RELATIONSHIP BETWEEN MAXIMUM TOE FLEXOR MUSCLE STRENGTH AND ANTHROPOMETRIC VARIABLES OF THE LOWER LIMB AND THE FOOT IN CALLEGIATE ATHLETES

The purpose of present study was to indicate reference values of toe flexor strength (TFS), and its relation with anthropometric variables of the lower limb and the foot in collegiate athletes. Subjects were 68 male and 26 female of collegiate athletes. Subjects were measured maximum TFS in standing position. In addition, it were carried out anthropometric measurements. And muscle thicknesses were measured with a B-mode ultrasonic apparatus in triceps surae, tibialis anterior, abductor halluces, flexor hallucis brevis, flexor digitorurn brevis, and abductor digit minimi. TFS were in male and female collegiate athletes were 256.7f 55.8N and 207.3f 36.9, respectively. Stepwise multiple linear regression analysis revealed that important factors to determine TFS were the muscle thickness of flexor hallucis brevis muscle and body weight

日本におけるアンプティサッカーの変遷と世界の動向

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大学ゼミ・地元企業ジョイント授業の取り組みに関する一報告

本稿では、2019年度に新たにキャリア教育の1つとして立ち上がった「大学ゼミ・地元企業ジョイント授業」の紹介とともに、その成果の一部を報告する。今回紹介するジョイント授業の教育プログラムでは、自動車部品の一種であるサイドカーテンエアバッグを製造している企業への会社訪問が主な内容であった。また、会社訪問に向けた事前教育として履歴書の作成を行い、事後教育では企業担当者からの総評ならびに履歴書の添削を学生にフィードバックを行った。学生はそれらを基に授業全体の振り返りとして感想文を作成した。さらに、会社訪問にて印象に残っていることについてグループ討議を行い、学生による会社説明資料を作成した。本ジョイント授業に参加した学生13名の感想文からは、当初、就職に対する理解や意欲が高くなかったが、授業を通して就職活動に向けた危機感が喚起されたことが伺えた。この学生の意識の変化には、企業の方々からのフィードバックが有効的な役割を果たしていたと推察できる。このことから、大学のみならず、地域企業や地域社会と連携し、培われてきた経験やノウハウを活用することは、キャリア教育の効果を高める一助になるといえるだろう

Development of Biotin-Prototrophic and -Hyperauxotrophic Corynebacterium glutamicum Strains

To develop the infrastructure for biotin production through naturally biotin-auxotrophic Corynebacterium glutamicum, we attempted to engineer the organism into a biotin prototroph and a biotin hyperauxotroph. To confer biotin prototrophy on the organism, the cotranscribed bioBF genes of Escherichia coli were introduced into the C. glutamicum genome, which originally lacked the bioF gene. The resulting strain still required biotin for growth, but it could be replaced by exogenous pimelic acid, a source of the biotin precursor pimelate thioester linked to either coenzyme A (CoA) or acyl carrier protein (ACP). To bridge the gap between the pimelate thioester and its dedicated precursor acyl-CoA (or -ACP), the bioI gene of Bacillus subtilis, which encoded a P450 protein that cleaves a carbon-carbon bond of an acyl-ACP to generate pimeloyl-ACP, was further expressed in the engineered strain by using a plasmid system. This resulted in a biotin prototroph that is capable of the de novo synthesis of biotin. On the other hand, the bioY gene responsible for biotin uptake was disrupted in wild-type C. glutamicum. Whereas the wildtype strain required approximately 1 mu g of biotin per liter for normal growth, the bioY disruptant (Delta bioY) required approximately 1 mg of biotin per liter, almost 3 orders of magnitude higher than the wild-type level. The Delta bioY strain showed a similar high requirement for the precursor dethiobiotin, a substrate for bioB-encoded biotin synthase. To eliminate the dependency on dethiobiotin, the bioB gene was further disrupted in both the wild-type strain and the Delta bioY strain. By selectively using the resulting two strains (Delta bioB and Delta bioBY) as indicator strains, we developed a practical biotin bioassay system that can quantify biotin in the seven-digit range, from approximately 0.1 mu g to 1 g per liter. This bioassay proved that the engineered biotin prototroph of C. glutamicum produced biotin directly from glucose, albeit at a marginally detectable level (approximately 0.3 mu g per liter).ArticleAPPLIED AND ENVIRONMENTAL MICROBIOLOGY. 79(15):4586-4594 (2013)journal articl

DIP during perioperative chemotherapy

Purpose : Drug-induced interstitial pneumonia (DIP) that occurs during chemotherapy for breast cancer is a rare but a serious adverse event. Treatments of DIP requires interruption of breast cancer treatment, which may affect the patient’s prognosis. However, there are few reports which discuss DIP during breast cancer treatments. Purpose of this report is to make clear how DIP occurred and influenced breast cancer treatment in our hospital. Patients and Methods : A total of 74 patients who started perioperative chemotherapy in Tokushima Municipal Hospital for breast cancer from January 2019 to December 2020 were evaluated for DIP. Patients’ and tumors’ characteristics, and regimens which caused DIP were investigated. The clinical courses of the DIP patients were also followed up. Results : Twelve of the 74 patients developed DIP. All 12 patients had histories of cyclophosphamide administration ; however, the causative drug could not be determined. Ten of the 12 patients were treated with steroids, and all the patients recovered ultimately from the interstitial pneumonia. While chemotherapy was administered in six patients after mild DIP, no relapse of pneumonia was observed. Conclusion : DIP during perioperative chemotherapy for breast cancer was resolved with appropriate treatment. Patients were able to resume breast cancer treatment with minimal interruption