TSpack: a unified tabu search code for multi-dimensional bin packing problems

We present a computer code that implements a general Tabu Search technique for the solution of two- and three-dimensional bin packing problems, as well as virtually any of their variants requiring the minimization of the number of bins. The user is only requested to provide a procedure that gives an approximate solution to the actual variant to be solve

Models and bounds for two-dimensional level packing problems

We consider two-dimensional bin packing and strip packing problems where the items have to be packed by levels. We introduce new mathematical models involving a polynomial number of variables and constraints, and show that their LP relaxations dominate the standard area relaxations. We then propose new (combinatorial) bounds that can be computed in O(nlog n) time. We show that they dominate the other bounds, and establish their absolute worst-case behavior. The quality of models and bounds is evaluated through extensive computational experiment

Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells

Mitotic perturbations frequently lead to chromosome mis-segregation that generates genome instability, thereby triggering tumor onset and/or progression. Error-free mitosis depends on fidelity-monitoring systems that ensure the temporal and spatial coordination of chromosome segregation. Recent investigations are focused on mitotic DNA damage response (DDR) and chromosome mis-segregations with the aim of developing more efficient anti-cancer therapies. We previously demonstrated that trichoplein keratin filament binding protein (TpMs) exhibits hallmarks of a tumor suppressor gene in cancer-derived cells and human tumors. Here, we show that silencing of TpMs expression results in chromosome mis-segregation, DNA damage and chromosomal instability. TpMs interacts with Mad2, and TpMs depletion results in decreased levels of Mad2 and Cyclin B1 proteins. All the genetic alterations observed are consistent with both defective activation of the spindle assembly checkpoint and mitotic progression. Thus, low levels of TpMs found in certain human tumors may contribute to cellular transformation by promoting genomic instability

Laser-driven muon production for material inspection and imaging

We numerically show that laser-wakefield accelerated electron beams obtained using a PetaWatt-scale laser system can produce high-flux sources of relativistic muons that are suitable for radiographic applications. Scalings of muon energy and flux with the properties of the wakefield electron beams are presented. Applying these results to the expected performance of the 10-PW class laser at the Extreme Light Infrastructure Nuclear Physics (ELI-NP) demonstrates that ultra-high power laser facilities currently in the commissioning phase can generate ultra-relativistic muon beams with more than 104 muons per shot reaching the detector plane. Simple magnetic beamlines are shown to be effective in separating the muons from noise, allowing for their detection using, for example, silicon-based detectors. It is shown that a laser facility like the one at ELI-NP can produce high-fidelity and spatially resolved muon radiographs of enclosed strategically sensitive materials in a matter of minutes

er.autopilot 1.0: The Full Autonomous Stack for Oval Racing at High Speeds

The Indy Autonomous Challenge (IAC) brought together for the first time in history nine autonomous racing teams competing at unprecedented speed and in head-to-head scenario, using independently developed software on open-wheel racecars. This paper presents the complete software architecture used by team TII EuroRacing (TII-ER), covering all the modules needed to avoid static obstacles, perform active overtakes and reach speeds above 75 m/s (270 km/h). In addition to the most common modules related to perception, planning, and control, we discuss the approaches used for vehicle dynamics modelling, simulation, telemetry, and safety. Overall results and the performance of each module are described, as well as the lessons learned during the first two events of the competition on oval tracks, where the team placed respectively second and third.Comment: Preprint: Accepted to Field Robotics "Opportunities and Challenges with Autonomous Racing" Special Issu

Inventory of available data and data sources and proposal for data collection on vector‐borne zoonoses in animals

n/

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO