5 research outputs found
Autoecology of an endemic calanoid copepod: The first step in biodiversity conservation in Lakes
- Publication venue
- Bureau of Fisheries and Aquatic Resources
- Publication date
- 01/01/2001
- Field of study
Get PDFAbstract only.Copepods, specifically calanoid copepods, play an important role in the productivity of aquatic ecosystems since they serve as a crucial link between primary producers and carnivores. In tropical reservoirs and lakes, they are not only a major source of food for many invertebrates and zooplanktivorous fish, but also good biological indicators. Calanoid/cyclopoid-cladoceran ratio is used in limnological studies as an indicator of water quality. In the past, studies in the Philippines on copepods and other freshwater zooplankton have dealt only on their taxonomy and distribution. Filipinodiaptomus insulanus is a calanoid copepod recognized as endemic to the country with its distribution restricted to the areas of Bulacan, Laguna and other parts of Rizal. Furthermore it is the only calanoid copepod found in the La Mesa Reservoir in Novaliches, Quezon City. This paper is a synthesis of three studies of F. insulanus obtained from La Mesa Reservoir. It aims to provide additional baseline information about the organism, particularly on its postembryonic development, feeding habits, and density fluctuations of its life history stage in the reservoir
Behavior of the burrowing shrimp Alpheus macellarius in varying gravel substrate conditions
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
No full textCandida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study
- Author
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- Abel P.
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- Xu Y.
- Yaguchi A.
- YagĂŒe G.
- Yaroshetskiy A.
- Young J.
- Yung M.
- Yuste I.
- Zahn P.
- Zakynthinos E.
- Zasmeta G.
- Zavala E.
- Zhan Q.
- Zhang L.
- Zhang Z.
- Zhao Y.
- Zimmermann R.
- Zink M.
- Zoremba Norbert
- Zuckermann-Becker H.
- Zykova I.
- Zöllei Ă.
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2011
- Field of study
No full textItem does not contain fulltextOBJECTIVES: To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection. DESIGN: A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge. SETTING: EPIC II included 1265 intensive care units in 76 countries. PATIENTS: Patients in participating intensive care units on study day. INTERVENTIONS: None. MEASUREMENT AND MAIN RESULTS: Of the 14,414 patients in EPIC II, 99 patients had Candida bloodstream infections for a prevalence of 6.9 per 1000 patients. Sixty-one patients had candidemia alone and 38 patients had combined bloodstream infections. Candida albicans (n = 70) was the predominant species. Primary therapy included monotherapy with fluconazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12). Combination therapy was infrequently used (n = 10). Compared with patients with Gram-positive (n = 420) and Gram-negative (n = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p < .05) and appeared to have been in an intensive care unit longer (14 days [range, 5-25 days], 8 days [range, 3-20 days], and 10 days [range, 2-23 days], respectively), but this difference was not statistically significant. Severity of illness and organ dysfunction scores were similar between groups. Patients with Candida bloodstream infections, compared with patients with Gram-positive and Gram-negative bloodstream infections, had the greatest crude intensive care unit mortality rates (42.6%, 25.3%, and 29.1%, respectively) and longer intensive care unit lengths of stay (median [interquartile range]) (33 days [18-44], 20 days [9-43], and 21 days [8-46], respectively); however, these differences were not statistically significant. CONCLUSION: Candidemia remains a significant problem in intensive care units patients. In the EPIC II population, Candida albicans was the most common organism and fluconazole remained the predominant antifungal agent used. Candida bloodstream infections are associated with high intensive care unit and hospital mortality rates and resource use
Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study
- Author
- 't Kindt H
- Abbruzzese C
- Abel P
- Abulmagd M
- Ad\ue9n F
- Adanir T
- Afessa B
- Afifi S
- Afonso S
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- Aguilar G
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- Aguirre G
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- Alheira Rocha R
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- Teves J
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- Yag\ufce G
- Yaguchi A
- Yaroshetskiy A
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- Yuste I
- Z\uf6llei \uc9
- Zahn P
- Zakynthinos E
- Zasmeta G
- Zavala E
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- Zhan Q
- Zhang L
- Zhang Z
- Zhao Y
- Zimmermann R
- Zink M
- Zoremba N
- Zuckermann Becker H
- Zykova I
- Publication venue
- Publication date
- 01/01/2011
- Field of study
No full textTo provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection.
DESIGN:
A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge.
SETTING:
EPIC II included 1265 intensive care units in 76 countries.
PATIENTS:
Patients in participating intensive care units on study day.
INTERVENTIONS:
None.
MEASUREMENT AND MAIN RESULTS:
Of the 14,414 patients in EPIC II, 99 patients had Candida bloodstream infections for a prevalence of 6.9 per 1000 patients. Sixty-one patients had candidemia alone and 38 patients had combined bloodstream infections. Candida albicans (n = 70) was the predominant species. Primary therapy included monotherapy with fluconazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12). Combination therapy was infrequently used (n = 10). Compared with patients with Gram-positive (n = 420) and Gram-negative (n = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p < .05) and appeared to have been in an intensive care unit longer (14 days [range, 5-25 days], 8 days [range, 3-20 days], and 10 days [range, 2-23 days], respectively), but this difference was not statistically significant. Severity of illness and organ dysfunction scores were similar between groups. Patients with Candida bloodstream infections, compared with patients with Gram-positive and Gram-negative bloodstream infections, had the greatest crude intensive care unit mortality rates (42.6%, 25.3%, and 29.1%, respectively) and longer intensive care unit lengths of stay (median [interquartile range]) (33 days [18-44], 20 days [9-43], and 21 days [8-46], respectively); however, these differences were not statistically significant.
CONCLUSION:
Candidemia remains a significant problem in intensive care units patients. In the EPIC II population, Candida albicans was the most common organism and fluconazole remained the predominant antifungal agent used. Candida bloodstream infections are associated with high intensive care unit and hospital mortality rates and resource use
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
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- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
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- Aleem Muhammad
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- Hooper Richard L
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- Kashchenko Victor A
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- Kopteyev Nikita R
- Korkolis Dimitrios
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- Longchamp Grégoire
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- Mazaz Khalid
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- Mba Emmanuel Louis
- Mcdermott Frank D
- Mcintosh Katrina
- McKay Siobhan
- Meharzi Sif El Islam
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- Miguel InĂȘs
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- Moffa Secondino
- Moglan Mihaela
- Mohamad Aya Haji
- Mohamed Haiba A
- Mohamed Mohamed
- Mohamed Nada
- Mohammad Saleh
- Mohammed Rabab
- Mohmmad Walid A S
- Mohsin Hassan
- Mohsine Raouf
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- Ozkan Omer Faruk
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- Pedro Luis
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- Peker YaĆar Subutay
- Pelipas Yuriy
- Pellicer-Franco Enrique M
- Pellino Gianluca
- Peltrini Roberto
- Peneva Kristin
- Pengerma Pasi
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- Perera Mariyan
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- Potter Mark A
- Prakash Sharath
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- Prem William
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- Pösteki Gökhan
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- Ramadan Mah'D
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- Ris Frédéric
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- Rodriguez Jose Luis Ramos
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- Yilmazlar Tuncay
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- Yoldas Tayfun
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- Yoshino Kenji
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- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Get PDFBackground
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)
