Gambaran Depresi pada Lanjut Usia di Panti Sosial Tresna Werdha Mulia Dharma Kabupaten Kubu Raya Tahun 2012

Problems that can lead to depression. Depression is one of the mostcommon mental disorder in elderly with quite high prevalence.Objective: The objective of this research was to describe depression inelderly in Panti Sosial Tresna Werdha Mulia Dharma Kubu Raya regencyand its distribution according to age and gender.Method: This research was descriptive study with cross-sectionalapproach. The sample was 26 elderly people ? 60 years old and with nocognitive dysfunction were recruited using consecutive samplingtechnique. This research was conducted in Panti Sosial Tresna WerdhaMulia Dharma Kubu Raya regency from July 11st 2012 until August 22th2012. Depression was detected by Geriatric Depression Scale.Result: There are 38,46% elderly have depression, among them are36,84% male and 42,86% female. Depression occur in 40,91% elderly 60-74 years old and 25% in elderly 75-90 years old.Conclusion: The incidence of depression in elderly conducted in PantiSosial Tresna Werdha Mulia Dharma Kubu Raya regency on 2012 is38,46%. The entire elderly with depression included in the category of milddepression. Depression in female elderly higher than male elderly.Depression mostly happened in elderly 60-74 years old

MODELING THE DEMAND FOR DURABLE INPUTS: DISTRIBUTED LAGS AND CAUSALITY

Vector-autoregressive-moving-average (VARMA) modeling was used to identify distributed lag relationships among farm tractor derived demand variables and to provide a basis for formally testing the hypothesis that the price of new tractor horsepower is exogeneous to its quantity demanded. Similar causality tests were used for a number of other explanatory variables, including the interest rate, price of diesel fuel, and price of used tractors. Results indicate that several lagged variables are significant causal factors and that the dynamic nature of the demand structure cannot be ignored when explaining tractor demand.Demand and Price Analysis,

A surgical treatment for anxiety-triggered palmar hyperhidrosis is not unlike treating tearfulness in major depression by severing the nerves to the lacrimal glands

not applicabl

The Locus Ceruleus in PTSD

NO ABSTRACT: This is 750 word encyclopedia entr

Role of Spectraplakin in Drosophila Photoreceptor Morphogenesis

BACKGROUND:Crumbs (Crb), a cell polarity gene, has been shown to provide a positional cue for the apical membrane domain and adherens junction during Drosophila photoreceptor morphogenesis. It has recently been found that stable microtubules in developing Drosophila photoreceptors were linked to Crb localization. Coordinated interactions between microtubule and actin cytoskeletons are involved in many polarized cellular processes. Since Spectraplakin is able to bind both microtubule and actin cytoskeletons, the role of Spectraplakin was analyzed in the regulations of apical Crb domain in developing Drosophila photoreceptors. METHODOLOGY/PRINCIPAL FINDINGS:The localization pattern of Spectraplakin in developing pupal photoreceptors showed a unique intracellular distribution. Spectraplakin localized at rhabdomere terminal web which is at the basal side of the apical Crb or rhabdomere, and in between the adherens junctions. The spectraplakin mutant photoreceptors showed dramatic mislocalizations of Crb, adherens junctions, and the stable microtubules. This role of Spectraplakin in Crb and adherens junction regulation was further supported by spectraplakin's gain-of-function phenotype. Spectraplakin overexpression in photoreceptors caused a cell polarity defect including dramatic mislocalization of Crb, adherens junctions and the stable microtubules in the developing photoreceptors. Furthermore, a strong genetic interaction between spectraplakin and crb was found using a genetic modifier test. CONCLUSIONS/SIGNIFICANCE:In summary, we found a unique localization of Spectraplakin in photoreceptors, and identified the role of spectraplakin in the regulation of the apical Crb domain and adherens junctions through genetic mutational analysis. Our data suggest that Spectraplakin, an actin-microtubule cross-linker, is essential in the apical and adherens junction controls during the photoreceptors morphogenesis

Charge distribution uncertainty in differential mobility analysis of aerosols

The inference of particle size distributions from differential mobility analyzer (DMA) data requires knowledge of the charge distribution on the particles being measured. The charge distribution produced by a bipolar aerosol charger depends on the properties of the ions produced in the charger, and on the kinetics of charge transfer from molecular ions or ion clusters to the particles. A single parameterization of a theoretically predicted charge distribution is employed in most DMA analyses regardless of the atmospheric conditions being probed. Deviations of the actual charge distribution from that assumed in the data analysis will bias the estimated particle size distribution. We examine these potential biases by modeling measurements and data inversion using charge distributions calculated for a range of atmospheric conditions. Moreover, simulations were performed using the ion-to-particle flux coefficients predicted for a range of properties of both the particles and ions. To probe the biases over the full range of particle sizes, the measurements were simulated through an atmospheric new particle formation event. The differences between the actual charge distribution and that according to the commonly used parametrization resulted in biases as large as a factor of 5 for nucleation-mode particles, and up to 80% for larger particles. Incorrect estimates of the relative permittivity of the particles or not accounting for the temperature and pressure effects for measurements at 10 km altitude produced biases in excess of 50%; three-fold biases result from erroneous estimates of the ion mobility distribution. We further report on the effects of the relative permittivity of the ions, the relative concentrations of negative and positive ions, and truncation of the number of charge states considered in the inversion

Therapeutic Potential of Annexins in Sepsis and COVID-19

Sepsis is a continuing problem in modern healthcare, with a relatively high prevalence, and a significant mortality rate worldwide. Currently, no specific anti-sepsis treatment exists despite decades of research on developing potential therapies. Annexins are molecules that show efficacy in preclinical models of sepsis but have not been investigated as a potential therapy in patients with sepsis. Human annexins play important roles in cell membrane dynamics, as well as mediation of systemic effects. Most notably, annexins are highly involved in anti-inflammatory processes, adaptive immunity, modulation of coagulation and fibrinolysis, as well as protective shielding of cells from phagocytosis. These discoveries led to the development of analogous peptides which mimic their physiological function, and investigation into the potential of using the annexins and their analogous peptides as therapeutic agents in conditions where inflammation and coagulation play a large role in the pathophysiology. In numerous studies, treatment with recombinant human annexins and annexin analogue peptides have consistently found positive outcomes in animal models of sepsis, myocardial infarction, and ischemia reperfusion injury. Annexins A1 and A5 improve organ function and reduce mortality in animal sepsis models, inhibit inflammatory processes, reduce inflammatory mediator release, and protect against ischemic injury. The mechanisms of action and demonstrated efficacy of annexins in animal models support development of annexins and their analogues for the treatment of sepsis. The effects of annexin A5 on inflammation and platelet activation may be particularly beneficial in disease caused by SARS-CoV-2 infection. Safety and efficacy of recombinant human annexin A5 are currently being studied in clinical trials in sepsis and severe COVID-19 patients

Happy Family Kitchen II, a community-based participatory research (CBPR) to enhance Family Health, Happiness and Harmony in Hong Kong: A cluster randomized control trial under FAMILY Project

Oral Poster Presentation SessionHong Kong Council of Social Service and School of Public Health, HKU conducted a three-arm cluster randomized control trial (cRCT) of a community-based participatory research (CBPR) “Happy Family Kitchen II” during July 2012 to June 2013. The present paper compared intervention arm A and control arm C to determine whether CBPR intervention improved family health, happiness and harmony (3Hs). 31 organizations in Tsuen Wan and Kwai Tsing districts were randomly allocated into: intervention arms A (n=11) and B (n=10), and waitlist control arm C (n=10).Within positive psychology and an agreed similar framework, each organization organized their own program on one selected theme of “Five-Taste Model” for people aged 6+ recruited by organization. Arm A had two intervention-sessions and one tea-gathering, and arm C had tea-gathering first (intervention at 3 months later). Participants were assessed four times (T1, pre-intervention; T2, immediately post-intervention; T3 and T4, 1 and 3 months after T2). Changes of primary outcomes from T1 to T3/T4 were compared in participants aged 12+ of arms A and C. Behavior score change was greater in arm A (n=416) than arm C (n=432) at both T3 (Effect size=0.11, p=0.03) and T4 (ES=0.21, p=0.003). Family health score and happiness score changes were greater in arm A than arm C at T3, with ES=0.23 (p=0.001) and ES=0.18 (p=0.01) respectively. Mental health score and intention score changes were greater in arm A than arm C at T4, with ES=0.16 (p=0.03) and ES=0.18 (p=0.01) respectively. All changes above indicated improvements in outcomes. This was the first cRCT to evaluate a CBPR short intervention in Hong Kong, which was effective with small effect size in increasing participants’ intention and practice in healthy behaviors and improving family 3Hs, suggesting that CBPR, evidence-based and evidence-generating programmes are feasible and effective.postprin

A 'Community Fit' Community-Based Participatory Research Program for Family Health, Happiness, and Harmony: Design and Implementation

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