1,390 research outputs found
Integrating landscapes that have experienced rural depopulation and ecological homogenization into tropical conservation planning
If current trends of declining fertility rates and increasing abandonment of rural land as a result of urbanization continue, this will signal a globally significant transformation with important consequences for policy makers interested in conservation planning. This transformation is presently evident in a number of countries and projections suggest it may occur in the future in many developing countries. We use rates of population growth and urbanization to project population trends in rural areas for 25 example countries. Our projections indicate a general decline in population density that has either occurred already (e.g., Mexico) or may occur in the future if current trends continue (e.g., Uganda). Using both temperate and tropical examples we present evidence that this process will lead to ecological homogenization as a dominant habitat (e.g., forest replaces a mosaic of human-maintained landscapes), resulting in declines in biodiversity at the local scale. Building on this information, we consider research programs that need to be conducted so that policy makers are prepared to effectively manage depopulated rural areas
Ethyl 1-(4-chlorophenyl)-3-[1-(4-methoxyphenyl)-4-oxo-3-phenylazetidin-2-yl]-2-nitro-2,3,10,10a-tetrahydro-1H,5H-pyrrolo[1,2-b]isoquinoline-10a-carboxylate
In the title compound, C37H34ClN3O6, the pyrrolidine and piperidine rings adopt envelope and boat conformations, respectively. The β-lactam ring is planar and forms dihedral angles of 21.3 (2) and 73.9 (2)°, respectively, with the attached methoxyphenyl and phenyl rings. Intramolecular C—H⋯O and C—H⋯N hydrogen bonds are observed. Centrosymmetrically related molecules are linked together by weak C—H⋯O hydrogen bonds to form dimers
Wigner-function description of quantum teleportation in arbitrary dimensions and continuous limit
We present a unified approach to quantum teleportation in arbitrary
dimensions based on the Wigner-function formalism. This approach provides us
with a clear picture of all manipulations performed in the teleportation
protocol. In addition within the framework of the Wigner-function formalism all
the imperfections of the manipulations can be easily taken into account.Comment: 8 pages, LaTeX, 1 figure (included). Accepted for publication in
Phys. Rev. A A minor correction added on May 2
Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
<p>Abstract</p> <p>Background</p> <p>Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors. We report the case of a 65-year-old woman who presented with progressive memory loss, chronic headaches, nausea, and a right hemisphere multi-centric tumor seen with magnetic resonance imaging (MRI). Following incomplete surgical resection, the patient was diagnosed with glioblastoma multiforme expressing hypermethylation of the <it>MGMT </it>gene promoter.</p> <p>Methods</p> <p>Prior to initiation of the standard therapy, the patient conducted water-only therapeutic fasting and a restricted 4:1 (fat: carbohydrate + protein) ketogenic diet that delivered about 600 kcal/day. The patient also received the restricted ketogenic diet concomitantly during the standard treatment period. The diet was supplemented with vitamins and minerals. Steroid medication (dexamethasone) was removed during the course of the treatment. The patient was followed using MRI and positron emission tomography with fluoro-deoxy-glucose (FDG-PET).</p> <p>Results</p> <p>After two months treatment, the patient's body weight was reduced by about 20% and no discernable brain tumor tissue was detected using either FDG-PET or MRI imaging. Biomarker changes showed reduced levels of blood glucose and elevated levels of urinary ketones. MRI evidence of tumor recurrence was found 10 weeks after suspension of strict diet therapy.</p> <p>Conclusion</p> <p>This is the first report of confirmed GBM treated with standard therapy together with a restricted ketogenic diet. As rapid regression of GBM is rare in older patients following incomplete surgical resection and standard therapy alone, the response observed in this case could result in part from the action of the calorie restricted ketogenic diet. Further studies are needed to evaluate the efficacy of restricted ketogenic diets, administered alone or together with standard treatment, as a therapy for GBM and possibly other malignant brain tumors.</p
AOSpine—Spine Trauma Classification System: The Value of Modifiers: A Narrative Review With Commentary on Evolving Descriptive Principles
Study Design: Narrative review.
Objectives: To describe the current AOSpine Trauma Classification system for spinal trauma and highlight the value of patient-specific modifiers for facilitating communication and nuances in treatment.
Methods: The classification for spine trauma previously developed by The AOSpine Knowledge Forum is reviewed and the importance of case modifiers in this system is discussed.
Results: A successful classification system facilitates communication and agreement between physicians while also determining injury severity and provides guidance on prognosis and treatment. As each injury may be unique among different patients, the importance of considering patient-specific characteristics is highlighted in this review. In the current AOSpine Trauma Classification, the spinal column is divided into 4 regions: the upper cervical spine (C0-C2), subaxial cervical spine (C3-C7), thoracolumbar spine (T1-L5), and the sacral spine (S1-S5, including coccyx). Each region is classified according to a hierarchical system with increasing levels of injury or instability and represents the morphology of the injury, neurologic status, and clinical modifiers. Specifically, these clinical modifiers are denoted starting with M followed by a number. They describe unique conditions that may change treatment approach such as the presence of significant soft tissue damage, uncertainty about posterior tension band injury, or the presence of a critical disc herniation in a cervical bilateral facet dislocation. These characteristics are described in detail for each spinal region.
Conclusions: Patient-specific modifiers in the AOSpine Trauma Classification highlight unique clinical characteristics for each injury and facilitate communication and treatment between surgeons
Atom Lasers, Coherent States, and Coherence:II. Maximally Robust Ensembles of Pure States
As discussed in Wiseman and Vaccaro [quant-ph/9906125], the stationary state
of an optical or atom laser far above threshold is a mixture of coherent field
states with random phase, or, equivalently, a Poissonian mixture of number
states. We are interested in which, if either, of these descriptions of
, is more natural. In the preceding paper we concentrated upon
whether descriptions such as these are physically realizable (PR). In this
paper we investigate another relevant aspect of these ensembles, their
robustness. A robust ensemble is one for which the pure states that comprise it
survive relatively unchanged for a long time under the system evolution. We
determine numerically the most robust ensembles as a function of the parameters
in the laser model: the self-energy of the bosons in the laser mode, and
the excess phase noise . We find that these most robust ensembles are PR
ensembles, or similar to PR ensembles, for all values of these parameters. In
the ideal laser limit (), the most robust states are coherent
states. As the phase noise or phase dispersion is increased, the
most robust states become increasingly amplitude-squeezed. We find scaling laws
for these states. As the phase diffusion or dispersion becomes so large that
the laser output is no longer quantum coherent, the most robust states become
so squeezed that they cease to have a well-defined coherent amplitude. That is,
the quantum coherence of the laser output is manifest in the most robust PR
states having a well-defined coherent amplitude. This lends support to the idea
that robust PR ensembles are the most natural description of the state of the
laser mode. It also has interesting implications for atom lasers in particular,
for which phase dispersion due to self-interactions is expected to be large.Comment: 16 pages, 9 figures included. To be published in Phys. Rev. A, as
Part II of a two-part paper. The original version of quant-ph/9906125 is
shortly to be replaced by a new version which is Part I of the two-part
paper. This paper (Part II) also contains some material from the original
version of quant-ph/990612
Identification of subgroups of early breast cancer patients at high risk of nonadherence to adjuvant hormone therapy: results of an italian survey.
The aim of this study was the identification of subgroups of patients at higher risk of nonadherence to adjuvant
hormone therapy for breast cancer. Using recursive partitioning and amalgamation (RECPAM) analysis, the
highest risk was observed in the group of unmarried, employed women, or housewives. This result might be
functional in designing tailored intervention studies aimed at improvement of adherence.
Background: Adherence to adjuvant endocrine therapy (HT) is suboptimal among breast cancer patients. A high rate
of nonadherence might explain differences in survival between clinical trial and clinical practice. Tailored interventions
aimed at improving adherence can only be implemented if subgroups of patients at higher risk of poor adherence are
identified. Because no data are available for Italy, we undertook a large survey on adherence among women taking
adjuvant HT for breast cancer. Patients and Methods: Patients were recruited from 10 cancer clinics in central Italy.
All patients taking HT for at least 1 year were invited, during one of their follow-up visit, to fill a confidential questionnaire.
The association of sociodemographic and clinical characteristics of participants with adherence was
assessed using logistic regression. The RECPAM method was used to evaluate interactions among variables and to
identify subgroups of patients at different risk of nonadherence. Results: A total of 939 patients joined the study and
18.6% of them were classified as nonadherers. Among possible predictors, only age, working status, and switching
from tamoxifen to an aromatase inhibitor were predictive of nonadherence in multivariate analysis. RECPAM analysis
led to the identification of 4 classes of patients with a different likelihood of nonadherence to therapy, the lowest being
observed in retired women with a low level of education, the highest in the group of unmarried, employed women, or
housewives. Conclusion: The identification of these subgroups of “real life” patients with a high prevalence of
nonadherers might be functional in designing intervention studies aimed at improving adherenc
Participation in thrill-seeking activities by patients with hypertrophic cardiomyopathy: Individual preferences, adverse events and physician attitude
Understorey structural complexity mediated by plantation management as a driver of predation events on potential eucalypt pests
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