Global Lipschitz extension preserving local constants

The intent of this short note is to extend real valued Lipschitz functions on metric spaces, while locally preserving the asymptotic Lipschitz constant. We then apply this results to give a simple and direct proof of the fact that Sobolev spaces on metric measure spaces defined with a relaxation approach à la Cheeger are invariant under isomorphism class of mm-structures

Sistema web en el proceso de vacunación del virus de Papiloma humano del Ministerio de Salud, Lima 2017

Cada año el número de mujeres recientemente afectadas por el cáncer de cuello uterino asciende a aproximadamente a medio millos de personas. De las 270,000 muertes estimadas por cáncer de cuello uterino al año, el 85% de estas se presenta en los países en desarrollo, de las cuales 33,000 corresponde a latino américa y el Caribe. En el Perú, el cáncer de cuello uterino es la causa principal de muerte entre las mujeres con una indecencia anual estimada en 5,400 caos y 2,663 muertes. El presente estudio denominado “Sistema web en el proceso de vacunación del virus de papiloma humano del ministerio de salud, Lima 2017”, tiene por objetivo determinar la influencia de un sistema de registro y control de vacunas que permita llevar a cabo el proceso de registro de las niñas vacunas, el acceso a esta vacuna y cobertura de la misma, mediante el control de las dosis aplicadas, en las niñas comprendidas entre las edades de 10 a 15 años de edad, determinando como afecta en el proceso de vacunación y la mejora de la misma. El tipo de investigación que hemos utilizado en el presente estudio de tipo correlacional causal, el cual determinamos que la muestra tendría que tener un mínimo de 231 usuarios de las direcciones de salud de lima metropolitana, a la cual le aplicamos el instrumento de recolección de datos, obteniendo un total 271 encuestas. Como resultado de nuestro estudio pudimos comprobar que el sistema web si afecta positivamente en el proceso de vacunación de las direcciones de salud del lima, 2017

Análisis jurisprudencial y doctrinario de la privatización de los centros penitenciarios y su viabilidad para el estado peruano

En el presente estudio de grado, se examina la iniciativa del autor por constituir en su desarrollo una investigación que permita abordar la necesidad de privatizar las cárceles en el Perú, basándose en el modelo norteamericano y europeo, el mismo que ha permitido acabar con el hacinamiento y que la finalidad de la pena se puede cumplir, es decir que sea realmente resocializadora y que el reo se reinserte a la sociedad. Para el desarrollo de la investigación se planteó como objetivo realizar un análisis jurisprudencial y doctrinario de la privatización de los centros penitenciarios y su viabilidad para el estado peruano. La metodología que se utilizó para obtener los datos del análisis, fue investigación mixta, por una parte, cuantitativa la misma que utilizó como método de investigación de campo, las encuestas, por medio de un cuestionario de preguntas con preguntas cerradas, ya que dan a los informantes que van a ser evaluados todas las alternativas posibles. Asimismo, se realizó un análisis de las tabulaciones presentadas mediante las tablas y figuras de acuerdo a la metodología APA, De acuerdo al estudio realizado, se obtuvo como conclusión la existencia de discrepancias teóricas, por cuanto existe desconocimiento de los beneficios de la privatización carcelaria y el sistema penitenciario estatal, debido al dando cumplimiento al fin de la pena que es resocializar y rehabilitar al reo.Tesi

IMAGE CYTOMETRY FOR DNA ANALYSIS IN ENDOMETRIAL CARCINOMA CORRELATED WITH OTHER PROGNOSTIC PARAMETERS

We evaluated by static cytometry DNA ploidy parameters in 30 stage I-IV endometrial carcinomas and correlated these data with standard clinical-pathological features and disease-free period. We observed a direct correlation between either non-diploid DNA content and deeper myometrial invasion (p<0.02) or D.I.greater than or equal to 1.2 and M2-M3 tumors (p<0.009). The Kaplan Meier survival curves illustrate a more rapid relapse of disease associated with non-diploidy, high 5cExR, high level of proliferation and D.I.greater than or equal to 1.2. while Cox regression model gave relative hazards for disease recurrence of 4, 6, 3.7 and 2.1 for non-diploidy, D.I.greater than or equal to 1.2, high 5cExR and high level of proliferation respectively. This prospective study confirmed the prognostic value of DNA Index, and its usefulness in clinical practice especially in stage I cases, otherwise characterised by favourable standard prognostic factors, is discussed

Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma ‘anandamide amidohydrolase’

AbstractThe endogenous cannabimimetic substance, anandamide (N-arachidonoyl-ethanolamine) and the recently isolated sleep-inducing factor, oleoyl-amide (cis-9,10-octadecenoamide), belong to two neuroactive fatty acid amide classes whose action in mammals has been shown to be controlled by enzymatic amide bond hydrolysis. Here we report the partial characterisation and purification of ‘anandamide amidohydrolase’ from membrane fractions of N18 neuroblastoma cells, and provide evidence for a further and previously unsuspected role of this enzyme. An enzymatic activity catalysing the hydrolysis of [14C]anandamide was found in both microsomal and 10,000 × g pellet fractions. The latter fractions, which displayed the highest Vmax for anandamide, were used for further characterisation of the enzyme, and were found to catalyse the hydrolysis also of [14C]oleoyl-amide, with an apparent Km of 9.0 ± 2.2 μM. [14C]anandamide- and [14C]oleoyl-amide-hydrolysing activities: (i) exhibited identical pH- and temperature-dependency profiles; (ii) were inhibited by alkylating agents; (iii) were competitively inhibited by the phospholipase A2 inhibitor arachidonyl-trifluoromethyl-ketone with the same IC50 (3 μM); (iv) were competitively inhibited by both anandamide (or other polyunsaturated fatty acid-ethanolamides) and oleoyl-amide. Proteins solubilised from 10,000 × g pellets were directly analysed by isoelectric focusing, yielding purified fractions capable of catalysing the hydrolysis of both [14C]anandamide and [14C]oleoyl-amide. These data suggest that ‘anandamide amidohydrolase’ enzymes, such as that characterised in this study, may be used by neuronal cells also to hydrolyse the novel sleep-inducing factor oleoyl-amide

Effect of Italian heavy pig diets based on different barley varieties with or without non-starch polysaccharides degrading enzymes on growth performance, carcass characteristics and fresh thigh quality

The effect of diets based on two different barley varieties, with or without non-starch polysaccharides (NSP) degrading enzymes was evaluated on growth performance, carcass characteristics and fresh thigh quality in Italian heavy growing-finishing pigs. Pigs (64) were assigned to four diets: two diets based on 85% of hulled normal-amylose barley (Cometa, with or without NSP enzyme complex) and two diets based on 85% of hulless low-amylose barley (Alamo, with or without NSP enzyme complex). The diets were formulated according to three growth phases with same lisyne:digestible energy ratio. The NSP enzyme complex did not improve the Cometa and Alamo diets in terms of pig growth performance, carcass characteristics and fresh thigh quality. Throughout the study, the Alamo group had greater (p < 0.05) final body weight, average daily gain and gain per megacalorie of digestible energy than the Cometa group. Higher (p < 0.05) carcass and thigh weights, and lower (p < 0.01) thigh chilling losses were observed for the Alamo group compared with the Cometa group. The Cometa diet decreased (p < 0.01) polyunsaturated fatty acids level, and increased (p < 0.01) monounsaturated fatty acid content and saturated fatty acids/polyunsaturated fatty acids ratio in subcutaneous fat of fresh thighs. No appreciable differences were observed in the color of subcutaneous fat and biceps femoris of pigs fed the Cometa and Alamo diets. Feeding hulless low-amylose barley to growing-finishing pigs can be valuable to promote growth performance and carcass characteristics. No NSP enzyme complex is needed when hulled normal-amylose barley or hulless low-amylose barley are used in diets for heavy pigs

Peeking beneath the precision floor I: metallicity spreads and multiple elemental dispersions in the globular clusters NGC 288 and NGC 362

The view of globular clusters (GCs) as simple systems continues to unravel, revealing complex objects hosting multiple chemical peculiarities. Using differential abundance analysis, we probe the chemistry of the Type I GC, NGC 288 and the Type II GC, NGC 362 at the 2\% level for the first time. We measure 20 elements and find differential measurement uncertainties on the order 0.01-0.02 dex in both clusters. The smallest uncertainties are measured for Fe I in both clusters, with an average uncertainty of $\sim$0.013 dex. Dispersion in the abundances of Na, Al, Ti I, Ni, Fe I, Y, Zr, Ba and Nd are recovered in NGC 288, none of which can be explained by a spread in He. This is the first time, to our knowledge, a statistically significant spread in $s$-process elements and a potential spread in metallicity has been detected in NGC 288. In NGC 362, we find significant dispersion in the same elements as NGC 288, with the addition of Co, Cu, Zn, Sr, La, Ce, and Eu. Two distinct groups are recovered in NGC 362, separated by 0.3 dex in average differential $s$-process abundances. Given strong correlations between Al and several $s$-process elements, and a significant correlation between Mg and Si, we propose that the $s$-process rich group is younger. This agrees with asymptotic giant branch star (AGB) enrichment between generations, if there is overlap between low- and intermediate-mass AGBs. In our scenario, the older population is dominated by the $r$-process with a $\Delta^{\mathrm{La}}-\Delta^{\mathrm{Eu}}$ ratio of $-0.16\pm0.06$. We propose that the $r$-process dominance and dispersion found in NGC 362 are primordial.Comment: First paper in a series. Accepted for publication in MNRA

Frequency of predischarge ventricular arrhythmias in postmyocardial infarction patients depends on residual left ventricular pump performance and is independent of the occurrence of acute reperfusion

AbstractObjective. To test whether acute reperfusion of the infarct-related vessel after an acute myocardial infarction is associated with a subsequent reduction in spontaneous ventricular arrhythmias that is independent of ventricular ejection fraction, 1,944 patients from the GISSI-2 study population were studied. The patients were selected on the basis of a first myocardial infarction and the availability of two-dimensional echocardiographic ejection fraction and data on the number of premature ventricular contractions per hour on Holter monitoring.Background. It has been suggested that postthrombolytic reperfusion of the culprit vessel may be associated with an increased electrical stability of the infarcted heart, irrespective of its residual pump performance.Methods. The predischarge relation between ejection fraction and number of premature ventricular contractions per hour was plotted according to the occurrence (1,309 ptients) or not (635 patients) of acute reperfusion, identified noninvasively according to the modifications of the ST segment in serial electrocardiograms obtained in the first 24 h after infarction.Results. The frequency of premature ventricular contractions increased in a linear fashion with decreasing ejection fraction in both cohorts (p < 0.005 and p < 0.0001); however, there was no significant difference between the slops and the intercepts of the two regression lines, so that the relation between ejection fraction and number of premature ventricular contractions per hour could be adequately described by a single equation: y (number of premature ventricular contractions) = 33.0 - 0.42x (ejection fraction) (r = −0.107, p < 0.0001). The results were the same even when differences between group characteristics were accounted for in a multiple regression model.Conclusions. It is concluded that 1) the number of premature ventricular contractions per hour after an acute myocardial infarction is dependent in a linear, inverse fashion on the residual ventricular ejection fraction, and 2) this relation is independent of the occurrence of reperfusion in the acute phase of infarction