The potential for production of the medically relevant 64Cu has been investigated by proton irradiation of highly enriched 67Zn targets. The excitation function of the 67Zn(p, α)64Cu a nuclear reaction was measured by the stacked-foil technique up to 30 MeV. The prediction of the TALYS code was also compared to the measured cross section results. Based on the improved database of the 67Zn(p, α)64Cu reaction, thick target yield as a function of energy was also deduced. Production possibility of 64Cu is discussed in detail, employing different energy proton beams and with regards to the 61Cu and 67Cu contamination levels as a function of the target enrichment level. By using 1 μA beam intensity, 6.3505 h irradiation time and enriched 67Zn target (64Zn ≤ 0.5%, 66Zn ≤ 9%, 67Zn ≥ 80%, 68Zn ≤ 10% and 70Zn ≤ 0.5%), the expected EOB (End Of bombardment) yields are 43.66, 88.80 and 156.14 MBq/μA at 12, 15 and 18 MeV proton energies, respectively. Application time-frames were also deduced where the total radio-copper contamination level remains below 1%
