Low temperature study of field induced antiferro-ferromagnetic transition in Pd doped FeRh

The first order antiferromagnetic (AFM) to ferromagnetic (FM) transition in the functional material Fe49(Rh0.93Pd0.07)51 has been studied at low temperatures and high magnetic fields. We have addressed the non-monotonic variation of lower critical field required for FM to AFM transition. It is shown that critically slow dynamics of the transition dominates below 50 K. At low temperature and high magnetic field, state of the system depends on the measurement history resulting in tunable coexistence of AFM and FM phases. By following cooling and heating in unequal magnetic field (CHUF) protocol it is shown that equilibrium state at 6 Tesla magnetic field is AFM state. Glass like FM state at 6 T (obtained after cooling in 8 T) shows reentrant transition with increasing temperature; viz. devitrification to AFM state followed by melting to FM state.Comment: 8 pages, 7 figure

Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions

Nevus sebaceus is a benign skin hamartoma of congenital onset that grows during puberty, and in adulthood can develop secondary benign and malignant neoplasms. The most common benign neoplasms occurring in nevus sebaceus are believed to be syringocystadenoma papilliferum, trichilemmoma, and trichoblastoma. A patient with nevus sebaceus developed not only syringocystadenoma papilliferum but also prurigo nodularis within her hamartomatous lesion; multiple biopsies were necessary to establish the diagnoses. Excision of the residual nevus sebaceus also revealed an apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma. Also, it is important to select the appropriate biopsy site and size when evaluating a patient for secondary neoplasms within their nevus sebaceous. Indeed, more than one biopsy may be required if additional diagnoses are suspected

Real Space Visualization of Thermomagnetic Irreversibility within Supercooling and Superheating Spinodals in Mn1.85Co0.15SbMn_{1.85}Co_{0.15}Sb using Scanning Hall Probe Microscopy

Phase coexistence across disorder-broadened and magnetic-field-induced first order antiferromagnetic to ferrimagnetic transition in polycrystalline $Mn_{1.85}Co_{0.15}Sb$ has been studied mesoscopically by Scanning Hall Probe Microscope at 120K and up to 5 Tesla magnetic fields. We have observed hysteresis with varying magnetic field and the evolution of coexisting antiferromagnetic and ferrimagnetic state on mesoscopic length scale. These studies show that the magnetic state of the system at low field depends on the path followed to reach 120 K. The low field magnetic states are mesoscopically different for virgin and second field increasing cycle when 120 K is reached by warming from 5K, but are the same within measurement accuracy when the measuring temperature of 120K is reached from 300K by cooling

G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.

Cancer cells often exhibit altered epigenetic signatures that can misregulate genes involved in processes such as transcription, proliferation, apoptosis and DNA repair. As regulation of chromatin structure is crucial for DNA repair processes, and both DNA repair and epigenetic controls are deregulated in many cancers, we speculated that simultaneously targeting both might provide new opportunities for cancer therapy. Here, we describe a focused screen that profiled small-molecule inhibitors targeting epigenetic regulators in combination with DNA double-strand break (DSB) inducing agents. We identify UNC0638, a catalytic inhibitor of histone lysine N-methyl-transferase G9a, as hypersensitising tumour cells to low doses of DSB-inducing agents without affecting the growth of the non-tumorigenic cells tested. Similar effects are also observed with another, structurally distinct, G9a inhibitor A-366. We also show that small-molecule inhibition of G9a or siRNA-mediated G9a depletion induces tumour cell death under low DNA damage conditions by impairing DSB repair in a p53 independent manner. Furthermore, we establish that G9a promotes DNA non-homologous end-joining in response to DSB-inducing genotoxic stress. This study thus highlights the potential for using G9a inhibitors as anti-cancer therapeutic agents in combination with DSB-inducing chemotherapeutic drugs such as etoposide.Research in the S.P.J. laboratory is funded by Cancer Research UK Program Grant C6/A18796 and the European Research Council (DDREAM) grant 268536-DDRREAM. Core infrastructure funding was provided by Cancer Research UK Grant C6946/ A14492 and Wellcome Trust Grant WT092096. S.P.J. receives a salary from the University of Cambridge, supplemented by Cancer Research UK. P.A. was financially supported by CRUK grant C6/ A11224 and ERC grant DDREAM.This is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.canlet.2016.07.00

An efficient resource sharing technique for multi-tenant databases

Multi-tenancy is one of the key components of cloud computing environment. Multi-tenant database system in SaaS (Software as a Service) has gained a lot of attention in academics, research and business arena. These database systems provide scalability and economic benefits for both cloud service providers and customers(organizations/companies referred as tenants) by sharing same resources and infrastructure in isolation of shared databases, network and computing resources with Service level agreement (SLA) compliances. In a multitenant scenario, active tenants compete for resources in order to access the database. If one tenant blocks up the resources, the performance of all the other tenants may be restricted and a fair sharing of the resources may be compromised. The performance of tenants must not be affected by resource-intensive activities and volatile workloads of other tenants. Moreover, the prime goal of providers is to accomplish low cost of operation, satisfying specific schemas/SLAs of each tenant. Consequently, there is a need to design and develop effective and dynamic resource sharing algorithms which can handle above mentioned issues. This work presents a model embracing a query classification and worker sorting technique to efficiently share I/O, CPU and Memory thus enhancing dynamic resource sharing and improvising the utilization of idle instances proficiently. The model is referred as Multi-Tenant Dynamic Resource Scheduling Model (MTDRSM) .The MTDRSM support workload execution of different benchmark such as TPC-C(Transaction Processing Performance Council), YCSB(The Yahoo! Cloud Serving Benchmark)etc. and on different database such as MySQL, Oracle, H2 database etc. Experiments are conducted for different benchmarks with and without SLA compliances to evaluate the performance of MTDRSM in terms of latency and throughput achieved. The experiments show significant performance improvement over existing Mute Bench model in terms of latency and throughput

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Vegetable Consumption Pattern and Health Consciousness of Urban Terrace Garden Farmers

A study was conducted to analyse the vegetable consumption pattern and health consciousness of urban households practicing terrace gardening at their homes. The survey was conducted among randomly selected 90 households in Pune city i.e., Pune Municipal Corporation and Pimpri - Chinchwad Municipal Corporation. The study revealed that among the urban wellers doing terrace gardening, everyone showed either moderate or high level of health consciousness and no one showed low level. The amount of vegetables consumed per household per day was taken in to consideration while collecting details regarding general consumption pattern of vegetables. As per the study, it was found that, 70 per cent were consuming moderate amount of vegetables on daily basis

Mechatronics: The Synergistic Integration of Mechanical Engineering with Electronics and Control Engineering

Mechatronics, the word itself signifies that it is a combination of “Mechanical” and “Electronics”. It comprises of computer technology, mechanical, electronics, electrical & control engineering. It is an Integration of all technologies together that forms a major part in the design, manufacture and maintenance of wide range engineering products and designs. In industries there is no limit of scope of Mechatronics. This article focuses on the synergistic integration of systems. DOI: 10.17762/ijritcc2321-8169.15057