2,031 research outputs found
The substellar population of the young cluster lambda Orionis
By collecting optical and infrared photometry and low resolution
spectroscopy, we have identified a large number of low mass stars and brown
dwarf candidates belonging to the young cluster (~5 Myr) associated with the
binary star lambda Orionis. The lowest mass object found is a M8.5 with an
estimated mass of 0.02 Msun (~0.01 Msun for objects without spectroscopic
confirmation).
For those objects with spectroscopy, the measured strength of the Halpha
emission line follows a distribution similar to other clusters with the same
age range, with larger equivalent widths for cooler spectral types. Three of
the brown dwarfs have Halpha emission equivalent widths of order 100 \AA,
suggestive that they may have accretion disks and thus are the substellar
equivalent of Classical T Tauri stars. We have derived the Initial Mass
Function for the cluster. For the substellar regime, the index of the mass
spectrum is alpha=0.60$+-0.06, very similar to other young associations.Comment: Astrophysica Journal, accepted April 2, 200
Application of Echocardiography on Transgenic Mice with Cardiomyopathies
Cardiomyopathies are common cardiac disorders that primarily affect cardiac muscle resulting in cardiac dysfunction and heart failure. Transgenic mouse disease models have been developed to investigate the cellular mechanisms underlying heart failure and sudden cardiac death observed in cardiomyopathy cases and to explore the therapeutic outcomes in experimental animals in vivo. Echocardiography is an essential diagnostic tool for accurate and noninvasive assessment of cardiac structure and function in experimental animals. Our laboratory has been among the first to apply high-frequency research echocardiography on transgenic mice with cardiomyopathies. In this work, we have summarized our and other studies on assessment of systolic and diastolic dysfunction using conventional echocardiography, pulsed Doppler, and tissue Doppler imaging in transgenic mice with various cardiomyopathies. Estimation of embryonic mouse hearts has been performed as well using this high-resolution echocardiography. Some technical considerations in mouse echocardiography have also been discussed
Reducing antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper
Antimicrobial resistance (AMR) continues to threaten global health. Although global and national AMR action plans are in place, infection prevention and control is primarily discussed in the context of health care facilities with home and everyday life settings barely addressed. As seen with the recent global SARS-CoV-2 pandemic, everyday hygiene measures can play an important role in containing the threat from infectious microorganisms. This position paper has been developed following a meeting of global experts in London, 2019. It presents evidence that home and community settings are important for infection transmission and also the acquisition and spread of AMR. It also demonstrates that the targeted hygiene approach offers a framework for maximizing protection against colonization and infections, thereby reducing antibiotic prescribing and minimizing selection pressure for the development of antibiotic resistance. If combined with the provision of clean water and sanitation, targeted hygiene can reduce the circulation of resistant bacteria in homes and communities, regardless of a country\u27s Human Development Index (overall social and economic development). Achieving a reduction of AMR strains in health care settings requires a mirrored reduction in the community. The authors call upon national and international policy makers, health agencies, and health care professionals to further recognize the importance of targeted hygiene in the home and everyday life settings for preventing and controlling infection, in a unified quest to tackle AMR
Heterogeneities in Supercooled liquids: A Density Functional Study
A metastable state, characterized by a low degree of mass localization is
identified using Density Functional Theory. This free energy minimum, located
through the proper evaluation of the competing terms in the free energy
functional, is independent of the specific form of the DFT used. Computer
simulation results on particle motion indicate that this heterogeneous state
corresponds to the supercooled state.Comment: 10 pages, 6 figure
Volatile Anesthetic and Outcome in Acute Trauma Care: Planned Secondary Analysis of the PROPPR Study
BACKGROUND: This retrospective analysis of prospectively collected data from the PROPPR study describes volatile anesthetic use in severely injured trauma patients undergoing anesthesia.
METHODS: After exclusions, 402 subjects were reviewed of the original 680, and 292 had complete data available for analysis. Anesthesia was not protocolized, so analysis was of contemporary practice.
RESULTS: The small group who received no volatile anesthetic (nâ=â25) had greater injury burden (Glasgow Coma Scale
CONCLUSION: In this acutely injured trauma population, choice of volatile anesthetic did not appear to influence short-term mortality and morbidity. Subjects who received no volatile were more severely injured with greater mortality, representing hemodynamic compromise where volatile agent was limited until stable. As anesthetic was not protocolized, these findings that choice of specific volatile was not associated with short-term survival require prospective, randomized evaluation
The Next Generation Virgo Cluster Survey - Infrared (NGVS-IR): I. A new Near-UV/Optical/Near-IR Globular Cluster selection tool
The NGVS-IR project (Next Generation Virgo Survey - Infrared) is a contiguous
near-infrared imaging survey of the Virgo cluster of galaxies. It complements
the optical wide-field survey of Virgo (NGVS). The current state of NGVS-IR
consists of Ks-band imaging of 4 deg^2 centered on M87, and J and Ks-band
imaging of 16 deg^2 covering the region between M49 and M87. In this paper, we
present the observations of the central 4 deg^2 centered on Virgo's core
region. The data were acquired with WIRCam on the Canada-France-Hawaii
Telescope and the total integration time was 41 hours distributed in 34
contiguous tiles. A survey-specific strategy was designed to account for
extended galaxies while still measuring accurate sky brightness within the
survey area. The average 5\sigma limiting magnitude is Ks=24.4 AB mag and the
50% completeness limit is Ks=23.75 AB mag for point source detections, when
using only images with better than 0.7" seeing (median seeing 0.54"). Star
clusters are marginally resolved in these image stacks, and Virgo galaxies with
\mu_Ks=24.4 AB mag arcsec^-2 are detected. Combining the Ks data with optical
and ultraviolet data, we build the uiK color-color diagram which allows a very
clean color-based selection of globular clusters in Virgo. This diagnostic plot
will provide reliable globular cluster candidates for spectroscopic follow-up
campaigns needed to continue the exploration of Virgo's photometric and
kinematic sub-structures, and will help the design of future searches for
globular clusters in extragalactic systems. Equipped with this powerful new
tool, future NGVS-IR investigations based on the uiK diagram will address the
mapping and analysis of extended structures and compact stellar systems in and
around Virgo galaxies.Comment: 23 pages, 18 figures. Accepted for publication in ApJ
Global survival trends for brain tumors, by histology: analysis of individual records for 556,237 adults diagnosed in 59 countries during 2000-2014 (CONCORD-3)
Background Survival is a key metric of the effectiveness of a health system in managing cancer. We set out to provide a comprehensive examination of worldwide variation and trends in survival from brain tumors in adults, by histology. Methods We analyzed individual data for adults (15-99 years) diagnosed with a brain tumor (ICD-O-3 topography code C71) during 2000-2014, regardless of tumor behavior. Data underwent a 3-phase quality control as part of CONCORD-3. We estimated net survival for 11 histology groups, using the unbiased nonparametric Pohar Perme estimator. Results The study included 556,237 adults. In 2010-2014, the global range in age-standardized 5-year net survival for the most common sub-types was broad: in the range 20%-38% for diffuse and anaplastic astrocytoma, from 4% to 17% for glioblastoma, and between 32% and 69% for oligodendroglioma. For patients with glioblastoma, the largest gains in survival occurred between 2000-2004 and 2005-2009. These improvements were more noticeable among adults diagnosed aged 40-70 years than among younger adults. Conclusions To the best of our knowledge, this study provides the largest account to date of global trends in population-based survival for brain tumors by histology in adults. We have highlighted remarkable gains in 5-year survival from glioblastoma since 2005, providing large-scale empirical evidence on the uptake of chemoradiation at population level. Worldwide, survival improvements have been extensive, but some countries still lag behind. Our findings may help clinicians involved in national and international tumor pathway boards to promote initiatives aimed at more extensive implementation of clinical guidelines
Kochen-Specker Vectors
We give a constructive and exhaustive definition of Kochen-Specker (KS)
vectors in a Hilbert space of any dimension as well as of all the remaining
vectors of the space. KS vectors are elements of any set of orthonormal states,
i.e., vectors in n-dim Hilbert space, H^n, n>3 to which it is impossible to
assign 1s and 0s in such a way that no two mutually orthogonal vectors from the
set are both assigned 1 and that not all mutually orthogonal vectors are
assigned 0. Our constructive definition of such KS vectors is based on
algorithms that generate MMP diagrams corresponding to blocks of orthogonal
vectors in R^n, on algorithms that single out those diagrams on which algebraic
0-1 states cannot be defined, and on algorithms that solve nonlinear equations
describing the orthogonalities of the vectors by means of statistically
polynomially complex interval analysis and self-teaching programs. The
algorithms are limited neither by the number of dimensions nor by the number of
vectors. To demonstrate the power of the algorithms, all 4-dim KS vector
systems containing up to 24 vectors were generated and described, all 3-dim
vector systems containing up to 30 vectors were scanned, and several general
properties of KS vectors were found.Comment: 19 pages, 6 figures, title changed, introduction thoroughly
rewritten, n-dim rotation of KS vectors defined, original Kochen-Specker 192
(117) vector system translated into MMP diagram notation with a new graphical
representation, results on Tkadlec's dual diagrams added, several other new
results added, journal version: to be published in J. Phys. A, 38 (2005). Web
page: http://m3k.grad.hr/pavici
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