Indicating Asynchronous Array Multipliers

Multiplication is an important arithmetic operation that is frequently encountered in microprocessing and digital signal processing applications, and multiplication is physically realized using a multiplier. This paper discusses the physical implementation of many indicating asynchronous array multipliers, which are inherently elastic and modular and are robust to timing, process and parametric variations. We consider the physical realization of many indicating asynchronous array multipliers using a 32/28nm CMOS technology. The weak-indication array multipliers comprise strong-indication or weak-indication full adders, and strong-indication 2-input AND functions to realize the partial products. The multipliers were synthesized in a semi-custom ASIC design style using standard library cells including a custom-designed 2-input C-element. 4x4 and 8x8 multiplication operations were considered for the physical implementations. The 4-phase return-to-zero (RTZ) and the 4-phase return-to-one (RTO) handshake protocols were utilized for data communication, and the delay-insensitive dual-rail code was used for data encoding. Among several weak-indication array multipliers, a weak-indication array multiplier utilizing a biased weak-indication full adder and the strong-indication 2-input AND function is found to have reduced cycle time and power-cycle time product with respect to RTZ and RTO handshaking for 4x4 and 8x8 multiplications. Further, the 4-phase RTO handshaking is found to be preferable to the 4-phase RTZ handshaking for achieving enhanced optimizations of the design metrics.Comment: arXiv admin note: text overlap with arXiv:1903.0943

Majority and Minority Voted Redundancy for Safety-Critical Applications

A new majority and minority voted redundancy (MMR) scheme is proposed that can provide the same degree of fault tolerance as N-modular redundancy (NMR) but with fewer function units and a less sophisticated voting logic. Example NMR and MMR circuits were implemented using a 32/28nm CMOS process and compared. The results show that MMR circuits dissipate less power, occupy less area, and encounter less critical path delay than the corresponding NMR circuits while providing the same degree of fault tolerance. Hence the MMR is a promising alternative to the NMR to efficiently implement high levels of redundancy in safety-critical applications

Within-host spatiotemporal dynamics of systemic Salmonella infection during and after antimicrobial treatment

$\textbf{Objectives:}$ We determined the interactions between efficacy of antibiotic treatment, pathogen growth rates and between-organ spread during systemic $\textit{Salmonella}$ infections. $\textbf{Methods:}$ We infected mice with isogenic molecularly tagged subpopulations of either a fast-growing WT or a slow-growing $\Delta$$\textit{aroC Salmonella}$ strain. We monitored viable bacterial numbers and fluctuations in the proportions of each bacterial subpopulation in spleen, liver, blood and mesenteric lymph nodes (MLNs) before, during and after the cessation of treatment with ampicillin and ciprofloxacin. $\textbf{Results:}$ Both antimicrobials induced a reduction in viable bacterial numbers in the spleen, liver and blood. This reduction was biphasic in infections with fast-growing bacteria, with a rapid initial reduction followed by a phase of lower effect. Conversely, a slow and gradual reduction of the bacterial load was seen in infections with the slow-growing strain, indicating a positive correlation between bacterial net growth rates and the efficacy of ampicillin and ciprofloxacin. The viable numbers of either bacterial strain remained constant in MLNs throughout the treatment with a relapse of the infection with WT bacteria occurring after cessation of the treatment. The frequency of each tagged bacterial subpopulation was similar in the spleen and liver, but different from that of the MLNs before, during and after treatment. $\textbf{Conclusions:}$ In $\textit{Salmonella}$ infections, bacterial growth rates correlate with treatment efficacy. MLNs are a site with a bacterial population structure different to those of the spleen and liver and where the total viable bacterial load remains largely unaffected by antimicrobials, but can resume growth after cessation of treatment.This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) grant number BB/M000982/1 (http://www.bbsrc.ac.uk/research/grants/grants/AwardDetails.aspx?FundingReference=BB/M000982/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Archaeological Geophysical Prospection in Peatland Environments: case studies and suggestions for future practice

Peatland environments, in contrast to ‘dry-land’ sites, preserve organic material, including anthropogenic objects, because they are anaerobic, and are therefore of great importance to archaeology. Peat also preserves macro- and micro- paleoenvironmental evidence and is the primary resource for understanding past climates and ecology. Archaeological sites often lie within or at the base of wet, deep, homogenous peat rendering them invisible to surface observers. As a result, they most often c..