Prevalence of acute oral mucosal damage secondary to the use of systemic antineoplastics: A systematic review and meta-analysis

OBJECTIVE: The aim of this study was to determine the prevalence of acute oral mucosal toxicities in non-irradiated patients treated with systemic antineoplastics agents. The secondary objective was to find out differences in its prevalence among the different types of systemic antineoplastics. STUDY DESIGN: A systematic review and meta-analysis was performed. Articles from 2010 to July 2022 were retrieved and included if patients were adults undergoing oral assessment after administration of commercially available systemic antineoplastics. Data was extracted and pooled proportions were estimated using random-effect model method (Der Simonian and Lair). RESULTS: Eighty-two articles were included in the study. The overall prevalence of acute oral mucosal damage across studies was 38.2% (95% CI: 33.1%-43.3%). The prevalence was 42.9% (95% CI: 32.8%-53%) in patients treated with chemotherapy alone, 38% (95% CI: 29.1%-47%) in patients treated with a combination of chemotherapy and targeted therapies, and 32.1% (95% CI: 26.8%-37.5%) in targeted therapies alone-treated patients. No statistically significant differences were found in the prevalence of oral mucosal toxicities between the different types of systemic antineoplastic treatments. CONCLUSIONS: Oral mucosal toxicity is a major side effect in non-irradiated cancer patients undergoing systemic antineoplastics

El pabellón de oficiales (2001)

Adrien Fournier; un joven teniente francés de ingenieros, es herido por uno de los primeros obuses de la Primera Guerra Mundial. Aunque sobrevive, presenta unas importantes lesiones en cara y cavidad oral por lo que es trasladado a un hospital de Paris. En el pabellón de oficiales del hospital, hay otros soldados con importantes heridas faciales. En la película se refleja el miedo al rechazo social, los intentos de suicidio, la labor de las enfermeras y del cirujano así como la camaradería y el apoyo entre pacientes

Assessment of the Economic and Health-Care Impact of COVID-19 (SARS-CoV-2) on Public and Private Dental Surgeries in Spain: A Pilot Study

Objectives: The COVID-19 (SARS-CoV-2) pandemic is an ongoing public health challenge, also for the dentistry community. The main objective of this paper was to determine the economic and health-care impact of COVID-19 on dentists in the Autonomous Region of Galicia (Spain). Methods: This was a descriptive observational study in which the data was collected by means of a self-administered survey (from 1 April 2020 to 30 April 2020). Results: A total of 400 dentists from Galicia responded to the survey. Only 12.3% of the participants could obtain personal protective equipment (PPE) including FFP2 masks. Of the male respondents, 33.1% suffered losses >€15,000 compared to 19.4% of female respondents (OR = 3.121, p < 0.001). Economic losses seem to have contributed to the applications for economic help as 29.5% of the respondents who applied for this measure recorded losses in excess of €15,000 (p = 0.03). Patients complained more about the fact that only emergency care was available during the State of Alarm, in dental surgeries that do not work with insurance companies or franchises. Only 4 professionals tested positive, 50% of whom worked exclusively in private practice and the other 50% who practised in both private and public surgeries. Dentists who practise in the public sector saw more urgent patients per week than those practising in private surgeries (p = 0.013). Conclusions: The COVID-19 pandemic has had economic repercussions in dentistry as only urgent treatment was available during the State of Alarm. These repercussions seem to be higher in male participants, as the majority of the participants have revealed higher economic losses than females. The level of assistance has also been affected, reducing the number of treated patients, although this quantity has been different in private and public surgeries. By presenting these findings we look to highlight the role that dentists play in society in treating dental emergencies in our surgeries, and this must be recognised and addressed by the relevant authorities, who must provide PPEs as a priority to this group as well as providing special economic aid in accordance with the losses incurred by the sectorS

La ansiedad en estudiantes de odontología: determinación de cortisol, alfa-amilasa salival y respuesta cardiovascular ante la realización de diversas actividades académicas

Tesis inédita presentada en la Universidad Europea de Madrid. Facultad de Ciencias BiomédicasRecientemente se ha demostrado que la ansiedad es un factor de riesgo para padecer problemas sistémicos a largo plazo, entre los que se incluyen problemas cardiovasculares, gastrointestinales y musculoesqueléticos entre otros. En el ámbito académico, existen diversas publicaciones que demuestran que los estudiantes sufren períodos de estrés intenso que podrían desencadenar la emoción de la ansiedad. La investigación sobre ansiedad en Odontología suele centrarse en el estudio de la ansiedad fóbica que sufren algunos pacientes ante la expectativa de la realización de un tratamiento odontológico, pero pocos estudios analizan la repercusión que puede tener la ansiedad a la que están sometidos nuestros estudiantes durante su período de formación. Los objetivos de nuestro trabajo son por tanto, determinar los cambios a nivel cardiovascular y en dos biomarcadores salivales para el estrés, cortisol y alfa amilasa, ante la realización de distintas actividades académicas, tales como la realización de un examen y la realización del primer tratamiento odontológico sobre paciente. De nuestros resultados se desprende que ambas actividades académicas deben considerarse fuentes de estrés en los estudiantes de Odontología, ya que fueron capaces de alterar la frecuencia cardiaca, tensión arterial y los niveles de cortisol, de manera estadísticamente significativa (p0.05). No se encontraron diferencias por sexos en los biomarcadores salivales, pero sí en la respuesta cardiovascular que fue mayor en los individuos del sexo masculino. La disminución de la ansiedad en el alumno sería un objetivo a perseguir debido a las consecuencias a largo plazo que podría tener sobre su salud. Los nuevos enfoques docentes y la evaluación continuada en el Grado de Odontología, probablemente disminuyan el grado de ansiedad en nuestros estudiantes y puedan influir positivamente en su rendimiento. Palabras clave: Ansiedad, estrés académico, estudiantes de odontología, respuesta cardiovascular, cortisol salival, alfa-amilasa salival. ABSTRACT Anxiety has been recently proven to be a risk factor for developing cardiovascular, gastrointestinal or musculoskeletal disorders. In an academic environment, it has been demonstrated that students suffer from long periods of intense stress that could trigger the emotion of anxiety. Anxiety research in Dentistry usually focus on the phobic anxiety some patients suffer when they should have some dental procedure done, but there aren¿t many studies that analyze the impact of the anxiety our students suffer while they are in their training period. The purpose of this study is to determine salivary cortisol and alpha-amylase, heart rate, oxygen saturation and pulse when performing different academic activities such as taking an exam or conducting for the first time one surgical and one restorative treatment on a patient. Both academic activities should be considered sources of stress for Dental students, since heart rate, blood pressure and cortisol levels were found to be increased before taking the exam or performing a procedure on a patient for the first time, to a statistically significant extent (p0.05). No differences were observed in salivary biomarkers concerning gender, though cardiovascular response was higher for male individuals. Due to the long-term consequences it could have on their health, the decline in the student¿s anxiety would be an objective to pursue. The new academic approaches as well as a continuous assessment in the Dentistry degree, will probably help decrease the level of anxiety in our students and influence their performance in a positive manner. Key words: Anxiety, academic stress, dental students, cardiovascular response, salivary cortisol, salivary alpha-amylase. [Resumen Teseo]UE

Grinspan’s syndrome in a diabetic woman

Sin financiaciónNo data (2009)UE

Salivaomics in oral cancer

The goal of cancer screening is to detect tumor at an early stage, and early cancer detection is the hallmark of successful treatment. In addition to traditional tissue biopsy-based diagnostics, more reliable, inexpensive, and noninvasive methods are required for early diagnosis of cancer. In this review, we highlight some of the recent advancements in the field of salivary diagnostics in oral cancer. RECENT FINDINGS: 'Salivaomics' is a broad collection of technologies used to explore different types of molecules contained in saliva. Although many protein and mRNA salivary biomarkers have been identified that can detect oral squamous cell carcinoma (OSCC), none have so far been validated for current clinical use. As the heterogeneity in carcinogenesis and multifactorial cause for OSCC, the most reliable results are gathered with the use of multiple biomarker candidates to improve accuracy and sensitivity of the test used. This further requires sensitive technology to detect salivary biomarkers in low quantities. SUMMARY: Large scale studies that incorporate proteomic, transcriptomic, and additional 'omics,' need to be initiated to bring technology to clinical point-of-care applications.Sin financiación1.607 JCR (2019) Q3, 23/42 Otorhinolaringology0.702 SJR (2019) Q2, 127/451 Surgery, 38/111 Otorhinolaryngology, 907/2754 Medicine (miscellaneous)No data IDR 2019UE

Salivary biomarkers in dental students under stress

Sin financiación2.011 JCR (2016) Q2, 27/90 Dentistry, Oral Surgery & MedicineUE

Úvula eréctil

Sin financiaciónNo data (2006)UE

La saliva, fluido vital

No data (2013

Uso de dispositivos moviles en el aula. Oralmedx, una “app” de ayuda al diagnóstico de lesiones orales

Actualmente son muchos los recursos disponibles en el aula como el uso de videos, CD-ROM, DVD, pero estos no dejan de ser recursos estáticos, sin posibilidad de modificación y es esa falta de dinamismo las que hace que resulten monótonos y poco atractivos para el aprendizaje. Uno de los aspectos mas interesantes en el uso de los smartphones y tablets en el aula es la utilización de las aplicaciones también conocidas como “apps” es que permiten la interacción del usuario con el contenido ya sea texto, imágenes, video, sonido o formatos de autoevaluación de manera que se consigue optimizar el proceso de aprendizaje y favorecer la adquisición de competencias.SIN FINANCIACIÓNNo data 2014UE