Zhodnocení a komparace vlivů tvorby hodnoty u vybrané české a čínské společnosti

The goal of the thesis is to estimate, analyze and compare the V/EBIT(1-t) multiplier for two companies and use decomposition to analyze the value creation. And we also analyze the financial characteristics of two companies, after that we use the quick test to rate the two companies. in energy industry, where one of two companies is from Czech and one from China.The goal of the thesis is to estimate, analyze and compare the V/EBIT(1-t) multiplier for two companies and use decomposition to analyze the value creation. And we also analyze the financial characteristics of two companies, after that we use the quick test to rate the two companies. in energy industry, where one of two companies is from Czech and one from China.154 - Katedra financídobř

Crystal structure of the outer membrane protein OmpU from Vibrio cholerae at 2.2 Å resolution

Vibrio cholerae causes a severe disease that kills thousands of people annually. The outer membrane protein OmpU is the most abundant outer membrane protein in V. cholerae, and has been identified as an important virulence factor that is involved in host-cell interaction and recognition, as well as being critical for the survival of the pathogenic V. cholerae in the host body and in harsh environments. The mechanism of these processes is not well understood owing to a lack of the structure of V. cholerae OmpU. Here, the crystal structure of the V. cholerae OmpU trimer is reported to a resolution of 2.2 Å. The protomer forms a 16-β-stranded barrel with a noncanonical N-terminal coil located in the lumen of the barrel that consists of residues Gly32–Ser42 and is observed to participate in forming the second gate in the pore. By mapping the published functional data onto the OmpU structure, the OmpU structure reinforces the notion that the long extracellular loop L4 with a β-hairpin-like motif may be critical for host-cell binding and invasion, while L3, L4 and L8 are crucially implicated in phage recognition by V. cholerae

An Ontology for the Materials Design Domain

In the materials design domain, much of the data from materials calculations are stored in different heterogeneous databases. Materials databases usually have different data models. Therefore, the users have to face the challenges to find the data from adequate sources and integrate data from multiple sources. Ontologies and ontology-based techniques can address such problems as the formal representation of domain knowledge can make data more available and interoperable among different systems. In this paper, we introduce the Materials Design Ontology (MDO), which defines concepts and relations to cover knowledge in the field of materials design. MDO is designed using domain knowledge in materials science (especially in solid-state physics), and is guided by the data from several databases in the materials design field. We show the application of the MDO to materials data retrieved from well-known materials databases.Comment: 16 page

Hodnocení rentability společnosti Apple

Import 02/11/2016In this thesis, we want to analyze the Financial assessment of the Apple company, especially in the profitability. Financial analysis aims to through the annual report, financial data and use all kinds of tools such as the Common-size analysis, financial ratios to assess the company. Financial analysis can evaluate the performance of a company, such as the solvency, activity ratios, return on equity and assets. On one hand, analyzing the performance of the company can help investors to select the right company, give some suggestions to the shareholders and creditors to do logical invest. On the other hand, financial analysis can help the managers to make right policies on the development, selling, advertisement and operating, change their strategy in time. Last but not least, financial analysis can give a review of a company in the last year, and depend on this, we can forecast the operating conditions of the company next year.In this thesis, we want to analyze the Financial assessment of the Apple company, especially in the profitability. Financial analysis aims to through the annual report, financial data and use all kinds of tools such as the Common-size analysis, financial ratios to assess the company. Financial analysis can evaluate the performance of a company, such as the solvency, activity ratios, return on equity and assets. On one hand, analyzing the performance of the company can help investors to select the right company, give some suggestions to the shareholders and creditors to do logical invest. On the other hand, financial analysis can help the managers to make right policies on the development, selling, advertisement and operating, change their strategy in time. Last but not least, financial analysis can give a review of a company in the last year, and depend on this, we can forecast the operating conditions of the company next year.154 - Katedra financídobř

Structural studies of the BAM complex, OmpU outer membrane protein and lipoprotein N-acyl transferase in Gram-negative bacteria

Structural studies of membrane proteins represent a significant challenge in the field owing to their hydrophobic nature, unstable property and resistance to be crystallized. In Gramnegative bacteria, membrane proteins contribute to the characteristic membranous architecture composed of an asymmetric layer of outer membrane (OM) and a symmetric inner cytoplasmic membrane (IM). Outer membrane proteins (OMPs) play essential roles in nutrient uptake, protein transport, outer membrane assembly, and pathogenesis of Gram-negative bacteria. In Escherichia coli, nearly all the outer membrane proteins are inserted into the outer membrane by the β-barrel assembly machinery (BAM), which contains one conserved membrane protein BamA and four lipoproteins BamBCDE. The individual protein structures of the BAM complex have been reported, but the mechanism of OMP assembly by the BAM complex is halted by a lack of structure of the whole complex. During the course of the collaborative BAM complex project, I participated in structural studies of the BAM complex and generated high resolution crystallographic diffraction data that contributes to one of the two determined structures of the BAM complex, and the structural insights have enlightened understanding of the in vivo insertion mechanism. Of diverse types of β-barrel OMPs that are inserted into the OM by the BAM complex, an outer membrane protein called OmpU from Vibrio cholerae is a potential virulence factor in addition to its porin identity with undefined atomic structure. I determined the crystal structure of this OMP, in which the long and flexible extracellular loop L4 and a novel Nterminal coil in the pore lumen provide direct structural evidence underlying its particular functions. The symmetric lipid bilayer of IM accommodates an even more diverse array of IMPs composed of the contrasting dominance of α-helices. Three IMPs are responsible for conducting post-translational modifications of lipoproteins in Gram-negative bacteria, a class of proteins destined to reside on the periplasmic side of either the IM or the OM via acyl chains post-translationally linked to the N-terminal cysteine residues, and they are called phosphatidylglycerol:prolipoprotein diacylglyceryl transferase (Lgt), Prolipoprotein signal peptidase (Lsp) and apolipoprotein N-acyltransferase (Lnt). Structural studies were carried out on Lnt but unsuccessful in determining the atomic structure. Recent structures of Lnt reported during the course of this project are consistent with earlier biochemical studies that piloted the understanding of its function and further elucidate the molecular mechanisms of its primary acyl-transfer function

(E)-N′-[4-(Dimethyl­amino)­benzyl­idene]-4-methyl­benzohydrazide methanol monosolvate

In the title compound, C17H19N3O·CH3OH, the hydrazone mol­ecule exists in a trans geometry with respect to the methyl­idene unit and the dihedral angle between the two substituted benzene rings is 42.6 (2)°. In the crystal, the components are linked through N—H⋯O and O—H⋯O hydrogen bonds, forming [100] chains of alternating hydrazone and methanol mol­ecules

(E)-N′-[4-(Dimethyl­amino)­benzyl­idene]-4-hy­droxy­benzohydrazide hemihydrate

In the title compound, C16H17N3O2·0.5H2O, the two hydrazide mol­ecules are approximately planar: the dihedral angles between the two substituted benzene rings are 7.7 (2) and 4.2 (2)°. Both hydrazone mol­ecules exist in a trans geometry with respect to their methyl­idene units. In the crystal, the water mol­ecule lies between the two organic mol­ecules and makes bifurcated O—H⋯(N,O) hydrogen bonds to both of them. The hydrazide mol­ecules form N—H⋯O and O—H⋯O hydrogen bonds, resulting in a three-dimensional network