8,124 research outputs found
Hard to recall but easy to judge: retrieval strategies in social information processing
The present research distinguishes two different retrieval modes: exhaustive and heuristic retrieval. Whereas exhaustive retrieval is elemental and retrieves specific memory traces, the output of heuristic retrieval is a memory composite. Different memory tasks depend upon these two retrieval modes in various degrees. Using a part-list cueing paradigm, we found a dissociation: providing part-list cues hindered the retrieval of the non-cued behaviors in free recall but boosted frequency estimates. In a second study, using a collaborative recall paradigm, each of three participants recalled one of the previously presented behaviors in turn. We hypothesized that behaviors recalled by other participants would become hyper-accessible, inhibiting the retrieval of non-recalled behaviors but boosting the corresponding frequency estimates relative to non-collaborative recall conditions. The results supported the hypotheses. The parallelism of the results of the two studies suggests that retrieval interference or inhibition is a crucial feature of social memory.info:eu-repo/semantics/acceptedVersio
Enhancing the comparability between part-list cueing and collaborative recall
The effects of part-list cueing and of collaborative recall in memory performance have
been recently addressed as parallel phenomena. Notably they both impair recall (and
boost frequency estimates) and they have been explained by the same underlying
mechanisms. However the comparability between the two paradigms is hindered by a
number of procedural differences. The main contribution of this paper is the
introduction of a new paradigm that makes standard part-list cueing and collaborative
recall more comparable. In our study we compared free recall and frequency estimates
of participants in a non-cueing condition with the same performance in a standard partlist cueing condition and in a condition in which part-list cues were gradually presented
during recall (as it occurs in collaborative recall). Results indicate that the effects of
part-list cueing continued to be reliable in both cueing conditions. Namely, recall was
impaired and frequency estimates were boosted relatively to a non-cueing condition.
The results obtained with this new method that enhances the direct comparability of the
two paradigms, provides further evidence for the parallel between the two effects.info:eu-repo/semantics/acceptedVersio
Automatic and controlled components of judgment under uncertainty
The categorization of inductive reasoning into largely
automatic processes (heuristic reasoning) and controlled
analytical processes (rule-based reasoning) put forward by
dual-process approaches of judgment under uncertainty (e.g.,
Stanovich & West, 2000) has been primarily a matter of
assumption with a scarcity of direct empirical findings
supporting it. We used the process dissociation procedure
(Jacoby, 1991) to provide convergent evidence validating a
dual-process perspective to judgment under uncertainty based
on the independent contributions of heuristic and rule-based
reasoning. Process dissociations based on experimental
manipulation of variables were derived from relevant
theoretical properties typically used to contrast the two forms
of reasoning. These included processing goals (Experiment 1)
and priming (Experiment 2). Results consistently supported
the present perspective. We conclude that judgment under
uncertainty is not either an automatic or controlled process,
but that it reflects both processes, with each making
independent contributions.info:eu-repo/semantics/publishedVersio
Besoins d'apprentissage et sentiment d'auto-efficacité chez des patients atteints d'un syndrome coronarien aigu, à Girona, Espagne
Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal
The urgent need to recover MHC class I in cancers for effective immunotherapy
We would like to thank Dr M Bernal who has helped us in preparing the figure for the manuscript. This work was supported by grants co-financed by FEDER funds (EU) from the Instituto de Salud Carlos III (CP03/0111, PI12/02031, PI 08/1265, PI 11/01022, PI11/01386, PI14/01978, PI15/00528, RETIC RD 06/020, RD09/0076/00165, PT13/0010/0039), Junta de Andalucia in Spain (Group CTS-143, and CTS-695, CTS-3952, CVI-4740 and PI 09/0382 grant), Worldwide Cancer Research 15-1166 grant, and by Dutch Cancer Society (UL 2010-4785, TvH).Immune escape strategies aimed to avoid T-cell recognition, including the loss of tumor MHC class I expression, are commonly found in malignant cells. Tumor immune escape has proven to have a negative effect on the clinical outcome of cancer immunotherapy, including treatment with antibodies blocking immune checkpoint molecules. Hence, there is an urgent need to develop novel approaches to overcome tumor immune evasion. MHC class I antigen presentation is often affected in human cancers and the capacity to induce upregulation of MHC class I cell surface expression is a critical step in the induction of tumor rejection. This review focuses on characterization of rejection, escape, and dormant profiles of tumors and its microenvironment with a special emphasis on the tumor MHC class I expression. We also discuss possible approaches to recover MHC class I expression on tumor cells harboring reversible/‘soft’ or irreversible/‘hard’ genetic lesions. Such MHC class I recovery approaches might well synergize with complementary forms of immunotherapy.FEDER funds (EU) from the Instituto de Salud Carlos III
CP03/0111
PI12/02031
PI 08/1265
PI 11/01022
PI11/01386
PI14/01978
PI15/00528
RETIC RD 06/020
RD09/0076/00165
PT13/0010/0039Junta de AndalucÃa
CTS-143
CTS-695
CTS-3952
CVI-4740
PI 09/0382Worldwide Cancer Research
15-1166KWF Kankerbestrijding
UL 2010-478
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