728 research outputs found
Plasma Concentrations of Short-Chain Fatty Acids in Active and Recovered Anorexia Nervosa
Anorexia nervosa (AN) is one of the most lethal psychiatric disorders. To date, we lack adequate knowledge about the (neuro)biological mechanisms of this disorder to inform evidence-based pharmacological treatment. Gut dysbiosis is a trending topic in mental health, including AN. Communication between the gut microbiota and the brain is partly mediated by metabolites produced by the gut microbiota such as short-chain fatty acids (SCFA). Previous research has suggested a role of SCFA in weight regulation (e.g., correlations between specific SCFA-producing bacteria and BMI have been demonstrated). Moreover, fecal SCFA concentrations are reported to be altered in active AN. However, data concerning SCFA concentrations in individuals who have recovered from AN are limited. In the present study, we analyzed and compared the plasma concentrations of seven SCFA (acetic-, butyric-, formic-, isobutyric-, isovaleric-, propionic-, and succinic acid) in females with active AN (n = 109), recovered from AN (AN-REC, n = 108), and healthy-weight age-matched controls (CTRL, n = 110), and explored correlations between SCFA concentrations and BMI. Significantly lower plasma concentrations of butyric, isobutyric-, and isovaleric acid were detected in AN as well as AN-REC compared with CTRL. We also show significant correlations between plasma concentrations of SCFA and BMI. These results encourage studies evaluating whether interventions directed toward altering gut microbiota and SCFA could support weight restoration in AN
Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study
10.1186/1471-2350-13-66BMC Medical Genetics13-BMGM
On Anomaly-free Supergravity as an Effective String Theory
The equations of motion of anomaly-free supergravity are shown to fulfil (to
all orders in ) a differential condition corresponding to the one
relating the Weyl anomaly coefficients for a non-linear sigma model
representing a (heterotic) string propagating in a non-trivial background. This
supports the possibility that anomaly-free supergravity could provide the
complete massless effective theory for the heterotic string.Comment: 7 pages, Latex, CERN-TH.6686/9
Heterotic instantons and solitons in anomaly-free supergravity
We extend the classical heterotic instanton solutions to all orders in
using the equations of anomaly-free supergravity, and discuss the
relation between these equations and the string theory -functions.Comment: 10 page
Deformation independent open brane metrics and generalized theta parameters
We investigate the consequences of generalizing certain well established
properties of the open string metric to the conjectured open membrane and open
Dp-brane metrics. By imposing deformation independence on these metrics their
functional dependence on the background fields can be determined including the
notorious conformal factor. In analogy with the non-commutativity parameter
in the string case, we also obtain `generalized' theta
parameters which are rank q+1 antisymmetric tensors (polyvectors) for open
Dq-branes and rank 3 for the open membrane case. The expressions we obtain for
the open membrane quantities are expected to be valid for general background
field configurations, while the open D-brane quantities are only valid for one
parameter deformations. By reducing the open membrane data to five dimensions,
we show that they, modulo a subtlety with implications for the relation between
OM-theory and NCYM, correctly generate the open string and open D2-data.Comment: 24 pages, LaTe
Effects of a Synbiotic on Plasma Immune Activity Markers and Short-Chain Fatty Acids in Children and Adults with ADHD—A Randomized Controlled Trial
Synbiotic 2000, a pre + probiotic, reduced comorbid autistic traits and emotion dysregulation in attention deficit hyperactivity disorder (ADHD) patients. Immune activity and bacteria-derived short-chain fatty acids (SCFAs) are microbiota–gut–brain axis mediators. The aim was to investigate Synbiotic 2000 effects on plasma levels of immune activity markers and SCFAs in children and adults with ADHD. ADHD patients (n = 182) completed the 9-week intervention with Synbiotic 2000 or placebo and 156 provided blood samples. Healthy adult controls (n = 57) provided baseline samples. At baseline, adults with ADHD had higher pro-inflammatory sICAM-1 and sVCAM-1 and lower SCFA levels than controls. Children with ADHD had higher baseline sICAM-1, sVCAM-1, IL-12/IL-23p40, IL-2Rα, and lower formic, acetic, and propionic acid levels than adults with ADHD. sICAM-1, sVCAM-1, and propionic acid levels were more abnormal in children on medication. Synbiotic 2000, compared to placebo, reduced IL-12/IL-23p40 and sICAM-1 and increased propionic acid levels in children on medication. SCFAs correlated negatively with sICAM-1 and sVCAM-1. Preliminary human aortic smooth-muscle-cell experiments indicated that SCFAs protected against IL-1β-induced ICAM-1 expression. These findings suggest that treatment with Synbiotic 2000 reduces IL12/IL-23p40 and sICAM-1 and increases propionic acid levels in children with ADHD. Propionic acid, together with formic and acetic acid, may contribute to the lowering of the higher-than-normal sICAM-1 levels
Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells
Many pathogenic mitochondrial DNA mutations are heteroplasmic, with a mixture of mutated and wild-type mtDNA present within individual cells. The severity and extent of the clinical phenotype is largely due to the distribution of mutated molecules between cells in different tissues, but mechanisms underpinning segregation are not fully understood. To facilitate mtDNA segregation studies we developed assays that measure m.3243A>G point mutation loads directly in hundreds of individual cells to determine the mechanisms of segregation over time. In the first study of this size, we observed a number of discrete shifts in cellular heteroplasmy between periods of stable heteroplasmy. The observed patterns could not be parsimoniously explained by random mitotic drift of individual mtDNAs. Instead, a genetically metastable, heteroplasmic mtDNA segregation unit provides the likely explanation, where stable heteroplasmy is maintained through the faithful replication of segregating units with a fixed wild-type/m.3243A>G mutant ratio, and shifts occur through the temporary disruption and re-organization of the segregation units. While the nature of the physical equivalent of the segregation unit remains uncertain, the factors regulating its organization are of major importance for the pathogenesis of mtDNA diseases
Enhanced T-odd P-odd Electromagnetic Moments in Reflection Asymmetric Nuclei
Collective P- and T- odd moments produced by parity and time invariance
violating forces in reflection asymmetric nuclei are considered. The enhanced
collective Schiff, electric dipole and octupole moments appear due to the
mixing of rotational levels of opposite parity. These moments can exceed
single-particle moments by more than two orders of magnitude. The enhancement
is due to the collective nature of the intrinsic moments and the small energy
separation between members of parity doublets. In turn these nuclear moments
induce enhanced T- and P- odd effects in atoms and molecules. First a simple
estimate is given and then a detailed theoretical treatment of the collective
T-, P- odd electric moments in reflection asymmetric, odd-mass nuclei is
presented and various corrections evaluated. Calculations are performed for
octupole deformed long-lived odd-mass isotopes of Rn, Fr, Ra, Ac and Pa and the
corresponding atoms. Experiments with such atoms may improve substantially the
limits on time reversal violation.Comment: 28 pages, Revte
Suppression of High-p_T Neutral Pion Production in Central Pb+Pb Collisions at sqrt{s_NN} = 17.3 GeV Relative to p+C and p+Pb Collisions
Neutral pion transverse momentum spectra were measured in p+C and p+Pb
collisions at sqrt{s_NN} = 17.4 GeV at mid-rapidity 2.3 < eta_lab < 3.0 over
the range 0.7< p_T < 3.5 GeV/c. The spectra are compared to pi0 spectra
measured in Pb+Pb collisions at sqrt{s_NN} = 17.3 GeV in the same experiment.
For a wide range of Pb+Pb centralities (N_part < 300) the yield of pi0's with
p_T > 2 GeV/c is larger than or consistent with the p+C or p+Pb yields scaled
with the number of nucleon-nucleon collisions (N_coll), while for central Pb+Pb
collisions with N_part > 350 the pi0 yield is suppressed.Comment: 5 pages, 4 figure
Pion Freeze-Out Time in Pb+Pb Collisions at 158 A GeV/c Studied via pi-/pi+ and K-/K+ Ratios
The effect of the final state Coulomb interaction on particles produced in
Pb+Pb collisions at 158 A GeV/c has been investigated in the WA98 experiment
through the study of the pi-/pi+ and K-/K+ ratios measured as a function of
transverse mass. While the ratio for kaons shows no significant transverse mass
dependence, the pi-/pi+ ratio is enhanced at small transverse mass values with
an enhancement that increases with centrality. A silicon pad detector located
near the target is used to estimate the contribution of hyperon decays to the
pi-/pi+ ratio. The comparison of results with predictions of the RQMD model in
which the Coulomb interaction has been incorporated allows to place constraints
on the time of the pion freeze-out.Comment: 9 pages, 12 figure
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