Achievable Outage Rate Regions for the MISO Interference Channel

We consider the slow-fading two-user multiple-input single-output (MISO) interference channel. We want to understand which rate points can be achieved, allowing a non-zero outage probability. We do so by defining four different outage rate regions. The definitions differ on whether the rates are declared in outage jointly or individually and whether the transmitters have instantaneous or statistical channel state information (CSI). The focus is on the instantaneous CSI case with individual outage, where we propose a stochastic mapping from the rate point and the channel realization to the beamforming vectors. A major contribution is that we prove that the stochastic component of this mapping is independent of the actual channel realization.Comment: Accepted for publication in IEEE Wireless Communications Letter

Efficient Computation of Pareto Optimal Beamforming Vectors for the MISO Interference Channel with Successive Interference Cancellation

We study the two-user multiple-input single-output (MISO) Gaussian interference channel where the transmitters have perfect channel state information and employ single-stream beamforming. The receivers are capable of performing successive interference cancellation, so when the interfering signal is strong enough, it can be decoded, treating the desired signal as noise, and subtracted from the received signal, before the desired signal is decoded. We propose efficient methods to compute the Pareto-optimal rate points and corresponding beamforming vector pairs, by maximizing the rate of one link given the rate of the other link. We do so by splitting the original problem into four subproblems corresponding to the combinations of the receivers' decoding strategies - either decode the interference or treat it as additive noise. We utilize recently proposed parameterizations of the optimal beamforming vectors to equivalently reformulate each subproblem as a quasi-concave problem, which we solve very efficiently either analytically or via scalar numerical optimization. The computational complexity of the proposed methods is several orders-of-magnitude less than the complexity of the state-of-the-art methods. We use the proposed methods to illustrate the effect of the strength and spatial correlation of the channels on the shape of the rate region.Comment: Accepted for publication in IEEE Transactions on Signal Processin

Dose-response effects of omega-3 on platelet aggregation: an observational study

ObjectiveThis study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers.MethodsTwelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids.ResultsThere were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA .ConclusionsSupplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA

Möglichkeiten und Probleme bei der Anwendung der Klebtechnik

Nur wenn eine klebgerecht ausgeführte Konstruktion mit dem richtigen Klebstoff nach optimaler Oberflächenbehandlung und mit angepssten Abbindebedingungen gefertigt wird, sind Klebverbindungen von maximaler Festigkeit und Alterungsbeständigkeit zu erzielen. Am Beispiel von Bremsbelägen wird gezeigt, dass bei einer entsprechenden Erprobung auch sogenannte Sicherheitsteile durch Kleben hergestellt werden könne

The impact of the ST131 clone on recurrent ESBL-producing E. coli urinary tract infection: a prospective comparative study

The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is of great concern. Almost one third of patients with UTI, develop recurrent UTI (RUTI). We followed 297 patients for one year after their first episode of UTI due to ESBL-E. coli. Our aim was to evaluate the impact of the globally dominant sequence type (ST)131 clone and its clades, on the risk of subsequent recurrences with ESBL-E. coli. Isolates from patients developing RUTI (68/297) were compared with those from patients with sporadic UTI (SUTI, 229/297). No association was found between RUTI and the two most prevalent phylogroups B2 and D, bla(CTX-M) genes, or resistance profile. Half of the patients with RUTI were infected with ST131 isolates. Clade C2 were in dominance (50/119) among ST131 isolates. They were more common in patients with RUTI than SUTI (28% vs 13%) and multivariate analysis showed an increased odds-ratio (OR = 2.21, p = 0.033) for recurrences in patients infected with these isolates as compared to non-ST131 isolates. Detecting specific biomarkers, as ST131 clade C2, in ESBL-E. coli UTI isolates may aid in prediction of RUTI and improve diagnostics and care of patients with a risk of ESBL-E. coli recurrences

Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach.

The receptors mediating the hemodynamic responses to cannabinoids are not clearly defined due to the multifarious pharmacology of many commonly used cannabinoid ligands. While both CB1 and TRPV1 receptors are implicated, G protein-coupled receptor 55 (GPR55) may also mediate some of the hemodynamic effects of several atypical cannabinoid ligands. The present studies attempted to unravel the pharmacology underlying the in vivo hemodynamic responses to ACEA (CB1 agonist), O-1602 (GPR55 agonist), AM251 (CB1 antagonist), and cannabidiol (CBD; GPR55 antagonist). Agonist and antagonist profiles of each ligand were determined by ligand-induced GTPcS binding in membrane preparations expressing rat and mouse CB1 and GPR55 receptors. Blood pressure responses to ACEA and O-1602 were recorded in anesthetized and conscious mice (wild type, CB1 / and GPR55 / ) and rats in the absence and presence of AM251 and CBD. ACEA demonstrated GTPcS activation at both receptors, while O-1602 only activated GPR55. AM251 exhibited antagonist activity at CB1 and agonist activity at GPR55, while CBD demonstrated selective antagonist activity at GPR55. The depressor response to ACEA was blocked by AM251 and attenuated by CBD, while O-1602 did not induce a depressor response. AM251 caused a depressor response that was absent in GPR55 / mice but enhanced by CBD, while CBD caused a small vasodepressor response that persisted in GPR55 / mice. Our findings show that assessment of the pharmacological profile of receptor activation by cannabinoid ligands in in vitro studies alongside in vivo functional studies is essential to understand the role of cannabinoids in hemodynamic control