The Impact of a Suggested Practical Programme on Improving Arts of English Seniors’ Translation Competences at the Islamic University of Gaza and their Attitudes towards …

The main research objective of this study is to examine the impact of a suggested practical programme on improving ‘Arts of English’seniors’ translation competences at the Islamic University of Gaza (IUG) and explore their attitudes towards translation. Researchers referred to previous studies, theoretical framework and some models for classifying translation competences and subsequently developed a modified and refereed model. The results showed that ‘Arts of English’seniors are required to have three main competences: knowledge, skills and attitudes. The researchers also prepared a programme including a handout for students, job experience, training methods and learning styles and evaluation tools. Additionally, data were collected using an assessment card with a supportive tool; self-assessment reports, and after the researchers ensured the validity and reliability of the tools the constructed programme was applied on 15 students selected randomly from the sample of the study, including 30 female students. Data collected were statistically analyzed, and the t-test independent sample and Eta square were used to measure the effect size after conducting the test of normality. After completing the programme the post assessment card results were compared with those of the pre-assessment card and there was a statistically significant improvement in the students’ performance as observed in the post assessment card. The researchers also constructed an attitude scale, and results showed that the programme had a significant impact on improving students' attitudes towards translation

Recent advances in the Biosynthesis of Zirconium Oxide Nanoparticles and their Biological Applications

أثار أكسيد الزركونيوم  ZrO2  اهتمام الباحثين في جميع أنحاء العالم، لا سيما منذ تطوير طرق لتصنيع جزيئات بحجم النانو. تم تحفيز الدراسة المكثفة في تكوين الجسيمات النانوية باستخدام تقنيات تركيبية مختلفة، بالإضافة إلى استخداماتها المحتملة، من خلال كفاءتها الضوئية العالية، وفجوة النطاق العريض، وطاقة ربط الأكسيتون العالية. في تغليف المواد الغذائية، يمكن استخدام الجسيمات النانوية لثاني أكسيد الزركونيوم كعوامل مضادة للميكروبات ومضادة للسرطان. استجابةً للاهتمام المتزايد بـ nano ZrO2 ، ابتكر الباحثون وطوروا طرقًا لتركيب الجسيمات النانوية. تم مؤخرًا إنشاء مركبات ZrO2 النانوية ذات الأشكال المختلفة باستخدام طرق بيولوجية ("الكيمياء الخضراء"). تساهم كل من الميكروبات والنباتات في إنتاج الزركونيا في المختبر. يتم توفير عوامل التثبيت بواسطة الجزيئات الحيوية الموجودة في المستخلصات النباتية، بينما يتم توفير الإنزيمات بواسطة الكائنات الحية الدقيقة كعوامل للتغطية والتثبيت (داخل الخلايا أو خارج الخلية). من الممكن تحليل الجسيمات النانوية المنتجة باستخدام مجموعة متنوعة من الأساليب التحليلية، بما في ذلك التحليل الطيفي للأشعة فوق البنفسجية المرئية، وحيود الأشعة السينية (XRD) ، والمجهر الإلكتروني للإرسال (TEM) ، والتحليل الطيفي للأشعة تحت الحمراء (FT-IR). عند تطبيقها على البكتيريا (موجبة الجرام وسالبة الجرام) والفطريات، تظهر ZrO2NPs قدرات واعدة مضادة للجراثيم. تعتبر الخلايا الطبيعية والخبيثة حساسة للجسيمات النانوية ZrO2 ، والتي يمكن تفسيرها من خلال توليد الأكسجين التفاعلي (ROS). يناقش هذا العمل ويصف الطرق العديدة لإنتاج جسيمات ZrO2 النانوية، بالإضافة إلى خصائصها وإمكانيات التطبيق المختلفة.A critical milestone in nano-biotechnology is establishing reliable and ecological friendly methods for fabricating metal oxide NPs. Because of their great biodegradable, electrical, mechanical, and optical qualities, zirconia NPs (ZrO2NPs) attract much interest among all zirconia NPs (ZrO2NPs). Zirconium oxide (ZrO2) has piqued the interest of researchers throughout the world, particularly since the development of methods for the manufacture of nano-sized particles. An extensive study into the creation of nanoparticles utilizing various synthetic techniques and their potential uses has been stimulated by their high luminous efficiency, wide bandgap, and high exciton binding energy. Zirconium dioxide nanoparticles may be used as antimicrobial and anticancer agents in food packaging. In response to the growing interest in nano ZrO2, researchers invented and developed methods for synthesizing nanoparticles. ZrO2 nanocomposites with various morphologies have recently been created using biological (green chemistry) methods. Microbes and plants both contribute to the production of zirconia in the laboratory. Capping and stabilizing agents are provided by the biomolecules found in plant extracts, whereas microorganisms provide enzymes as capping and stabilizing agents (intracellular or extracellular). It is possible to analyze the nanoparticles produced using a variety of analytical approaches, including ultraviolet-visible spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR). When applied to bacteria (both Gram-positive and Gram-negative) and fungi, ZrO2NPs show promising antibacterial capabilities. Normal and malignant cells are sensitive to ZrO2 nanoparticles, which can be explained by the generation of reactive oxygen (ROS). This work discusses and describes many ways of producing ZrO2 nanoparticles, their properties, and various application possibilities

Markers characterizing corneal damage during aging of rat

Aging is a biological phenomenon that involves an increase of oxidative stress associated with gradual degradation of the structure and function of the cornea. Gender differences and subsequent deterioration of cornea is an interesting topic, especially yet few data are available concerning the impact of age, especially on the corneal. One hundred male and female Wistar albino rats ages 3, 6, 18, 24, and 30 months (n=10 equal for male and female) were used. At the time interval, cornea were investigated by light and transmission electron microscopy (TEM), immunohistochemistry of caspase 3 (casp3), glial fibrillar acidic protein(GFAP) and CD45 and  flow cytometry of DNA, bcl-2-like protein 4 (BAX), transforming growth factor beta (TGF-β) and Cd45 (lymphocyte common antigen). Light and TEM investigation  revealed apparent deterioration of atrophy of corneal epithelium with vesicular vacuolar degeneration, hyalinization of stromal collagen fibrils and swelling and degeneration of the endothelial lining the descemet's membrane. There was apparent loss of keratocytes within corneal stroma. Immunohistochemistry of casp 3 and CD45 were markedly increased manifesting cell damage. GFAP showed apparent reduction of innervation of corneal stroma and endothelium layer. Flow cytometry of DNA, Bax and TGF revealed increased apoptic cell death of cornea of 30M-old rats. We concluded that aging contributed to an apparent increase of cellular damage of different corneal region associated with alterations of cell markers

Amelioration Of Snap Bean Growth, Yield, Quantity And Nutritional Status Under Salinity Stress By Using Spirulina Algae Extract And Amino Acids

Salinity stress is a major abiotic stress that limits agricultural production and threatens global food security due to rapid climate change. Salt stress negatively affects the growth, yield and quality of crops.  Amino Acids and Spirulina Algae Extract are well-known biostimulants that have positive effects on plant growth and productivity and significantly reduce damage caused by abiotic stress. Therefore, this study investigated the effect of several treatments with spirulina extract and amino acids on snap bean plant growing under saline soil stress. Field experiment was carried out during the two successive summer seasons of 2021 and 2022 under saline soil at private farm in Faqus - Sharkia Governorate, to study the effect of spirulina algae and amino acid concentrations as foliar spray on growth, yield quantity and quality and nutritional status of snap bean cv, Bronco. The experiment was executed in split plot design, three rates of spirulina algae extracts (0, 1 and 2 cm3 L-1) were distributed on main plot and another three level of amino acids (0, 500 and 1000 mg L-1) were arranged on subplot. Finally, main and subplot were replicated three times. The results can be summarized as follows: Under saline soil condition, spraying snap bean plants with different concentrations of spirulina extract and amino acids three times led to an improvement in plant growth, crop quantity and quality as well as nutritional status, compared to the experimental treatment in which both were not used. The highest values of growth, yield and content of nitrogen, phosphorus and potassium were obtained by spraying 2 cm3 L-1 of spirulina extract with 1000 mg L-1 of amino acids under two consecutive seasons. Thus, it can be said that Therefore, the spirulina algae extract and amino acids are considered one of the safe solutions to get rid of the effect of soil salinity on the  snap bean plant, and then obtain a high yield and also high quality

IN SILICO PHARMACOKINETICS AND MOLECULAR DOCKING OF THREE LEADS ISOLATED FROM TARCONANTHUS CAMPHORATUS L.

Objective: To investigate the pharmacokinetic and toxicity profiles and spectrum of biological activities of three phytochemicals isolated from Tarconanthus camphoratus L. Methods: Several integrated web based in silico pharmacokinetic tools were used to estimate the druggability of Hispidulin, Nepetin and Parthenolide. Afterward, the structural based virtual screening for the three compounds' potential targets was performed using PharmMapper online server. The molecular docking was conducted using Auto-Dock 4.0 software to study the binding interactions of these compounds with the targets predicted by PharmMapper server. Results: The permeability properties for all compounds were found within the limit range stated for Lipinski׳s rule of five. Only Parthenolide proved to be able to penetrate through blood brain barrier. Isopentenyl-diphosphate delta-isomerase (IPPI), uridine-cytidine kinase-2 (UCK-2) and the mitogen-activated protein kinase kinase-1 (MEK-1) were proposed as potential targets for Hispidulin, Nepetin and Parthenolide, respectively. Nepetin and Parthenolide were predicted to have anticancer activities. The activity of Nepetin appeared to be mediated through UCK-2 inhibition. On the other hand, inhibition of MEK-1 and enhancement of TP53 expression were predicted as the anticancer mechanisms of Parthenolide. The three compounds showed interesting interactions and satisfactory binding energies when docked into their relevant targets. Conclusion: The ADMET profiles and biological activity spectra of Hispidulin, Nepetin and Parthenolide have been addressed. These compounds are proposed to have activities against a variety of human aliments such as tumors, muscular dystrophy, and diabetic cataracts.Keywords: Tarconanthus camphoratus L., Hispidulin, Nepetin, Parthenolide, In silico pharmacokinetic, Molecular docking, PharmMapper server, and Auto-Dock 4.0 softwareÂ

THE ROLE OF CEMENT DUST IN BASALT-DE-ALUMINATED KAOLIN BRICKS

ABSTRACT Effect of gradual substitution of altered basalt by a few percent of cement dust (0, 5, 10, and wt.15%) on the ceramic properties of basalt-de-aluminated kaolin fired up to 1100ºC was studied. The results show that the samples containing 5 and 10 wt% cement dust give the higher suitable ceramic properties than the other samples. As the cement dust contents increases in the sample the apparent porosity enhances and the bulk density decreases at all temperature. Also, The XRD results reveal that the peaks of plagioclase and pyroxene of the altered basalt completely disappears in the sample containing cement dust and the intensity peaks of diopside sharply increase with cement dust content and firing temperature

Detection Some Trace Elements in Human Milk and Effect of Some Factors on its Concentrations

Study aim to determination some trace elements in lactating mothers human milk and study effect different factors on its concentration, Age , Body mass index, Home and Smoking habitat, atomic absorption flame less used to measured (Mn, Cd, Co and Zn) in 70 sample of lactating mothers milk which digested using tricolor acetic acid 24%. Result show that concentration of these elements increasing than normal value of these elements,Mn was 1801.40, Cd was 114.64, Co was 288.52 and Zn was 212.10.Also factors were studied effect on minerals concentration,  increasing age was  non effected on minerals concentration, over weight causes increasing it, urban resident causesincreasing in Mn concentration while rural residence causes increasing in others minerals, negative smoking habitat causes increasing in Cd and Co concentrations. Key words: trace element, lactating mother’s human milk, atomic absorptio

Peptidomimetic and Non- Peptidomimetic Derivatives as Possible SARS-CoV-2 Main Protease (Mpro) Inhibitors

To design novel inhibitors of the SARS-CoV-2 main protease (Mpro), we investigated the binding mode of the recently reported α-ketoamide inhibitors of this enzyme. Following, we utilized in-silico screening to identify 168 peptidomimetic and non-peptidomimetic compounds that are high probability Mpro binding candidates. The compounds were synthesized in 5 to 10 mg for initial screening for their potential inhibition of Mpro using Fluorescence Resonance Energy Transfer (FRET) assay. The study was conducted using the main protease, MBP-tagged (SARS-CoV-2) Assay Kit (BPS Bioscience, #79955-2), and the fluorescence due to enzymatic cleavage of substrate measured using BMG LABTECH CLARIOstar™, a fluorescent microplate reader, with an excited/emission wavelength of 360 nm/460 nm, respectively. The FRET assay showed 29 compounds to exhibit lower fluorescence compared to the positive control, indicating inhibitory activity, with three of the compounds exhibiting over 50% enzymatic inhibition. The assay average scores were plotted as dose inhibition curves using variable parameter nonlinear regression to calculate the IC50 values. To design more potent inhibitors, an in-silico molecular docking simulation using the SARS-CoV-2 Mpro crystal structure was conducted to investigate on a molecular level the key binding residues at the active site, as well as the possible binding modes and affinity of the lead inhibitors. Additionally, an in-silico study of the compounds\u27 molecular properties and physicochemical profiles was performed to predict their pharmacokinetic properties and assess their suitability as potential orally active drug candidates.https://scholarscompass.vcu.edu/gradposters/1139/thumbnail.jp

Archaeometric Study of the Historic Terrazzo Pavement of Prince Mohamed Ali Museum, Cairo, Egypt

This research will shed light on studying a terrazzo pavement in Prince Mohamed Ali Museum (the case study). The authors used visual inspection, stereo microscope, USB microscope, XRPD analysis, and SEM.EDX to identify its components, deterioration aspects and execution techniques. The XRPD and SEM.EDX results revealed that Portland cement was used in the three layers of terrazzo because of the detection of Hatrurite, Alite, Anorthite, Albite, Aragonite, etc. Many pigments were used in the topping terrazzo layer as; Goethite, Greenalite, Hematite, Azurite and Magnetite. The divider strips were made of brass alloy and the topping layer chips were prepared from basalt, marble and sea shells