, whereas distinct functions related to object identity are observed in the sensory cortices and hippocampus
Are language production problems apparent in adults who no longer meet diagnostic criteria for attention-deficit/hyperactivity disorder?
In this study, we examined sentence production in a sample of adults (N = 21) who had had attention-deficit/hyperactivity disorder (ADHD) as children, but as adults no longer met DSM-IV diagnostic criteria (APA, 2000). This “remitted” group was assessed on a sentence production task. On each trial, participants saw two objects and a verb. Their task was to construct a sentence using the objects as arguments of the verb. Results showed more ungrammatical and disfluent utterances with one particular type of verb (i.e., participle). In a second set of analyses, we compared the remitted group to both control participants and a “persistent” group, who had ADHD as children and as adults. Results showed that remitters were more likely to produce ungrammatical utterances and to make repair disfluencies compared to controls, and they patterned more similarly to ADHD participants. Conclusions focus on language output in remitted ADHD, and the role of executive functions in language production
Quantized Majorana conductance
Majorana zero-modes hold great promise for topological quantum computing.
Tunnelling spectroscopy in electrical transport is the primary tool to identify
the presence of Majorana zero-modes, for instance as a zero-bias peak (ZBP) in
differential-conductance. The Majorana ZBP-height is predicted to be quantized
at the universal conductance value of 2e2/h at zero temperature. Interestingly,
this quantization is a direct consequence of the famous Majorana symmetry,
'particle equals antiparticle'. The Majorana symmetry protects the quantization
against disorder, interactions, and variations in the tunnel coupling. Previous
experiments, however, have shown ZBPs much smaller than 2e2/h, with a recent
observation of a peak-height close to 2e2/h. Here, we report a quantized
conductance plateau at 2e2/h in the zero-bias conductance measured in InSb
semiconductor nanowires covered with an Al superconducting shell. Our
ZBP-height remains constant despite changing parameters such as the magnetic
field and tunnel coupling, i.e. a quantized conductance plateau. We distinguish
this quantized Majorana peak from possible non-Majorana origins, by
investigating its robustness on electric and magnetic fields as well as its
temperature dependence. The observation of a quantized conductance plateau
strongly supports the existence of non-Abelian Majorana zero-modes in the
system, consequently paving the way for future braiding experiments.Comment: 5 figure
Electric field tunable superconductor-semiconductor coupling in Majorana nanowires
We study the effect of external electric fields on
superconductor-semiconductor coupling by measuring the electron transport in
InSb semiconductor nanowires coupled to an epitaxially grown Al superconductor.
We find that the gate voltage induced electric fields can greatly modify the
coupling strength, which has consequences for the proximity induced
superconducting gap, effective g-factor, and spin-orbit coupling, which all
play a key role in understanding Majorana physics. We further show that level
repulsion due to spin-orbit coupling in a finite size system can lead to
seemingly stable zero bias conductance peaks, which mimic the behavior of
Majorana zero modes. Our results improve the understanding of realistic
Majorana nanowire systems.Comment: 10 pages, 5 figures, supplemental information as ancillary fil
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