Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P < .05) and less refractoriness (4.5% vs 14.1%; P < .05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P < .05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P < .001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX

Un cole de cine

Convocatoria proyectos de innovación de Extremadura 2019/2020Se describe un proyecto llevado a cabo en los centros CEIP Camilo Hernández y CEIP Virgen de Argeme de Coria (Cáceres) en el que partiendo de la experiencia de la realización de un cortometraje se pretende, entre otras cuestiones, promover la creatividad audiovisual desde la educación, conseguir que los alumnos conozcan los lenguajes audiovisuales en los que la interacción de los códigos verbales y no verbales es más rica para la transmisión de significados, facilitar un medio para el conocimiento y la expresión que beneficia el desarrollo de las capacidades creativas, cognoscitivas, artísticas y expresivas, crear un espacio para la exhibición de trabajos propios dirigido a la comunidad educativa, transmitir valores útiles para trabajar la resolución de conflictos, etc. Todo ello utilizando la gamificación y el aprendizaje activo y cooperativoExtremaduraES