Проблеми оцінки якості індустріального розвитку соціально-економічної системи України

Розглянуті особливості процесу системної трансформації індустріального базису соціально-економічної системи України в умовах соціальної поляризації світового суспільства. Доведено існування дихотомії типу базису економіки України: індустріального в межах національної підсистеми та доіндустріального в межах світової соціально-економічної системи. Ключові слова: трансформація, система, промисловість, якість.Рассмотрены особенности процесса системной трансформации индустриального базиса социально-экономической системы Украины в условиях социальной поляризации мирового сообщества. Доказано существование дихотомии базиса экономики Украины: индустриального в рамках национальной подсистемы и доиндустриальной в рамках мировой социально-экономической системы. Ключевые слова: трансформация, система, промышленность, качество.Features of process of system transformation of industrial basis of social and economic system of Ukraine in the conditions of social polarisation of the world community are considered. Existence of a dichotomy of basis of economy of Ukraine is proved: industrial within the limits of a national subsystem and befor industrial in frames of world social and economic system. Key words: transformation, system, industry, quality

Dataset of the phospholipidome and transcriptome of Campylobacter jejuni under different growth conditions

The membrane phospholipid composition is not a stable bacterial characteristic but can change in response to altered environmental conditions. Here we provide the dataset of the phospholipidome and transcriptome of the microaerophilic human pathogen Campylobacter jejuni under different environmental conditions. These data have been used in Cao (2020), The unique phospholipidome of the enteric pathogen C. jejuni: Lysolipids are required for motility at low oxygen availability. Here the abundance of each phospholipid is shown during the growth of C. jejuni for 0-108 h under low and high oxygen conditions (0.3 vs 10% O2). The phospholipid data were obtained by applying high performance liquid chromatography tandem-mass spectrometry (LC-MS/MS). The transcriptomic data obtained by RNA-seq show the differential expressed genes between logarithmic and stationary grown bacteria. In addition, our data might serve as a reference information for further in-depth investigation to understand the relation between specific phospholipids and the activity of membrane associated proteins

Synovial Fluid Fatty Acid Profiles Differ between Osteoarthritis and Healthy Patients

Objective: Free fatty acids (FAs) may influence cartilage metabolism and osteoarthritis (OA) disease progression. It is not clearly studied which FAs are present in the synovial fluid of knee joints and whether there are differences in FA content between nonsymptomatic and OA knee joints. The aim of this study was to investigate the presence of different types of FAs in synovial fluid of both OA- and nonsymptomatic control joints, and to analyze differences between both groups. Design: A total of 23 synovial fluid samples were collected from patients with end-stage knee OA undergoing total knee replacement, with approval of the medical ethical committee. As controls, 6 synovial fluid

Imagecalc: a Microsoft(R) Windows(TM) application for quantitative image analysis and comparison

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Elimination of autofluorescence in immunofluorescence microscopy with digital image processing

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Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: a longitudinal experimental study.

INTRODUCTION: Inflammation is an important feature of many joint diseases, and levels of cartilage biomarkers measured in synovial fluid may be influenced by local inflammatory status. Little is known about the magnitude and time course of inflammation-induced changes in cartilage tissue turnover as measured in vivo by synovial fluid markers. We aimed to study temporal changes in concentrations of inflammatory mediators, matrix metalloproteinase activity and cartilage biomarkers over 1 week in joints with experimentally induced inflammation. METHODS: Localized inflammation was induced in the intercarpal joint of six horses by sterile injection of 0.5 ng lipopolysaccharide, and synovial fluid was collected at post-injection hours (PIH) 0, 8, 24 and 168. Concentrations of inflammatory mediators (prostaglandin E(2), substance P, and bradykinin), general matrix metalloproteinase activity and markers of collagen II turnover (CPII and C2C) as well as aggrecan turnover (CS846 and glycosaminoglycans) were measured with appropriate assays. One-way analysis of variance on repeated measures was used to analyze differences in synovial fluid marker levels over time. RESULTS: Lipopolysaccharide-injection led to a sharp rise in prostaglandin E(2 )at PIH 8, while substance P, bradykinin and matrix metalloproteinase activity showed more sustained increases at PIH 8 and 24. Glycosaminoglycan release paralleled changes in the CS846 epitope, with an increase by PIH 8, a peak at PIH 24, and return to baseline by PIH 168. For type II collagen, a parallel time course between catabolic (C2C) and anabolic (CPII) markers was also observed, but the time course differed from that seen for proteoglycan markers: collagen II markers peaked later, at PIH 24, and were still elevated over baseline at PIH 168. CONCLUSIONS: A primary intra-articular inflammatory insult, characterized by local release of peptide and lipid mediators and matrix metalloproteinase activation, can alter synovial fluid levels of proteoglycan biomarkers as early as 8 hours post-induction, and can lead to sustained rises in collagen II biomarkers during at least 1 week after onset

Imagecalc: a Microsoft-Windows(TM) application for quantitative image analysis and image comparison

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Induction of emphysematous lesions in rat lung by beta-D-xyloside, an inhibitor of proteoglycan synthesis

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A versatile salt-based method to immobilize glycosaminoglycans and create growth factor gradients

Contains fulltext : 204547.pdf (publisher's version ) (Open Access