Wearable Bluetooth sensors for capturing relational variables and temporal variability in relationships: A construct validation study

The advent of wearable sensor technologies has the potential to transform organizational research by offering the unprecedented opportunity to collect continuous, objective, highly granular data over extended time periods. Recent evidence has demonstrated the potential utility of Bluetooth-enabled sensors, specifically, in identifying emergent networks via colocation signals in highly controlled contexts with known distances and groups. Although there is proof of concept that wearable Bluetooth sensors may be able to contribute to organizational research in highly controlled contexts, to date there has been no explicit psychometric construct validation effort dedicated to these sensors in field settings. Thus, the two studies described here represent the first attempt to formally evaluate longitudinal Bluetooth data streams generated in field settings, testing their ability to (a) show convergent validity with respect to traditional self-reports of relational data; (b) display discriminant validity with respect to qualitative differences in the nature of alternative relationships (i.e., advice vs. friendship); (c) document predictive validity with respect to performance; (d) decompose variance in network-related measures into meaningful within- and between-unit variability over time; and (e) complement retrospective self-reports of time spent with different groups where there is a "ground truth" criterion. Our results provide insights into the validity of Bluetooth signals with respect to capturing variables traditionally studied in organizational science and highlight how the continuous data collection capabilities made possible by wearable sensors can advance research far beyond that of the static perspectives imposed by traditional data collection strategies

THE RAT PROBASIN GENE PROMOTER DIRECTS HORMONALLY AND DEVELOPMENTALLY-REGULATED EXPRESSION OF A HETEROLOGOUS GENE SPECIFICALLY TO THE PROSTATE IN TRANSGENIC MICE

An expression cassette carrying 426 basepairs of the rat probasin (PB) gene promoter and 28 basepairs of 5’-untranslated region is sufficient to target the expression of the bacterial chloramphenicol acetyltransferase (CAT) gene specifically to the prostate in transgenic mice. The PB-CAT transgene was expressed in three of five (60%) independent lines of mice, and this expression, as reported previously for the endogenous rat gene, was male specific, restricted primarily to the lateral, dorsal, and ventral lobes of the prostate, with only very low levels of CAT activity detected in the anterior prostate and seminal vesicles. The developmental and hormonal regulation of the transgene also paralleled that reported for the rat gene, with a 70-fold increase in CAT activity in the mouse prostate observed between 2-7 weeks of age, a time corresponding to sexual maturation. PB-CAT activity in the prostate declined after castration to 3.5% of the precastration level, and the CAT activity in castrated males approached precastration levels when mice were supplemented with testosterone. Transgene expression in castrated males was not induced by dexamethasone. Coinjection of PB-CAT with a chicken lysozyme gene matrix attachment region resulted in their cointegration and further restricted the pattern of PB-CAT to the dorsolateral prostate, with suppressed expression observed in the ventral prostate. These studies demonstrate that a minimal rat probasin promoter can target heterologous gene expression specifically to the prostate in a developmentally and hormonally regulated fashion

The "why"\u80\u9d of international entrepreneurship: uncovering entrepreneurs personal values

Previous studies investigating the "why"\u80\u9d of entrepreneurial internationalization have focused on firm-level motivations, overlooking the relationships between firm-level and individual-level motivations and why entrepreneurs differ in the goals they intend to achieve. We investigate the role of personal values as desirable end states that motivate international entrepreneurship by functioning as superordinate cognitive structures that underlie the practical internationalization goals set by entrepreneurs. By adopting an idiographic approach based on a laddering methodology in a sample of 140 new domestic technology-based firms located in Northern Italy, we uncover and map the hierarchies of goals that motivate entrepreneurs' internationalization intentions, which are anchored in five personal values: achievement, power, self-direction, benevolence, and security. We discuss our theoretical and methodological contributions and the policy implications of our findings