3,844 research outputs found

    Harmonic Generation in a Terawatt X-Ray Free-Electron Laser

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    Terawatt x-ray free-electron lasers (XFELs) require high current densities with strong transverse focusing. The implications on harmonic generation are discussed using the MINERVA simulation code which self-consistently includes harmonic generation. We consider helical and planar undulators where the fundamental is at 1.5 Angstrom and study the associated harmonic generation. While tapered undulators are needed to reach TW powers at the fundamental, the taper does not enhance the harmonics because the taper must start before saturation of the fundamental, with the harmonics saturating earlier. Nevertheless, the harmonics reach substantial powers and enable enhanced applications.Comment: 4 pages, 4 figure

    The prediction and management of aquatic nitrogen pollution across Europe: an introduction to the Integrated Nitrogen in European Catchments project (INCA)

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    International audienceExcess nitrogen in soils, fresh water, estuarine and marine systems contributes to nutrient enrichment in key ecosystems throughout Europe, often leading to detrimental environmental impacts, such as soil acidification or the eutrophication of water bodies. The Integrated Nitrogenmodel for European Catchments (INCA) project aims to develop a generic version of the Integrated Nitrogen in Catchments (INCA) model to simulate the retention and transport of nitrogen within river systems, thereby providing a tool to aid the understanding of nitrogen dynamics and for river-basin management/policy-making. To facilitate the development of the model, 10 partners have tested the INCA model with data collected in study sites located in eight European countries as part of the INCA project. This paper summarises the key nitrogen issues within Europe, describes the main aims and methodology of the INCA project, and sets the project in the context of the current major research initiatives at a European level. Keywords: Europe, European Union, nitrogen, nitrate, ammonium, river basin management, modelling, water chemistry, acidification, eutrophication, Water Framework Directive, INCA

    Orotracheal intubation in infants performed with a stylet versus without a stylet

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    Background: Neonatal endotracheal intubation is a common and potentially life-saving intervention. It is a mandatory skill for neonatal trainees, but one that is difficult to master and maintain. Intubation opportunities for trainees are decreasing and success rates are subsequently falling. Use of a stylet may aid intubation and improve success. However, the potential for associated harm must be considered. Objectives To compare the benefits and harms of neonatal orotracheal intubation with a stylet versus neonatal orotracheal intubation without a stylet. Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library; MEDLINE; Embase; the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and previous reviews. We also searched cross-references, contacted expert informants, handsearched journals, and looked at conference proceedings. We searched clinical trials registries for current and recently completed trials. We conducted our most recent search in April 2017. Selection criteria All randomised, quasi–randomised, and cluster-randomised controlled trials comparing use versus non-use of a stylet in neonatal orotracheal intubation. Data collection and analysis: Two review authors independently assessed results of searches against predetermined criteria for inclusion, assessed risk of bias, and extracted data. We used the standard methods of the Cochrane Collaboration, as documented in the Cochrane Handbook for Systemic Reviews of Interventions, and of the Cochrane Neonatal Review Group. Main results: We included a single-centre non-blinded randomised controlled trial that reported a total of 302 intubation attempts in 232 infants. The median gestational age of enrolled infants was 29 weeks. Paediatric residents and fellows performed the intubations. We judged the study to be at low risk of bias overall. Investigators compared success rates of first-attempt intubation with and without use of a stylet and reported success rates as similar between stylet and no-stylet groups (57% and 53%) (P = 0.47). Success rates did not differ between groups in subgroup analyses by provider level of training and infant weight. Results showed no differences in secondary review outcomes, including duration of intubation, number of attempts, participant instability during the procedure, and local airway trauma. Only 25% of all intubations took less than 30 seconds to perform. Study authors did not report neonatal morbidity nor mortality. We considered the quality of evidence as low on GRADE analysis, given that we identified only one unblinded study. Authors' conclusions: Current available evidence suggests that use of a stylet during neonatal orotracheal intubation does not significantly improve the success rate among paediatric trainees. However, only one brand of stylet and one brand of endotracheal tube have been tested, and researchers performed all intubations on infants in a hospital setting. Therefore, our results cannot be generalised beyond these limitations
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