Extracting ππ\pi\pi SS-wave scattering lengths from cusp effect in heavy quarkonium dipion transitions

Charge-exchange rescattering $\pi^+\pi^-\to \pi^0\pi^0$ leads to a cusp effect in the $\pi^0\pi^0$ invariant mass spectrum of processes with $\pi^0\pi^0$ in the final state which can be used to measure $\pi\pi$ $S$-wave scattering lengths. Employing a non-relativistic effective field theory, we discuss the possibility of extracting the scattering lengths in heavy quarkonium $\pi^0\pi^0$ transitions. The transition $\Upsilon(3S)\to\Upsilon(2S)\pi^0\pi^0$ is studied in details. We discuss the precision that can be reached in such an extraction for a certain number of events.Comment: 15 pages, 7 figures, 1 tabl

New spectrum of negative-parity doubly charmed baryons: Possibility of two quasistable states

The discovery of $\Xi_{cc}^{++}$ by the LHCb Collaboration triggers predictions of more doubly charmed baryons. By taking into account both the $P$-wave excitations between the two charm quarks and the scattering of light pseudoscalar mesons off the ground state doubly charmed baryons, a set of negative-parity spin-1/2 doubly charmed baryons are predicted already from a unitarized version of leading order chiral perturbation theory. Moreover, employing heavy antiquark-diquark symmetry the relevant low-energy constants in the next-to-leading order are connected with those describing light pseudoscalar mesons scattering off charmed mesons, which have been well determined from lattice calculations and experimental data. Our calculations result in a spectrum richer than that of heavy mesons. We find two very narrow $J^P=1/2^-$ $\Omega_{cc}^P$, which very likely decay into $\Omega_{cc}\pi^0$ breaking isospin symmetry. In the isospin-1/2 $\Xi_{cc}^P$ sector, three states are predicted to exist below 4.2~GeV with the lowest one being narrow and the other two rather broad. We suggest to search for the $\Xi_{cc}^{P}$ states in the $\Xi_{cc}^{++}\pi^-$ mode. Searching for them and their analogues are helpful to establish the hadron spectrum.Comment: 6 pages, 3 figures; accepted for publication as a Rapid Communication in Physical Review

脑舒胶囊对衰老小鼠免疫功能的调节作用

Objective: To observe the effects of NaoShu capsule on immune function of aging mice. Methods: Aging mice was induced by subcutaneous injections model was induced by subcutaneous injections with 5% D-galactose at the neck for 6 weeks, IL-2 and IL-6 content in serum were detected by means of radio-immunity, and calculating the index of organ by a ratio of the weight of thymus and spleen and the weight of mice. Results: Compared with the control group, the thymus and spleen index of mice was decreased obvious; the IL-2 content was obvious decreased, and the IL-6 content was obvious increased in aging model group. Compared with the model group, the the IL-2 content was enhanced and the IL-6 content was obvious decreased in the therapeutic group with 1.33g/kg and 2.66g/kg Naoshu capsule (P<0.05, 0.01). Conclusion: There has a certain correlation between aging and immune, and there are obvious accommodation of Naoshu capsule on immune function of aging mice.目的  观察脑舒胶囊对衰老小鼠免疫功能的调节作用。方法  5%D-半乳糖颈背部皮下注射连续6周制备衰老小鼠模型；放射免疫法测小鼠血清IL-2和IL-6含量；胸腺、脾脏重量比小鼠体重，计算脏器指数。结果  与对照组比较，衰老模型组小鼠胸腺、脾脏指数明显下降，血清IL-2含量明显降低，IL-6的含量明显提高。与模型组比较，1.33g/kg和2.66g/kg脑舒胶囊可明显提高衰老小鼠的胸腺和脾指数（P<0.05，0.01），升高衰老小鼠血清IL-2含量（P<0.05，0.01），降低血清IL-6含量（P<0.05，0.01）。结论  衰老与免疫存在相关性，脑舒胶囊对衰老小鼠的免疫功能具有明显的调节作用

Inhibitory effects of adenovirus mediated tandem expression of RhoA and RhoC shRNAs in HCT116 cells

<p>Abstract</p> <p>Background</p> <p>RhoA and RhoC are deregulated by over expression in many human tumors, including colorectal cancer. Some reports show that they play a pivotal role in the carcinogenesis, tumor development and infiltration metastasis. In this study, for the first time we constructed recombinant adenovirus to investigate the inhibitory effects of RhoA and RhoC shRNAs in tandem expression on the cell proliferation and invasion of colorectal cancer HCT116 cells.</p> <p>Methods</p> <p>The recombinant adenovirus carrying RhoA and RhoC shRNAs in tandem expression was transfected into HCT116. The mRNA transcription and protein expressions of RhoA and RhoC were examined by RT-FQPCR and Western blot respectively. Cellular proliferation inhibitory activity was determined by methyl thiazolyl tetrazolium (MTT) assay and invasive and migrating potential was detected through in vitro Matrigel coated invasion and migration assay.</p> <p>Results</p> <p>Both mRNA and proteins Levels of RhoA and RhoC were significantly reduced in HCT116 cells transfected with Ad-A1+A2+C1+C2 than those in Ad-HK group and control one. The relative RhoA and RhoC mRNA transcriptions were decreased to 40% and 36% (P < 0.05), while proteins expression reducing 42% and 35%, respectively (P < 0.05). Growth curves analysis showed that alive cell number in the Ad-A1+A2+C1+C2 group was lower than others in the third to sixth day and transwell chamber analysis showed that migration/invasion activity was significantly suppressed in Ad-A1+A2+C1+C2 group.</p> <p>Conclusion</p> <p>Our results indicate recombinant adenovirus carrying RhoA and RhoC shRNAs in tandem expression may inhibit the growth and invasion of HCT116 cells. Application of such vector to inhibit one or more genes may be a new method to cancer therapy.</p

Method for Thermo-optic Analysis in a Star Sensor

An autonomous star sensor is a highly accurate attitude-measuring instrument used in spacecraft, and its performance is restricted by ambient temperature of the outer space. This paper puts forward an effective scheme to the thermooptic analysis using finite element analysis (FEA) and ray tracing in star sensor. Specific difficulties: (a) how to evaluate thermo-optic effect in star sensor, and (b) how to make FEA results useful in optical design mode have been resolved using the scheme. Based on this scheme, the errors of star sensor, which are caused by thermo-optic effects, can be investigated in any complicated temperature condition, and the required temperature scope for the thermal design can be achieved. For example, the errors of the star sensor were 0.0863" and 2.2933", when the temperature differences of the experimental optical system were 10 °C and 5 °C in axial and lateral, respectively.Defence Science Journal, 2010, 60(3), pp.276-281, DOI:http://dx.doi.org/10.14429/dsj.60.35

The Chromatin Remodeler CHD7 Regulates Adult Neurogenesis via Activation of SoxC Transcription Factors

SummaryChromatin factors that regulate neurogenesis in the central nervous system remain to be explored. Here, we demonstrate that the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7), a protein frequently mutated in human CHARGE syndrome, is a master regulator of neurogenesis in mammalian brain. CHD7 is selectively expressed in actively dividing neural stem cells (NSCs) and progenitors. Genetic inactivation of CHD7 in NSCs leads to a reduction of neuronal differentiation and aberrant dendritic development of newborn neurons. Strikingly, physical exercise can rescue the CHD7 mutant phenotype in the adult hippocampal dentate gyrus. We further show that in NSCs, CHD7 stimulates the expression of Sox4 and Sox11 genes via remodeling their promoters to an open chromatin state. Our study demonstrates an essential role of CHD7 in activation of the neuronal differentiation program in NSCs, thus providing insights into epigenetic regulation of stem cell differentiation and molecular mechanism of human CHARGE syndrome

Optical and Gamma-Ray Variability Behaviors of 3C 454.3 from 2006 to 2011

We present our photometric monitoring of a flat spectrum radio quasar (FSRQ) 3C 454.3 at Yunnan observatories from 2006 to 2011. We find that the optical color of 3C 454.3 shows obvious redder-when-brighter trend, which reaches a saturation stage when the source is brighter than 15.15 mag at V band. We perform a simulation with multiple values of disk luminosity and spectral index to reproduce the magnitude-color diagram. The results show that the contamination caused by the disk radiation alone is difficult to produce the observed color variability. The variability properties during the outburst in December 2009 are also compared with $\gamma$-ray data derived from Fermi $\gamma$-ray space telescope. The flux variation of these two bands follow a linear relation with $F_{\gamma} \propto F_R^{1.14\pm0.07}$, which provides an observational evidence for external Compton process in 3C 454.3. Meanwhile, this flux correlation indicates that electron injection is the main mechanism for variability origin. We also explore the variation of the flux ratio $F_{\gamma}/F_R$ and the detailed structures in the lightcurves, and discuss some possible origins for the detailed variability behaviors.Comment: accepted for publication in The Astrophysical Journal, 5 figures, 2 table