Convection-reaction equation based magnetic resonance electrical properties tomography (cr-MREPT)

Cataloged from PDF version of article.Images of electrical conductivity and permittivity of tissues may be used for diagnostic purposes as well as for estimating local specific absorption rate distributions. Magnetic resonance electrical properties tomography (MREPT) aims at noninvasively obtaining conductivity and permittivity images at radio-frequency frequencies of magnetic resonance imaging systems. MREPT algorithms are based on measuring the B1 field which is perturbed by the electrical properties of the imaged object. In this study, the relation between the electrical properties and the measured B1 field is formulated for the first time as a well-known convection-reaction equation. The suggested novel algorithm, called “cr-MREPT,” is based on the solution of this equation on a triangular mesh, and in contrast to previously proposed algorithms, it is applicable in practice not only for regions where electrical properties are relatively constant but also for regions where they vary. The convective field of the convection-reaction equation depends on the spatial derivatives of the B1 field, and in the regions where its magnitude is low, a spot-like artifact is observed in the reconstructed electrical properties images. For eliminating this artifact, two different methods are developed, namely “constrained cr-MREPT” and “double-excitation cr-MREPT.” Successful reconstructions are obtained using noisy and noise-free simulated data, and experimental data from phantoms

Anti-inflammatory activity of some medicinal plants extracts commonly used in traditional medicine in healthy and diabetic rats.

Inflammation is a protective immune system reaction that guards the individual against infection. It is a big global issue. many anti-inflammation drugs have side effects. As a result, a different therapy module may be required. Due to their great efficacy and lack of side effects. This study examined the anti-inflammation activity of Rhus coriaria, Globularai arabica, and Malva slyvesitris in diabetic rats with paw edema caused by carrageenan. Rats were separated into two groups: non diabetic and diabetic rats. Each group have five sub groups seven rats/ group. Group 1, treated with saline for non diabetic and diabetic rats. Groups 2, treated with aspirin as a positive control for non diabetic and diabetic rats. Groups 3, 4 and 5, were treated orally with pants extract with concentration 50, 100 and 200 mg/kg for non diabetic and diabetic rats. Il-6 levels were measured in all treated groups after 7 hr of treatment. The results showed that methanolic extracts of R. coriaria and G. arabica at 200 mg/kg significantly (P< 0.01) decreases paw edema in diabetic rats compared with non-diabetic rats (P< 0.01). This resuts may imply that R. coriaria and G. arabica have potent anti-inflammatory properties in response to paw edema. The level of Il-6 was decreased in groups treated with 200 mg/kg R. coriraia and G. arabica indicating high efficacy on anti-inflammatory activity. in addition, M. slyversries has low activity. conclusion, extracts of R. coriaria and G. arabica exhibit anti-inflammatory effect in diabetic rats with paw edema

Thermonuclear Supernovae: Simulations of the Deflagration Stage and Their Implications

Large-scale three-dimensional numerical simulations of the deflagration stage of a thermonuclear supernova explosion show the formation and evolution of a highly convoluted turbulent flame in a gravitational field of an expanding carbon-oxygen white dwarf. The flame dynamics is dominated by the gravity-induced Rayleigh-Taylor instability that controls the burning rate. The thermonuclear deflagration releases enough energy to produce a healthy explosion. The turbulent flame, however, leaves large amounts of unburnt and partially burnt material near the star center, whereas observations imply these materials only in outer layers. This disagreement could be resolved if the deflagration triggers a detonation.Comment: 17 pages, 5 figures. To appear in Science, January 200

Structural, Electronic, and Magnetic Properties of LaNi₅₋ₓTₓ (T = Fe, Mn) Compounds

Structures and magnetic properties of the LaNi5-xFex and LaNi5-xMnx compounds have been investigated using neutron diffraction and first-principles tight-binding-linear-muffin-tin-orbital methods. Both neutron diffraction refinement data and total energy calculations show that the Fe and Mn atoms preferentially occupy the 3g sites in the hexagonal CaCu5-type structure. The calculated magnetic moments of Fe and Ni atoms are of 2.4-2.5μB and 0.2-0.5μB in LaNi5-xFex, respectively. The magnetic structure exhibits more localized moments at Fe atoms in LaNi5-xFex when x ≤ 1.0. Electronic structure calculations indicate that s-conduction electron spin polarization from the Ni or La atoms strongly interacts with Fe(Mn) d-spin moments in LaNi5-xFe(Mn)x (x ≠ 0) compounds, which gives rise to a very large valence transferred hyperfine field on the Ni or La sites. This s-d hybridization may lead to an interaction among magnetic clusters in these kinds of materials and may cause a spin freezing effect at low temperature when the Fe(Mn) content is very low in LaNi5-xFe(Mn)x. Mn atoms show magnetic moments of 3.0μB per atom due to a large exchange splitting in LaNi5-xMnx (x ≠ 0). LaNi4Mn is found to be ferrimagnetic, whereas antiferromagnetic exchange coupling between the Mn atoms is preferred for LaNi3Mn2. Both ferrimagnetic and ferromagnetic exchange interactions between Mn atoms are found in the LaNi2Mn3 compounds. The calculated results are in good agreement with the experimental neutron data

Spontaneous Transition of Turbulent Flames to Detonations in Unconfined Media

Deflagration-to-detonation transition (DDT) can occur in environments ranging from experimental and industrial systems to astrophysical thermonuclear (type Ia) supernovae explosions. Substantial progress has been made in explaining the nature of DDT in confined systems with walls, internal obstacles, or pre-existing shocks. It remains unclear, however, whether DDT can occur in unconfined media. Here we use direct numerical simulations (DNS) to show that for high enough turbulent intensities unconfined, subsonic, premixed, turbulent flames are inherently unstable to DDT. The associated mechanism, based on the nonsteady evolution of flames faster than the Chapman-Jouguet deflagrations, is qualitatively different from the traditionally suggested spontaneous reaction wave model, and thus does not require the formation of distributed flames. Critical turbulent flame speeds, predicted by this mechanism for the onset of DDT, are in agreement with DNS results.Comment: 4 pages, 3 figures; accepted to Physical Review Letter

Statistical modeling of health space based on metabolic stress and oxidative stress scores

Abstract Background Health space (HS) is a statistical way of visualizing individuals health status in multi-dimensional space. In this study, we propose a novel HS in two-dimensional space based on scores of metabolic stress and of oxidative stress. Methods These scores were derived from three statistical models: logistic regression model, logistic mixed effect model, and proportional odds model. HSs were developed using Korea National Health And Nutrition Examination Survey data with 32,140 samples. To evaluate and compare the performance of the HSs, we also developed the Health Space Index (HSI) which is a quantitative performance measure based on the approximate 95% confidence ellipses of HS. Results Through simulation studies, we confirmed that HS from the proportional odds model showed highest power in discriminating health status of individual (subject). Further validation studies were conducted using two independent cohort datasets: a health examination dataset from Ewha-Boramae cohort with 862 samples and a population-based cohort from the Korea association resource project with 3,199 samples. Conclusions These validation studies using two independent datasets successfully demonstrated the usefulness of the proposed HS

Micro-Electro-Mechanical-Systems (MEMS) and Fluid Flows

The micromachining technology that emerged in the late 1980s can provide micron-sized sensors and actuators. These micro transducers are able to be integrated with signal conditioning and processing circuitry to form micro-electro-mechanical-systems (MEMS) that can perform real-time distributed control. This capability opens up a new territory for flow control research. On the other hand, surface effects dominate the fluid flowing through these miniature mechanical devices because of the large surface-to-volume ratio in micron-scale configurations. We need to reexamine the surface forces in the momentum equation. Owing to their smallness, gas flows experience large Knudsen numbers, and therefore boundary conditions need to be modified. Besides being an enabling technology, MEMS also provide many challenges for fundamental flow-science research

Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreaks

Introduction: Contact tracing has the potential to control outbreaks without the need for stringent physical distancing policies, e.g. civil lockdowns. Unlike forward contact tracing, backward contact tracing identifies the source of newly detected cases. This approach is particularly valuable when there is high individual-level variation in the number of secondary transmissions (overdispersion). Methods: By using a simple branching process model, we explored the potential of combining backward contact tracing with more conventional forward contact tracing for control of COVID-19. We estimated the typical size of clusters that can be reached by backward tracing and simulated the incremental effectiveness of combining backward tracing with conventional forward tracing. Results: Across ranges of parameter values consistent with dynamics of SARS-CoV-2, backward tracing is expected to identify a primary case generating 3-10 times more infections than a randomly chosen case, typically increasing the proportion of subsequent cases averted by a factor of 2-3. The estimated number of cases averted by backward tracing became greater with a higher degree of overdispersion. Conclusion: Backward contact tracing can be an effective tool for outbreak control, especially in the presence of overdispersion as is observed with SARS-CoV-2

Origins of the Ambient Solar Wind: Implications for Space Weather

The Sun's outer atmosphere is heated to temperatures of millions of degrees, and solar plasma flows out into interplanetary space at supersonic speeds. This paper reviews our current understanding of these interrelated problems: coronal heating and the acceleration of the ambient solar wind. We also discuss where the community stands in its ability to forecast how variations in the solar wind (i.e., fast and slow wind streams) impact the Earth. Although the last few decades have seen significant progress in observations and modeling, we still do not have a complete understanding of the relevant physical processes, nor do we have a quantitatively precise census of which coronal structures contribute to specific types of solar wind. Fast streams are known to be connected to the central regions of large coronal holes. Slow streams, however, appear to come from a wide range of sources, including streamers, pseudostreamers, coronal loops, active regions, and coronal hole boundaries. Complicating our understanding even more is the fact that processes such as turbulence, stream-stream interactions, and Coulomb collisions can make it difficult to unambiguously map a parcel measured at 1 AU back down to its coronal source. We also review recent progress -- in theoretical modeling, observational data analysis, and forecasting techniques that sit at the interface between data and theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue connected with a 2016 ISSI workshop on "The Scientific Foundations of Space Weather." 44 pages, 9 figure