In the business of doing good: Effective return on donation (ROD) mechanisms in philanthropy and impact investing

The Business of Doing Good is not made up of organizations but people. People bring change, substantial change to society as a whole as well as individuals. I was born in India and saw severe injustice that affected me profoundly. I vowed to myself that a day would come and I would do my share to contribute and leave behind a world that is a little bit better than I found it. After a few good years in the business world, I received the opportunity to establish and run two philanthropic foundations that operated in a large variety of areas like science and medical research, K-12 and higher education, leadership, environment and social issues and managed over $10M a year with philanthropists that preferred to enjoy the fruits of their giving by seeing actual bottom line results and change rather than having their names on a plaque. In the work that follows, I would like to demonstrate to you that it is possible as well as highly recommended and essential to run effective philanthropic organizations with tools from the world of business and just as businesses are profit oriented through Return on Investment (ROI), philanthropies can be impact oriented. Just as the investor in the world of business looks for the ROI, the donor can look for the unconventional bottom line, and measure impact of his giving through Return on Donation (ROD). ROD is a phrase I coined to represent measurable impact just as ROI in businesses. I also realized that just the tools from the business world would not suffice. Something additional was missing and needed to be an integral part in order to succeed in impactful giving. Since I entered the philanthropic world, this Business of Doing Good, as I term it, I have gradually evolved with an understanding how successful philanthropy and impact investing should look like. This paper is centered upon my journey, my successes and failures and my insights after eighteen years of constantly evaluating and reflecting on this question. This search warranted that I develop proper research methodologies within my own organizations that would lead us to achieve objectivity, reliability and validity for our work processes, so we could learn and grow from it. All this while understanding that in philanthropy we act as change agents and as such we affect people’s lives. Therefore, the most important rule to follow is to – Do no harm. The second rule is to – Do your best and in order to be objective as possible the third rule is – Practice Humility. As a believer in leading by example, and embracing my role as a First Person Action Researcher in the process, I set to explore if business practices that led to ROI could be incorporated in the Business of Doing Good by means of ROD and to understand what ROD mechanisms needed to be put in place for successful impact and sustainability. In the scope of my work, although I have vast experience in a variety of fields, I have chosen to concentrate on two main examples which are in the fields of leadership and education. During my years of practice, I was on a quest to seek counsel of philosophers like Spinoza and Aristotle, psychologists and social influencers like Maslow and Tom Friedman and many other authors, who have given us management models in the field of business. I have studied a wide range of research methodologies that have developed over the years. All this together with my own inner compass and my personal experience, have led me to build effective mechanisms for ROD in philanthropy and impact investing. Based on a solid intention over the years to find a mechanism for effective giving, there has been a process of knowing, and I have developed a model which I call the Goodness Factor Model, which has been tested and proven to be the most effective tool for practicing effective philanthropy and impact investing

Rising-plate rheometer

Technique eliminates hazards of handling propellants and permits determination of structure index of gel by remote control. Rheometer weighs cone of propellant gel which remains on a disc that has been slowly pulled out of the gel

Cryogenic gel flow viscometer

Coiled section of tubing measures viscous properties of gelled cryogenic propellants under conditions closely resembling flow in rocket engine systems. Characteristic flow curve provides data necessary for the design of prototype hardware systems using the liquid or gel of interest

Magnetic collimation of meridional-self-similar general relativistic MHD flows

We present a model for the spine of relativistic MHD outflows in the Kerr geometry. Meridional self-similarity is invoked to derive semi-analytical solutions close to the polar axis. The study of the energy conservation along a particular field line gives a simple criterion for the collimation of jets. Such parameter have already been derived in the classical case by Sauty et al. 1999 and also extended to the Schwarzschild metric by Meliani et al. 2006. We generalize the same study to the Kerr metric. We show that the rotation of the black hole increases the magnetic self-confinement.Comment: 16 pages, 6 figures, accepted for publication in Physical Review

The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading

Skeletal unloading results in osteopenia. To examine the involvement of vitamin D in this process, the rear limbs of growing rats were unloaded and alterations in bone calcium and bone histology were related to changes in serum calcium (Ca), inorganic phosphorus (P sub i), 25-hydroxyvitamin D (25-OH-D), 24,25-dihydroxyvitamin D (24,25(OH)2D and 1,25-dihydroxyvitamin D (1,25(OH)2D. Acute skeletal unloading induced a transitory inhibition of Ca accumulation in unloaded bones. This was accompanied by a transitory rise in serum Ca, a 21% decrease in longitudinal bone growth (P 0.01), a 32% decrease in bone surface lined with osteoblasts (P .05), no change in bone surface lined with osteoclasts and a decrease in circulating (1,25(OH)2D. No significant changes in the serum concentrations of P sub i, 25-OH-D or 24,25(OH)2D were observed. After 2 weeks of unloading, bone Ca stabilized at approximately 70% of control and serum Ca and 1,25(OH)2D returned to control values. Maintenance of a constant serum 1,25(OH)2D concentration by chronic infusion of 1,25(OH)2D (Alza osmotic minipump) throughout the study period did not prevent the bone changes induced by acute unloading. These results suggest that acute skeletal unloading in the growing rat produces a transitory inhibition of bone formation which in turn produces a transitory hypercalcemia

Simulated Space Radiation and Weightlessness: Vascular-Bone Coupling Mechanisms to Preserve Skeletal Health

Weightlessness causes a cephalad fluid shift and reduction in mechanical stimulation, adversely affecting both cortical and trabecular bone tissue in astronauts. In rodent models of weightlessness, the onset of bone loss correlates with reduced skeletal perfusion, reduced and rarified vasculature and lessened vasodilation, which resembles blood-bone symbiotic events that can occur with fracture repair and aging. These are especially serious risks for long term, exploration class missions when astronauts will face the challenge of increased exposure to space radiation and abrupt transitions between different gravity environments upon arrival and return. Previously, we found using the mouse hindlimb unloading model and exposure to heavy ion radiation, both disuse and irradiation cause an acute bone loss that was associated with a reduced capacity to produce bone-forming osteoblasts from the bone marrow. Together, these findings led us to hypothesize that exposure to space radiation exacerbates weightlessness-induced bone loss and impairs recovery upon return, and that treatment with anti-oxidants may mitigate these effects. The specific aims of this recently awarded grant are to: AIM 1 Determine the functional and structural consequences of prolonged weightlessness and space radiation (simulated spaceflight) for bone and skeletal vasculature in the context of bone cell function and oxidative stress. AIM 2 Determine the extent to which an anti-oxidant protects against weightlessness and space radiation-induced bone loss and vascular dysfunction. AIM 3 Determine how space radiation influences later skeletal and vasculature recovery from prolonged weightlessness and the potential of anti-oxidants to preserve adaptive remodeling

Role of Mitochondrial Oxidative Stress in Spaceflight-Induced Tissue Degeneration

Microgravity and ionizing radiation in the spaceflight environment poses multiple challenges to homeostasis and may contribute to cellular stress. Effects may include increased generation of reactive oxygen species (ROS), DNA damage and repair error, cell cycle arrest, cell senescence or death. Our central hypothesis is that prolonged exposure to the spaceflight environment leads to the excess production of ROS and oxidative damage, culminating in accelerated tissue degeneration. The main goal of this project is to determine the importance of cellular redox defense for physiological adaptations and tissue degeneration in the space environment

A Comparison of Astronaut Near-Earth Object Missions

NASA intends to send astronauts to a near Earth object (NEO) in or around 2025. This is expected to involve a six month mission with a few weeks stay-time at the NEO. Problems with this concept include lack of abort modes, vulnerability to solar flares, and lack of resupply opportunities. Studies by the authors (the Asteroid Mining Group) and a recent workshop at JPL organized by the Keck Institute opens the door to an alternative that addresses these problems and creates additional opportunities. Both groups investigated the feasibility of bringing one of more small NEOs into Earth or Lunar orbit. Particularly for High Earth Orbits (HEO) or High Lunar Orbits (HLO), this appears feasible with near-term technology, especially high-propellant-velocity, low-thrust solar electric propulsion (SEP) inspace vehicles. This paper compares the currently planned mission with an alternative: bringing one or more NEOs into HEO or HLO using SEP and lunar gravity assist. An astronaut mission to the NEO is then similar to a mission to the Moon without a landing. Trip times are measured in days, the NEO can be used for solar flare protection for most of the mission, and resupply within a few days is practical. Furthermore, materials derived from the NEO, e.g., propellant, water, radiation shielding, metals, silicon, and others, are available for projects in cis-lunar space, including satellite refueling, habitats, and space solar power. The alternative mission also develops much of the technology, experience, and infrastructure needed to protect Earth from potentially hazardous NEOs. As an outcome of these studies we are proposing a process whereby early missions can lead to large-scale industrialization of cis-lunar space based on solar energy and asteroidal resources

Grain size measurement using magnetic and acoustic Barkhausen noise

Results on annealed nickel show that the total number of counts of both magnetic and acoustic Barkhausen signals vary inversely with grain size. In decarburized steels the total number of counts and the amplitude of both Barkhausen signals increase in proportion to grain size. The paper addresses these results in context of grain size, grain‐boundary segregation, and precipitate effect

Neutrophil to Lymphocyte Ratio: A Prognostic Indicator for Astronaut Health

Short-term and long-term spaceflight missions can cause immune system dysfunction in astronauts. Recent studies indicate elevated white blood cells (WBC) and polymorphonuclear neutrophils (PMN) in astronaut blood, along with unchanged or reduced lymphocyte counts, and reduced T cell function, during short-(days) and long-(months) term spaceflight. A high PMN to lymphocyte ratio (NLR) can acts as a strong predictor of poor prognosis in cancer, and as a biomarker for subclinical inflammation in humans and chronic stress in mouse models, however, the NLR has not yet been identified as a predictor of astronaut health during spaceflight. For this, complete blood cell count data collected from astronauts and rodents that have flown for short- and long-term missions on board the International Space Station (ISS) was repurposed to determine the NLR pre-, in-, and post-flight. The results displayed that the NLR progressively increased during spaceflight in both human and mice, while a spike in the NLR was observed at post-flight landing, suggesting stress-induced factors may be involved. In addition, the ground-based chronic microgravity analog, hindlimb unloading in mice, indicated an increased NLR, along with induced myeloperoxidase expression, as measured by quantitative (q)PCR. The mechanism for increased NLR was further assessed in vitro using the NASA-developed rotating wall vessel (RWV) cell culture suspension system with human WBCs. The results indicated that simulated microgravity led to increased mature PMN counts, NLR profiles, and production of reactive oxygen species (ROS). Collectively, these studies show that an increased NLR is observed in spaceflight missions, and in chronic microgravity-analog simulation in mice, and that this effect may be potentiated by the oxidative stress response in blood cells under microgravity conditions. Furthermore, these results suggest that a disrupted NLR profile in spaceflight may further disrupt immune homeostasis, potentially causing chronic immune-mediated inflammatory diseases. Thus, we propose that the health status of astronauts during short- and long-term space missions can be monitored by their NLR profile, in addition to utilizing this measurement as a tool for interventions and countermeasure development to restore homeostatic immunity