15 research outputs found
Hereditary Trichodysplasia: Marie Unna'S Hypotrichosis
This is a study of eight members of one family with Marie Unna hypotrichosis occurring in five generations. All affected individuals were born with widespread facial “milia”, sparse scalp hair and decreased body hair. Laboratory studies including urinary amino acids and plasma testosterone were normal. On histologic examination the hair follicles of the scalp showed proliferation of the internal root sheath and horn pearl formation in the lower third of the follicle. Abnormal hairs were flat and ribbon-like and twisted at irregular intervals. Extensive peeling of the cuticle was demonstrated by scanning electron microscopy. Electron microscopy of the hair shafts revealed intracellular fractures of the cuticular cells, increased interfibrillar matrix and fractures of the cortical cell fibrils and fractures of the medullary cells. X-ray diffraction studies were normal. On amino acid analysis of affected hairs a small decrease in cysteine-cystine and an increase in methionine content was noted. Since the hair shafts are clearly abnormal in this disorder, the name hereditary trichodysplasia is suggested. The condition is inherited as an autosomal dominant trait
CORRELATION AND IMPORTANCE OFSOCIALLY RESPONSIBLE BUSINESSAND ORGANIZATIONAL CULTURE OFCOMPANIES
Pri definiranju strategije poslovanja treba voditi računa o odnosu koje poduzeće ima sa svojim stakeholderima i kakvu sliku stvara o sebi na tržištu. Pojam društvene odgovornosti ili društveno odgovornoga poslovanja definira se preko normi, vrijednosti i ponašanja poduzeća prema internome i
eksternom okruženju. Društveno odgovorno poslovanje poduzeća tako pridonosi poboljšanju odnosa
s ključnim akterima, te pridonosi dugoročnoj održivosti tvrtke i diferencijaciji iste među uspješnim
poduzećima. Rad ukazuje na značajnu svezu između korporativne društvene odgovornosti (CSR) i
organizacijske kulture poduzeća. Radom se daje teorijski pregled koncepta društvene odgovornosti
poduzeća (CSR), usredotočuje se na značaj organizacijske kulture poduzeća kao bitnoga segmeta kojim se kreira uspješan odnos prema internome i eksternom okruženju. U radu je definiran CSR, kao
i njegov značaj te posebne značajke u primjeni u poduzećima. U radu je definiran i objašnjen pojam
organizacijske kulture poduzeća, kao i ono što je čini. Također, definirana je i objašnjena sveza između društveno odgovornoga poduzeća i njegove organizacijske kulture. Objašnjeno je koliki je značaj
u definiranju pravih sustava vrijednosti i normi u poduzeća, kako za samo poduzeće tako i za sve
njegove stakeholdere te, na kraju, za konkurentsku prednost koju poduzeće na taj način ostvaruje. Rad
sadrži i praktični dio koji objašnjava svezu između društveno odgovornoga poslovanja i organizacijske kulture tvrtki i to na primjeru Fakulteta za biznis i turizam.When defining a business strategy, companies should take into consideration the relationship that a company has with its stakeholders and what kind of image it creates on the market. The concept of
social responsibility or socially responsible business is defining the norms, values, and behaviour of the company according to the internal and external environment. In this way, the socially responsible business of the company contributes to the improvement of relations with the key players, which contributes to the long-term sustainability of the company and the differentiation of the same among successful enterprises. The paper points to the important link between corporate social responsibility and the organizational culture of the company. The paper gives a theoretical overview of the CSR
concept, focusing on the importance of the organizational culture of the company as an important segment that creates a successful relationship with the internal and external environment. The paper defines the term CSR as well as its significance and special characteristics in the application in companies. Paper defines and explains the term organizational culture of the company, as well as what the organizational culture of the company makes. Also, a link between the socially responsible companies and the organizational culture has been defined and explained, as well as the importance in defining the right systems of values and norms in companies, both for the company itself and for all its stakeholders, and ultimately for the competitive advantage that the company in this way does.
The paper also has a practical part in which is explained the link between social responsibility and the organizational culture of the company on the example of Faculty of Business and Tourism
Cutaneous granulomas with two clinical presentations in a patient with common variable immunodeficiency
Ultramicroscopic Phagocytosis of Synthetic Melanin by Epidermal Cells In Vivo**From the Veterans Administration Hospital, Hines, Illinois and the Department of Dermatology, University of Illinois College of Medicine.
Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?
: Obesity is an epidemic that has led to a rise in the incidence of many comorbidities: among others, reduced fertility is often under-evaluated in clinical practice. The mechanisms underlying the link between reduced fertility and obesity are numerous, with insulin resistance, hyperglycaemia and the frequent coexistence of polycystic ovary syndrome being the most acknowledged. However, several other factors concur, such as gut microbiome alterations, low-grade chronic inflammation and oxidative stress. Not only do women with obesity take longer to conceive, but in vitro fertilization (IVF) is also less likely to succeed. We herein provide an updated state-of-the-art regarding the molecular bases of what we could define as dysmetabolic infertility, focusing on the clinical aspects, as well as possible treatment
A Comparative Light and Electron Microscopic Study of Primary Irritant Contact Dermatitis and Allergic Contact Dermatitis
Die Geschichte einer unbekannten dermatologischen Wachsgusssammlung der Universität „Iuliu Hatieganu“, Klausenburg, Rumänien
Among the dermatological wax collections across Europe, one of the latest created is the collection from Cluj-Napoca University, Romania. The initiator was Professor Coriolan Tataru and the moulage artist employed was Dr. Richard Hoffmann. Between the years 1923 and 1928, around 200 wax moulages were made, all realised after patients hospitalised in the clinic. The majority of cases represent the dermatological infectious pathology of that time: syphilis, cutaneous tuberculosis and mycetomas. Other interesting moulages represent genodermatoses, pelagra, different cutaneous cancers, and atypical aspects of common diseases like psoriasis and eczemas. The models depicting different stages of syphilis won the gold medal at the Ninth International Congress of Dermato-Venereology held in Budapest in 1935. We believe that the collection has a great value from a historical, artistic, didactic and scientific point of view, and it is organised as a museum within the Dermatology Clinic
International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia
Objective: Streptococcus pneumoniae is the most frequent bacterial pathogen isolated in subjects with Community-acquired pneumonia (CAP) worldwide. Limited data are available regarding the current global burden and risk factors associated with drug-resistant Streptococcus pneumoniae (DRSP) in CAP subjects. We assessed the multinational prevalence and risk factors for DRSP-CAP in a multinational point-prevalence study.
Design: The prevalence of DRSP-CAP was assessed by identification of DRSP in blood or respiratory samples among adults hospitalized with CAP in 54 countries. Prevalence and risk factors were compared among subjects that had microbiological testing and antibiotic susceptibility data. Multivariate logistic regressions were used to identify risk factors independently associated with DRSP-CAP.
Results: 3,193 subjects were included in the study. The global prevalence of DRSP-CAP was 1.3% and continental prevalence rates were 7.0% in Africa, 1.2% in Asia, and 1.0% in South America, Europe, and North America, respectively. Macrolide resistance was most frequently identified in subjects with DRSP-CAP (0.6%) followed by penicillin resistance (0.5%). Subjects in Africa were more likely to have DRSP-CAP (OR: 7.6; 95% CI: 3.34-15.35, p < 0.001) when compared to centres representing other continents.
Conclusions: This multinational point-prevalence study found a low global prevalence of DRSP-CAP that may impact guideline development and antimicrobial policies. Published by Elsevier Ltd on behalf of The British Infection Association