180 research outputs found
Excitation function of (p, alpha) nuclear reaction on enriched 67Zn: Possibility of production of 64Cu at low energy cyclotron
The potential for production of the medically relevant 64Cu has been investigated by proton irradiation of highly enriched 67Zn targets. The excitation function of the 67Zn(p, α)64Cu a nuclear reaction was measured by the stacked-foil technique up to 30 MeV. The prediction of the TALYS code was also compared to the measured cross section results. Based on the improved database of the 67Zn(p, α)64Cu reaction, thick target yield as a function of energy was also deduced. Production possibility of 64Cu is discussed in detail, employing different energy proton beams and with regards to the 61Cu and 67Cu contamination levels as a function of the target enrichment level. By using 1 μA beam intensity, 6.3505 h irradiation time and enriched 67Zn target (64Zn ≤ 0.5%, 66Zn ≤ 9%, 67Zn ≥ 80%, 68Zn ≤ 10% and 70Zn ≤ 0.5%), the expected EOB (End Of bombardment) yields are 43.66, 88.80 and 156.14 MBq/μA at 12, 15 and 18 MeV proton energies, respectively. Application time-frames were also deduced where the total radio-copper contamination level remains below 1%
Investigation of deuteron-induced reactions on natGd up to 30 MeV: possibility of production of medically relevant 155Tb and 161Tb radioisotopes
The formation of isomeric pair in the natTi(3He,x)44m,gSc reactions: Effect of spin cut-off parameter on the isomeric ratio
Excitation functions for the natTi(3He, x)44g,mSc nuclear reactions were measured from respective threshold up to 55 MeV by using a conventional stacked-foil activation technique combined with HPGe γ-ray spectroscopy. Individual cross-section values for the production of 44mSc and 44gSc were separated using a proper mathematical method on the basis of their individual gamma lines and the data for 44gSc are reported here for the first time. The default parameters of TALYS-1.8 are unable to provide the 44mSc/44gSc isomeric cross-section ratio values consistent with those obtained experimentally. However, an adjustment of the level density model and optical model potentials together with some other relevant parameters, especially the spin cut-off parameter with the variation of η (=Ieff/Irigid) were found to be effective to reproduce the measured cross-sections. A similar parameter adjustment could be useful for accurate prediction of other medium mass isomeric pairs (i.e., when the metastable state is longer-lived than the ground state) where either experimental data are not available, or an expensive experiment is required to obtain them
Practical experiences on the production and application of Ac-225 and related radiopharmaceuticals
Practical experiences on the production and application of Ac-225 and related radiopharmaceuticals
世界的な供給不足が予想されているアクチニウム225の製造に関する国際共同研究(CRP)を立ち上げるため,本製造法の概要について報告する。The Status of Alpha Emitter Radiopharmaceutical
Cyclotron production of Ac-225 from electroplated Ra-226 target
第65回IAEA総会に伴う日本のサイドイベントにて表記のタイトルにて口頭発表を行う。The 65th IAEA General Conference Side Events [Japan
Research and development for cyclotron production of 225Ac from 226Ra -The challenges in a country lacking natural resources for medical applications-
Development of the production methods for emerging radionuclides applicable to the theranostical basic research
Transition-metal-free Nucleophilic 211At-astatination of Spirocyclic Aryliodonium Ylides
The transition-metal-free At-211-astatination of spirocyclic aryliodonium ylides via a nucleophilic aromatic substitution reaction is described. This method enables the preparation of At-211-radiolabeled compounds derived from multi-functionalized molecules and heteroarenes in good to excellent radiochemical yields
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