A pan-European epidemiological study reveals honey bee colony survival depends on beekeeper education and disease control

Reports of honey bee population decline has spurred many national efforts to understand the extent of the problem and to identify causative or associated factors. However, our collective understanding of the factors has been hampered by a lack of joined up trans-national effort. Moreover, the impacts of beekeeper knowledge and beekeeping management practices have often been overlooked, despite honey bees being a managed pollinator. Here, we established a standardised active monitoring network for 5 798 apiaries over two consecutive years to quantify honey bee colony mortality across 17 European countries. Our data demonstrate that overwinter losses ranged between 2% and 32%, and that high summer losses were likely to follow high winter losses. Multivariate Poisson regression models revealed that hobbyist beekeepers with small apiaries and little experience in beekeeping had double the winter mortality rate when compared to professional beekeepers. Furthermore, honey bees kept by professional beekeepers never showed signs of disease, unlike apiaries from hobbyist beekeepers that had symptoms of bacterial infection and heavy Varroa infestation. Our data highlight beekeeper background and apicultural practices as major drivers of honey bee colony losses. The benefits of conducting trans-national monitoring schemes and improving beekeeper training are discussed

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Construction and characterization of the Central Neutron Detector for CLAS12

The Central Neutron Detector (CND) is part of the CLAS12 apparatus, at the Jefferson Lab, and it was primary designed to detect the recoil neutrons in Deeply Virtual Compton Scatterings events on neutrons (n-DVCS). This measurement is an important step to complete our understanding in the description of the structure of the nucleon in terms of Generalized Parton Distributions. In order to match the experiment requirements in terms of photon-neutron rejection the CND must provide good time properties. With the conclusion of the R&D phase, we defined the final design of the detector, which will make use of scintillator bars read-out with PMTs organized in a three layer barrel. The CND will count then 24 elements of 6 scintillators each optically coupled two-by-two with a U-turn light guide, for a total of 144 scintillators and PMTs. In this communication we will report on the status of the CND construction and characterization. In particular we will present the different steps necessary to assemble each block of the detector; we will discuss the outcomes on the tests performed to fully characterize each block in terms of time resolution, charge collection, light attenuation and velocity in the scintillators; finally we will show as well the mechanic structure designed to integrate the CND in the full apparatus

Design and time properties of the Central Neutron Detector for CLAS12

The primary goal of the experiments using the CLAS12 detector at energies up to 12 GeV, at the Continuous Electron Beam Accelerator Facility at the Jefferson Laboratory, is the study of the structure of the nucleons in terms of the Generalized Parton Distributions. One of the necessary steps to complete our understanding in this field is the measure of the Deeply Virtual Compton Scattering on the neutron (n-DVCS) and so, to this aim, we are constructing a scintillator detector dedicated to the detection for the recoil neutron to be placed in the Central Detector system of the CLAS12 apparatus. To match the requirements of the experiment the Central Neutron Detector must provide good time properties in order to ensure good photon-rejection capabilities.In this communication we will report on the study and R&D of the Central Neutron Detector for CLAS12. In particular, we will describe the results on the tests that lead us to the final choice of the detector’s design and we will discuss the outcomes of the study on the time resolution properties of the prototype

Study of light yield for different configurations of plastic scintillators and wavelength shifting fibers

International audienceIn the effort of the AugerPrime scintillator surface detector R&D; activity, we investigated the performances of different extruded and cast plastic scintillators that were read out with wavelength-shifting (WLS) optical fibers and then coupled to a PMT. In particular we compared the light yield of eighteen scintillator/fiber configurations, obtained combining eight different scintillator bars with six fiber types, in order to investigate which was satisfying the AugerPrime specifications in terms of light production ( >12 photoelectrons per minimum ionizing particle). In this paper, we present the results of the study on different scintillator bar geometries, scintillator production techniques, and wavelength-shifting optical fiber types. We also propose an effective way to optically couple the fibers to the PMT entrance window

Dip-coated screen for gain calibration and alignment of gamma-ray telescope mirrors

In this communication, we will present a dual-purpose calibration system of NectarCAM, a medium-size-telescope camera proposed for the Cherenkov Telescope Array (CTA). The device is based on a white diffuse-reflective screen mounted on an XY motorization to reach every location in the focal plane, including a parking position when not in use. The design of the system was led by the requirements to perform the mirror alignment and the study of the telescope Point Spread Function (PSF) on one side (A), and to calibrate the photodetection chains (one for each of the 1855 photomultiplier tubes) of the camera in single photoelectron mode on the other side (B). The main requirement for the calibration device consists in producing a high-reflective (> 90% between 450 nm and 700 nm) and diffusive (following Lambert's cosine law) surface for side A. The other side, B, should emit an homogeneous amount of light over the surface. To satisfy these requirements, we developed a unique screen made out of PMMA and coated with the BC-620 paint from Saint-Gobain. For single-photoelectron calibration purposes, light is produced by a pulsed light source and injected into the screen via a fishtail light guide. We studied the optimal screen shape, paint, and painting process. To do so, we produced several prototypes and compared the light output intensity over the screen surface. These studies led to the definition of a specific painting pattern that enhances the light emission uniformity over the final octagonal screen surface. After having briefly described the developed prototypes that led to the current calibration device, we will focus on the calibration system performances and will describe the dip-coating application process, which is an essential technique to achieve reliable and reproducible optical performances

Dip-coated screen for gain calibration and alignment of gamma-ray telescope mirrors

In this communication, we will present a dual-purpose calibration system of NectarCAM, a medium-size-telescope camera proposed for the Cherenkov Telescope Array (CTA). The device is based on a white diffuse-reflective screen mounted on an XY motorization to reach every location in the focal plane, including a parking position when not in use. The design of the system was led by the requirements to perform the mirror alignment and the study of the telescope Point Spread Function (PSF) on one side (A), and to calibrate the photodetection chains (one for each of the 1855 photomultiplier tubes) of the camera in single photoelectron mode on the other side (B). The main requirement for the calibration device consists in producing a high-reflective (> 90% between 450 nm and 700 nm) and diffusive (following Lambert's cosine law) surface for side A. The other side, B, should emit an homogeneous amount of light over the surface. To satisfy these requirements, we developed a unique screen made out of PMMA and coated with the BC-620 paint from Saint-Gobain. For single-photoelectron calibration purposes, light is produced by a pulsed light source and injected into the screen via a fishtail light guide. We studied the optimal screen shape, paint, and painting process. To do so, we produced several prototypes and compared the light output intensity over the screen surface. These studies led to the definition of a specific painting pattern that enhances the light emission uniformity over the final octagonal screen surface. After having briefly described the developed prototypes that led to the current calibration device, we will focus on the calibration system performances and will describe the dip-coating application process, which is an essential technique to achieve reliable and reproducible optical performances

Design and characterization of a single photoelectron calibration system for the NectarCAM camera of the medium-sized telescopes of the Cherenkov Telescope Array

International audienceIn this work, we describe the optical properties of the single photoelectron (SPE) calibration system designed for NectarCAM, a camera proposed for the Medium Sized Telescopes (MST) of the Cherenkov Telescope Array (CTA). One of the goals of the SPE system, as integral part of the NectarCAM camera, consists in measuring with high accuracy the gain of its photo-detection chain. The SPE system is based on a white painted screen where light pulses are injected through a fishtail light guide from a dedicated flasher. The screen – placed 15 mm away from the focal plane – is mounted on an XY motorization that allows movements over all the camera plane. This allows in-situ measurements of the SPE spectra via a complete scan of the 1855 photo-multiplier tubes (PMTs) of NectarCAM. This calibration process will enable the reduction of the systematic uncertainties on the energy reconstruction of γ -rays coming from distant astronomical sources and detected by CTA.We discuss the design of the screen used in the calibration system and we present its optical performances in terms of light homogeneity and timing of the signal

Dip-coated screen for gain calibration and alignment of gamma-ray telescope mirrors

In this communication, we will present a dual-purpose calibration system of NectarCAM, a medium-size-telescope camera proposed for the Cherenkov Telescope Array (CTA). The device is based on a white diffuse-reflective screen mounted on an XY motorization to reach every location in the focal plane, including a parking position when not in use. The design of the system was led by the requirements to perform the mirror alignment and the study of the telescope Point Spread Function (PSF) on one side (A), and to calibrate the photodetection chains (one for each of the 1855 photomultiplier tubes) of the camera in single photoelectron mode on the other side (B). The main requirement for the calibration device consists in producing a high-reflective (> 90% between 450 nm and 700 nm) and diffusive (following Lambert's cosine law) surface for side A. The other side, B, should emit an homogeneous amount of light over the surface. To satisfy these requirements, we developed a unique screen made out of PMMA and coated with the BC-620 paint from Saint-Gobain. For single-photoelectron calibration purposes, light is produced by a pulsed light source and injected into the screen via a fishtail light guide. We studied the optimal screen shape, paint, and painting process. To do so, we produced several prototypes and compared the light output intensity over the screen surface. These studies led to the definition of a specific painting pattern that enhances the light emission uniformity over the final octagonal screen surface. After having briefly described the developed prototypes that led to the current calibration device, we will focus on the calibration system performances and will describe the dip-coating application process, which is an essential technique to achieve reliable and reproducible optical performances

Dip-coated screen for gain calibration and alignment of gamma-ray telescope mirrors

International audienceIn this communication, we will present a dual-purpose calibration system of NectarCAM, a medium-size-telescope camera proposed for the Cherenkov Telescope Array (CTA). The device is based on a white diffuse-reflective screen mounted on an XY motorization to reach every location in the focal plane, including a parking position when not in use. The design of the system was led by the requirements to perform the mirror alignment and the study of the telescope Point Spread Function (PSF) on one side (A), and to calibrate the photodetection chains (one for each of the 1855 photomultiplier tubes) of the camera in single photoelectron mode on the other side (B). The main requirement for the calibration device consists in producing a high-reflective (> 90% between 450 nm and 700 nm) and diffusive (following Lambert's cosine law) surface for side A. The other side, B, should emit an homogeneous amount of light over the surface. To satisfy these requirements, we developed a unique screen made out of PMMA and coated with the BC-620 paint from Saint-Gobain. For single-photoelectron calibration purposes, light is produced by a pulsed light source and injected into the screen via a fishtail light guide. We studied the optimal screen shape, paint, and painting process. To do so, we produced several prototypes and compared the light output intensity over the screen surface. These studies led to the definition of a specific painting pattern that enhances the light emission uniformity over the final octagonal screen surface. After having briefly described the developed prototypes that led to the current calibration device, we will focus on the calibration system performances and will describe the dip-coating application process, which is an essential technique to achieve reliable and reproducible optical performances