Adherence to Visits to Medical Institutions and Quality of Therapy after Acute Coronary Syndrome (according to the LIS Registry 3)

Aim. The aim of the research is to evaluate the relationship between patients' adherence to visiting polyclinics after acute coronary syndrome (ACS) and the quality of the therapy they receive.Material and methods. The study was conducted on the basis of the LIS registers (LIS and LIS-3) (Lyubertsy study of mortality) in the Lyubertsy district of the Moscow region. To clarify the vital status of all patients discharged in the first 9 months of 2014 and 2018. from Lyubertsy district hospital 2, contact was established no earlier than 1 year after discharge, and in case of death, its cause was clarified. In the course of a telephone survey, information was obtained on the therapy taken, adherence to visits to medical institutions, a record of cases of cardiovascular events and invasive treatment, hospitalizations due to worsening of the course of the underlying disease for the period after discharge from the hospital was carried out. The search for patients who did not answer the phone call was carried out by studying the archives of polyclinics, using the Megaclinic statistical database, and the data of the individual rehabilitation program for the disabled. In the course of a telephone survey, the response was 60.5%, the search for the remaining patients through statistical databases, the archive of polyclinics made it possible to increase the total response to 87.2%.Results. In the LIS-3 registry, out of 104 patients discharged in 2014, the status was determined in 90 (86.5%) patients, out of 223 patients in 2018 – in 195 (87.4%) patients. During the survey, it was found that 172 patients are observed after discharge from the hospital, 53 patients are not observed at all in the medical facility after discharge. 11 (4.9%) people did not take any groups of medications at the time of the survey. In the group of patients who are highly committed to attending a health facility, the best quality of taking essential medications after discharge from the hospital was noted according to the survey: statins (88.2%, p<0.001), beta-blockers (86.4%, p<0.001) and antiplatelets (90.9%, p=0.001). In both groups, committed and not committed to attending a medical facility, there is a negative dynamics in the quality of taking medications after discharge from the hospital, however, in the group of patients committed to attending a medical facility, it was noted that the odds of taking antiplatelet agents after discharge was 3.4 times higher (OR 3.449, p=0.002), beta-blockers – 4 times (OR 4.103, p<0.001), statins – 4.5 times (OR 4.450, p<0.001), in relation to the group of patients who are not observed in the medical facility after discharge from the hospital.Conclusion. 1-6 years after discharge from the hospital after the reference event, the quality of therapy deteriorated significantly in both groups, mostly in non-adherent patients. Significant differences in the quality of medication intake (antiplatelet agents, statins, β-blockers) were noted in the group of adherents to visiting health care facilities in comparison with those who were not committed to visiting health facilities. It is obvious that high adherence to visits to healthcare facilities after discharge from the hospital is associated with better quality of medication intake. Despite improvements in the quality of adherence to clinical recommendations, the percentage of patients who independently refuse to take drug therapy (4.9%), regardless of visits to healthcare facilities after discharge from the hospital, remains

Changes in Long-term Mortality in Patients with Myocardial Infarction History According to the LIS Luberetskiy registry

Aim. The aim of the research was to study the dynamics of distant cases of the disease that underwent AMI in 2005-2007 (LIS registry) and in 2014 and 2018 (LIS-3 registry), discharged from the same hospital of the Lyubertsy District Hospital (LDH).Material and methods. The study was conducted on the basis of two registries - a retrospective-prospective register LIS (Lyubertsy investigation of death), which was conducted in the Lyubertsy district of the Moscow region, all cases of check-ups in the AMI hospital for a 3-year period (2005- 2007) and the prospective register LIS-3 (11/01/2013 – to the present), which included patients admitted to the cardiology department of the Lyubertsy District Hospital No. 2 with the correct diagnosis of Acute coronary syndrome with and without ST segment elevation. With patients discharged from the hospital, a telephone contact was established no earlier than 1 year after discharge to clarify the life status, and in case of death – to find out its causes. Search for patients who did not answer the phone call, was using by the study of the archive of the polyclinic, with database statistics. Longterm cases of the LIS were compared with LIS-3 registers, clinical demographic characteristics and risk indicators in patients in the LIS and LIS-3 registers were also compared, differences in drug therapy before the onset of AMI and after discharge from the hospital register between LIS and LIS3 were analyzed.Results. Out of 327 patients, the registry included 104 (31.8%) patients discharged in 2014 and 223 (68.2%) in 2018. When comparing the longterm mortality curves of the LIS and LOS-3 registers, a significant difference was noted. The LIS-3 study revealed more frequent referrals for antiplatelet agents (20% vs 16%), statins (11.6% vs 2.0%). Less commonly, diuretics began to be prescribed at the prehospital level. After discharge from the hospital in the LIS-3 registry, a decrease compared to the LIS registry, more frequent prescription of antiplatelet agents (97.5% vs 85.0%), anticoagulants (1.1% vs 0%), statins (96.5% vs 67.0%), beta-blockers (93.3% vs 81.0%). Less commonly, diuretics are prescribed at discharge from the hospital.Conclusion. The present study of the LIS-3 registry showed a significant decrease in the incidence of those who had AMI, which occurred 15-20 years after the LIS registry was conducted

The genus Alchemilla L. In the flora of Sverdlovsk Region

Based on own authors' collections and revised collections in herbaria (SVER, UFU, LE, MW, NNSU), checklist of the genus Alchemilla for Sverdlovsk Region (Middle Urals) was compiled. Each species in the checklist was followed by a nomenclature reference, information on type, habitats, distribution in the region by its botanical-geographical areas. 62 species of Alchemilla were registered in the region. Seven species (A. cheirochlora, A. decalvans, A. filicaulis, A. glabricaulis, A. iremelica, A. pseudocalycina, A. tichomirovii) were revealed in the region flora for the first time. For three species (A. argutiserrata, A. sarmatica, A. submamillata) erroneously noted for this flora, the presence in the region was confirmed. A. filicaulis and A. exsculpta are new for Asian part of Russia. The presence of a true A. glabricaulis (as adventive species) was confirmed in the Asian part of Russia. Noted for trans-Urals endemic species A. gorodkovii had been placed to synonyms of east-european A. semilunaris and was listed under corresponding name. Among them, 57 species are found in the mountainous part of the region, 27 species of Alchemilla grow in the cis-Urals area, and 12 species in the eastern plain part of the region. Most of the Alchemilla-species complex of Sverdlovsk Region are plain-mountainous and plain species - 27 and 16 species respectively. Alchemillaspecies complex of the region includes 14 East European species, and 7 species associated with West European mountain systems, 27 species associated with Central Asian mountain systems (22 species of continuous and 5 of disjunctive ranges). As for soil moisture factor, mesophytes (17 species) prevail. Most of the species are the components of meadow (29 species), marginal-meadow (10 species) and meadow-steppe (5) communities. 18 species, distributed in the highlands of the Northern Urals, were attributed to the group of alpine-meadow species. An original key has been made to identify 62 Alchemilla-species, occurring in Sverdlovsk Region. © 2019 Altai State University. All rights reserved

METHOD TO PRODUCE THE ACTIVATED COKE FROM HEAVY OIL RESIDUES

В работе рассмотрено влияние различных факторов на формирование сорбционных свойств углеродных адсорбентов, описан способ получения, при котором продукт характеризуется повышенными адсорбционными показателями. Представлены основные границы технологических параметров для получения активированного кокса с высокими адсорбционными характеристиками и соответствующие математические модели описания процесса.In the article the influence of various factors on the formation of sorption properties of carbon adsorbents is considered, a method of obtaining in which the product has increased adsorption characteristics is described. The main boundaries of technological parameters to produce activated coke with high adsorption characteristics and the corresponding mathematical models of the process description are presented

Big Five Traits as Predictors of a Healthy Lifestyle during the COVID-19 Pandemic: Results of a Russian Cross-Sectional Study

The healthy lifestyle of people around the world has changed dramatically during the COVID-19 pandemic. The personality risk factors for these processes from around the world remain understudied. This study aimed to examine the associations of the Big Five traits with a healthy lifestyle during the COVID-19 pandemic. In a cross-sectional study, data from 1215 Russian university students were analyzed. Participants completed the Big Five Inventory-10 and Short Multidimensional Inventory Lifestyle Evaluation. The results showed that personality traits predicted many dimensions of a healthy lifestyle during the COVID-19 pandemic. Diet and nutrition were positively predicted by extraversion, agreeableness, and conscientiousness, and it was negatively predicted by neuroticism. Substance abuse was positively predicted by agreeableness and conscientiousness, and it was negatively predicted by extraversion. Physical activity was positively predicted by extraversion and conscientiousness, and it was negatively predicted by neuroticism. Stress management was positively predicted by extraversion and conscientiousness, and it was negatively predicted by neuroticism. Restorative sleep was positively predicted by extraversion and conscientiousness, and it was negatively predicted by neuroticism. Social support for healthy practices was positively predicted by extraversion, agreeableness, and conscientiousness. Environmental exposures were positively predicted by extraversion, and neuroticism was positively and negatively predicted by conscientiousness. Our findings may be useful for further exploration of personality risk factors for healthy practices in challenging life circumstances. © 2022 by the authors.AAAA-A21-121012090090-9; Russian Foundation for Basic Research, РФФИ: 20-515-55003This study was funded by RFBR (project No. 20-515-55003) and partly by the Government contract of the Institute of Immunology and Physiology (AAAA-A21-121012090090-9)

Whole exome sequencing links dental tumor to an autosomal-dominant mutation in ANO5 gene associated with gnathodiaphyseal dysplasia and muscle dystrophies

Tumors of the jaws may represent different human disorders and frequently associate with pathologic bone fractures. In this report, we analyzed two affected siblings from a family of Russian origin, with a history of dental tumors of the jaws, in correspondence to original clinical diagnosis of cementoma consistent with gigantiform cementoma (GC, OMIM: 137575). Whole exome sequencing revealed the heterozygous missense mutation c.1067G \u3e A (p.Cys356Tyr) in ANO5 gene in these patients. To date, autosomal-dominant mutations have been described in the ANO5 gene for gnathodiaphyseal dysplasia (GDD, OMIM: 166260), and multiple recessive mutations have been described in the gene for muscle dystrophies (OMIM: 613319, 611307); the same amino acid (Cys) at the position 356 is mutated in GDD. These genetic data and similar clinical phenotypes demonstrate that the GC and GDD likely represent the same type of bone pathology. Our data illustrate the significance of mutations in single amino-acid position for particular bone tissue pathology. Modifying role of genetic variations in another gene on the severity of the monogenic trait pathology is also suggested. Finally, we propose the model explaining the tissue-specific manifestation of clinically distant bone and muscle diseases linked to mutations in one gene

Secondary Prevention and Quality of Life of Patients with Stable Coronary Heart Disease

Aim. To assess the quality of life of patients with stable coronary heart disease (CHD) initially and 12 months after drug and non-drug secondary prophylaxis according to clinical guidelines.Material and methods. 73 patients (57 men, 16 women) with confirmed stable coronary artery disease were included in the study, of which 44 patients described a clinic for angina pectoris of functional class I-IV. The study included 2 patient visits: an initial treatment visit (V0) and a repeat visit after 12 months (V2). At both visits, blood pressure (BP), low-density lipoprotein cholesterol (LDL-c), quality of life (QL) were assessed using SAQ (Seattle Angina Questionnaire), drug therapy. Compliance with 5 basic principles of prevention was also assessed, which included: (1) healthy lifestyle (healthy lifestyle) (rejection of bad habits (smoking), moderate physical activity, lowcholesterol and low-carb diet); (2) normalization of body weight; (3) optimal drug therapy (the frequency of taking medications was evaluated using the original questionnaire); (4) achievement of target values of LDL-c in the entire group; (5) blood pressure in hypertensive patients. During V0, if necessary, drug therapy was adjusted in accordance with clinical recommendations. During V2, 57 patients (47 men and 10 women) were examined. The response was 80.8%.Results. After 12 months of follow-up, a statistically significant improvement in exercise tolerance (p=0.003), angina stability index (p=0.045) and the frequency of stress angina attacks (p=0.003) was noted when assessing the median of QL indicators. After 12 months of follow-up, 59% of patients used optimal drug therapy, including 4 drugs according to clinical guidelines. A healthy lifestyle (regular physical activity and smoking cessation) was achieved in 20.4% after 12 months of follow-up, the target level of LDL-c ˂ 1.8 mmol/L was achieved in 44.5% of patients, and the target blood pressure was achieved in 74,6%. The achievement of all 5 principles of secondary prevention of coronary heart disease according to the results of the work carried out by the visit after 12 months of follow-up was revealed only in 7% of patients (4 patients), and the implementation of 4 principles of prevention was noted in a quarter of patients from the group (24.5%, n=14).Conclusions. With drug and non-drug secondary prevention of coronary heart disease in patients with stable CHD after a year of follow-up, a statistically significant increase in QL indicators was noted due to increased exercise tolerance and a decrease in the frequency of angina attacks. Nevertheless, the basic principles of prevention were fully implemented only in 7% of patients

Implementation of preventive measures to reduce the incidence of HIV infection in the population of the Tyumen region

Problems of HIV infection prevalence in the Tyumen region is relevant due to the deterioration of the epidemiological situation, increase of incidence, while the subject of ongoing organizational prevention efforts aimed at all groups of the population through close interagency cooperation. Thanks to antiretroviral therapy prolongs life duration of HIV-infected and quality of life does not suffer.Проблемы пораженности населения ВИЧ-инфекцией в Тюменской области актуальны, что обусловлено ухудшением эпидемической ситуации, ростом заболеваемости, при этом в субъекте ведется постоянная организационная профилактическая работа, направленная на все группы населения при тесном межведомственном взаимодействии. Благодаря антиретровирусной терапии продлевается жизнь ВИЧ-инфицированных и не страдает качество жизн

Новые виды и наиболее интересные находки для флоры Урала и прилегающих территорий

The article provides information about rare and newly described species for the flora of the Urals and adjacent territories, namely: Astragalus saphronovae Kulikov, Atraphaxis decipiens Jaub. et Spach., Carex amgunensis F. Schmidt, Galium densiflorum Ledeb., Jovibarba globifera (L.) J. Parn., Najas minor All., Potamogeton nodosus Poir., Pseudorchis albida (L.) Á. Löve et D. Löve, Salix myrsinites L., Veronica agrestis L. Essays include the information on the species ecology and short taxonomic notes. © 2021 Altai State University. All rights reserved.The work was supported by the state assignments: АААА-А19-119031290052-1 “Sosudistye rasteniia Evrazii: sistematika, flora, rastitelʹnye resursy” [“Vascular plants of Eurasia: systematics, flora, plant resources”], АААА-А18-118011990151-7 “Izucheniye, sokhraneniye i rasshireniye bioraznoobraziya rasteniy v prirode i pri introduktsii na Yuzh nom Urale i Priuralye” [“Study, conservation and expansion of plant biodiversity in nature and during introduction in the Southern Urals and the Cis- and Trans-Urals region”], AAAA-A17-117050400146-5 “Otsenka prostranstvennovremennoy izmenchivosti bioraznoobraziya i usloviy yego formirovaniya na Severe Zapadnoy Sibiri v svyazi s izmeneniyem klimata i osvoyeniyem neftegazovykh resursov” [“Assessment of the spatio-temporal variability of biodiversity and the conditions for its formation in the north of Western Siberia in connection with climate change and the development of oil and gas resources”], and by “Programmoy povysheniya konkurentosposobnosti Uralskogo federalnogo universiteta” [“The program for improving the competitiveness of the Ural Federal University”] (the decree no. 211 of the Government of the Russian Federation, contract no. 02.A03.21.0006)

Pteridophyte Distribution of the Urals and Adjacent Areas: a Dataset

Background Data on the species diversity and distribution of pteridophytes (lycophytes and ferns) in the Urals and adjacent areas are presented. The dataset includes 13,742 observations of two classes Lycopodiopsida and Polypodiopsida. In total, the dataset contains information on 16 families, 28 generas, 65 species, four subspecies and nine interspecies hybrids. All records are for lycophytes and ferns collected over 170 years between 1853 and 2021. The dataset presented is based on herbarium specimens, published data and field research conducted by the authors. This dataset is the first and important step towards generalising information on the current diversity and geographical distribution of pteridophytes in the Urals and adjacent areas. © Melnikov D et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Funding: This work was supported in part by the Program for Improving the Competitiveness of the Ural Federal University (the decree no. 211 of the Government of the Russian Federation, contract No. 02.A03.21.0006), the state assignments АААА-А19-119031290052-1 (Komarov Botanical Institute RAS), no. 0111-2019-0001 (Tsitsin Main Botanical Garden of the RAS), no. AAAA-A17-117072810011-1 (Institute Botanical Garden UB RAS) and no. АААА-А19-119031890084-6 (Institute of Plant and Animal Ecology UB RAS). This research was carried out within the project No. 121041600045-8 "Western Siberia in the context of Eurasian ties: man, nature, society". We thank the Ministry of Higher Education and Science of Russian Federation for the supportgiven to the Center of Collective Use “Herbarium MBG RAS” (Agreement No. 075-15-2021-678). The work was carried out as part of the Russia 2021 project