1,374 research outputs found

    Adaptation of coordination mechanisms to network structures

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    The coordination efficiency of Supply Chain Management is determined by two opposite poles: benefit from improved planning results and associated coordination cost. The centralization grade, applied coordination mechanisms and IT support have influence on both categories. Therefore three reference types are developed and subsequently detailed in business process models for different network structures. In a simulation study the performance of these organization forms are compared in a process plant network. Coordination benefit is observed if the planning mode is altered by means of a demand planning IT tool. Coordination cost is divided into structural and activity-dependent cost. The activity level rises when reactive planning iterations become necessary as a consequence of inconsistencies among planning levels. Some characteristic influence factors are considered to be a reason for uninfeasible planning. In this study the effect of capacity availability and stochastic machine downtimes is investigated in an uncertain demand situation. Results that if the network runs with high overcapacity, central planning is less likely to increase benefit enough to outweigh associated cost. Otherwise, if capacity constraints are crucial, a central planning mode is recommendable. When also unforeseen machine downtimes are low, the use of sophisticated IT tools is most profitablePeer Reviewe

    Sentinel-1 Imaging Performance Verification with TerraSAR-X

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    This paper presents dedicated analyses of TerraSAR-X data with respect to the Sentinel-1 TOPS imaging mode. First, the analysis of Doppler centroid behaviour for high azimuth steering angles, as occurs in TOPS imaging, is investigated followed by the analysis and compensation of residual scalloping. Finally, the Flexible-Dynamic BAQ (FD-BAQ) raw data compression algorithm is investigated for the first time with real TerraSAR-X data and its performance is compared to state-of-the-art BAQ algorithms. The presented analyses demonstrate the improvements of the new TOPS imaging mode as well as the new FD-BAQ data compression algorithm for SAR image quality in general and in particular for Sentinel-1

    The Core-Wing Anomaly of Cool Ap Stars: Abnormal Balmer Profiles

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    Paper by Cowley et al. The Core-Wing Anomaly Etc. The profiles of Hα\alpha in a number of cool Ap stars are anomalous. Broad wings, indicative of temperatures in the range 7000-8000K end abruptly in narrow cores. The widths of these cores are compatible with those of dwarfs with temperatures of 6000K or lower. This profile has been known for Przybylski's star, but it is seen in other cool Ap's. The Hβ\beta profile in several of these stars shows a similar core-wing anomaly (CWA). In Przybylski's star, the CWA is probably present at higher Balmer members. We are unable to account for these profiles within the context of LTE and normal dwarf atmospheres. We conclude that the atmospheres of these stars are not ``normal.'' This is contrary to a notion that has long been held.Comment: 4 Pages 5 Figures. Submitted to Astronomy and Astrophysics 4 Dec. 200

    Indirect Fluorescent Antibody Test in Diagnosis of Trichinellosis in Man

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    Die Gestaltung des Selbstmanagements und die damit verbundenen Herausforderungen von an einheimischer Sprue erkrankten Personen

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    Die einheimische Sprue ist eine chronische Erkrankung, die durch eine Glutenunverträglichkeit charakterisiert ist. Die einzige Behandlungsmöglichkeit ist die strikte lebenslang einzuhaltende gluten-freie Diät. Für den deutschsprachigen Raum existieren kaum Forschungsarbeiten, die sich mit dieser Problematik auseinandersetzen. Aus diesem Grund greift die vorliegende Arbeit diese Thematik auf und stellt folgende Fragestellung in den Mittelpunkt der Betrachtung: „Wie beeinflusst die einheimische Sprue das Leben von betroffenen Personen?“ Um auf diese Forschungsfrage eingehen zu können, wurden sieben halb-standardisierte Interviews durchgeführt, die mit Hilfe der Grounded Theory ausgewertet wurden. Das vorrangige Ziel dieser Arbeit besteht darin, den Einfluss der einheimischen Sprue auf das alltägliche Leben von Betroffenen aufzuzeigen. Ein maßgebliches Problem stellt insbesondere die späte Feststellung der einheimischen Sprue dar. Viele Betroffene müssen nicht selten Jahre mit den vielfältigen Symptomen leben, ohne genau zu wissen, woran sie eigentlich erkrankt sind. Vor allem, wenn die betroffene Person zum Zeitpunkt der Diagnosestellung bereits ein fortgeschrittenes Alter erreicht hat, wird diese chronische Erkrankung als Belastung erlebt. Diese Person sieht sich mit der Tatsache konfrontiert, das bisher gewohnte Leben umzustrukturieren und eine für sie vollkommen unbekannte Diät zu erlernen. Interessant ist, dass die Öffentlichkeit noch immer nicht ausreichend über die Erkrankung und über die für Betroffene lebensnotwendige Diät informiert ist. Aus diesem Grund sollte man sich verstärkt auf die Öffentlichkeitsarbeit konzentrieren, um somit das Bewusstsein für diese chronische Erkrankung zu erweitern. Dies könnte nicht nur das Leben von bereits diagnostizierten Personen erleichtern, sondern auch die Diagnose von Personen, die an den typischen Beschwerden der einheimischen Sprue leiden, beschleunigen

    Effects of Ocean Acidification on the Transcriptome of Larval Atlantic Cod and Impacts of Parental Acclimation

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    Ocean acidification, caused by the uptake of carbon dioxide (CO2) from the atmosphere, is impacting many marine organisms. This dissertation investigated the effects of direct exposure and parental acclimation to simulated ocean acidification on the larval stages of Atlantic cod (Gadus morhua, L.). For this, ocean acidification levels predicted for the year 2100 were applied on cod eggs from hatch to 36 days post hatch in in vivo laboratory experiments. The direct exposure experiment clearly showed that Atlantic cod larvae were severely affected by simulated ocean acidification on a phenotypic level (chapter 1). Changes in growth, bone and gill development as well as increased frequency of organ damages were observed under predicted ocean acidification levels compared to controls. Then, the underlying molecular phenotype was assessed, using whole transcriptome sequencing (RNA-Seq), to couple transcriptomic mechanisms to the observed phenotypes (chapter 2). Transcriptome analysis revealed 1413 differentially expressed genes in late larval stages, corresponding to the observed changes in growth and developmental patterns, leading to the conclusion that these changes represent an accelerated development under ocean acidification. Surprisingly, only few genes (3 and 16, respectively) were differentially expressed in the early larval stages. An experiment set to address the effects of long-term parental acclimation (5 month) was performed to assess whether or not this kind of acclimation can mediate the identified detrimental direct effects on the larvae (chapter 3). However, none of the previously observed phenotypes under ocean acidification were found in this experiment, making it impossible to draw any conclusion on the effectiveness of parental acclimation on larval susceptibility to simulated ocean acidification. A concluding meta-analysis between experiments shows that the larvae of Atlantic Cod are to be considered vulnerable to simulated ocean acidification

    Detection and Tracking of Mobile Channel Impulse Responses

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    The exchange of information in today’s society requires for developing more pow-erful wireless transmission systems like positioning by global navigation satellite systems and mobile communications. However, the available frequency bands are limited with regard to the high data rates and an increased need for spectral efficiency will occur. Thus, a good understanding of the wireless channel is essen-tial, where propagation paths ’ parameters show a time-variant behavior in terms of assuming a moving receiver. This thesis describes a novel algorithm which is able to both detect individual propagation paths and track how these paths evolve with time. A simulation based on a wireless transmission channel with a moving receiver is given, shows that the algorithm outperforms the standard snapshot-based algorithms in terms of identifying the number of individual paths and estimation accuracy. During the further procedure we assure the algorithm to be even superior to other tracking methods in cognition of individual propagation paths. i i

    In-Orbit SAR Performance of TerraSAR-X

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    TerraSAR-X is the first German Radar satellite for scientific and commercial applications. The project is a public-private partnership between DLR and EADS Astrium GmbH. TerraSAR-X consists of a high resolution Synthetic Aperture Radar at X-Band. The radar antenna is based on active phased array technology that allows the control of many different instrument parameters and operational modes (Stripmap, ScanSAR and Spotlight) with various polarizations. Following the TerraSAR-X launch, scheduled for February 2007, it is planned a six month Commissioning Phase covering the characterization and verification of the SAR mission. Within this phase, the Overall SAR System Performance (OSSP) takes care of the correct working and interaction of all SAR system elements essential for obtaining an optimum SAR Performance. The paper covers the first in-orbit characterization and verification results of the SAR system performance for TerraSAR-X operational and experimental modes. This characterization is divided into four phases: Initial Characterization, Scene Characterization –both mostly based on basic and experimental products-, and Verification of TS-X Instrument Command Generation. The different optimization strategies and performance trade-offs are discussed and presented in the paper, including very first TerraSAR-X images. The result of the real SAR data analysis determines the final system baseline and thus the final image quality, e.g. Temperature compensation, Total Zero Doppler Steering, Up/down chirp toggling, transmitted bandwidth, timing interferences, etc. The first section of the paper introduces the activities carried out during the Commissioning Phase for the TerraSAR-X SAR system performance characterization/verification. In the second section, the strategies for the performance optimization and characterization are presented. Finally, the in-orbit SAR performance results are given in section three

    Evaluation of configurations of supply networks supported by it systems

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    Los sistemas transaccionales tales como los programas informáticos para la planificación de recursos empresariales (ERP software) se han implementado ampliamente mientras que los sistemas analíticos para la gestión de la cadena de suministro (SCM software) no han tenido el éxito deseado por la industria de tecnología de información (TI). Aunque se documentan beneficios importantes derivados de las implantaciones de SCM software, las empresas industriales son reacias a invertir en este tipo de sistemas. Por una parte esto es debido a la falta de métodos que son capaces de detectar los beneficios por emplear esos sistemas, y por otra parte porque el coste asociado no está identificado, detallado y cuantificado suficientemente. Los esquemas de coordinación basados únicamente en sistemas ERP son alternativas válidas en la práctica industrial siempre que la relación coste-beneficio esta favorable. Por lo tanto, la evaluación de formas organizativas teniendo en cuenta explícitamente el coste debido a procesos administrativos, en particular por ciclos iterativos, es de gran interés para la toma de decisiones en el ámbito de inversiones en TI. Con el fin de cerrar la brecha, el propósito de esta investigación es proporcionar métodos de evaluación que permitan la comparación de diferentes formas de organización y niveles de soporte por sistemas informáticos. La tesis proporciona una amplia introducción, analizando los retos a los que se enfrenta la industria. Concluye con las necesidades de la industria de SCM software: unas herramientas que facilitan la evaluación integral de diferentes propuestas de organización. A continuación, la terminología clave se detalla centrándose en la teoría de la organización, las peculiaridades de inversión en TI y la tipología de software de gestión de la cadena de suministro. La revisión de la literatura clasifica las contribuciones recientes sobre la gestión de la cadena de suministro, tratando ambos conceptos, el diseño de la organización y su soporte por las TI. La clasificación incluye criterios relacionados con la metodología de la investigación y su contenido. Los estudios empíricos en el ámbito de la administración de empresas se centran en tipologías de redes industriales. Nuevos algoritmos de planificación y esquemas de coordinación innovadoras se desarrollan principalmente en el campo de la investigación de operaciones con el fin de proponer nuevas funciones de software. Artículos procedentes del área de la gestión de la producción se centran en el análisis de coste y beneficio de las implantaciones de sistemas. La revisión de la literatura revela que el éxito de las TI para la coordinación de redes industriales depende en gran medida de características de tres dimensiones: la configuración de la red industrial, los esquemas de coordinación y las funcionalidades del software. La literatura disponible está enfocada sobre todo en los beneficios de las implantaciones de SCM software. Sin embargo, la coordinación de la cadena de suministro, basándose en el sistema ERP, sigue siendo la práctica industrial generalizada, pero el coste de coordinación asociado no ha sido abordado por los investigadores. Los fundamentos de diseño organizativo eficiente se explican en detalle en la medida necesaria para la comprensión de la síntesis de las diferentes formas de organización. Se han generado varios esquemas de coordinación variando los siguientes parámetros de diseño: la estructura organizativa, los mecanismos de coordinación y el soporte por TI. Las diferentes propuestas de organización desarrolladas son evaluadas por un método heurístico y otro basado en la simulación por eventos discretos. Para ambos métodos, se tienen en cuenta los principios de la teoría de la organización. La falta de rendimiento empresarial se debe a las dependencias entre actividades que no se gestionan adecuadamente. Dentro del método heurístico, se clasifican las dependencias y se mide su intensidad basándose en factores contextuales. A continuación, se valora la idoneidad de cada elemento de diseño organizativo para cada dependencia específica. Por último, cada forma de organización se evalúa basándose en la contribución de los elementos de diseño tanto al beneficio como al coste. El beneficio de coordinación se refiere a la mejora en el rendimiento logístico - este concepto es el objeto central en la mayoría de modelos de evaluación de la gestión de la cadena de suministro. Por el contrario, el coste de coordinación que se debe incurrir para lograr beneficios no se suele considerar en detalle. Procesos iterativos son costosos si se ejecutan manualmente. Este es el caso cuando SCM software no está implementada y el sistema ERP es el único instrumento de coordinación disponible. El modelo heurístico proporciona un procedimiento simplificado para la clasificación sistemática de las dependencias, la cuantificación de los factores de influencia y la identificación de configuraciones que indican el uso de formas organizativas y de soporte de TI más o menos complejas. La simulación de eventos discretos se aplica en el segundo modelo de evaluación utilizando el paquete de software ‘Plant Simulation’. Con respecto al rendimiento logístico, por un lado se mide el coste de fabricación, de inventario y de transporte y las penalizaciones por pérdida de ventas. Por otro lado, se cuantifica explícitamente el coste de la coordinación teniendo en cuenta los ciclos de coordinación iterativos. El método se aplica a una configuración de cadena de suministro ejemplar considerando diversos parámetros. Los resultados de la simulación confirman que, en la mayoría de los casos, el beneficio aumenta cuando se intensifica la coordinación. Sin embargo, en ciertas situaciones en las que se aplican ciclos de planificación manuales e iterativos el coste de coordinación adicional no siempre conduce a mejor rendimiento logístico. Estos resultados inesperados no se pueden atribuir a ningún parámetro particular. La investigación confirma la gran importancia de nuevas dimensiones hasta ahora ignoradas en la evaluación de propuestas organizativas y herramientas de TI. A través del método heurístico se puede comparar de forma rápida, pero sólo aproximada, la eficiencia de diferentes formas de organización. Por el contrario, el método de simulación es más complejo pero da resultados más detallados, teniendo en cuenta parámetros específicos del contexto del caso concreto y del diseño organizativo. ABSTRACT Transactional systems such as Enterprise Resource Planning (ERP) systems have been implemented widely while analytical software like Supply Chain Management (SCM) add-ons are adopted less by manufacturing companies. Although significant benefits are reported stemming from SCM software implementations, companies are reluctant to invest in such systems. On the one hand this is due to the lack of methods that are able to detect benefits from the use of SCM software and on the other hand associated costs are not identified, detailed and quantified sufficiently. Coordination schemes based only on ERP systems are valid alternatives in industrial practice because significant investment in IT can be avoided. Therefore, the evaluation of these coordination procedures, in particular the cost due to iterations, is of high managerial interest and corresponding methods are comprehensive tools for strategic IT decision making. The purpose of this research is to provide evaluation methods that allow the comparison of different organizational forms and software support levels. The research begins with a comprehensive introduction dealing with the business environment that industrial networks are facing and concludes highlighting the challenges for the supply chain software industry. Afterwards, the central terminology is addressed, focusing on organization theory, IT investment peculiarities and supply chain management software typology. The literature review classifies recent supply chain management research referring to organizational design and its software support. The classification encompasses criteria related to research methodology and content. Empirical studies from management science focus on network types and organizational fit. Novel planning algorithms and innovative coordination schemes are developed mostly in the field of operations research in order to propose new software features. Operations and production management researchers realize cost-benefit analysis of IT software implementations. The literature review reveals that the success of software solutions for network coordination depends strongly on the fit of three dimensions: network configuration, coordination scheme and software functionality. Reviewed literature is mostly centered on the benefits of SCM software implementations. However, ERP system based supply chain coordination is still widespread industrial practice but the associated coordination cost has not been addressed by researchers. Fundamentals of efficient organizational design are explained in detail as far as required for the understanding of the synthesis of different organizational forms. Several coordination schemes have been shaped through the variation of the following design parameters: organizational structuring, coordination mechanisms and software support. The different organizational proposals are evaluated using a heuristic approach and a simulation-based method. For both cases, the principles of organization theory are respected. A lack of performance is due to dependencies between activities which are not managed properly. Therefore, within the heuristic method, dependencies are classified and their intensity is measured based on contextual factors. Afterwards the suitability of each organizational design element for the management of a specific dependency is determined. Finally, each organizational form is evaluated based on the contribution of the sum of design elements to coordination benefit and to coordination cost. Coordination benefit refers to improvement in logistic performance – this is the core concept of most supply chain evaluation models. Unfortunately, coordination cost which must be incurred to achieve benefits is usually not considered in detail. Iterative processes are costly when manually executed. This is the case when SCM software is not implemented and the ERP system is the only available coordination instrument. The heuristic model provides a simplified procedure for the classification of dependencies, quantification of influence factors and systematic search for adequate organizational forms and IT support. Discrete event simulation is applied in the second evaluation model using the software package ‘Plant Simulation’. On the one hand logistic performance is measured by manufacturing, inventory and transportation cost and penalties for lost sales. On the other hand coordination cost is explicitly considered taking into account iterative coordination cycles. The method is applied to an exemplary supply chain configuration considering various parameter settings. The simulation results confirm that, in most cases, benefit increases when coordination is intensified. However, in some situations when manual, iterative planning cycles are applied, additional coordination cost does not always lead to improved logistic performance. These unexpected results cannot be attributed to any particular parameter. The research confirms the great importance of up to now disregarded dimensions when evaluating SCM concepts and IT tools. The heuristic method provides a quick, but only approximate comparison of coordination efficiency for different organizational forms. In contrast, the more complex simulation method delivers detailed results taking into consideration specific parameter settings of network context and organizational design
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