6,309 research outputs found
Inter- and Intra-Chain Attractions in Solutions of Flexible Polyelectrolytes at Nonzero Concentration
Constant temperature molecular dynamics simulations were used to study
solutions of flexible polyelectrolyte chains at nonzero concentrations with
explicit counterions and unscreened coulombic interactions. Counterion
condensation, measured via the self-diffusion coefficient of the counterions,
is found to increase with polymer concentration, but contrary to the prediction
of Manning theory, the renormalized charge fraction on the chains decreases
with increasing Bjerrum length without showing any saturation. Scaling analysis
of the radius of gyration shows that the chains are extended at low polymer
concentrations and small Bjerrum lengths, while at sufficiently large Bjerrum
lengths, the chains shrink to produce compact structures with exponents smaller
than a gaussian chain, suggesting the presence of attractive intrachain
interactions. A careful study of the radial distribution function of the
center-of-mass of the polyelectrolyte chains shows clear evidence that
effective interchain attractive interactions also exist in solutions of
flexible polyelectrolytes, similar to what has been found for rodlike
polyelectrolytes. Our results suggest that the broad maximum observed in
scattering experiments is due to clustering of chains.Comment: 12 pages, REVTeX, 15 eps figure
Relativistic Compact Objects in Isotropic Coordinates
We present a matrix method for obtaining new classes of exact solutions for
Einstein's equations representing static perfect fluid spheres. By means of a
matrix transformation, we reduce Einstein's equations to two independent
Riccati type differential equations for which three classes of solutions are
obtained. One class of the solutions corresponding to the linear barotropic
type fluid with an equation of state is discussed in detail.Comment: 9 pages, no figures, accepted for publication in Pramana-Journal of
Physic
Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202
CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at approximately equal rates. However, the subsequent 17,20 carbon–carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17α-hydroxypregnenlone (OHPREG) versus 17α-hydroxyprogesterone (OHPROG). Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme’s native preference for OHPREG. Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. In a series of resonance Raman experiments, it was observed that, in contrast with the case for the wild-type protein, in the mutant the 17α alcohol of OHPROG tends to form a H-bond with the proximal rather than terminal oxygen of the oxy–ferrous complex. When OHPREG was a substrate, the mutant enzyme was found to have a H-bonding interaction with the proximal oxygen that is substantially weaker than that of the wild type. These results demonstrate that a single-point mutation in the active site pocket of CYP17A1, even when far from the heme, has profound effects on steroidogenic selectivity in androgen biosynthesis
The Influence of Gamma-rays on the Injury and Chromosomal Aberrations of Long Bean (Vigna sesquipedalis, Fruw.)
The effects of gamma-rays on three varieties of long bean (Vigna sesquipedalis, Fruw), namely
Melaka, Local Black and Local Long were studied using Jive doses ranging from 10 to 50 kR. Both
Chromosomal aberrations and characteristics related to physiological damage were used to study
radiation sensitivity of the varieties. In general, gamma radiation did not affect % seed germination
but caused a significant reduction in characteristics related to survival, growth and fertility. Percentage
chromosomal aberrations also increased with increasing dose. As the measurement of seedling
height is simple, quick and highly correlated with most characteristics studied, it could be a useful
parameter in the study of radiation effects on long bean. Using a critenrion of approximately 30%
reduction in seedling height or 50% lethality, it is suggested that doses ranging from 30 to 50 kR
would be suitable for mutation induction in long bean
Causal Bulk Viscous Dissipative Isotropic Cosmologies with Variable Gravitational and Cosmological Constants
We consider the evolution of a flat Friedmann-Robertson-Walker Universe,
filled with a causal bulk viscous cosmological fluid, in the presence of
variable gravitational and cosmological constants. The basic equation for the
Hubble parameter, generalizing the evolution equation in the case of constant
gravitational coupling and cosmological term, is derived, under the
supplementary assumption that the total energy of the Universe is conserved. By
assuming that the cosmological constant is proportional to the square of the
Hubble parameter and a power law dependence of the bulk viscosity coefficient,
temperature and relaxation time on the energy density of the cosmological
fluid, two classes of exact solutions of the field equations are obtained. In
the first class of solutions the Universe ends in an inflationary era, while in
the second class of solutions the expansion of the Universe is non-inflationary
for all times. In both models the cosmological "constant" is a decreasing
function of time, while the gravitational "constant" increases in the early
period of evolution of the Universe, tending in the large time limit to a
constant value.Comment: 14 pages, 15 figure
Measurement Invariance of the Internet Addiction Test Among Hong Kong, Japanese, and Malaysian Adolescents
There has been increased research examining the psychometric properties on the Internet Addiction Test across different ages and populations. This population-based study examined the psychometric properties using Confirmatory Factory Analysis and measurement invariance using Item Response Theory (IRT) of the IAT in adolescents from three Asian countries. In the Asian Adolescent Risk Behavior Survey (AARBS), 2,535 secondary school students (55.91% girls) in Grade 7 to Grade 13 (Mean age = 15.61 years; SD=1.56) from Hong Kong (n=844), Japan (n=744), and Malaysia (n=947) completed a survey on their Internet use that incorporated the IAT scale. A nested hierarchy of hypotheses concerning IAT cross-country invariance was tested using multi-group confirmatory factor analysis. Replicating past finding in Hong Kong adolescents, the construct of IAT is best represented by a second-order three-factor structure in Malaysian and Japanese adolescents. Configural, metric, scalar, and partial strict factorial invariance was established across the three samples. No cross-country differences on Internet addiction were detected at latent mean level. This study provided empirical support to the IAT as a reliable and factorially stable instrument, and valid to be used across Asian adolescent populations
Crossover from Fermi liquid to Wigner molecule behavior in quantum dots
The crossover from weak to strong correlations in parabolic quantum dots at
zero magnetic field is studied by numerically exact path-integral Monte Carlo
simulations for up to eight electrons. By the use of a multilevel blocking
algorithm, the simulations are carried out free of the fermion sign problem. We
obtain a universal crossover only governed by the density parameter . For
, the data are consistent with a Wigner molecule description, while
for , Fermi liquid behavior is recovered. The crossover value is surprisingly small.Comment: 4 pages RevTeX, 3 figures, corrected Tabl
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