Updated Planetary Mass Constraints of the Young V1298 Tau System Using MAROON-X

The early K-type T-Tauri star, V1298 Tau ($V=10\,{\rm mag}$, ${\rm age}\approx20-30\,{\rm Myr}$) hosts four transiting planets with radii ranging from $4.9-9.6\,R_\oplus$. The three inner planets have orbital periods of $\approx8-24\,{\rm d}$ while the outer planet's period is poorly constrained by single transits observed with \emph{K2} and \emph{TESS}. Planets b, c, and d are proto-sub-Neptunes that may be undergoing significant mass loss. Depending on the stellar activity and planet masses, they are expected to evolve into super-Earths/sub-Neptunes that bound the radius valley. Here we present results of a joint transit and radial velocity (RV) modelling analysis, which includes recently obtained \emph{TESS} photometry and MAROON-X RV measurements. Assuming circular orbits, we obtain a low-significance ($\approx2\sigma$) RV detection of planet c implying a mass of $19.8_{-8.9}^{+9.3}\,M_\oplus$ and a conservative $2\sigma$ upper limit of $<39\,M_\oplus$. For planets b and d, we derive $2\sigma$ upper limits of $M_{\rm b}<159\,M_\oplus$ and $M_{\rm d}<41\,M_\oplus$. For planet e, plausible discrete periods of $P_{\rm e}>55.4\,{\rm d}$ are ruled out at a $3\sigma$ level while seven solutions with $43.3<P_{\rm e}/{\rm d}<55.4$ are consistent with the most probable $46.768131\pm000076\,{\rm d}$ solution within $3\sigma$. Adopting the most probable solution yields a $2.6\sigma$ RV detection with mass a of $0.66\pm0.26\,M_{\rm Jup}$. Comparing the updated mass and radius constraints with planetary evolution and interior structure models shows that planets b, d, and e are consistent with predictions for young gas-rich planets and that planet c is consistent with having a water-rich core with a substantial ($\sim5\%$ by mass) H$_2$ envelope.Comment: 18 pages, 13 figures, accepted for publication in A

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Meka ou le lent retour à soi

Inspired by Ferdinand Oyono’s novel Le vieux nègre et la médaille and relying on the works of Albert Memmi and a number of critics of the negro-african novel, what we are proposing here is a reflection on the relation between the colonizer and the colonized. At the very core of our analysis is the character of Meka, Oyono’s main character, who symbolizes the people’s strive for freedom and self-rediscovery and reconquest. Step by step, we follow him through his long and difficult “walk” or journey towards himself, towards his own truth. In our understanding of that whole liberation process, we are inevitably forced to rethink not only what we call “the origins”, but also the concept of laughter and the power of language in itself

Potential source regions of biogenic aerosol number concentration apportioning at King George Island, Antarctic Peninsula

Nowadays it is well accepted that background aerosols in the boundary layer over remote oceans are of marine origin and not aged continental. Particularly in the Atlantic sector of the Southern Ocean at least four main important regions exhibit significant ocean primary productivity. They are the Bellingshausen–Amundsen Sea, the Weddell Sea, the southern Argentinean shelf and the southern Chilean coast. In this work, we have combined ground-based continuous atmospheric sampling of aerosol number concentration (ANC), over-sea dimethyl sulphide (DMS) measurements, chlorophyll a (chl a) concentration provided by Sea-viewing Wide Field-of-view Sensor (SeaWiFS) satellite images, in situ meteorological data and monthly regional NCEP-NCAR re-analysis wind fields in order to investigate the relative contribution of each of the above regions to the apportionment of the ANC at King George Island (KGI), South Shetland Islands. Our results suggest that, at least during the period from September 1998–December 1999, the southern Argentinean shelf acted as the main contributor to the ANC measured in KGI