Transductive hyperspectral image classification: toward integrating spectral and relational features via an iterative ensemble system

Remotely sensed hyperspectral image classification is a very challenging task due to the spatial correlation of the spectral signature and the high cost of true sample labeling. In light of this, the collective inference paradigm allows us to manage the spatial correlation between spectral responses of neighboring pixels, as interacting pixels are labeled simultaneously. The transductive inference paradigm allows us to reduce the inference error for the given set of unlabeled data, as sparsely labeled pixels are learned by accounting for both labeled and unlabeled information. In this paper, both these paradigms contribute to the definition of a spectral-relational classification methodology for imagery data. We propose a novel algorithm to assign a class to each pixel of a sparsely labeled hyperspectral image. It integrates the spectral information and the spatial correlation through an ensemble system. For every pixel of a hyperspectral image, spatial neighborhoods are constructed and used to build application-specific relational features. Classification is performed with an ensemble comprising a classifier learned by considering the available spectral information (associated with the pixel) and the classifiers learned by considering the extracted spatio-relational information (associated with the spatial neighborhoods). The more reliable labels predicted by the ensemble are fed back to the labeled part of the image. Experimental results highlight the importance of the spectral-relational strategy for the accurate transductive classification of hyperspectral images and they validate the proposed algorithm

A novel spectral-spatial co-training algorithm for the transductive classification of hyperspectral imagery data

The automatic classification of hyperspectral data is made complex by several factors, such as the high cost of true sample labeling coupled with the high number of spectral bands, as well as the spatial correlation of the spectral signature. In this paper, a transductive collective classifier is proposed for dealing with all these factors in hyperspectral image classification. The transductive inference paradigm allows us to reduce the inference error for the given set of unlabeled data, as sparsely labeled pixels are learned by accounting for both labeled and unlabeled information. The collective inference paradigm allows us to manage the spatial correlation between spectral responses of neighboring pixels, as interacting pixels are labeled simultaneously. In particular, the innovative contribution of this study includes: (1) the design of an application-specific co-training schema to use both spectral information and spatial information, iteratively extracted at the object (set of pixels) level via collective inference; (2) the formulation of a spatial-aware example selection schema that accounts for the spatial correlation of predicted labels to augment training sets during iterative learning and (3) the investigation of a diversity class criterion that allows us to speed-up co-training classification. Experimental results validate the accuracy and efficiency of the proposed spectral-spatial, collective, co-training strategy

Using PPI network autocorrelation in hierarchical multi-label classification trees for gene function prediction

BACKGROUND: Ontologies and catalogs of gene functions, such as the Gene Ontology (GO) and MIPS-FUN, assume that functional classes are organized hierarchically, that is, general functions include more specific ones. This has recently motivated the development of several machine learning algorithms for gene function prediction that leverages on this hierarchical organization where instances may belong to multiple classes. In addition, it is possible to exploit relationships among examples, since it is plausible that related genes tend to share functional annotations. Although these relationships have been identified and extensively studied in the area of protein-protein interaction (PPI) networks, they have not received much attention in hierarchical and multi-class gene function prediction. Relations between genes introduce autocorrelation in functional annotations and violate the assumption that instances are independently and identically distributed (i.i.d.), which underlines most machine learning algorithms. Although the explicit consideration of these relations brings additional complexity to the learning process, we expect substantial benefits in predictive accuracy of learned classifiers. RESULTS: This article demonstrates the benefits (in terms of predictive accuracy) of considering autocorrelation in multi-class gene function prediction. We develop a tree-based algorithm for considering network autocorrelation in the setting of Hierarchical Multi-label Classification (HMC). We empirically evaluate the proposed algorithm, called NHMC (Network Hierarchical Multi-label Classification), on 12 yeast datasets using each of the MIPS-FUN and GO annotation schemes and exploiting 2 different PPI networks. The results clearly show that taking autocorrelation into account improves the predictive performance of the learned models for predicting gene function. CONCLUSIONS: Our newly developed method for HMC takes into account network information in the learning phase: When used for gene function prediction in the context of PPI networks, the explicit consideration of network autocorrelation increases the predictive performance of the learned models. Overall, we found that this holds for different gene features/ descriptions, functional annotation schemes, and PPI networks: Best results are achieved when the PPI network is dense and contains a large proportion of function-relevant interactions

Dealing with spatial autocorrelation when learning predictive clustering trees

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Mining Multi-Relational Gradual Patterns

International audienceGradual patterns highlight covariations of attributes of the form " The more/less X, the more/less Y ". Their usefulness in several applications has recently stimulated the synthesis of several algorithms for their automated discovery from large datasets. However, existing techniques require all the interesting data to be in a single database relation or table. This paper extends the notion of gradual pattern to the case in which the co-variations are possibly expressed between attributes of different database relations. The interestingness measure for this class of " relational gradual patterns " is defined on the basis of both Kendall's τ and gradual supports. Moreover, this paper proposes two algorithms, named τ RGP Miner and gRGP Miner, for the discovery of relational gradual rules. Three pruning strategies to reduce the search space are proposed. The efficiency of the algorithms is empirically validated, and the usefulness of relational gradual patterns is proved on some real-world databases

Computational annotation of UTR cis-regulatory modules through Frequent Pattern Mining

<p>Abstract</p> <p>Background</p> <p>Many studies report about detection and functional characterization of cis-regulatory motifs in untranslated regions (UTRs) of mRNAs but little is known about the nature and functional role of their distribution. To address this issue we have developed a computational approach based on the use of data mining techniques. The idea is that of mining frequent combinations of translation regulatory motifs, since their significant co-occurrences could reveal functional relationships important for the post-transcriptional control of gene expression. The experimentation has been focused on targeted mitochondrial transcripts to elucidate the role of translational control in mitochondrial biogenesis and function.</p> <p>Results</p> <p>The analysis is based on a two-stepped procedure using a sequential pattern mining algorithm. The first step searches for frequent patterns (FPs) of motifs without taking into account their spatial displacement. In the second step, frequent sequential patterns (FSPs) of spaced motifs are generated by taking into account the conservation of spacers between each ordered pair of co-occurring motifs. The algorithm makes no assumption on the relation among motifs and on the number of motifs involved in a pattern. Different FSPs can be found depending on different combinations of two parameters, i.e. the threshold of the minimum percentage of sequences supporting the pattern, and the granularity of spacer discretization. Results can be retrieved at the UTRminer web site: <url>http://utrminer.ba.itb.cnr.it/</url>. The discovered FPs of motifs amount to 216 in the overall dataset and to 140 in the human subset. For each FP, the system provides information on the discovered FSPs, if any. A variety of search options help users in browsing the web resource. The list of sequence IDs supporting each pattern can be used for the retrieval of information from the UTRminer database.</p> <p>Conclusion</p> <p>Computational prediction of structural properties of regulatory sequences is not trivial. The presented data mining approach is able to overcome some limits observed in other competitive tools. Preliminary results on UTR sequences from nuclear transcripts targeting mitochondria are promising and lead us to be confident on the effectiveness of the approach for future developments.</p

Molecular and lifestyle factors modulating obesity disease

Obesity adversely affects bone health by means of multiple mechanisms, e.g., alterations in bone-regulating hormones, inflammation, and oxidative stress. Substantial evidence supports the relationship between adiposity and bone disorders in overweight/obese individuals. It is well known that the balance between mutually exclusive differentiation of progenitor cells into osteoblasts or adipocytes is controlled by different agents, including growth factors, hormones, genetic and epigenetic factors. Furthermore, an association between vitamin D deficiency and obesity has been reported. On the other hand, regular physical activity plays a key role in weight control, in the reduction of obesity-associated risks and promotes osteogenesis. The aim of this review is to highlight relevant cellular and molecular aspects for over-weight containment. In this context, the modulation of progenitor cells during differentiation as well as the role of epigenetics and microbiota in obesity disease will be discussed. Furthermore, lifestyle changes including an optimized diet as well as targeted physical activity will be suggested as strategies for the treatment of obesity disease