11 research outputs found
Building a food-resilient city through urban agriculture: The case of Ilorin, Nigeria
- Author
- Publication venue
- 'University of the Free State'
- Publication date
- 30/12/2020
- Field of study
The rise in urban population, accompanied by growing poverty and hunger, has triggered debates on the relevance of urban agriculture in addressing the challenges of food insecurity in urban centres. This article examines the effects of urban planning practice on urban agriculture (UA) in Ilorin, Nigeria, and how it has contributed to improving the resilience of the city to food shock. Adopting a cross-sectional survey design, primary and secondary data were used. A structured questionnaire was used to obtain primary data from randomly selected urban farmers. Secondary data were obtained from the publications of the Central Bank of Nigeria, the National Bureau of Statistics, and the Food and Agricultural Organization. Data collected were analysed using descriptive statistical techniques. Respondents’ Agreement Index (RAI) was used to measure the variables influencing the performance of UA. Findings revealed that UA contributed 16.9% to meat/fish/egg requirements in the city; 4.5% to yam/cassava/potato requirements; 0.58% to vegetable requirements; 0.6% to fruit requirements, and 0.5% to grain requirements. RAI results indicated poor access to finance (0.93), limited land area (0.75), and lack of tenure security (0.44) as the dominant variables influencing the poor contribution of UA to food security. It is recommended that UA be integrated into urban planning and that more land for farming be provided
Climate change effects and livelihood-adaptation strategies by the urban poor in Ibadan, Nigeria
- Author
- Publication venue
- 'University of the Free State'
- Publication date
- 01/12/2022
- Field of study
As with many developing countries, one of Nigeria’s major challenges to socio-economic development is climate change. This article examines the effects of climate change on the livelihood activities of the urban poor in Ibadan, Nigeria. Adopting a cross-sectional survey design, the research relied essentially on primary data. A structured questionnaire was used to obtain primary data from 481 purposively selected urban residents engaging in different livelihood activities. Data collected were analysed using descriptive and inferential statistical techniques. The Respondents’ Agreement Index was used to measure the respondents’ awareness of climate change and climate change adaptation strategies. Tobit Regression Model was used to analyse the factors influencing climate change adaptation strategies, while the effects of climate change on residents’ livelihood were measured using Multinomial Logistic Regression. Findings revealed that respondents were involved in diverse livelihood activities, ranging from trading to civil service. Long dry seasons, excessive heat, irregular rainfall patterns, and frequent floods make respondents aware of climate change. Low patronage by buyers, low productivity, and reduction in income were the major effects of climate change on livelihood activities. Diversifying income sources was the main adaptation strategy. Strengthening the physical planning system to build the city’s resilience and adaptive capacity to climate-related disasters was recommended
Effective Environmental Planning Management (EPM) as Panacea to Sustainable Urban Development
- Publication venue
- Publication date
- Field of study
The rapid rate of urban growth in most developing countries of the world in recent times is alarming. Mass movement of people from rural areas to the urban centres, the consequence of the uncontrolled rapid urbanisation resulting to many un-conforming environmental challenges such as inadequate infrastructure, land, water and air pollution, poor environmental sanitation, poor and inadequate housing, urban degradation, sprawl and slums, urban violence, crime, robbery and prostitution as well as many other social vices that make the cities unsustainable. The resultant effects of all these are abysmal failure in the management of cities on the part of the governing authorities and other relevant stakeholders as well as unconducive and unwholesome condition of living of the people. This paper attempts to examine holistically the issue of environmental planning management (EPM) process development and management concept with a view for dynamic and interactive approach for various stakeholders as partners in achieving sustainable cities of our dream. The areas of discussion including conceptual and contextual issues, sustainable cities concept, good urban governance including literature review. The paper goes further to examine opportunities and challenges of built environment generally, the nature and context of environmental problems in particular, the role and duties of environmental planning and management (EPM) process in sustainable urban development. The paper further reviewed briefly the various levels of institutionalisation of EPM process with a typical case study of sustainable Ibadan project (SIP). The paper concludes with a list of recommendations to ensure effective and lasting solutions to cities problems through initiation of EPM process achievable in a sustainable manner
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Efficacy and Safety of Carfilzomib-Lenalidomide-Dexamethasone (KRd) in Newly Diagnosed Multiple Myeloma: Pooled Analysis of 4 Single-Arm Studies
- Author
- Publication venue
- Publication date
- 13/11/2019
- Field of study
Introduction: Carfilzomib (K) is a second-generation proteasome inhibitor that is approved as a single agent and in combination with lenalidomide and dexamethasone (KRd) or dexamethasone alone for the treatment of patients with relapsed and/or refractory multiple myeloma (RRMM) (Siegel et al., Blood, 2012; Siegel et al., JCO, 2018; Dimopoulos et al., Lancet Oncol, 2017). While KRd is not approved for patients with newly diagnosed multiple myeloma (NDMM), the efficacy and safety of this regimen have been examined in several independent investigator-driven studies (Kazandjian et al., ASH 2018, Abstract 1957; Jakubowiak et al., ASCO 2013, Abstract 8543; Roussel et al., ASH 2016, Abstract 1142; Zimmerman et al., ASH 2016, Abstract 675). The four phase 1 and phase 2 studies (NCT01029054 [N=55], NCT01402284 [N=45], NCT01816971 [N=76], NCT02405364 [N=46]) have shown that KRd is safe and effective in NDMM. However, the studies were single-arm with relatively small numbers of enrolled patients. A pooled analysis of individual patient data would provide an overall assessment of clinical outcomes for KRd, allowing further assessment of the efficacy and safety of KRd in NDMM.
Methods: Patient-level data from four single-arm phase 1 and phase 2 studies of KRd in NDMM were combined (3 in the U.S. and one in France); three of the four studies were multicenter studies. Patients were treated in 28-day cycles of KRd: carfilzomib (most received 20/36 mg/m2, days 1, 2, 8, 9, 15, and 16), lenalidomide (25 mg/day, days 1‒21), and dexamethasone (20‒40 mg/week).
The primary endpoint was to estimate the rate of very good partial response or better (≥VGPR). The secondary endpoints included assessments of overall response rate (ORR), the rate of complete response or better (≥CR), median progression-free survival (mPFS), landmark PFS, and safety. Response rate analyses were based on best overall response for stringent CR, CR, VGPR, or partial response (PR) that were reported in each study.
The patients were separated into two cohorts: those who received stem cell transplant (SCT) (NCT01816971 and NCT02405364) and those who did not (NCT01029054 and NCT01402284).
Results: The first cohort of patients from the SCT studies included 122 patients (table). The average age for this cohort was 57.1 years, and 63% were male. The percentages of patients with ISS stages I, II, and III were 46%, 37%, and 11%, respectively. High-risk cytogenetics were observed in 25% of patients (table). The pooled proportion of patients who had ≥VGPR was 93% (95% CI: 89%, 98%), while the pooled ≥CR rate was 79% (95% CI: 72%, 86%). All patients had at least a partial response or better. The 1- and 2-year PFS rates were 95% (95% CI: 89%, 98%) and 88% (95% CI: 80%, 93%), respectively. The limited patient follow-up beyond 2 years did not allow estimation of mPFS. 109 patients (89%) reported at least one grade 3 or 4 treatment-emergent adverse event (TEAE). Selected grade 3 or 4 TEAEs of interest were acute renal failure (2%), cardiac failure (2%), and hypertension (2%) (table).
The second cohort of patients from the non-SCT studies included 99 patients (table). The average age for this cohort was 60.9 years, and 67% were male. The percentages of patients with ISS stages I, II, and III were 44%, 39%, and 16%, respectively. High-risk cytogenetics were observed in 35% of patients (table). The pooled proportion of patients who had ≥VGPR was 90% (95% CI: 84%, 96%). The pooled ORR was of 98% (95% CI: 95%, >99%), while the pooled ≥CR rate of 71% (95% CI: 62%, 80%). The 1- and 2-year PFS rates were 96% (95% CI: 90%, 98%) and 85% (95% CI: 76%, 90%), respectively. The limited patient follow-up beyond 2 years did not allow estimation of mPFS. 91 patients (92%) reported at least one grade 3 or 4 TEAE. Selected grade 3 or 4 TEAEs of interest were peripheral neuropathy (1%), acute renal failure (4%), cardiac failure (3%), and hypertension (5%) (table). Additionally, the results of the individual studies are consistent in efficacy and safety.
Conclusion: The results of this study demonstrate deep and sustained responses, highlighting KRd as an effective and tolerable treatment option for patients with NDMM in both the transplant and non-transplant settings. The promising results presented here should be evaluated against standard of care regimens.
Disclosures
Landgren: Adaptive: Honoraria, Membership on an entity's Board of Directors or advisory committees; Abbvie: Membership on an entity's Board of Directors or advisory committees; Sanofi: Membership on an entity's Board of Directors or advisory committees; Karyopharm: Membership on an entity's Board of Directors or advisory committees; Janssen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Merck: Other: IDMC; Theradex: Other: IDMC; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding. Roussel:Celgene Corporation: Consultancy, Other: travel fees, lecture fees, Research Funding; Janssen: Honoraria, Other: travel fees, lecture fees, Research Funding; Amgen: Other: travel fees, lecture fees, Research Funding; takeda: Other: travel fees, lecture fees, Research Funding. Anderson:Statistics Collaborative, Inc.: Employment. Kervin:Statistics Collaborative, Inc.: Employment. Iskander:Amgen Inc.: Employment, Other: stockholder of Amgen. Mezzi:Amgen Inc.: Employment, Other: stockholder of Amgen. Welliver:Amgen Inc.: Employment, Other: stockholder of Amgen. Yusuf:Amgen Inc.: Employment, Other: stockholder of Amgen. Jakubowiak:Adaptive Biotechnologies: Consultancy, Honoraria; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; KaryoPharm Therapeutics: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Millennium: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Sanofi: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; SkyLineDx: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Juno: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; GSK: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees
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Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): updated outcomes from a randomised, multicentre, open-label, phase 3 study
- Author
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Despite recent advances in therapeutic options, there remains an unmet need for treating patients with relapsed or refractory multiple myeloma, especially in those previously exposed or refractory to lenalidomide. This updated efficacy and safety analysis from the phase 3 CANDOR study compared carfilzomib, daratumumab, and dexamethasone (KdD) with carfilzomib and dexamethasone (Kd) in patients with relapsed or refractory multiple myeloma.
In this updated analysis of the randomised, multicentre, open-label, phase 3 CANDOR study, patients (aged ≥18 years) with relapsed or refractory multiple myeloma, at least a partial response to between one and three previous therapies, and Eastern Cooperative Oncology Group performance status of 0-2, were recruited from 102 medical centres globally and randomly assigned (2:1) by interactive voice or web response software to receive KdD or Kd. Participants were stratified by disease stage, previous proteasome inhibitor or anti-CD38 antibody exposure, and number of previous therapies. All patients received intravenous infusions of carfilzomib twice per week at 56 mg/m
(20 mg/m
on days 1 and 2 during cycle 1) on days 1, 2, 8, 9, 15, and 16 of each 28-day cycle. Daratumumab (8 mg/kg) was administered intravenously on days 1 and 2 of cycle 1 and at 16 mg/kg weekly for the remaining doses of the first two cycles, then every 2 weeks for four cycles (cycles 3-6), and every 4 weeks thereafter. Patients received 40 mg dexamethasone weekly (20 mg for patients >75 years old). This analysis was a preplanned interim analysis for overall survival; however, at the time of data cutoff, overall survival data were not mature. The primary endpoint was progression-free survival. Here, we provide updated progression-free survival data, assessed centrally by Onyx Response Computer Algorithm in the intention-to-treat population, with 11 months additional follow-up. Adverse events were assessed in the safety population, which included all participants who received at least one dose of trial treatment. CANDOR is registered with ClinicalTrials.gov, NCT03158688, and is active but not recruiting.
Between June 13, 2017, and June 25, 2018, 466 patients were enrolled, of whom 312 received KdD and 154 received Kd. At data cutoff (June 15, 2020), median follow-up was 27·8 months (IQR 25·6-29·5) for KdD and 27·0 months (13·2-28·6) for Kd. Median progression-free survival was 28·6 months (95% CI 22·7-not estimable [NE]) in the KdD group and 15·2 months (11·1-19·9) in the Kd group (hazard ratio 0·59 [95% CI 0·45-0·78], log-rank p<0·0001). Treatment-emergent adverse events in the safety population were consistent with the primary analysis. Grade 3 or worse treatment-emergent adverse events occurred in 268 (87%) patients in the KdD group and 116 (76%) in the Kd group; most commonly thrombocytopenia (76 [25%] vs 25 [16%], respectively), hypertension (65 [21%] vs 23 [15%]), pneumonia (54 [18%] vs 14 [9%]), and anaemia (53 [17%] vs 23 [15%]). Serious adverse events occurred in 194 (63%) patients with KdD and 76 (50%) with Kd. Adverse events leading to death occurred in 27 (9%) patients in the KdD group and seven (5%) in the Kd group; most commonly septic shock (five [2%] vs one (1%]) and pneumonia (four [1%] vs none). No new treatment-related deaths have occurred since the primary analysis.
A clear, maintained progression-free survival benefit of KdD over Kd with longer follow-up was confirmed, making KdD an emerging standard-of-care for patients with relapsed or refractory multiple myeloma.
Amgen and Janssen
Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic
- Author
- A M Umar
- Abdallah Elshenawy
- Abdallah R Allam
- Abdelbasit Ali
- Abdeljawad Mazloum
- Abdelrahman Azzam
- Abdelrahman Bahaa
- AbdulBasit Fehintola
- Abdulhakim Awadh SalimAl-Rawas
- Abdullahi Nuhu-Koko
- Abdulrahman AlMirza
- Abdulrahman Almjersah
- Abdulrahman Ghassan Qasem
- Abdulrahman Omar Taha
- Abdulrahman Omar Taha
- Abdurahaman Aremu
- Abiodun Folashade Adekanmbi
- Abiodun Idowu Okunlola
- Abubakari Bawa Abdulai
- Adeseye M Akinsete
- Adesoji Ademuyiwa
- Adesoji O Ademuyiwa
- Adewumi B Oyesakin
- Adnan Dağçınar
- Agata Chylinska
- Agnes Vojcek
- Agnes Vojcek
- Ahmad Al Ayed
- Ahmad Bouhuwaish
- Ahmad Ozair
- Ahmed Moussa
- Ahmed Saleh
- Ahmed Samir
- Ahmed Sherif
- Ahmed Tawheed
- Ahmed Y Azzam
- Ahsan Nadeem
- Aishah Mughal
- Aishwarya Ashwinee
- Ajiboye L Olalekan
- Akila Muthukumar
- Akm Amirul Morshed
- Akm Khairul Basher
- Akram Ahmed
- Al-Mudeer Ali
- Alaa Ahmed
- Alaa Guzlan
- Alaa Hamdan
- Alaa Hamdan
- Alan Siegel
- Aleksandar Stanimirovic
- Aleksandra Paunovic
- Alexander S Roth
- Alexandra Valetopoulou
- Alexandre Dukundane
- Alhassan Abdul-Mumin
- Ali Abodest
- Ali Al Sharqi
- Ali Farid Alelayan
- Alonja Reiter
- Alqasim Abdulkarim
- Alzhraa Salah Abbas
- Amani Alamre
- Amani Twaha
- Amanpreet Brar
- Amanpreet Brar
- Amer Harky
- Aminu Muhammed Umar
- Amir Labib
- Amit Sehrawat
- Ammar Al-Basiti
- Ammar Ayman
- Ammar Omran
- Ammar Saif AlShabibi
- Amon Ngongola
- Amon Ngongola
- Anas Shikha
- Andrea Hayes-Jordan
- Andrea Mingoli
- Andreea C Matei
- Andrew Nwankwo Osuigwe
- Anette S Jacobsen
- Anfel Bouderbala
- Anisa Al Shamsi
- Ankur Bajaj
- Ankur Bajaj
- Anna Casey
- Anna Maria Testi
- Anneqa Tahir
- Annette Jacobsen
- Annika Heuer
- Aouabed Nesrine
- Arda Isik
- Ariana Axiaq
- Arissa Ikeda
- Arkha Yasser
- Armin Nazari
- Ashfaque Nabi
- Ashrarur Rahman Mitul
- Asim Noor Rana
- Asimina Galli-Tsinopoulou
- Asmaa Am Albanna
- Assimina Galli-Tsinopoulou
- Athanasios Tragiannidis
- Atiqa Amirali
- Atique Anwar
- Atul Suroy
- Aubrey L Pagaduan
- Augusto Zani
- Ayah Al Shraideh
- Ayah Bassam Ibrahim
- Ayat M Saadeldin
- Ayesha Mehmood
- Ayesha Saleem
- Ayten Saraçoğlu
- Azad Patel
- Azrina Syarizad Khutubul Zaman
- Baba Jibrin
- Bal Krishna Ojha
- Bardisan Gawrieh
- Bashar Dawud
- Bechri Hajar
- Bekir Can Kendirlioglu
- Bekir Can Kendirlioglu
- Benjamin J O'Sullivan
- Benjamin Martin
- Benjamin Martin
- Benjamin Shou
- Bernard Mbwele
- Bibekanand Jindal
- Bikash Kumar Naredi
- Bilal Matola
- Biobele J Brown
- Bioud Belkacem
- Bobby John
- Bouaoud Souad
- Boutheyna Drid
- Brahim Saada
- Brian T Craig
- Bruce Bvulani
- Bruno Cirillo
- C-Khai Loh
- Calogero Virgone
- Can Kıvrak
- Catherine Dominic
- Catherine Yang
- Cecilia Paasche
- Chan Hon Chui
- Charlotte Smith
- Chisom Adaobi Nri-Ezedi
- Christine Nitschke
- Christopher O Bode
- Christopher S Lukong
- Danelle Erwee
- Danica Grujicic
- Daniel Rhee
- Daniel Robinson
- Daniella Melamed
- Darica Au
- Dauda E Suleiman
- Dave R Lal
- David Nelson Jaisingh
- Dayang Anita Abdul Aziz
- Dayang AnitaAbdul Aziz
- Denis Cozzi
- Dhruva Ghosh
- Dhruva Ghosh
- Dhruva Ghosh
- Dhruva Nath Ghosh
- Diella Munezero
- Digamber Chaubey
- Divya Parwani
- Doris Lau
- Dragana Janic
- Duha Jasim
- Edamisan O Temiye
- Edmund M Der
- Ehab Alameer
- Ehab Alameer
- Ehab El Refaee
- Ehab Hanafy
- El Ouahabi Abdessamad
- Elaine Carrolan
- Elana Kleinman
- Eleni Tsotridou
- Elif Akova
- Elif Akova
- Elliott H Taylor
- Elvercio Pereira de Oliveira Junior
- Eman Abdulwahed
- Eman Ibrahim Hager
- Eman Salem Muftah Burzeiza
- Emily Christison-Lagay
- Emily Hamilton
- Emmanuel A Ameh
- Emmanuel Hatzipantelis
- Enono Yhoshu
- Eric Mwangi Irungu
- Eric Mwangi Irungu
- Eric Okechukwu Umeh
- Eric W Etchill
- Essam Elhalaby
- Etai Adam
- Evren Aydogmus
- Evren Aydogmus
- Ezekiel I Ajayi
- Fabianne Altruda de Moraes Costa Carlesse
- Fabiola Leonelli Diz
- Fakher Rahim
- Farah Sameer Yahya
- Farah Sameer Yahya
- Faris Abu Za'nouneh
- Faris Ayasra
- Faris Ayasra
- Farman Ali Laghari
- Fashie Andrew Patrick
- Fatema Naser AlFayez
- Fatema Sayed
- Fatima Ambreen Imran
- Fatma Mohammed Masoud
- Fatma Saleh Benkhial
- Fayza Haider
- Felix M Alakaloko
- Fernanda Kelly Marques de Souza
- Fernanda Lobo
- FernandaFerreira daSilva Lima
- Francesco Pata
- Francis A Abantanga
- Francis Abantanga
- Gabriela Guillén
- Gaetano Gallo
- Gamal Amira
- George C Ihediwa
- Georgios Karagiannidis
- Georgios Tsoulfas
- Ghazwani Salman
- Ghazwani Salman
- Ghazwani Yahia
- Ghita Chaoui
- Gideon Karplus
- Gilbert B Bonsaana
- Gioia Brachini
- Gopal Nambi
- Guido Seitz
- Gul Kalra
- Gunaseelan Karunanithi
- Gül Nihal Özdemir
- Gül Çakmak
- Hafeez Abdelhafeez
- Hajar Benaouda
- Hajar Moujtahid
- Hajar Moujtahid
- Halwani Yaninga Fuseini
- Hamidah Alias
- Harmit Ghattaura
- Hassan Salloum
- Hazim Ababneh
- Hazim Elfatih
- Heidi Barola
- Helga Nauhaus
- Hend Mohammed Masoud
- Hessissen Laila
- Hira Khalid Zuberi
- Hira Zuberi
- Hoda Tawel
- Hritik Nautiyal
- Humaida Hemlae
- Hunar Mahal
- Hytham Ks Hamid
- Ibiyeye Taiye Taibat
- Ibrahim Sallam
- Ibukunolu Olufemi Ogundele
- Igor Lazic
- Imane Ammouze
- Imane Ammouze
- Imogen Harrison
- Iqra Effendi
- Irene Nguma
- Isaac Dare Olulana
- Ismail Al Bulushi
- Israel Fernandez Pineda
- Ivan Bogdanovic
- Iyad Sultan
- J Hudson Barnett
- Jacqueline Elizabeth Montoya Vásquez
- Jake A Kloeber
- Jan Godzinsky
- Janice Hui Ling Wong
- Janita Zarrish
- Jasmin Meyer
- Jawaher Al Sharqi
- Jessica Luyt
- Jingdan Fan
- Joana Mafalda Monteiro
- Joana Monteiro
- John George Massoud
- John Mathew
- Joshua Erhabor
- José Andrés Molino
- Juan Luis García León
- Judith Lindbert
- Justina O Seyi-Olajide
- Jyoti Dhiman
- K S Rajkumar
- Kalu Ukoha
- Kamel Hamizi
- Kamrun Nahar
- Kareem O Musa
- Karl-Heinz Frosch
- Kashaf Turk
- Kate Cross
- Kaushal Kishor Singh
- Kefas John Bwala
- Keffi Mubarak Musa
- Kellie McClafferty
- Kelvin Ifeanyichukwu Egbuchulem
- Kemal Tolga Saracoglu
- Kemal Tolga Saracoglu
- Ken Muma
- Kerri Becktell
- Kevin Crow
- Khaled Mamdouh
- Khalil Ghandour
- Khozairi Waleed
- Khushman Kaur Bhullar
- King-David Nweze
- Kingsley Appiah Bimpong
- Kingsley Aseye Hattor
- Kirk David Wyatt
- Kirstie Wright
- Kishwer Nadeem
- Kıvılcım Karadeniz Cerit
- Kokila Lakhoo
- Kokila Lakhoo
- Kokila Lakhoo
- Kokila Lakhoo
- Krishna Kumar Govindarajan
- Kumaravel Sambandan
- Kwizera Festus
- Laila Hessissen
- Leanne Gentle
- Lennart Viezens
- Leon Köpke
- Licia Portela
- Lily Saldana
- Lorraine Ochieng
- Lubna Samad
- Lubna Samad
- Luca Pio
- Lucas Garschagen deCarvalho
- Lucas Krauel
- Lucien P Jay
- M Joseph John
- Mabroukah Saeid Alshamikh
- Madhivanan Karthigeyan
- Mahan Salehi
- Mahmoud Adly
- Mahmoud Bassiony
- Mahmoud Elfiky
- Mahmoud M Saad
- Mahmoud Maher Abdelnaby Alrahawy
- Manasi Shirke
- Manjul Tripathi
- Manoj Gupta
- Marc Dreimann
- Marco Aurelio Ciriaco Padilha
- Maria do Bom-Sucesso
- Maria Teresa Peña Gallardo
- Mariam Lami
- Marianne Monteiro Garrigo
- Maricarmen Olivos
- Marta deAndres Crespo
- Martin Stangenberg
- Martina Zambon
- Marwa Biala
- Marwa Shelft
- Mary Joan Kpiniong
- Maryam Ghavami Adel
- Maryam Khan
- Matthew Hv Byrne
- Matthew R Schuelke
- Matthias Priemel
- Max Pachl
- Max Pachl
- Max Pachl
- Mayara Caroline Amorim Fanelli
- Md Afruzul Alam
- Md Asaduzzaman
- Md Asif Iqbal
- Md Hasanuzzaman
- Md Masud Rana
- Mebarki Malika
- Megan Murphy
- Mehdi Anouar Zekkour
- Mehdi Khan
- Mehnaz Akter
- Meryem Gounni
- Michael Boettcher
- Mihailo Milicevic
- Mihir Sheth
- Mihir Sheth
- Milind Chitnis
- Milind Chitnis
- Mitchelle Obat
- Moawia Mohammed AliElhassan
- Mohamad K Abou Chaar
- Mohamed Abdel-Maboud
- Mohamed Abdelwahab
- Mohamed Adwi
- Mohamed Ahmed
- Mohamed Atef
- Mohamed Atef Mohamed Ghamry
- Mohamed Bahaaeldin
- Mohamed Bella Jalloh
- Mohamed Bonna
- Mohamed El Kassas
- Mohamed Elbahnasawy
- Mohamed Faried
- Mohamed Hassanin
- Mohamed Sherief
- Mohamed Yazid Kadir
- Mohamedraed Elshami
- Mohammad Ahmad Almahmod Alkhalil
- Mohammad Ali Deeb
- Mohammad K Abou Chaar
- Mohammed A Azab
- Mohammed Alhendy
- Mohammed Miftah Faraj Almihashhish
- Mohammed Tanvir Ahammed
- Monica Dobs
- Morgan Drucker
- Moshi Moshi Shabani
- Mostafa Qatora
- Muath Alser
- Muhammad Arshad
- Muhammad Arshad
- Muhammad Arshad
- Muhammad Rafie Raza
- Muhammad Rahil Khan
- Muhammed Elhadi
- Muhammed Elhadi
- Muna Alshahri
- Munawar Hraib
- Murad Almasri
- Musliu Adetola Tolani
- Mustafa Sakar
- N Otene ThankGod
- Nacer Khernane
- Nada Osman Yousif Elhaj
- Naema Khayyam
- Naif Al Bolowi
- Narjiss Aji
- Nathalie Galea
- Nathan Thompson
- Nazmul Islam
- Nehal Rahim
- Nellie Bell
- Nellie Bell
- Nensi Melissa Ruzgar
- Nida Zia
- Ninad R Patil
- Nisreen Ali
- Nitin James Peter
- Nitin James Peters
- Nitin James Peters
- Noel Peter
- Noel Peter
- Noel Peter
- Noorainun Mohd Yusof
- Norehan Johari
- Nsimire Mulanga Roseline
- Nyararai Togarepi
- Okechukwu Hyginus Ekwunife
- Okorie Ikechukwu
- Ola Al Hamadani
- Olagundoye Goke
- Olakayode Olaolu Ogundoyin
- Olanrewaju Moses
- Olivia White
- Olubunmi Motunrayo Fatungase
- Olubunmi Obafemi Obadaini
- Olufemi Oni
- Olumide Abiodun Elebute
- Oluseyi Oyebode Ogunsua
- Oluwasegun Joshua Afolaranmi
- Oluwaseun Ladipo-Ajayi
- Omaima El-Qurneh
- Omar Elmandouh
- Omar Hamam
- Orindom Shing Pulock
- Oudrhiri Mohammed Yassaad
- Outani Oumaima
- Pablo Velasco
- Paolo Musiu
- Paolo Sapienza
- Patricia Shinondo
- Patricia Shinondo
- Paul J Galardy
- Peter Gyamfi Kwarteng
- Philip Mari Mshelbwala
- Pierfrancesco Lapolla
- Pierfranco Cicerchia
- Pooja Kumari
- Poorvaprabha Patil
- Prasanna Gomes
- Pravin Salunke
- Priyansh Nathani
- R M Jeffri Ismail
- Rabbey Raza Khan
- Rachel Levinson
- Radovan Mijalcic
- Raja Mari Mohammed Nasef
- Rajat Piplani
- Ramsha Saleem
- Ranya M Baddourah
- Raphael N Vuille-Dit-Bille
- Rasaq Olaosebikan
- Ravi Kishore
- Reem Ghamgh
- Reema Alnajjar
- Rejin Kebudi
- Renu Madan
- Reto Baertschiger
- Reto M Baertschiger
- Rhea Raj
- Ricardo Vianna deCarvalho
- Richa Jain
- Rim Elmandouh
- Rima Rahmoun
- Robert L Owen
- Robin Simpson
- Robyn Brown
- Rochelle Fayngor
- Rohan Pancharatnam
- Rohini Dutta
- Rosanda Ilic
- Roserahayu Idros
- Roshni Dasgupta
- Ruaa Bassam Ibrahim
- S M Rezanur Rahman
- Sabbir Karim
- Sadaf Altaf
- Sadi A Abukhalaf
- Sadia Muhammad
- Safia Lorabi
- Safia Lorabi
- Sai Pillarisetti
- Salma Naje Abu Teir
- Sameer Saleem Tebha
- Samson Olori
- Sana Tahir
- Sandeep Mohindra
- Sandip Kumar Rahul
- Santosh Kumar Mahalik
- Sara Ali
- Sara Kader Alsaeiti
- Sarah Al-Furais
- Sarah Muma
- Sarah Ullrich
- Sareya Al Sibai
- Sebastián Shu Yip
- Seham M Ragab
- Sema Bay Buyukkapu
- Sergio López
- Shady Fadel
- Shahnoor Islam
- Shaima' Al-Dabaibeh
- Shaina Kamboj
- Shashwat Kala
- Shaun Wilson
- Sheba Mary Pognaa Kunfah
- Sherief Abdelsalam
- Sherief Ghozy
- Shireen Anne Nah
- Shireen Anne Nah
- Shruti Kakkar
- Shweta Madhusudanan
- Sima Ester Ferman
- Simona Meneghini
- Simone de Campos Vieira Abib
- Simone deCamposVieira Abib
- Simone deOliveira Coelho
- Smita Kayal
- Smrithi Sriram
- Soha Zahid
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Soham Bandyopadhyay
- Somy Charuvila
- Sonal Nagras
- Sravani Royyuru
- Sreylis Nay
- Stacy Cooper
- Stephanie Ajinkpang
- Suraj Gandhi
- Suraj Singh
- Susana Nunes
- Swati Daniel
- Syeda Namayah Fatima Hussain
- Syukri Ahmad Zubaidi
- Tahmina Banu
- Taimur Iftikhar Qureshi
- Taiwo Akeem Lawal
- Taiwo Jones
- Tania Akter
- Tasmiah Tahera Aziz
- Taylor Ibelli
- Thomas Smith
- Tijana Nastasovic
- Toqa Fahmawee
- Tufan Hicdonmez
- Tufan Hicdonmez
- Tunde Talib Sholadoye
- Tybat Aliyu
- Tzvi Najman
- Tümay Umuroğlu
- Uduak Offiong
- Usama Eldaly
- Uttam Kumar Nath
- Vaishnavi Govind
- Victor Calvagna
- Victor Calvagna
- Victor Khoury
- Vijayendra Kumar
- Vinay Suresh
- Vincent E Nwatah
- Vishal Kumar
- Vishal Michael
- Vivek Singh
- Vladimir Bascarevic
- Vrisha Madhuri
- Vuk Scepanovic
- Waha Rahama
- Waseem Shater
- William B Lo
- William Bhatti
- Win SabaiPhyu Han
- Yahya Elkaoune
- Yakubu Alfa
- Yasin Kara
- Yasmine El Chazli
- Yassine Zerizer
- Yen Yan Lim
- Yousef Alalawi
- Youssef Sameh Badran
- Yuki Julius Ng
- Zahidah Ahmad
- Zainab Al Balushi
- Zannat Ara
- Zarina Abdul Latiff
- Zineb Bentounsi
- Zonaira Qayyum
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2022
- Field of study
Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
- Author
- Aamir Junaid
- Abaalkhail Muath
- Ababneh Adnan
- Ababneh Hazim
- Ababneh Laila
- Ababneh Roba
- Abad-Motos Ane
- Abaker Mussab
- Abary Ryan
- Abass Adam
- Abate Emmanuele
- Abayomi Olukayode
- Abazeed Alaa
- Abbad Bader
- Abbadessa Francesco
- Abbadi Osaid
- Abbakar Malaz
- Abbas Ahmed
- Abbas Alzhraa
- Abbas Asad
- Abbas Aya
- Abbas Jihad
- Abbas Manzar
- Abbas Mohammad
- Abbas Omer
- Abbasov Aykhan
- Abbo Olivier
- Abbott Daniel
- Abbott Tom
- Abboud Omar
- Abd Waleed
- Abd-Elkariem Ahmed
- Abd-Elsalam Sherief
- Abdalah Ahmad
- Abdalhadi Alya
- Abdalla Ahmed
- Abdalla Eman
- Abdalla Samir
- Abdalla Shimaa
- Abdalla Siddig
- Abdallah Emne
- Abdallah Ghaida
- Abdallah Lubna
- Abdallah Munir
- Abdallah Murad Al
- Abdallah Rasha
- Abdalnour Hani
- Abdeen Bashar
- Abdeewi Saedah
- Abdeh Louai
- Abdel-Aleem Mahmoud
- Abdel-Elsalam Wafaa
- Abdel-Fattah Areej
- Abdel-Fattah Nour
- Abdel-Hafez Ibrahim
- Abdelaal Abdelrahman
- Abdelaty Ahmed Adel
- Abdelazeem Khaled
- Abdelaziz Areej
- Abdelaziz Mohammed
- Abdelbagi Mohamad
- Abdelbaset Abouelnour
- Abdeldayem Hesham
- Abdelfattah Mahmoud
- Abdelgadir Alwaleed
- Abdelgalel Khaled
- Abdelghafar Moslem
- Abdelhafez Mohammed
- Abdeljalil Abdelkarim
- Abdelkabir Mohammed
- Abdelkareem Mohamed
- Abdelkarem Mohamed
- Abdelkarim Mostafa
- Abdelkhalek Mohamed
- Abdellah Fatima
- Abdelmajeed Ahmed
- Abdelmalik Abubaker
- Abdelmawla Ahmed
- Abdelrahman Abdelrahman
- Abdelrahman Haneen
- Abdelraouf Ali
- Abdelsamed Ahmed
- Abdelwahab Omar
- Abderrazaq Hafni
- Abdissa Desalegn
- Abdo Adnan Sayid
- Abdou Hossam
- Abdou Mostafa
- Abdoun Meriem
- Abdow Mohammad
- Abdrabou Ahmed
- Abdualqader Mahmmoud
- Abdul-Jabar Hani
- Abdul-Mumin Alhassan
- Abdulaal Safaa
- Abdulateef Omar
- Abdulfattah Ammar Yasser
- Abdulkareem Amal
- Abdull Mohammed
- Abdullaev Abakar
- Abdullah Abdullah
- Abdullah Bahiyah
- Abdullah Duha Milad
- Abdullah Muhammad Tariq
- Abdullah Nabila
- Abdullah Saleha
- Abdullah Shahbaz
- Abdullaha Lamess
- Abdullahi Alhassan
- Abdullahi Habiba
- Abdullahi Lawal
- Abdullahi Mohammed Kabir
- Abdullahi Sani
- Abdullahi Yasir Younis
- Abdulmalek Abdulmalek
- Abdulmalik Abdulmuez
- Abdulmohsen Ahmed
- Abdulqawi Nabil
- Abdulrahem Abdullah
- Abdulrahman Mamuda
- Abdulrahman Mohamed
- Abdulrahman Taha
- Abdulsalam Albaraa
- Abdulsalam Fareed
- Abdulsalam Khalifa
- Abdulsalam Moruf
- Abdulwahab Taiceer
- Abdulwahed Eman
- Abdunabi Murad
- Abdur-Rahman Lukman
- Abdurab Ebrahim
- Abdurehman Oumer
- Abdurrazzaaq Abdussemee
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abe Anthonia
- Abe Nobutsugu
- Abe Tatsuro
- Abebe Engida
- Abebe Kirubel
- Abebe Metasebia
- Abebe Nebyou
- Abebrese John Tabiri
- Abed Arsan Abu
- Abed Francisco
- Abed Haneen
- Abed Laith Abu
- Abedalqader Lina
- Abedin Yasmin
- Abel Joel Reuben
- Abel Livingston
- Abel Mary Kathryn
- Abelevich Alexander
- Abella Andrei Cesar
- Abichou Wijden
- Abid Rubaba
- Abiodun Adekunle
- Abiola Olajide
- Abiola Paul
- Abiyere Henry
- Aboalsamh Ghaleb
- Aboazamazem Hajir
- Abodeeb Aya
- Aboelkhel Roger
- Abojeila Farah
- Abosamak Nour Eldin
- Abosnaina Yahya
- Abostate Ahmed
- Abou-Abbass Hussein
- Abou-Khalil Jad
- Abouassi Layth
- Abouassi Majd
- Aboubakr Samar
- Aboubeirah Mohammed
- Abouelazayem Mohamed
- Abouelnagah Galal
- Abouelnagah Yossof
- Aboutaleb Shereen
- Aboutrab Ayham
- Abouzid Amr
- Abozied Hesham
- Abraham Bejoy
- Abrahams Jenevive
- Abramowicz Shelly
- Abrate Alberto
- Abreha Tassew
- Abrha Teklebirhan
- Abu-Arish Hamdoon
- Abu-Eisheh Basil
- Abu-Ishkerih Nizar
- Abu-Ismail Luai
- Abu-Libdeh Tareq
- Abu-Mehsen Marah
- Abu-Zaid Ahmed
- Abualteen Faisal
- Abuawad Carla
- Abubakar Abdullah
- Abubakar Ahmed
- Abubakar Mohammed Kabir
- Abubakr Abubakr
- Abubakr Asmaa
- Abubeih Hossam
- Abud Burçin
- Abudari Hadeel
- Abudher Abdulhafid
- Abuhamour Ehab
- Abuissa Khatab
- Abukhadra Mahmoud
- Abukhalaf Sadi A
- Abukhater Muhammad
- Abulafia Daniel
- Abuleil Amro
- Abulshuwashi Nayrouz Abdullah
- Abumahara Saleh
- Abunawas Huthifa
- Aburahmah Mohammad
- Aburayyan Fatima
- Aburima Sarah
- Abusabeib Abdelrahman
- Abusadah Samer
- Abusalem Marwa
- Abusannoga Malek
- Abushahma Ahmed Omar
- Abutaka Ahmad
- Abutaleb Malak
- Abuzaina Khalil
- Acatrinei Eduard
- Accarino Giulio
- Accorsi Guilherme
- Acharya Hriday
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- Acharya Shivanie
- Achimas-Cadariu Patriciu
- Ackermann Travis
- Acosta Jesus
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- Acquaye Jane
- Acra-Tolari Ricardo
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- Adam John
- Adamala Soujanya
- Adamina Michel
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- Addas Bassam
- Adebajo Emmanuel
- Adebanjo Ademola
- Adebara Idowu
- Adebayo Olaolu
- Adebayo Sikiru A
- Adeboyejo Oluwaseun
- Adegbola Samuel
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- Adelaja Aderinsola
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- Adil Md Tanveer
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- Adrees Mohammed
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- Advani Rajeev
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- Aeed Majed
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- Afolabi Abdulrahman O
- Afolabi Akinwale
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- Afzal Ameer
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- Afzal Mohamed
- Afzal Muhammad Farooq
- Afzal Sadia
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- Agapov Mikhail
- Agarwal Anjoo
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- Agastra Ervis
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- Agboadoh Nelson
- Agbonrofo Peter
- Ageeli Mohammed
- Aggarwal Gaurav
- Aggarwal Manisha
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- Aghababyan Kristina
- Aghadi Ifeanyi
- Aghalarov Ilgar
- Aghamaliyev Ughur
- Aghayeva Afag
- Aghazadeh Kayvan
- Agida Eyaofun
- Agnes Annamaria
- Agnes Salvatore
- Agoncillo Anika Johanna
- Agossou Hermann
- Agrawal Amit
- Agrawal Mansi
- Agrawal Rachit
- Agrawal Sanjit Kumar
- Agrawal Tulika
- Agro Felice Eugenio
- Aguado Héctor J
- Aguayo Omar
- Aguilar Ana
- Aguilar Ruben
- Aguilera-Arevalo Maria-Lorena
- Aguinagalde Borja
- Aguirre Asier
- Aguzzoli Lorenzo
- Agyapong Meshach Manu
- Agyei Fareeda
- Agyeman-Duah Nana Kwaku
- Agyemang-Prempeh Akosua
- Agyen Thomas
- Ahamed Waseem
- Ahangari Roghayyeh
- Aherne Thomas
- Ahlaou Hamza
- Ahluwalia Saravpreet
- Ahmad Afaf
- Ahmad Ahmad Mustafa
- Ahmad Aline
- Ahmad Amer
- Ahmad Ashfaq
- Ahmad Aya
- Ahmad Basel
- Ahmad Fateen
- Ahmad Jameel Ismail
- Ahmad Maleeha
- Ahmad Manzoor
- Ahmad Misbahu
- Ahmad Mohamad
- Ahmad Muzaffar Ahmad
- Ahmad Niarah
- Ahmad Qamar Ashfaq
- Ahmad Quazi
- Ahmad Reyaz
- Ahmad Rofida
- Ahmad Saad Bilal
- Ahmad Shabir
- Ahmad Shahrukh
- Ahmad Sheraz
- Ahmad Siddique
- Ahmad Tareq
- Ahmad Zeeshan
- Ahmadi Navid
- Ahmadi Sayedali
- Ahmadvand Ali
- Ahmed Abdelkareem
- Ahmed Abdullah
- Ahmed Abedelrahman
- Ahmed Ahme
- Ahmed Aishah
- Ahmed Aminat Olayinka
- Ahmed Arooj
- Ahmed Ayman
- Ahmed Azaz
- Ahmed Ehsan
- Ahmed Faazil
- Ahmed Faryal
- Ahmed Ghazia
- Ahmed Haseeb
- Ahmed Hassaan
- Ahmed Idrees
- Ahmed Iffat
- Ahmed Irshad
- Ahmed Islam
- Ahmed Jawad
- Ahmed Kaleem
- Ahmed Khalid
- Ahmed Maira
- Ahmed Malik Shakeel
- Ahmed Manhal
- Ahmed Mariam
- Ahmed Moaiad Eldin
- Ahmed Mohamme
- Ahmed Muhammed
- Ahmed Nasir
- Ahmed Nauman
- Ahmed Omar
- Ahmed Safia
- Ahmed Sara
- Ahmed Shahnoor
- Ahmed Shakil
- Ahmed Sheraz
- Ahmed Waheed-Ul-Rahman
- Ahmed Waqas
- Ahmed Zubair
- Ahmedin Mahlet
- Ahsan Kunwar Armash
- Ahseen Naeimah
- Ahtash Abdurahman
- Aidarov Askar
- Aigner Felix
- Aiken Taylor
- Ailabouni Ramez
- Aimé Adeline
- Aiolfi Alberto
- Airoldi Angelo
- Aisuodionoe-Shadrach Oseremen
- Aitken Jake
- Aizza Giada
- Ajab Shereen
- Ajagha Okeoghene
- Ajai Olalekan
- Ajaj Hatem
- Ajami Dany
- Ajao Akinlabi
- Ajayi Adekunle
- Ajayi Peter
- Ajcip Gaby
- Ajekwu Samuel
- Ajekwu Temitope
- Aji Narjiss
- Aji Sani Ali
- Ajibola Hafees
- Ajiboye Olalekan
- Ajlan Abdulrazag
- Ajmi Ghadeer Al
- Ajmi Khalil Al
- Ajomah Nadia
- Akaba Godwin
- Akadh Ali
- Akalin Murat
- Akani Chris
- Akanni Bolaji
- Akbar Ali
- Akbar Bilal
- Akbar Hazrat Akbar
- Akbari Amir Ali
- Akbas Ahmet
- Akdeniz Yesim
- Akeel Nouf
- Akgor Utku
- Akhavizadegan Hamed
- Akhbari Melika
- Akhtar Amina
- Akhtar Fahad
- Akhtar Muhammad Adeel
- Akhtar Muhammad Shaheer
- Akhtar Munazza
- Akhtar Naseem
- Akhtar Tasleem
- Akhund Ramsha
- Akiely Jehad
- Akililu Yemisirach Bizuneh
- Akin Emrah
- Akinajo Opeyemi
- Akindoyin Success
- Akinloa Olufemi
- Akinmade Akinola
- Akinsola Sanusi
- Akinyemi Tosin
- Akkour Khalid
- Akl Michel
- Aklilu Abenezer Tirsit
- Akmercan Ahmet
- Akpla Marcellin
- Akpoghor Oghenevwegba
- Akram Shahzad
- Aktaa Nazeeh Al
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- Aktimur Yunus Emre
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- Akyol Cihangir
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- Al-Houssami Salma
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- Al-Isawi Ali
- Al-Jadaan Mohammad
- Al-Jarrah Amar
- Al-Jarrah Hothaifa
- Al-Jarrah Salsabeel
- Al-Kasaji Farah
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- Al-Maghrabi Sanabel
- Al-Mahdi Shehab
- Al-Mahmeed Husain
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- Al-Mandeel Hazem
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- Al-Masari Hayder
- Al-Masood Mohammed
- Al-Masri Mahmoud
- Al-Maswari Sakhr Abdulhakeem
- Al-Mohammad Abdulrahman
- Al-Mouakeh Ahmad
- Al-Mujaini Abdullah
- Al-Mukhaizeem Youssef
- Al-Naggar Hamza
- Al-Najjar Dania
- Al-Najjar Hani
- Al-Nawas Bilal
- Al-Oqabi Ayman
- Al-Oribi Saeid
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- Al-Shazly Mohammed Hamdy
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- Al-Slaibi Ibrahim
- Al-Sukaini Ahmad
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- Al-Tamimi Yahia
- Al-Tarakji Mohannad
- Al-Terki Abdullatif
- Al-Thaher Mohammad
- Al-Urfan Mohammed
- Al-Uzri Muntadhir
- Al-Wandi Amna Salam
- Al-Yahri Omer
- Al-Yaseen Mustafa
- Al-Zaazaai Zakarya Abdullah
- Al-Zazay Karim
- Al-Zyadat Reham
- Alaa Sherif
- Alabbad Jasim
- Alabbasi Amira
- Alabdulkarim Yousof
- Alabi Ibrahim Abolaji
- Alabras Mohamad
- Aladaileh Ammar
- Aladawi Omar
- Alade Samuel
- Aladelusi Timothy
- Alafif Ali
- Alaglan Abeer
- Alahaidib Adel
- Alahdal Hani
- Alahmad Feras
- Alahmadi Ibrahim
- Alahmari Ahmed
- Alahmed Salman
- Alajaji Nouf
- Alajalen Amer
- Alajmi Suha
- Alajmi Turki
- Alakaloko Felix
- Alakeel Deem
- Alakhdury Amira
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- Alalawi Yousef
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- Alameen Hind
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- Alaqel Sara
- Alarabi Alarabi
- Alarabi Rehab
- Alaradi Zuhair
- Alarcón Isaias
- Alarood Salameh
- Alarza Raquel
- Alasadi Ala
- Alasia Datonye
- Alasmari Mohammed
- Alassaf Mohammad
- Alassiri Ali
- Alatar Abdullah
- Alateeq Mohammed
- Alatiiga John Abanga
- Alatise Olusegun Isaac
- Alattas Zainab
- Alawadhi Abdulbari
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- Alawami Huda
- Alawami Mohammed
- Alawi Ahmed
- Alawi Khalil
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- Alayan Mohammed
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- Alayed Ahmad
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- Alazabi Basma
- Alazzeh Ghaleb
- Alba J Jr
- Albaba Basil
- Albadawi Ismail
- Albader Ibtisam
- Albadi Zamzam
- Albaini Obey
- Albaiti Adel
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- Albanese Erminia
- Albanopoulos Konstantinos
- Albargawi Ali
- Albarrak Abdullah
- Albarrak Majed
- Albasheer Mohammad
- Albastaki Aysha
- Albawardy Nof
- Albdah Abdullah
- Albendary Mohamed
- Alberici Laura
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- Albers Kim
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- Albiol Maria Teresa
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- Aldaghiri Khalid
- Aldahma Mohamed
- Aldakhil Ahmad
- Aldakhyel Lateefa
- Aldakkan Abdulrahman
- Aldalal Shuaib
- Aldana Joel
- Aldebeyan Wassim
- Alderazi Amer
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- Aldrighetti Luca Antonio
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- Alelwany Aisha
- Alemanno Giovanni
- Alemu Berhanu
- Alemu Megersa
- Alemán María
- Alesmail Abdulkarim
- Alexakis Nicholas
- Alexander Dinesh
- Alexander Golomidov
- Alexander Philip
- Alexander Tamara
- Alexander Thomas
- Alexandrou Andreas
- Alexe Vlad
- Alfarah Mohammad
- Alfaro Hilda
- Alfaro Valeria Cormane
- Alfaro-Goldaracena Alejandro
- Alfarra Dina
- Alfayez Fatema
- Alfeqeeh Ahmed
- Alferdaus Abdallah
- Alfieri Alex
- Alfieri Sergio
- Alford Stephanie
- Alfraidy Doaa
- Algadi Noran
- Algar-Yañez Barbara
- Algarni Mohammed
- Algarni Saad
- Alghafour Tayma
- Alghamdi Abdulaziz
- Alghamdi Abdullah A
- Alghamdi Ahmad
- Alghamdi Ibtihal
- Alghamdi Rami
- Alghamdi Susan
- Alghazal Thabet
- Alghazo Abdallah
- Alghuson Lolowah
- Alhabdan Sultan
- Alhaddad Amani
- Alhaddad Wafa
- Alhadeethi Ahmed
- Alhadi Abdulmueti
- Alhag Albrra
- Alhaidari Ammar
- Alhaje Awatif
- Alhajji Zahrah
- Alhakami Nuraddin
- Alhalal Hani
- Alhami Haneen Ahmad
- Alhamid Ahmad
- Alhamid Aos
- Alhamid Mohammad
- Alhammad Othman
- Alhammali Tariq
- Alharthi Bandar
- Alharthi Mohammed
- Alharthi Nawaf
- Alharthi Sultan
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- Martinez Yicel Alvarez
- Maryam A
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- Mendoza Veronica Alonso
- Mensah Kwasi Agyen
- Mintah Dominic Annor
- Moagal Rehab Al
- Moawad Karim Abdelraouf
- Mohamed Mohamed Ali
- Mohsen Mustafa Abo
- Momani Tareg Al
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- Obead Hamza Abu
- Oliver Renato Aguera
- Omair Shehanah Al
- Otaibi Faisal Al
- Picciochi Maria
- Pinto João Almeida
- Polo Miriam Abdulkarim
- Qadhi Hani Al
- Qudhaya Rashed Al
- Qureshi Talha Ahmed
- Rahim Norazila
- Rahman Noorneza Abdul
- Rahman Norhafiza
- Raisi Amani Al
- Rashed Asmaa Al
- Rego Juliana Almeida
- Riaz Shujat Ahmed
- Riobello Eva Andreu
- Riyami Nihal Al
- Riyami Salim Al
- Ros Conrado Andrés
- Roselló Irene Vives
- Rubio Eva Corral
- Rueda Ignacio Alcalá
- Saad Sarah Ahmed
- Sabti Hilal Al
- Saez Iago Alvarez
- Saied Ghiath Al
- Salam Omar Abdul
- Salama Ibrahim Abdelkader
- Sanany Ghadeer Al
- Santos Daniel Costa
- Sayed Mohamed Al
- Sebastian Isabel Alonso
- Shaalah Ahmed Abdullah
- Shaibi Maha Al
- Shaikh Shafqat Ali
- Shanab Ahmed Abo
- Sharie Ahmed Al
- Shukri Asmaa Al
- Simoes Joana
- Smadi Omar Al
- Soares Rui Costa
- Soucheiron Maria Coronas
- Subaie Saud Al
- Suyyagh Kais Al
- Tarieh Ammar Abu
- Torres Eva Alvarez
- Victoria Czarlo Dela
- Villamayor Verónica Alen
- Vinayagam Raman
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- Vishwakarma Sunil Kumar
- Vishwani Vartika
- Vissapragada Ravi
- Viste Claire
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- Viveiros Octavio
- Viveros-Carreño David
- Vives Inmaculada
- Vives-Barquiel Marian
- Vivian-Taylor Josephine
- Vix Michel
- Vlad Ioan Catalin
- Vlad Schitcu
- Vladimir Novgorodskii
- Vleminckx Nils
- Vo Uyen Giao
- Vogel Jon
- Vogel Keianna
- Vogel Rachel
- Vogelsang Holger
- Vogler Thomas
- Vogt Kelly
- Vohra Ravinder
- Vokshi Ismail
- Volkova Olga
- Volpe Gustavo Jardim
- Volpin Enrico
- Volpin Francesco
- von Ehrlich-Treuenstätt Viktor H
- von Renesse Janusz
- von Rundstedt Friedrich-Carl
- Voonna Murali Krishna
- Voppuru Saiesh Reddy
- Vora Sameer
- Voros Peter
- Vosoughi Fardis
- Vossler Kristen
- Vounckx Manon
- Vourganti Srinivas
- Vovola Fernanda
- Vozian Marin
- Vrakopoulou Gavriella Zoi
- Vömel Jacob
- Wadei Hajr Al
- Yahya Zakaria Al
- Zahran Mohammed
- Zahrani Attiya Al
- Zahrani Turki Ai
- Zaid Muna
- Zein Zeina Al
- Álvarez Sofia
- Älgå Andreas
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.
Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty.
Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year.
Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
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- Ye Geoffrey
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- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdağ Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
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- Ghonaim Mennatullah
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- Innocent Aryon
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- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
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- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research
Global economic burden of unmet surgical need for appendicitis
- Author
- A A Essam
- Abd El-Rahman Hegazy Khedr
- Abd Elkhalek Sallam
- Abd Elrahman Elshafay
- Abdalla Gamal Saad
- Abdalla Gharib
- Abdalla Kenibar
- Abdallah Salah Elsherbiny
- Abdalrahman Adel
- Abdelaziz Abdelaal
- Abdelaziz Osman Abdelaziz Elhendawy
- Abdelfatah Hussein
- Abdelkader Belkouchi
- Abdelmalek Hrora
- Abdelrahman Adelshone
- Abdelrahman Alkammash
- Abdelrahman Assal
- Abdelrahman Geuoshy
- Abdelrahman Haroun
- Abdelrahman Mohammed
- Abdelrahman Sayed
- Abdelrahman Soliman
- Abdelrhman Essam Elnemr
- Abdelrhman Kz Darwish
- Abdelrhman Osama Elsebaaye
- Abdul Khalique
- Abdul Rehman Alvi
- Abdul Wahid Anwar
- Abdulaziz Altwijri
- Abdullah Al-Mallah
- Abdullah Almoflihi
- Abdullah Altamimi
- Abdullah Daqeeq
- Abdullah Dwydar
- Abdullah Gouda
- Abdullah Hashim
- Abdulmalik Altaf
- Abdulmalik Huwait
- Abdulrahman Abdel-Aty
- Abdulrahman M Altwigry
- Abdulrahman Sheshe
- Abdulrasheed A Nasir
- AbdulRazzaq Oluwagbemiga Lawal
- Abdulshafi Khaled Abdrabou
- Abdurrahaman Sheshe
- Abdussemiu Abdurrazzaaq
- Abebe Bekele Zerihun
- Abeer Al-Shammari
- Abeer El Gendy
- Abeer Esam
- Abeer Marey
- Abhishek Mittal
- Abiboye Yifieyeh
- Abid Bin Mahamood
- Abidemi Adesuyi
- Abouelatta Khairy Aly
- Abrar Nawawi
- Adam Gyedu
- Ade Waterman
- Adedapo Osinowo
- Adedeji Fatuga
- Adel Albiety
- Adel B Hassanein
- Adel Denewar
- Adeleke Adekoya
- Ademola Adebanjo
- Ademola Adeyeye
- Ademola Popoola
- Adesina Adedeji
- Adesoji O Ademuyiwa
- Adesoji Tade
- Adewale Adeniyi
- Adewale O Adisa
- Adham Tarek
- Adomas Ladukas
- Adrian F Palma
- Afifatun Hasanah
- Afizah Salleh
- Afnan Abdelfatah
- Afnan Altamimi
- Afnan Altamini
- Agazi Fitsum
- Agboola Taiwo
- Ahamed Hassan
- Ahed Ghaben
- Ahmad Abdel Fattah
- Ahmad Abdel Razaq Al Rafati
- Ahmad Aboelkassem Ibrahem
- Ahmad Aldalaq
- Ahmad Ali
- Ahmad Almallah
- Ahmad Alrifaie
- Ahmad Ashour
- Ahmad Bakr
- Ahmad Bani-Sadar
- Ahmad Bin Adnan
- Ahmad Elbatahgy
- Ahmad Faraz
- Ahmad Gudal
- Ahmad Hasan
- Ahmad Khaled Sabe
- Ahmad Khoja
- Ahmad Nashaat
- Ahmad Qaissieh
- Ahmad Sabe
- Ahmad Saber Sleem
- Ahmad Sakr
- Ahmad Shalabi
- Ahmad Uzair Qureshi
- Ahmed Aamer
- Ahmed Abd El Galeel
- Ahmed Abd Elmoen Elhusseiny
- Ahmed Abd Elsameea
- Ahmed Abdelkareem
- Ahmed Abdelmotaleb Ghazy
- Ahmed Abo El Magd
- Ahmed Abo Elazayem
- Ahmed Adamu
- Ahmed Adel
- Ahmed Afandy
- Ahmed Ahmed
- Ahmed Al-Khatib
- Ahmed Alghamdi
- Ahmed Ali
- Ahmed Altibi
- Ahmed Alzahrani
- Ahmed Ata
- Ahmed Badr
- Ahmed Dahy
- Ahmed Diab
- Ahmed El Kashash
- Ahmed El Kholy
- Ahmed El-Sehily
- Ahmed Elgaili Khalid Musa
- Ahmed Elgebaly
- Ahmed Elkelany
- Ahmed Elkholy
- Ahmed Essam
- Ahmed Fahiem
- Ahmed Farag
- Ahmed Fawzy
- Ahmed Fouad
- Ahmed Gad
- Ahmed Ghanem
- Ahmed Gheith
- Ahmed Gomaa
- Ahmed Hafez El-Badri Kotb
- Ahmed Hammad
- Ahmed Hassan
- Ahmed Hossam Eldin Fouad Rida
- Ahmed Ismail
- Ahmed Karim
- Ahmed Khyrallh
- Ahmed Lasheen
- Ahmed M Rashed
- Ahmed Magdy
- Ahmed Mahmoud Abdelraouf
- Ahmed Menshawy
- Ahmed Meshref
- Ahmed Mohamed Afifi
- Ahmed Mohamed Ibrahim
- Ahmed Mohameden
- Ahmed Mohammed
- Ahmed Mokhtar
- Ahmed Mosad
- Ahmed Moustafa
- Ahmed Moustafa Saeed
- Ahmed Negida
- Ahmed Rabeih Mohammed
- Ahmed Rabie Mohamed
- Ahmed Ragab Nayel
- Ahmed Ragab Soliman
- Ahmed Raslan
- Ahmed Raza
- Ahmed Refaat
- Ahmed Rslan
- Ahmed Sabry
- Ahmed Sabry El-Hamouly
- Ahmed Safwan Marey
- Ahmed Saidbadr
- Ahmed Sakr
- Ahmed Samir
- Ahmed Shahine
- Ahmed Sheta
- Ahmed Soliman
- Ahmed Tammam
- Ahmed Tarek Abdelbaset Hassan
- Ahmed W Shamsedine
- Ahmed Zaki
- Ahmed Zaki Eldeeb
- Ahmed Zohair
- Ahmedali M Kandil
- Ahmedglal Elnagar
- Ahsan Zil-E-Ali
- Aijaz Jabbar
- Ailsa Claire Snaith
- Ainhoa Costas-Chavarri
- Aiste Austraite
- Ajayesh Mistry
- Akin Olaolorun
- Akinlabi E Ajao
- Al Faifi Jubran
- Ala Shamasneh
- Alaa Abouelnasr
- Alaa Al-Buhaisi
- Alaa Bowabsak
- Alaa El Jamassi
- Alaa Elazab
- Alaa Elhadad
- Alaa Fergany
- Alaa Habeebullah
- Alaa Hassan
- Alaa Shabkah
- Alaa Shaheen
- Alaba Adesina
- Alan Baird
- Alan Grant
- Alasdair Ball
- Alban Cacurri
- Albert Mohale Mphatsoe
- Alberto Realis Luc
- Alejandro Matheu
- Alejandro Munera
- Alemayehu Ginbo Bedada
- Alessandro Favero
- Alessio Maniscalco
- Alexander Canta Calua
- Alexander J Fowler
- Alexandra Gerosa
- Alexandre Horobjowsky
- Alexandre Venancio De Sousa
- Alexia Farrugia
- Alexis Pierre Arnaud
- Alfio Alessandro Russo
- Alfredo Gulielmi
- Ali Ababneh
- Ali Abo El Dahab
- Ali Amin Ahmed Ata
- Ali Khan Niazi
- Ali Kiasat
- Ali Mohamed Hammad
- Ali Zardab
- Ali Zeynel Abidin Balkan
- Aliaa Gamal Toeema
- Aliaa Sadek
- Aliaksandr Filatau
- Aliang Latif
- Alibeth Andres Baquero Suarez
- Alice Faure
- Alice Niragire
- Alina Robledo-Rabanal
- Aline Broch
- Alireza Hasheminia
- Alisdair Macdonald
- Aliyu Ndajiwo
- Allan Novak
- Alphonse Zeta Mutabazi
- Alvaro Enrique Mendoza Beleño
- Alvin Ee Zhiun Cheah
- Aly Abd Elrazek
- Aly Nasr
- Aly Sanad
- Alyaa Halim Elgendy
- Alyne Daltri Lazzarini Cury
- Amal Ibrahim
- Amandine Martin
- Amani Althwainy
- Amany Abouzahra
- Amany Eldosouky Mohammed
- Amar Kourdouli
- Amel Hashish
- Amerdip Birring
- Amgad Al Meligy
- Amina Abdelhamid
- Aminah Hanum Haji Abdul Majid
- Aminu Mohammad
- Amir Ait Kaci
- Amira Atef Omar
- Amira Elsawy
- Amira Hassan Bekhet
- Amira Reda
- Amjad Abu Qumbos
- Amjad Elmashala
- Ammar Gado
- Amna Mamdouh Mohamed
- Amna Mohamed
- Amoudtha Rasendran
- Amr Ahmed Saleh
- Amr Fadel
- Amr Hasan
- Amr Hassaan
- Amr Hossameldin
- Amr Muhammad Elkorashy
- Amr Tarek Hafez
- Amreen Faruq
- Amro Aglan
- Ana Cecilia Manchego Bautista
- Ana Lucia Contreras-Vergara
- Ana Maria Sandoval Barrantes
- Ana Vega Carreiro De Freitas
- Ana Vega Freitas
- Anam Rashid
- Anan Rady Abdelazeam
- Anand Kirishnan
- Anass Majbar
- Anastasia Bamicha
- Anastasios Stefanopoulos
- Anders Thorell
- Andre Das
- Andre Dubois
- Andre L Mihaljevic
- Andre Navarro
- Andrea Allegri
- Andrea Armellini
- Andrea Belli
- Andrea Bondurri
- Andrea Echevarria Rosas Moran
- Andrea Natili
- Andrea Ruzzenente
- Andrea Simioni
- Andreass Haloho
- Andrei Tanase
- Andrej Kolosov
- Andrejus Subocius
- Andrew G N Robertson
- Andrew Kirby
- Andrew Mcguigan
- Andrew Spina
- Andrey Litvin
- Andrius Burmistrovas
- Andrius Strazdas
- Andy Arenas
- Aneel Bhangu
- Anele Rudzenskaite
- Angel David Pérez Rojas
- Angela Dell
- Angelica Genoveva Vergara Mejia
- Angeline Charles
- Angelo Antoniozzi
- Angelo Benevento
- Angelos Tselos
- Angham Solaiman El-Ma'doul
- Anjana Sreedharan
- Ankur Bhatnagar
- Ann Kjellin
- Anna Lasek
- Anna Maffioli
- Anna Powell
- Anna Rinaldi
- Anna Watts
- Annalisa Lo Conte
- Annamaria Bigaran
- Annelisse Ashton
- Annisa Dewi Fitriana Mukin
- Antanas Gulbinas
- Antanas Zadoroznas
- Anthonius Santoso Rulie
- Anthony Ajiboye
- Anthony Avoka
- Anthony Chuk-Him Lai
- Anthony Davor
- Anthony Sander
- Antje Oosterkamp
- Antoinette Bediako-Bowan
- Antonella La Brocca
- Antonio Nocito
- Antonio Ramos-De La Medina
- Antonio Taddei
- Antônio Leal
- Anwar Atiyeh
- Anyomih Theophilus Teddy Kojo
- Aoife Driscoll
- Apar Shah
- Apostolos Vlachogiorgos
- April Camilla Roslani
- Aram Abdelhaq
- Arazzelly Del Pilar Paucar
- Arcangelo Picciariello
- Areej Tarek
- Arezo Kanani
- Ari Leppäniemi
- Arianna Birindelli
- Arij Ibrahim
- Arjun Nesaratnam
- Arlindawati Suyadi
- Armando José Román Velásquez
- Arnaud Bonnard
- Arnav Agarwal
- Aroub Alkaaki
- Arturas Vaicius
- Arvin Khamajeet
- Arvo Reinsoo
- Arwa Abouzaid
- Arwa Elfarargy
- Arwa Ibrahim
- Arwa Mohamed
- Asaf Kedar
- Asdaq Ahmed
- Ased Ali
- Aseel Alnusairat
- Aseel Hamarshi
- Aseel Musleh
- Ash Prabhudesai
- Ashraf A Maghrabi
- Ashraf Morsi
- Ashrarur Rahman Mitul
- Asmaa Abdel-Rahman Al-Aarag
- Asmaa Abdelgelil
- Asmaa Rezq
- Asmaa Salah
- Aspasia Papailia
- Assmaa Badwy
- Astrid Leusink
- Ata Khan
- Ataa Ahmed
- Athanasia Bamicha
- Athar Eysa
- Athirah Zulkifli
- Atif Mahdi
- Attia Attia
- Attia Mohamed Attia
- Audrey Clarissa
- Audrius Dulskas
- Audrius Parseliunas
- Augusto Zani
- Aung Kyaw Tun
- Aurel Mironescu
- Aurel Sandu Mironescu
- Aurelien Scalabre
- Aurora Mariani
- Aurore Haffreingue
- Aurore Thollot
- Ausrine Usaityte
- Austė Skardžiukaitė
- Awais Raza
- Aya Abdel Fatah Ibraheem
- Aya Aboarab
- Aya Adel Elsharkawy
- Aya El-Sawy
- Aya Elwaey
- Aya Firwana
- Aya Hagar
- Aya Hammad
- Aya Mohamed Fathy
- Aya Reda
- Aya Yehia Ata
- Ayah Hamdan
- Ayat Hassaan
- Ayman And Taher
- Ayman Elwan
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- Ayman Shwky
- Ayokunle Ogunyemi
- Azher Herebat
- Azmina Verjee
- Babajide Adenekan
- Babatunde Odeyemi
- Badr Eldin Adel
- Badreldin Adel Tawfik
- Bahar Busra Ozkan
- Bakeer Mohamed
- Bakhtiar Nighat
- Bandar Albeladi
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- William J Lossius
- William Milligan
- Willy Alcca Ticona
- Wing Sum Li
- Witold Chachulski
- Xavier Delforge
- Xianelle Rodriguez
- Xinwei Low
- Xue Wei Chan
- Ya Theng Neo
- Yacoubou Imorou Souaibou
- Yahaya Ukwenya
- Yahya Salama
- Yaseen Rajjoub
- Yasmein Ibrahim
- Yasmin Abd-Elrasoul
- Yasmin Elfouly
- Yasmin Hegazy
- Yasmin Soliman
- Yasser Abd El Salam
- Yee Wen Tan
- Yehia Zakaria
- Yella Reddy
- Yi Koon Tan
- Yi Ting Mok
- Yih Jeng Cheong
- Yiing Yee Gan
- Yishan Der
- Yogendra Praveen Mogan
- Yomna Allam
- Yomna Hosny Asar
- Yong Yong Tew
- Yousef Abuowda
- Yousra El Shoura
- Ysabel Esthefany Alejos Bermúdez
- Yuk Hong Eric Cheung
- Yuksel Altinel
- Yung Kok Ng
- Yuri Macchitella
- Yves Aigrain
- Yücel Cengiz
- Zaher Mikwar
- Zahra Jaffry
- Zain Ali Khan
- Zainab Iftikhar
- Zaynab M Elsayed
- Zhongtao Zhang
- Zi Hao Sam
- Zigmantas Urniežius
- Zilvinas Dambrauskas
- Zineb Bentounsi
- Zygimantas Tverskis
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially