684 research outputs found
Conservation status of New Zealand freshwater invertebrates, 2013
The conservation status of 644 freshwater invertebrate taxa, across five Phyla, 28 Orders and 75 Families, was assessed using the New Zealand Threat Classification System (NZTCS) criteria. Forty-six species were ranked Nationally Critical, 11 Nationally Endangered and 16 Nationally Vulnerable. One hundred and seventy-two taxa were listed as Data Deficient. A full list is presented, along with summaries and brief notes on the most important changes. This list replaces all previous NZTCS lists for freshwater invertebrates
The Ecology of New World Rodent Borne Hemorrhagic Fevers
Few, if any, human settlements are free of peridomestic rodent populations. The threat of rodent borne zoonotic diseases has been widely recognized since the bubonic plague outbreaks of the Middle Ages. In the last decades, outbreaks of human disease caused by the rodent borne hemorrhagic fever viruses, the arenaviruses (family Arenaviridae), and the hantaviruses (family Bunyaviridae, genus Hantavirus) have again generated interest in the general public and scientific community regarding the biology of these types of diseases. Recent studies have identified more than 30 new members of these two groups of viruses. Most are associated with rodents in the family Muridae and many are known to be pathogenic. Ongoing studies are investigating aspects of the ecology and systematics of these viruses and their reservoirs. Ecological studies are currently examining modes of transmission between members of the host species, and environmental factors associated with increased frequency of infection. Systematic research is identifying patterns of co-evolution between the viruses and their hosts. The overall goal of these research efforts is develop predictive models that will identify times and places of increased risk and therefore provide an opportunity for risk reduction in these areas. The information resulting from these efforts will benefit individuals who live or work in close proximity to known wild rodent reservoirs and are at risk of contracting rodent borne diseases
The effects of six herbal supplements commonly used by women on expression of aromatase (CYP19) and the activation of the estrogen receptor alpha (HER a) in HEPG2, H295R, and CHO-K1-BH4 cells
Potential mammalian filovirus reservoirs
Centers for Disease Control and Prevention
http://www.cdc.gov/ncidod/EID/vol10no12/04-0346.htmEbola and Marburg viruses are maintained in unknown
reservoir species; spillover into human populations results
in occasional human cases or epidemics. We attempted to
narrow the list of possibilities regarding the identity of those
reservoir species. We made a series of explicit assumptions
about the reservoir: it is a mammal; it supports persistent,
largely asymptomatic filovirus infections; its range
subsumes that of its associated filovirus; it has coevolved
with the virus; it is of small body size; and it is not a species
that is commensal with humans. Under these assumptions,
we developed priority lists of mammal clades that coincide
distributionally with filovirus outbreak distributions and
compared these lists with those mammal taxa that have
been tested for filovirus infection in previous epidemiologic
studies. Studying the remainder of these taxa may be a
fruitful avenue for pursuing the identity of natural reservoirs
of filoviruses
Regulatory T Cell Induction and Retention in the Lungs Drives Suppression of Detrimental Type 2 Th Cells During Pulmonary Cryptococcal Infection
Lethal disease caused by the fungus, Cryptococcus neoformans, is a consequence of the combined failure to control pulmonary fungal replication and immunopathology caused by induced type-2 helper T (Th2) cell responses in animal models. In order to gain incites into immune regulatory networks, we examined the role of regulatory T (Treg) cells in suppression of Th2 cells, using a mouse model of experimental cryptococcosis. Upon pulmonary infection with Cryptococcus, Treg cells accumulated in the lung parenchyma independently of priming in the draining lymph node. Using peptide-MHCII molecules to identify Cryptococcus-specific Treg cells combined with genetic fate-mapping, we noted that a majority of the Treg cells found in the lungs were induced during the infection. Additionally, we found that Treg cells utilized the transcription factor, Interferon Regulatory Factor 4 (IRF4), to dampen harmful Th2 cell responses, as well as mediate chemokine retention of Treg cells in the lungs. Taken together, induction and IRF4-dependent localization of Treg cells in the lungs allow Treg cells to suppress the deleterious effects of Th2 cells during cryptococcal infection
Difference in severity of porcine circovirus type two-induced pathological lesions between Landrace and Pietrain pigs
Anecdotal information from the field suggests that there are host genetic differences in susceptibility to porcine circovirus type 2 (PCV2) associated disease among Landrace and Pietrain breeds. The objective of this study was to determine if a difference exists in PCV2 susceptibility between Landrace and Pi-etrain pigs under experimental conditions. Thirty-nine Landrace pigs and 39 Pietrain pigs were blocked by breed, sire, dam, and litter and randomly divided into the following 4 groups: Landrace noninoculated negative control (Landrace-NEG; n = 13), Pietrain noninoculated negative control (Pietrain-NEG; n = 13), Landrace-PCV2 (n = 26; Landrace), and Pietrain-PCV2 (n = 26; Pietrain). After waning of passively acquired anti-PCV2 antibodies, Landrace-PCV2 and Pietrain-PCV2 groups were inoculated with PCV2 isolate ISU-40895. The Landrace-NEG and Pietrain-NEG groups were housed in a separate room, remained noninoculated, and served as negative controls. All pigs in all groups were necropsied at 21 d post PCV2-inoculation. Onset of seroconversion and concentrations of anti-PCV2-IgM, anti-PCV2-IgG, and anti-PCV2 neutralizing antibodies were similar in Landrace-PCV2 and Pietrain-PCV2 groups. Furthermore, the amount of PCV2 DNA and cytokine concentrations in serum and plasma samples were not different between the 2 PCV2-inoculated groups. The severity of PCV2-associated microscopic lesions was different between Landrace and Pietrain pigs; Landrace-PCV2 pigs had significantly (P \u3c 0.05) more severe lymphoid lesions than the Pietrain-PCV2 pigs. Although the pigs originated from the same farm where their dams were commingled, passively acquired anti-PCV2-antibodies waned in Pietrain pigs by approximately 12 wk of age, whereas the majority of the Landrace pigs remained PCV2 seropositive until 18 wk of age and beyond. The results from this study indicate that a genetic difference exists between these 2 breeds of pigs in susceptibility to PCV2-associated lesions
Weight-Gain Reduction Among 2-Year College Students: The CHOICES RCT
The young adult years have been recognized as an influential period for excess weight gain. Non-traditional students and those attending 2-year community colleges are at particularly high risk for a range of adverse weight-related outcomes
Architecture of Kepler's Multi-transiting Systems: II. New investigations with twice as many candidates
We report on the orbital architectures of Kepler systems having multiple
planet candidates identified in the analysis of data from the first six
quarters of Kepler data and reported by Batalha et al. (2013). These data show
899 transiting planet candidates in 365 multiple-planet systems and provide a
powerful means to study the statistical properties of planetary systems. Using
a generic mass-radius relationship, we find that only two pairs of planets in
these candidate systems (out of 761 pairs total) appear to be on Hill-unstable
orbits, indicating ~96% of the candidate planetary systems are correctly
interpreted as true systems. We find that planet pairs show little statistical
preference to be near mean-motion resonances. We identify an asymmetry in the
distribution of period ratios near first-order resonances (e.g., 2:1, 3:2),
with an excess of planet pairs lying wide of resonance and relatively few lying
narrow of resonance. Finally, based upon the transit duration ratios of
adjacent planets in each system, we find that the interior planet tends to have
a smaller transit impact parameter than the exterior planet does. This finding
suggests that the mode of the mutual inclinations of planetary orbital planes
is in the range 1.0-2.2 degrees, for the packed systems of small planets probed
by these observations.Comment: Accepted to Ap
On the Relative Sizes of Planets within Kepler Multiple-candidate Systems
We present a study of the relative sizes of planets within the multiple-candidate systems discovered with the Kepler mission. We have compared the size of each planet to the size of every other planet within a given planetary system after correcting the sample for detection and geometric biases. We find that for planet pairs for which one or both objects are approximately Neptune-sized or larger, the larger planet is most often the planet with the longer period. No such size-location correlation is seen for pairs of planets when both planets are smaller than Neptune. Specifically, if at least one planet in a planet pair has a radius of ≳ 3 R_⊕, 68% ± 6% of the planet pairs have the inner planet smaller than the outer planet, while no preferred sequential ordering of the planets is observed if both planets in a pair are smaller than ≾ 3 R_⊕
WormBase: a multi-species resource for nematode biology and genomics
WormBase (http://www.wormbase.org/) is the central data repository for information about Caenorhabditis elegans and related nematodes. As a model organism database, WormBase extends beyond the genomic sequence, integrating experimental results with extensively annotated views of the genome. The WormBase Consortium continues to expand the biological scope and utility of WormBase with the inclusion of large-scale genomic analyses, through active data and literature curation, through new analysis and visualization tools, and through refinement of the user interface. Over the past year, the nearly complete genomic sequence and comparative analyses of the closely related species Caenorhabditis briggsae have been integrated into WormBase, including gene predictions, ortholog assignments and a new synteny viewer to display the relationships between the two species. Extensive site-wide refinement of the user interface now provides quick access to the most frequently accessed resources and a consistent browsing experience across the site. Unified single-page views now provide complete summaries of commonly accessed entries like genes. These advances continue to increase the utility of WormBase for C.elegans researchers, as well as for those researchers exploring problems in functional and comparative genomics in the context of a powerful genetic system
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