A Rare Case of Prostatic Stromal Tumour of Uncertain Malignant Potential Surrounding Ejaculatory Ducts in a Patient With Concurrent Prostate Adenocarcinoma

© 2022 Chan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., https://creativecommons.org/licenses/by/4.0/Stromal tumour of uncertain malignant potential (STUMP) is exceedingly rare. Diagnosis and management of STUMP present a challenge to the urologist due to the absence of specific clinical findings and its unpredictable clinical course. Thus, radical resection is often recommended. Here, we present a case of a 64-year-old male, who presented with mild obstructive voiding symptoms with a raised age-specific prostate-specific antigen (PSA) of 3.1. Magnetic resonance imaging (MRI) showed an area of suspicion, in an area thought to be the left seminal vesicle, containing a malignant lesion within it. Biopsy of this area and the prostate confirmed concurrent prostatic STUMP and Gleason 3+3=6 adenocarcinoma of the prostate, managed with robotic-assisted laparoscopic radical prostatectomy with wide local excision.Peer reviewe

Biocompatibility of PCL-Graphene Nanostructured Scaffolds with Mouse Embryonic Stem Cell-derived Cardiomyocytes

Since adult cardiomyocytes are not readily available for clinical use, numerous efforts have been made to derive functional cardiomyocytes from pluripotent stem cells. [1,2]. A variety of cardiovascular tissue engineering strategies have been explored to develop engineered cardiac tissues for in vitro and in vivo applications utilizing fibrous tissue scaffolds, both single polymer scaffolds and hybrids of polymers with hydrogels, coatings or embedded materials[3-9]. While graphene, a single layer carbon crystal, has recently become a material of interest for tissue engineering applications including osteogenic, neural and stem cell differentiation [10-12], its potential for cardiac tissue engineering is yet unknown. The inherent electro-activity of the myocardium makes graphene an especially attractive option for cardiac tissue engineering due to its high electrical conductivity. Thus, a novel hybrid 3D scaffold with graphene has been developed and its effect on the function of stem cell derived cardiomyocytes is examined

An intrauterine insemination audit at tertiary care hospital: A 4½ years' retrospective analysis of 800 intrauterine insemination cycles

Background: There are many variables that may influence the success rates of intrauterine insemination (IUI) treatment. Therefore, a regular audit program is needed for planning effective infertility treatment and improving pregnancy outcomes. Aims and Objectives: The main objective of this study was to identify the crucial predicting factors that can influence the IUI success. Materials and Methods: A retrospective analysis of 800 IUI cycles done from January, 2013 to August, 2017 in 651 couples with various etiologies of infertility. The common etiologies included female factor of ovulatory dysfunction, tubal, endocrinal, male factor, male and female factors combined, and unexplained factors. Ovulation induction was done either by clomiphene citrate (CC) alone or in combination of CC with gonadotropins or pure gonadotropins only. Human chorionic gonadotropin trigger was given when at least one dominant follicle measuring ≥18 mm with an endometrial thickness of >7 mm was obtained. IUI was done post 36 h of trigger. The double-density gradient method was the preferred method of sperm preparation. Results: In 800 cycles in corresponding 651 couples, the total outcome was 113 pregnancies (14.1%) per cycle with overall pregnancy rate (PR) per couple of 17.3%. The highest PR was observed in the patient with ovulatory dysfunction (21.2%), followed by patients with combined factor (15.1%) and male factor (14.7%). In the study, a higher PR was achieved in the female ≤25 years (18.9%) P < 0.04 with significant findings with duration of infertility ≤5 years (15.1%) having primary infertility (14.5%) with low body mass index <25 (14.1%). IUI success rate was highest in the first cycle (14.6%) followed by second cycle (14.0%) and third cycle (3.5%). Conclusion: IUI audit enables the characterization of prognostic factors to achieve improved PR. This study identifies the factors that can predict improved pregnancy outcome in women age ≤25 years and endometrium thickness between 9 and 11 mm. We also recommend IUI as a first line of infertility treatment for couples in low-income setting provided the women age and duration of infertility are acceptably low

raghavnarula/MovieRecommender: Sentiment Analysis on Coments

&lt;p&gt;Added sentiment analysis on comments so as to separate them into three categories:&lt;/p&gt; &lt;ul&gt; &lt;li&gt;Supportive&lt;/li&gt; &lt;li&gt;Critical&lt;/li&gt; &lt;li&gt;Neutral&lt;/li&gt; &lt;/ul&gt; &lt;h2&gt;What's Changed&lt;/h2&gt; &lt;ul&gt; &lt;li&gt;Added Sentiment Analysis by @AtharvaThorve in https://github.com/raghavnarula/MovieRecommender/pull/20&lt;/li&gt; &lt;li&gt;Updated README.md by @raghavnarula in https://github.com/raghavnarula/MovieRecommender/pull/21&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;&lt;strong&gt;Full Changelog&lt;/strong&gt;: https://github.com/raghavnarula/MovieRecommender/compare/v2.0...v2.5&lt;/p&gt

Neurovascular structure-adjacent frozen-section examination robotic-assisted radical prostatectomy: outcomes from 500 consecutive cases in the UK

© 2021 Springer Nature. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1007/s11701-021-01324-2The purpose is to report the United Kingdom’s largest single-centre experience of robotically assisted laparoscopic radical prostatectomies (RALP), using the neurovascular structure-adjacent frozen-section (NeuroSAFE) technique. We describe the utilisation and outcomes of this technique. This is a retrospective study from 2012 to 2019 on 520 patients undergoing NeuroSAFE RALP at our Institution. Our Institution’s database was analysed for false-positive frozen-section (FS) margins as confirmed on paraffin histopathological analysis: functional outcomes of potency, continence, and biochemical recurrence (BCR). The median (range) of console time was 145 (90–300) min. In our cohort, positive FS was seen in 30.7% (160/520) of patients, with a confirmatory paraffin analysis in 91.8% of our patients’ cohort (147/160). The neurovascular bundles (NVBs) that underwent secondary resection contained tumour in 26.8% (43/160) of the cases. Biochemical recurrence (BCR) was 6.7% (35/520), of which FS was positive in 40% (14/35) of those cases. There were insufficient evidence of a statistical association of urinary incontinence and positive surgical margin rates according to NS or NVB resection. NeuroSAFE enables intraoperative confirmation of the oncologic safety of a NS procedure. Patients with a positive FS on NeuroSAFE can be converted to a negative surgical margin (NSM) by ipsilateral wide resection. This spared 1 in 4 men from positive margins posterolaterally in our series. Limitations are the absence of a matched contemporary cohort of NS RALP without NeuroSAFE in our centre.Peer reviewe

nihitmittal/MovieRecommender: Web Scrapping of Comments from IMBD

As a part of our curriculum at NCSU CSC 510, we have a developed a movie-recommender, which will recommend movies. Movies are recommended by this