Petrology, geochemistry and tectonomagmatic evolution of Hezar Igneous Complex (Rayen - south of Kerman - Iran): the first description of an arc remnant of the Neotethyan subduction zone

The Hezar Igneous Complex (HIC) in the south-eastern part of Urumieh-Dokhtar magmatic arc, is the most prominent magmatic feature in the Kerman Porphyry Copper Belt, that understanding magmatic evolution of which may shed light on the tectonomagmatic development of this less-studied part of an important magmatic arc in the Neotethys realm. The HIC has been developed in the the intersection of the N-S striking Sabzevaran fault and the NW-SE striking Rafsanjan-Rayen fault. It is indicated that the possible place of the conduit and vent is in Jalas Mountain which has been splitted later by the Sabzevaran fault into Minor and Major Jalas. The current summit had been constructed by ascending magma chamber under the HIC that constitutes the Kamali Mountain at the south of the summit. Some plutonic rocks of the HIC are exposed at Kamali Mountain. The subalkaline rocks of this complex mainly are composed of different pyroclastic and lava flow rocks, acidic to basic in composition, showing the evidences of fractional crystallization and mineral segregation. Sequential explosive and effusive eruptions with Strombolian to Vulcanian types are evident in the successive volcanic layers. The compositional trend shows the melting of spinel lherzolite, not garnet lherzolite. The subduction-related mechanism of the magma genesis has been indicated by IAB nature of the magma formation in geochemical diagrams.publishe

Organoids and organ chips in ophthalmology

Recent advances have driven the development of stem cell-derived, self-organizing, three-dimensional miniature organs, termed organoids, which mimic different eye tissues including the retina, cornea, and lens. Organoids and engineered microfluidic organ-on-chips (organ chips) are transformative technologies that show promise in simulating the architectural and functional complexity of native organs. Accordingly, they enable exploration of facets of human disease and development not accurately recapitulated by animal models. Together, these technologies will increase our understanding of the basic physiology of different eye structures, enable

A facile and efficient method for the synthesis of quinoxaline derivatives using 2-(sulfooxy)ethylsulfamic acid as a novel difunctional bronsted acid, recyclable and organocatalyst

A novel, mild, eco-friendly and efficient method has been developed for the preparation of quinoxaline derivatives in high yields via a one-pot condensation of aromatic diamine and 1,2-dicarbonyl compounds in the presence of 2-(sulfooxy)ethylsulfamic acid (SESA). Moreover, sulfamic acid has been employed as a solid acid catalyst. Recycling of the catalyst is one of the most significant advantages of the proposed method

Model-Free Geometric Fault Detection and Isolation for Nonlinear Systems Using Koopman Operator

This paper presents a model-free fault detection and isolation (FDI) method for nonlinear dynamical systems using Koopman operator theory and linear geometric technique. The key idea is to obtain a Koopman-based reduced-order model of a nonlinear dynamical system and apply the linear geometric FDI method to detect and isolate faults in the system. Koopman operator is an infinite-dimensional, linear operator which lifts the nonlinear dynamic data into an infinite-dimensional space where the correlations of dynamic data behave linearly. However, due to the infinite dimensionality of this operator, an approximation of the operator is needed for practical purposes. In this work, the Koopman framework is adopted toward nonlinear dynamical systems in combination with the linear geometric approach for fault detection and isolation. In order to demonstrate the efficacy of the proposed FDI solution, a mathematical nonlinear dynamical system, and an experimental three-tank setup are considered. Results show a remarkable performance of the proposed geometric Koopman-based fault detection and isolation (K-FDI) technique.Scopu

Studying the correlation between balance assessment by Biodex Stability System and Berg Scale in stroke individuals

Introduction: Balance disorders are considered to be a serious clinical manifestation after stroke. Therefore, to assess stroke patients' balance performance, use of a quantitative method appears essential. A fundamental step would be the approval of the efficiency of the measurement instruments. The current study aimed to investigate correlations between balance assessment as examined by Biodex Stability System (BSS)and the clinical Berg Balance Scale (BBS)in post-stroke hemiparesis. Methods: Twenty-five stroke survivors and 25 healthy age-sex matched subjects were recruited. The subjects were assessed using BSS during 3 days, with a 24-h interval. The high interclass correlation coefficient (ICC)values showed that the system was reliable enough to continue the study. The clinical evaluation was performed by the standard BBS. Results: There was a significant moderate negative correlation between the Biodex overall indices and BBS scores in the stroke groups (ravg = �0.68)and in the healthy cohort (ravg = -0.55). Also, a significant moderate negative correlation was found between the Biodex antero-posterior stability indices and BBS scores in the stroke groups (ravg = �0.67)and in healthy cohort (ravg = �0.55). The correlation between the Biodex mediolateral stability indices and BBS scores was moderate to low in the stroke and healthy groups (ravg = �0.67 and �0.39 respectively). Discussion and conclusion: Moderate negative correlation between the stability indices of the Biodex Stability System and BBS scores indicates that dynamic balance status of the participants partially reflects their functional balance status. © 2019 Elsevier Lt

A Novel Proportional Navigation Based Method for Robotic Interception Planning with Final Velocity Control

This paper presents a new method for robot interception planning based on the proportional navigation. Guidance laws are basically developed for aerospace applications where a pursuer impacts a target using these methods, however in the robotic application it is required to have a smooth grasp between the robot and the goal. In this method, a new term is considered for longitude axis to have the control on the final approaching velocity. The proposed method not only ensures the position and velocity match (also referred to as rendezvous) but also can be used to set the final closing velocity to any desired value. Approaching velocity can be zero for grasping the goal or a specific known velocity for hitting it in a controlled manner. It is shown that the capture region of the proposed approach is wider that other proportional navigation based methods. The proposed method is implemented on Qbot-2 and its performance is experimentally validated.Scopu

A Cyber-Security Methodology for a Cyber-Physical Industrial Control System Testbed

Due to recent increase in deployment of Cyber-Physical Industrial Control Systems in different critical infrastructures, addressing cyber-security challenges of these systems is vital for assuring their reliability and secure operation in presence of malicious cyber attacks. Towards this end, developing a testbed to generate real-time data-sets for critical infrastructure that would be utilized for validation of real-time attack detection algorithms are indeed highly needed. This paper investigates and proposes the design and implementation of a cyber-physical industrial control system testbed where the Tennessee Eastman process is simulated in real-time on a PC and the closed-loop controllers are implemented on the Siemens PLCs. False data injection cyber attacks are injected to the developed testbed through the man-in-the-middle structure where the malicious hackers can in real-time modify the sensor measurements that are sent to the PLCs. Furthermore, various cyber attack detection algorithms are developed and implemented in real-time on the testbed and their performance and capabilities are compared and evaluated.North Atlantic Treaty Organization; Qatar Foundation; Qatar National Research FundScopu

Long-Acting Injectable Antipsychotics: A Systematic Review of Their Non-Systemic Adverse Effect Profile

Monica Zolezzi,1 Rawan Abouelhassan,1 Yassin Eltorki,2 Peter M Haddad,2 Mahtab Noorizadeh1 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Mental Health Hospital, Hamad Medical Corporation, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, Qatar University, PO Box 2713, Doha, QatarEmail [email protected]: Long acting injectable (LAI) antipsychotics are commonly used in the treatment of schizophrenia to improve adherence and clinical outcomes. Concerns have been reported in relation to their non-systemic or injection site adverse effect profile. As such, this study aims to review and evaluate all evidence reporting injection site adverse effects with LAI antipsychotics.Methods: An electronic search was systematically conducted through four databases (PubMed, Embase, SCOPUS, Cochrane) in order to identify studies investigating injection-site reactions associated with LAI antipsychotics. Unpublished studies such as conference proceedings and clinical trial registries were also searched. The search was limited to literature published in English without year limits.Results: Of a total of 189 citations that were identified from the electronic database search, 12 were selected for inclusion in this review. Various injection site reactions were reported in these studies, including pain, bleeding, and swelling. Overall, the studies reported a low incidence of these injection site reactions. Only a minority of the included articles compared injection site reactions between different LAI antipsychotics.Conclusion: Injection site pain was the most commonly reported injection site adverse effect across all articles reviewed. The low incidence of injection site adverse effects associated with LAI antipsychotics indicates that these formulations appear to be well tolerated by patients. More head-to-head trials comparing second generation LAI antipsychotics are needed.Keywords: intramuscular preparations, depot antipsychotics, injection site adverse effect