Chapter 19 Uncertainty

This handbook brings together leading international academic experts to provide a comprehensive and authoritative survey of Global Environmental Politics. Fully revised, updated and expanded to 45 chapters, the book: • Describes the history of global environmental politics as a discipline and explains the various theories and perspectives used by scholars and students to understand it. • Examines the key actors and institutions in global environmental politics, explaining the roles of states, international organizations, regimes, international law, foreign policy institutions, domestic politics, corporations and transnational actors. • Addresses the ideas and themes shaping the practice and study of global environmental politics, including sustainability, consumption, expertise, uncertainty, security, diplomacy, North-South relations, globalization, justice, ethics, public participation and citizenship. • Assesses the key issues and policies within global environmental politics, including energy, climate change, ozone depletion, air pollution, acid rain, transport, persistent organic pollutants, hazardous wastes, rivers, wetlands, oceans, fisheries, marine mammals, biodiversity, migratory species, natural heritage, forests, desertification, food and agriculture. This second edition includes new chapters on plastics, climate change, energy, earth system governance and the Anthropocene. It is an invaluable resource for students, scholars, researchers and practitioners of environmental politics, environmental studies, environmental science, geography, globalization, international relations and political science

Drivers of change in the UK Fire Service: an operations management perspective

The UK Fire and Rescue Service is subject to reform, along with other public sector services, resulting in later retirement age and budget limitations; the fire service is also subject to other societal changes such as shifts in fitness levels and a reduction in call outs. This chapter reviews these changes and considers them from an operations management perspective. A method for how to measure operational effectiveness is proposed and its use in informing changes to operating practice in the fire service is advocated

Chapter 19 Uncertainty

This handbook brings together leading international academic experts to provide a comprehensive and authoritative survey of Global Environmental Politics. Fully revised, updated and expanded to 45 chapters, the book: • Describes the history of global environmental politics as a discipline and explains the various theories and perspectives used by scholars and students to understand it. • Examines the key actors and institutions in global environmental politics, explaining the roles of states, international organizations, regimes, international law, foreign policy institutions, domestic politics, corporations and transnational actors. • Addresses the ideas and themes shaping the practice and study of global environmental politics, including sustainability, consumption, expertise, uncertainty, security, diplomacy, North-South relations, globalization, justice, ethics, public participation and citizenship. • Assesses the key issues and policies within global environmental politics, including energy, climate change, ozone depletion, air pollution, acid rain, transport, persistent organic pollutants, hazardous wastes, rivers, wetlands, oceans, fisheries, marine mammals, biodiversity, migratory species, natural heritage, forests, desertification, food and agriculture. This second edition includes new chapters on plastics, climate change, energy, earth system governance and the Anthropocene. It is an invaluable resource for students, scholars, researchers and practitioners of environmental politics, environmental studies, environmental science, geography, globalization, international relations and political science

More than skin deep

Regular readers of the Australian Journal of Physiotherapy will have noticed a number of cosmetic changes made to the journal since it received its last major facelift at the beginning of 1999. Most of these changes have been designed to make the journal a more attractive “read”. But the real changes go more than skin deep. The Editorial Board has been implementing structural changes to the way that the journal is produced and disseminated, with the aim of ensuring that scientifically credible and clinically important information is delivered to as wide an audience as possible

Community-Clinical Integration in the Connecticut Medicaid Context

It is well established that interventions that address social determinants of health (SDHs) are an optimal strategy to improve health equity, however the efficacy of these interventions is limited by the challenges of addressing SDHs in clinical care. As a result, building linkages between clinical providers and community-based providers of social services, formally known as community-clinical integration, is crucial to helping vulnerable populations achieve holistic, long-term health. Our team employed a mixed-methods design to understand community-clinical integration in the Connecticut Medicaid context. We conducted a realist literature review to identify models of community-clinical integration throughout the United States. We supplemented our literature review with 7 semi-structured interviews with staff from federally qualified health centers to identify best practices for and barriers to integrating community-based services into clinical care. Using insights gained from our literature review and qualitative interviews, we provide a set of recommendations to improve community-clinical integration implementation for Medicaid enrolled children and families throughout Connecticut.https://elischolar.library.yale.edu/ysph_pbchrr/1025/thumbnail.jp

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.

Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or direct AR antagonist treatment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) via compensatory mechanisms including resurgence of AR and AR splice variant (ARV) signaling. Emerging evidence suggests that Sigma1 (also known as sigma-1 receptor) is a unique chaperone or scaffolding protein that contributes to cellular protein homeostasis. We reported previously that some Sigma1-selective small molecules can be used to pharmacologically modulate protein homeostasis pathways. We hypothesized that these Sigma1-mediated responses could be exploited to suppress AR protein levels and activity. Here we demonstrate that treatment with a small-molecule Sigma1 inhibitor prevented 5α- dihydrotestosterone-mediated nuclear translocation of AR and induced proteasomal degradation of AR and ARV, suppressing the transcriptional activity and protein levels of both full-length and splice-variant AR. Consistent with these data, RNAi knockdown of Sigma1 resulted in decreased AR levels and transcriptional activity. Furthermore, Sigma1 physically associated with ARV7 and A

Congenital imprinting disorders: EUCID.net - a network to decipher their aetiology and to improve the diagnostic and clinical care

Imprinting disorders (IDs) are a group of eight rare but probably underdiagnosed congenital diseases affecting growth, development and metabolism. They are caused by similar molecular changes affecting regulation, dosage or the genomic sequence of imprinted genes. Each ID is characterised by specific clinical features, and, as each appeared to be associated with specific imprinting defects, they have been widely regarded as separate entities. However, they share clinical characteristics and can show overlapping molecular alterations. Nevertheless, IDs are usually studied separately despite their common underlying (epi) genetic aetiologies, and their basic pathogenesis and long-term clinical consequences remain largely unknown. Efforts to elucidate the aetiology of IDs are currently fragmented across Europe, and standardisation of diagnostic and clinical management is lacking. The new consortium EUCID.net (European network of congenital imprinting disorders) now aims to promote better clinical care and scientific investigation of imprinting disorders by establishing a concerted multidisciplinary alliance of clinicians, researchers, patients and families. By encompassing all IDs and establishing a wide ranging and collaborative network, EUCID.net brings together a wide variety of expertise and interests to engender new collaborations and initiatives

Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci

Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years have seen a great expansion in the range of alterations in regulation, dosage or DNA sequence shown to disturb imprinted gene expression, and the correspondingly broad range of resultant clinical syndromes. At the same time, however, it has become clear that this diversity of IDs has common underlying principles, not only in shared molecular mechanisms, but also in interrelated clinical impacts upon growth, development and metabolism. Thus, detailed and systematic analysis of IDs can not only identify unifying principles of molecular epigenetics in health and disease, but also support personalisation of diagnosis and management for individual patients and families

Recycled effluent irrigation in vineyards : an Australian case study. II. management for sustainability

The grape industry is reliant on water, and the future of the Australian viticulture industry could be affected by the rising salinity of irrigation water. Areas irrigated with recycled waters are especially at risk. Management can often ameliorate the adverse affects of low quality water, however this may require land-use practices that reduce commercial return from farming activities. With land application of wastewater in agriculture becoming an increasingly popular practice, the scientific challenge for viticulture will be to identify appropriate management strategies for sustainability of soil resources, so that maximum returns are achieved without the operation being compromised

Recycled effluent irrigation in vineyards : an Australian case study. I. issues and monitoring

The viticultural industry is becoming an increasingly significant part of the Australian agricultural sector, with gross earnings of over $4 billion in 2002. Expansion of the industry in the last decade has been rapid, however its heavy reliance on irrigation has resulted in further expansion in many wine growing regions being limited by the availability of water. This problem is not confined to the viticultural industry, with ever increasing pressures on water resources worldwide. As demands for water continue to rise, new strategies to meet demands must be adopted. One of the strategies being increasingly employed is the recycling of waste waters for a number of applications such as irrigation and industrial uses. The use of recycled water for vineyard irrigation provides a number of benefits. Among them are the reduced demands on potable supplies, reduced waste discharges to surface waters, and the opportunity for expansion of production. Recycled waters however, contain constituents which have the potential to cause deleterious effects to both production and the environment. Therefore, the use of recycled water for irrigation requires targetted monitoring and management to ensure the long-term sustainability of both the vineyard and the surrounding environment. Traditional monitoring techniques including water quality monitoring and soil testing can be complimented by new technologies and techniques which provide large quantities of information with relatively less labour and time. Such techniques can be used to monitor the vineyard environment to identify impacts arising from management practices, allowing vineyard managers to adjust management for sustainable production<br /