Neutron cross sections in stellar nucleosynthesis: Study of the key isotope 25Mg

In this document the important role of 25Mg within nucleosynthesis processes is studied. In fact the initial conditions of s-process in massive and AGB stars depend on neutron-induced reactions on 25Mg, being this isotope involved both in neutron production and as a neutron poison. Because of the importance of 25Mg, very accurate and precise measurements of its capture cross section, at the n TOF CERN facility, and of its total cross section, at the EC-JRC-IRMM facility in Belgium, were performed. The aims of these measurements are both to weight the contribution of 25Mg as a neutron poison and to give constraints for the reaction rate of one of the main neutron sources for the s-process

Insulin signaling in insulin resistance states and cancer: A modeling analysis

Insulin resistance is the common denominator of several diseases including type 2 diabetes and cancer, and investigating the mechanisms responsible for insulin signaling impairment is of primary importance. A mathematical model of the insulin signaling network (ISN) is proposed and used to investigate the dose-response curves of components of this network. Experimental data of C2C12 myoblasts with phosphatase and tensin homologue (PTEN) suppressed and data of L6 myotubes with induced insulin resistance have been analyzed by the model. We focused particularly on single and double Akt phosphorylation and pointed out insulin signaling changes related to insulin resistance. Moreover, a new characterization of the upstream signaling of the mammalian target of rapamycin complex 2 (mTORC2) is presented. As it is widely recognized that ISN proteins have a crucial role also in cell proliferation and death, the ISN model was linked to a cell population model and applied to data of a cell line of acute myeloid leukemia treated with a mammalian target of rapamycin inhibitor with antitumor activity. The analysis revealed simple relationships among the concentrations of ISN proteins and the parameters of the cell population model that characterize cell cycle progression and cell death

SUSTAINABLE FOOD SYSTEM: A SHARING RESPONSIBILITY

The food system has slowly passed from a natural process into an industrial one, becoming increasingly affordable and abundant, but more standard and approved. This has modified our relationship with food: we eat more than we need; we buy more than we can consume. These shortcomings lead separating our choices from their effects on health and territory. The purpose of our work is to define how the systemic approach increases the level of resilience of small companies, helping to raise the endogenous processes and the variety within the territory system in order to define an economic potential on a local scale

A mathematical model of the euglycemic hyperinsulinemic clamp

BACKGROUND: The Euglycemic Hyperinsulinemic Clamp (EHC) is the most widely used experimental procedure for the determination of insulin sensitivity, and in its usual form the patient is followed under insulinization for two hours. In the present study, sixteen subjects with BMI between 18.5 and 63.6 kg/m(2 )were studied by long-duration (five hours) EHC. RESULTS: From the results of this series and from similar reports in the literature it is clear that, in obese subjects, glucose uptake rates continue to increase if the clamp procedure is prolonged beyond the customary 2 hours. A mathematical model of the EHC, incorporating delays, was fitted to the recorded data, and the insulin resistance behaviour of obese subjects was assessed analytically. Obese subjects had significantly less effective suppression of hepatic glucose output and higher pancreatic insulin secretion than lean subjects. Tissue insulin resistance appeared to be higher in the obese group, but this difference did not reach statistical significance. CONCLUSION: The use of a mathematical model allows a greater amount of information to be recovered from clamp data, making it easier to understand the components of insulin resistance in obese vs. normal subjects

The Relevance of Academic Libraries in the Twenty-First Century

The biggest challenge facing the library profession in the twenty-first century is staying relevant to its users. It is often stated that the Internet and Google have changed librarianship. This challenge, while significant, does not mean that libraries will go away. It is causing us to re-evaluate what we do, how we do it, and what role libraries have in the academy and in our culture at large. This column addresses some of the ways in which academic libraries can stay relevant throughout the twenty-first century

Can liquid biopsies for MASH help increase the penetration of metabolic surgery? A narrative review

This narrative review highlights current evidence on non-invasive tests to predict the presence or absence as well as the severity of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common condition characterized by fat accumulation in the liver that affects 32 % of the world population. The most severe form of MASLD is MASH in which hepatocyte ballooning and inflammation are present together with steatosis; MASH is often associated with liver fibrosis. MASH diagnosis is determined by invasive liver biopsy. Hence, there is a critical need for non-invasive MASH tests. Plasma biomarkers for MASH diagnosis generally have low sensitivity (62-66 %), and specificity (78-82 %). Monocyte levels of Perilipin2 (PLIN2) predict MASH with an accuracy of 92-93 %, and sensitivity and specificity of 90-95 % and 88-100 %, respectively. This liquid biopsy test can facilitate the study of MASH prevalence in general populations and also monitor the effects of lifestyle, surgical, and pharmacological interventions. Without any FDA-approved MASH therapeutic, and with metabolic surgery markedly surpassing the efficacy of lifestyle modification, an accurate and reliable liquid biopsy could help more people choose surgery as a treatment for MASH

Un período breve en un pequeño lugar : 1973-1975 en Tres de Febrero

Este trabajo reconstruye la historia de una exigua zona del Gran Buenos Aires en un breve período. Sin embargo, no es una historia pequeña. El 25 de mayo de 1973 Roberto Heredia asumió el gobierno municipal de Tres de Febrero. El 10 de agosto de 1975, tras una larga serie de acusaciones y disputas, Heredia fue destituido y reemplazado por Rubén Novoa, hasta entonces presidente del Concejo Deliberante y parte, también, del justicialismo tresfebrerense. En estas páginas se relatará la historia del gobierno de Heredia, las instancias de la conformación de las alianzas electorales y las circunstancias de su destitución como un estudio de caso que nos permitirá reconstruir aquel corto pero tumultuoso período.MESA V: Organizaciones políticas y movimientos sociales. Coordinadoras y comentaristas: Vera Carnovale, Laura Lenci y Natalia Vega.Facultad de Humanidades y Ciencias de la Educació

Effect of Oral Sebacic Acid on Postprandial Glycemia, Insulinemia, and Glucose Rate of Appearance in Type 2 Diabetes

Dicarboxylic acids are natural products with the potential of being an alternate dietary source of energy. We aimed to evaluate the effect of sebacic acid (a 10-carbon dicarboxylic acid; C10) ingestion on postprandial glycemia and glucose rate of appearance (Ra) in healthy and type 2 diabetic subjects. Furthermore, the effect of C10 on insulin-mediated glucose uptake and on GLUT4 expression was assessed in L6 muscle cells in vitro

The Perón who returned: memories in dispute. A comparative analysis of the testimonial works of Jorge Alberto Taiana, Miguel Bonasso and Juan Manuel Abal Medina

Este trabajo presenta un análisis de las obras testimoniales de Jorge Alberto Taiana, Miguel Bonasso y Juan Manuel Abal Medina. El objetivo es observar las diferentes operaciones memorísticas que los autores ponen en juego a la hora de reconstruir la figura y el rol de Juan Domingo Perón durante el proceso abierto con la apertura electoral de mayo de 1971 hasta la muerte del viejo líder tres años después.This paper presents an analysis of the testimonial books by Jorge Alberto Taiana, Miguel Bonasso and Juan Manuel Abal Medina. The article’s main aim is to observe the different memory operations that the authors turn on when reconstructing the figure and the role of Juan Domingo Perón during the process opened with the electoral calling on May 1971 until the old leader’s death three years later.Dossier: A 50 años de 1973. Argentina, Chile y UruguayFacultad de Humanidades y Ciencias de la Educació