Efficacy of tofacitinib monotherapy in methotrexate-naive patients with early or established rheumatoid arthritis.

IntroductionTofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Tofacitinib monotherapy was previously shown to inhibit structural damage, reduce clinical signs and symptoms of RA, and improve physical functioning over 24 months in methotrexate (MTX)-naive adult patients with RA. In this post hoc analysis, we compared efficacy and safety of tofacitinib in patients with early (disease duration <1 year) versus established (≥1 year) RA.MethodsMTX-naive patients ≥18 years with active RA received tofacitinib monotherapy (5 or 10 mg two times a day, or MTX monotherapy, in a 24-month Phase 3 trial.ResultsOf 956 patients (tofacitinib 5 mg two times a day, n=373; tofacitinib 10 mg two times a day, n=397; MTX, n=186), 54% had early RA. Baseline disease activity and functional disability were similar in both groups; radiographic damage was greater in patients with established RA. At month 24, clinical response rates were significantly greater in patients with early versus established RA in the tofacitinib 5 mg two times a day group. Both tofacitinib doses had greater effects on clinical, functional and radiographic improvements at 1 and 2 years compared with MTX, independent of disease duration. No new safety signals were observed.ConclusionsTreatment response was generally similar in early and established RA; significantly greater improvements were observed at month 24 with tofacitinib 5 mg two times a day in early versus established RA. Tofacitinib 5 and 10 mg two times a day demonstrated greater efficacy versus MTX irrespective of disease duration. No difference in safety profiles was observed between patients with early or established RA.Trial registration numberNCT01039688; Results

Intelligent Playful Environments for Animals

© Owner/Author 2015. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in Interacción '15 Proceedings of the XVI International Conference on Human Computer Interaction, http://dx.doi.org/10.1145/2829875.2829879We are evolving towards an interconnected and ubiquitous world, where digital devices and interfaces progressively adapt themselves to fit our needs and ease our daily activities. Although we coexist with plenty of animal species, such as our pets, we are approaching the evolution of technology in a strictly human-centric manner. A new field in Computer Science, called Animal-Computer Interaction (ACI), aims at filling this technological gap by developing systems and interfaces specifically designed for animals. Supporting animals' natural behavior and habits with suitable technology could improve both humans and animals' wellbeing. As a consequence, this doctoral research aims to explore, design and develop animal-centered intelligent systems that focus on enhancing one of the most natural animal behaviors: play. Therefore, the main goal of this research is to expand ACI with the ability of automatically manage and adapt animals play activity in order to improve their wellbeing.Work supported by MINECO (TIN2010-20488 and TIN2014-60077-R), UPV (UPV-FE-2014-24), MECD (FPU13/03831) and GVA (APOSTD/2013/013).Pons Tomás, P.; Jaén Martínez, FJ.; Catalá Bolós, A. (2015). Intelligent Playful Environments for Animals. ACM. https://doi.org/10.1145/2829875.2829879SHu, F., Silver, D., and Trude, A. LonelyDog@Home. 2007 IEEE/WIC/ACM International Conferences on Web Intelligence and Intelligent Agent Technology - Workshops, IEEE (2007), 333--337.Huizinga, J.Homo ludens. Wolters-Noordhoff, Groningen, The Nederlands, 1985.Mancini, C. Animal-computer interaction: a manifesto. Magazine interactions 18, 4 (2011), 69--73.Mancini, C. Animal-computer interaction (ACI): changing perspective on HCI, participation and sustainability. CHI '13 Extended Abstracts on Human Factors in Computing Systems, ACM Press (2013), 2227--2236.Matsuzawa, T. The Ai project: historical and ecological contexts. Animal cognition 6, 4 (2003), 199--211.Pons, P., Jaen, J., and Catala, A. Animal Ludens: Building Intelligent Playful Environments for Animals. 11th Conference on Advances in Computer Entertainment - Workshop on Animal Human Computer Interaction, (2014).Pons, P., Jaen, J., and Catala, A. Envisioning Future Playful Interactive Environments for Animals. In A. Nijholt, ed., More Playful User Interfaces. Springer, 2015.Robinson, C., Mancini, C., van der Linden, J., Guest, C., and Harris, R. Empowering assistance dogs: an alarm interface for canine use. Intelligent Systems for Animal Welfare, (2014).Rumbaugh, D.M., Gill, T. V., Brown, J. V., et al. A computer-controlled language training system for investigating the language skills of young apes. Behavior Research Methods & Instrumentation 5, 5 (1973), 385--392.Westerlaken, M. and Gualeni, S. Felino: The Philosophical Practice of Making an Interspecies Videogame. The Philosophy of Computer Games Conference, (2014), 1--12.Wingrave, C.A., Rose, J., Langston, T., and LaViola, J.J.J. Early explorations of CAT: canine amusement and training. CHI '10 Extended Abstracts on Human Factors in Computing Systems, (2010), 2661--2669.SpeakDolphin. http://www.speakdolphin.com

395 OSTEOPHYTES AND JOINT SPACE NARROWING ARE INDEPENDENTLY ASSOCIATED WITH PAIN IN FINGER JOINTS IN HAND OSTEOARTHRITIS

Objective To study the associations between structural abnormalities on ultrasound (US) or conventional x-rays (CR) and pain in hand osteoarthritis (HOA). Methods In 55 consecutive patients with HOA (mean age 61 years, 86% women) fulfilling the American College of Rheumatology criteria, pain in 30 separate hand joints was assessed upon palpation; osteophytes were assessed by US and CR and joint space narrowing (JSN) by CR. Associations between structural abnormalities and pain per joint were analysed using generalised estimated equations to account for patient effects and adjusted for age, sex, body mass index, US inflammatory features and other remaining structural abnormalities. Results In 1649 joints, 69% and 46% had osteophytes on US and CR, respectively and 47% had JSN. Osteophytes and JSN showed independent associations with pain per joint adjusted: OR for osteophytes: 4.8 (95% CI 3.1 to 7.5) for US and 4.1 (95% CI 2.4 to 7.1) for CR; for JSN: 4.2 (95% CI 2.0 to 9.0). Conclusions Osteophytes and JSN are independently associated with pain in individual HOA joints, taking into account patient effects

De grafemische buffer : aspecten van een spellingstoornis

Ce riche volume de 373 pages rassemble les contributions pour un colloque qui fut organisé les 30 novembre et 1 décembre 2012 par le “Centro Studi Sigismondo Castromediano e Gino Rizzo” à Cavallino di Lecce. Le personnage historique de premier plan qui fait l’objet du volume est Sigismondo Castromediano (Cavallino 1811-1895), surnommé le « Bianco Duca », noble de la région des Pouilles, arrêté en 1848 pour activité patriotique au sein de la Giovine Italia, condamné à trente ans de bagne, puis..