16 research outputs found
Peripheral somatic nerve function in relation to glucose tolerance in an elderly Caucasian population: The Hoorn study
Randomized study of two different target levels of glycemic control within the acceptable range in type 2 diabetes - Effects on well-being at 1 year
OBJECTIVE - A randomized trial with 1-year follow-up was conducted in 23 general practices to study the relationship between target values for glycemic control and well-being in type 2 diabetes. RESEARCH DESIGN AND METHODS - A total of 176 patients with type 2 diabetes, aged 40-75 years, were included. General practitioners were encouraged to make decisions according to a standardized step-up regimen until the target level of glycemic control was reached. The random allocation to a strict or a less strict target level of glycemic control (fasting capillary glucose <6.5 or <8.5 mmol/l), change in HbA(1c) and fasting glucose, and initiating insulin or treatment with oral hypoglycemic agents were studied as putative determinants of scores on a type 2 diabetes symptom checklist, a profile of mood states, an affect balance scale, and general well-being. Adjustments were made for baseline scores on the outcome at issue. RESULTS - Positive affect (an odds ratio [OR] [95% CI] of 0.39 [0.19-0.83]) and perceived treatment burden (OR 0.48 [0.23-0.98]) were unfavorably altered in the group randomly allocated to stricter target levels (fasting capillary glucose <6.5 mmol/l). Patients who had a decrease in HbA(1c) of 1% or more tended to have comparatively favorable mood (OR displeasure score 0.35 [0.13-0.94]) and general well-being scores at 1 year (ORs of having unfavorable scores ranged from 0.4 to 0.5, NS). CONCLUSIONS - Perceived treatment burden and positive effect are unfavorably affected by random allocation to a strict target level for glycemic control. Improved glycemic control is associated with favorable mood and possibly general well-being in type 2 diabetes
Π‘Π²ΡΠ·ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΡΠ΅Π΄Π½Π΅ΠΌΠ΅ΡΡΡΠ½ΡΡ ΠΠ‘Π Π½Π°Π΄ ΠΠ½ΡΠ°ΡΠΊΡΠΈΠΊΠΎΠΉ ΠΈ ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ ΡΠ΅ΠΏΠ»ΠΎΠ³ΠΎ ΡΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π±Π°ΡΡΠ΅ΠΉΠ½Π° Π’ΠΈΡ ΠΎΠ³ΠΎ ΠΎΠΊΠ΅Π°Π½Π° ΠΏΡΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΏΠΎΡΠ΅ΠΏΠ»Π΅Π½ΠΈΠΈ ΠΊΠ»ΠΈΠΌΠ°ΡΠ°
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΠ±ΡΠ°Π½Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ
ΡΡΠ΅Π΄Π½Π΅ΠΌΠ΅ΡΡΡΠ½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΠΠ‘Π Π½Π°Π΄ ΠΠ½ΡΠ°ΡΠΊΡΠΈΠΊΠΎΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ Π’Π’Π Π² Π·Π°ΠΏΠ°Π΄Π½ΠΎΠΌ ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΠΈ. ΠΡΠ΅Π΄ΠΌΠ΅ΡΠΎΠΌ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΅ΡΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΊΠ°Π·Π°Π½Π½ΡΠΌΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌΠΈ, ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΠ²ΡΠΈΠΌΠΈ
Π·Π° ΠΏΠ΅ΡΠΈΠΎΠ΄ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅ΠΏΠ»Π΅Π½ΠΈΡ ΠΊΠ»ΠΈΠΌΠ°ΡΠ°. Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ Π΅ΡΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈΡ
ΡΠ²ΡΠ·Π΅ΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ Π½Π°
ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅ΠΏΠ»Π΅Π½ΠΈΡ ΠΊΠ»ΠΈΠΌΠ°ΡΠ° ΡΡΠΈΠ»ΠΈΠ²Π°Π»ΠΈΡΡ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎ ΠΈ Π½ΡΠ½Π΅ ΡΠ²Π»ΡΡΡΡΡ
Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ