7 research outputs found
Stem cell survival is severely compromised by the thymidineanalog EdU (5-ethynyl-2'-deoxyuridine), an alternative to BrdU for proliferation assays and stem cell tracing
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Infliximab biosimilar-to-biosimilar switching in patients with inflammatory rheumatic disease:clinical outcomes in real-world patients from the DANBIO registry
- Author
- Andersen Marlene
- Christensen Louise Brot
- Chrysidis Stavros
- Colic Ada
- Danebod Kamilla
- Glintborg Bente
- Hendricks Oliver
- Hetland Merete Lund
- Jensen Dorte Vendelbo
- Just Søren Andreas
- Kalisz Maren Høgberget
- Kristensen Salome
- Krogh Niels Steen
- Linauskas Asta
- Loft Anne Gitte
- Lomborg Niels
- Manilo Natalia
- Mehnert Frank
- Munk Heidi Lausten
- Nabi Hafsah
- Pedersen Jens Kristian
- Raun Johnny Lillelund
- Thygesen Pia Høger
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2022
- Field of study
OBJECTIVE: Successful uptake of biosimilars in rheumatology is limited by lack of real-world evidence regarding effectiveness of biosimilar-to-biosimilar switching. We investigated infliximab biosimilars CT-P13-to-GP1111 switching among patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA). METHODS: Observational cohort study from the DANBIO registry. Patients were classified as originator-naïve or originator-experienced. Retention rates of 1-year GP1111 treatment were explored (Kaplan-Meier). We identified baseline factors (at the time of switch) associated with withdrawal of GP1111 (multivariable Cox-regression analyses with HRs including originator treatment history). Changes in subjective and objective measures of disease activity 4 months before and after the switch were assessed in individual patients. RESULTS: Of 1605 patients (685 RA, 314 PsA and 606 AxSpA, median disease duration was 9 years, 37% in Clinical Disease Activity Index/Ankylosing Spondylitis Disease Activity Score remission), 1171 were originator-naïve. Retention rates at 1-year were 83% (95% CI: 81% to 85%) and 92% (95% CI: 90% to 95%) for the originator-naïve and originator-experienced, respectively. GP1111 retention rates were higher in originator-experienced compared to originator-naïve with RA (HR=0.4 (95% CI: 0.2 to 0.7)) and PsA (HR=0.2 (95% CI: 0.1 to 0.8)), but not significantly for AxSpA: HR=0.6 (95% CI: 0.3 to 1.2). Lower disease activity was associated with higher retention. Changes in disease activity preswitch and postswitch were close to zero. CONCLUSION: This real-world observational study of more than 1600 patients with inflammatory arthritis showed high 1-year retention following a nationwide infliximab biosimilar-to-biosimilar switch. Retention was higher in originator-experienced and in patients with low disease activity, suggesting outcomes to be affected by patient-related rather than drug-related factors
Biosimilar-to-Biosimilar Switching in Routine Care - Results on > 1,600 Patients with Inflammatory Arthritis in the DANBIO Registry
- Author
- Andersen Marlene
- Christensen Louise
- Chrysidis Stavros
- Colic Ada
- Danebod Kamilla
- Glintborg Bente
- Hendricks Oliver
- Hetland Merete L
- Jensen Dorte Vendelbo
- Just Søren
- Kalisz Maren Høgberget
- Kristensen Salome
- Krogh Niels Steen
- Linauskas Asta
- Loft Anne Gitte
- Lomborg Niels
- Manilo Natalia
- Mehnert Frank
- Munk Heidi
- Nabi Hafsah
- Pedersen Jens
- Raun Johnny
- Thygesen Pia Høger
- Publication venue
- 'Wiley'
- Publication date
- 01/09/2022
- Field of study
Stem cell survival is severely compromised by the thymidineanalog EdU (5-ethynyl-2′-deoxyuridine), an alternative to BrdU for proliferation assays and stem cell tracing
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Waking Up in Pain:a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm
- Author
- Aasvang Eske Kvanner
- Awada Hussein Nasser
- Brahe Nicole
- Brandsborg Birgitte
- Charalampidis Georgios
- Christensen Amalie Prien
- Dirks Jesper
- Dybdal Bitten
- Falcon Lars
- Geisler Anja
- Grøfte Thorbjørn
- Hansen Kristian Kraft
- Hansen Maria Aagaard
- Hasfeldt-Hansen Dorthe
- Haugstvedt Aleksander Fjeld
- Hägi-Pedersen Daniel
- Jacobsen Stig
- Jakobsen Karina
- Jauho Kristian
- Jensen Elin H
- Jensen Mette Skov
- Jensen Pernille Pia
- Jørgensen Marlene
- Kirkegaard Ellen
- Kristensen Danja Lykke
- Kroh Charlotte Loumann
- Kromberg Laurits Schou
- Køppen Kasper Storm
- Larsen Thomas Egemose
- Lund Caterina Amanti
- Meyhoff Christian Sylvest
- Mohr Tróndur Høgnason
- Mørk Emilie Louise Schjøtt
- Nielsen Anne Staal
- Nielsen Christian Viggo
- Nielsen Hans Fjeldsøe
- Odder Lillian
- Pedersen Christian Alves Kohler
- Pælestik Maria Bolther
- Rasmussen Anders Mølgaard
- Rasmussen Bodil Steen
- Rasmussen Christina Kirkegaard
- Rasmussen Line Kirkegaard
- Rosager Chirstine Linaa
- Salam Idress Ahmad
- Schroder Save
- Selter Hansjörg
- Skjold Christine
- Skjønnemand Martin
- Sommer Trine Nyboe
- Steen Nick Phaff
- Sundskard Martin
- Svensson Camilla Kara
- Sølling Christoffer
- Sørensen Johan Kløvgaard
- Sørensen Martin Kryspin
- Toft Mette Helene
- Wolsted Henrik
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2021
- Field of study
Recommended from our members
Special Reviewers
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- Abma Joyce
- Acock Alan
- Acs Gregory
- Adams Michele
- Adams Ryan
- Adler Marina A.
- Adler-Baeder Francesca
- Ainsworth James W.
- Amin Sajeda
- Anderson Kathryn
- Anderson Kristin
- Anderson Peter
- Anderson Siwan
- Angel Jacqueline
- Ann Powell Mary
- Arnet Connidis Ingrid
- Arrighi Barbara
- Atkinson Alice M.
- Avellar Sarah
- Babcock Renee
- Baber Kristine
- Bachman Heather
- Badgett M. V. Lee
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- Bahr Stephen
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- Bartell Denise S.
- Bartfeld Judi
- Bartkowski John
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- Greenhaus Jeffrey H.
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- Guo Shenyang
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- Heaton Tim B.
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- Hertlein Katherine
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- Hill E. Jeffrey
- Hiller Harry H.
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- Hoffmann John P.
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- Honeycutt James M.
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- Horwitz Allan V.
- Hosley Cheryl A.
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- Huang Chien-Chung
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- Humble Aine M.
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- Hwang Sean-Shong
- Iacovou Maria
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- Impett Emily A.
- Ispa Jean
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- Joesch Jutta M.
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- Johnson Michael P.
- Johnson Rosalind B.
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- Lundquist Jennifer
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- Openshaw D. Kim
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- Publication venue
- Publication date
- 01/12/2005
- Field of study
1994 Annual Selected Bibliography: Asian American Studies and the Crisis of Practice
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- Abe Jennifer
- Abrahamse Allan F
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- Adler S. R.
- Affons Dyanne D
- Affonso Dyanne D
- Afkhami Mahnaz
- Agbayani-Siewert Pauline
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- Agluca Jacqueline
- Agnew Vijay
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- Airriess Christopher A
- Akerman Harold
- Alan-Williams Gregory
- Aldama Frederick Luis
- Alexander G. R.
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- America
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- Anaya S. James.
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- Ancheta Angelo N
- Anderson J.
- Anderson Nick
- Anderton Douglas L
- Anh
- Anthias
- Anthias Floya
- Appleby Jerry L
- Archibald C. P.
- Artists
- Asia America
- Asian American Curriculum Project
- Asian American Institute
- Asian American Literature
- Asian American Studies Programs
- Asian and Pacific Islander Center for Census Information and Services.
- Asian Immigrant Women Advocates
- Asian Pacific American Film
- Atkinson D. R.
- Atkinson D. R. A.
- Attinasi John J
- Avanzo Carolyn Erickson
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- Confucius Plaza
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- Der Henry
- Desai Kappu
- Deshpande Shekhar
- Destinations
- Detroit
- Dhruvarajan Vanaja
- Di Chiro Giovanna
- Diego Annie T
- Dion Kenneth L
- Diversity
- Dizon Lily
- Dodge Chris
- Dominguez Virginia A
- Donnelly Nancy D
- Doshisha Daigaku Jinbunkagaku Kenkyujo
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- Doyle James
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- Durvasula Ramani Suryakantham
- Dymski G. A.
- Echeverria Raul
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- Edgeworth Mary Ella
- Edmonston
- Enchautegui Maria
- Eng David L
- Environmental Equity
- Eoff Karen
- Erie Steven P
- Espenshade Thomas J
- Eternal Voices
- Ethnic Minority Populations
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- Fang Di.
- Farber Don
- Farley J. E.
- Fawcett James T
- Feagin Joe R
- Featherson Elena
- Feng Jianhua
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- Fitisemanu Dianna
- Fix Michael
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- Frank Dana
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- Freeman Richard
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- Fujikane Candance
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- Glodava
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- Haddad
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- Hawaii Business
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- History
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- Hong Jean Y
- Hong Minne
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- Hood Marlowe
- Hori Victor Sogen
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- Huang
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- Huang Karen
- Huang Larke Nahme
- Huggan Graham
- Hughes Diane
- Huie Wing Young
- Hundal Sukhwant S
- Hutchison Ray
- Huttlinger Kathleen
- Hyer Eric
- Ichioka Yuji
- Igoa Cristina
- Iino Masako
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- Immigration America's Newcomers
- Industry
- Ingrassia Michele
- Interracial Identity
- Ip D. F.
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- Lange Cynthia Juarez
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- Le Tri Huu
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- Lee Elisa
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- Leong Frederick T. L.
- Leong Frederick T. L.
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- Leong Russell C
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- Li
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- Light I.
- Light I.
- Lim Gerard
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- Little Gom-Benn
- Liu Aimee E
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- Los Angeles County
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- Mak Anita S
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- Manalansan Martin F. IV.
- Mandell Phyllis Levy
- Mangaoang Gil
- Manley Theodoric Jr
- Marable Manning
- Marie Calude-Valentin
- Marignay Bisola
- Martin
- Martinez Ramiro
- Mason Jim
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- National Asian American Telecommunications Association.
- National Asian Pacific American Legal Consortium.
- Naturalization Service
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- Nayyar Deepak
- Nee Victor
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- Planting Seeds Coalition
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- San Francisco
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- San Juan E. Jr.
- San Juan E. Jr.
- San Juan E. Jr.
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- Santos Bienvenido
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- Sasao Toshiaki
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- Schoenberger Karl
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- Schram Tom
- Schwartz
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- Seattle
- Seattle Chinese Yellow Pages
- Selected Bibliography
- Sensitivity
- Serran Tony
- Serxner Seth
- Sev'er Aysan
- Sexton
- Sexton Ken
- Sexton Ken
- Shaffer Donald R
- Shaffer Gwen
- Shah N.
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- Shepherd Verene
- Shimabukuro Bob
- Shimizu Yon
- Shin Kyung Rim
- Shintani
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- Sodowsky Gargi Roysircar
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- Song John
- Sovereignty
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- St. Raphael's Parish
- Stanfield J. H.
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- Stoos
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- Strona Proserfina A
- Strong James
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- Tatum Beverly Daniel
- Taufer Alison
- Taylor Lawrence Douglas H
- TDR
- Tehranian Katharine
- Tehranian Majid
- The Filipino Directory
- The Peoples Multicultural Almanac
- the United States
- The Western Massachusetts Vietnamese Association Directory (Springfield Massachusetts
- Thobani Sunera
- Tien Liang
- Tirrito Terry
- Tobin Jeffrey
- Tohmatsu Akiko Judith
- Tong Benson
- Totten George O
- Townley Annette
- Tran Qui-Phiet
- Tran Thanh V
- Trask Haunani-Kay
- Trask Mililani
- Trevison Catherine
- Truong Monique
- Tsang Daniel C
- Tseng Yen-Fen
- Tsuchida John Nobuya
- Turner Marlene
- Tuttle C. R.
- Tworkov Helen
- U.S. Department of State
- Uba Laura
- Ueda Reed
- Uehara Edwina S
- Ueki Teruyo
- Uno Roberta
- Van Arsdale Peter W
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- Van Steenberg Carol
- Vander Kathryn
- Vapiwala Neha
- Vargas Luis A
- Vecoli Rudolph J
- Vera Arleen
- Veugelers John W. P.
- Vietnamese Consumers
- Villalba
- Volpp Leti
- Wake Barbara
- Waldinger Roger
- Waldinger Roger
- Waldinger Roger
- Wallace Patricia
- Walter Pierre
- Walz Eric
- Wang
- Wang Gungwu
- Wang Linna
- Wang Ping
- Wang Quingjia Edward
- Wang V.
- Wang Y .
- War
- Ward Bud
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- Wassem
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- Webb T. D.
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- Wetherell
- Whang Patricia A
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- Whiteley Marilyn Fardig
- Wial Howard
- Wiecha John M
- Wiesendanger B.
- Wilgoren Jodi
- Wilkinson Alec
- Willard Walter
- Williams Teresa Kay
- Winant Howard
- Winland Daphne N
- Winn Nancy Nishimura
- Wolf Eric R
- Wong Cynthia
- Wong Deborah
- Wong Gil
- Wong L. Mun.
- Wong William
- Wong-Liane Eirene Ming
- Woo Alan H
- Woods Nancy Fugate
- Workplace
- Wright Debbie Hippolite
- Wright Robert E
- Wu Edna
- Wu Jenai
- Wu T. C.
- Xiong Phua
- Ya Va Thai
- Yamamoto Hisaye
- Yamamoto Joe
- Yamamoto Yasushi
- Yamanaka Keiko
- Yamanaka Lois-Ann
- Yamashita Kanshi Stanley
- Yamato Alexander
- Yamauchi Wakako
- Yan Wenfan
- Yang Dao
- Yang Jeff
- Yang P.
- Yang Pai
- Yang Philip Q
- Yang Philip Q
- Yang Xiaoyun
- Yasmin Marziya
- Yau Jenny
- Ye Weili
- Yee A. H.
- Yee Marsha W
- Yeh May
- Yeh May
- Yep G. A.
- Yep Kathy
- Yi Jenny Kisuk
- Ying Yu-Wen
- Yinger J. Milton.
- Yong Fung L
- Yoon In-Jin
- Yoshida Ryo
- Young Wanda
- Yu Diana
- Yu Eui-Young
- Yu M. C.
- Zackrison James Willard
- Zaharlick Amy
- Zane Nolan
- Zane Nolan
- Zane Nolan
- Zhou Min
- Ziegler R. G.
- Zlotkin Hania
- Zuvekas Ann
- Publication venue
- 'UCLA American Indian Studies Center'
- Publication date
- Field of study