8 research outputs found
Aspect économiques de la régulation des pollutions par les pesticides
No full textExtrait de documentCe chapitre prĂ©sente une synthĂšse des rĂ©sultats de principales Ă©tudes micro-Ă©conomiques de la demande de produits phytosanitaires et de la rĂ©gulation par les pesticides. Bien entendu, cette analyse bibliogrpahique ne prĂ©tend pas ĂȘtre exhaustive et s'appuie sur des synthjĂšses dĂ©jĂ rĂ©alisĂ©es sur ce domaine. Les rĂ©sultats prĂ©sentĂ©s ne concernent que le cas des pesticides utilisĂ©s en agriculture
198: The use of recombinant human erythropoietin (rHuEpo) after reduced intensity conditioning (RIC) allogeneic hematopoietic peripheral blood stem cell transplantation (ASCT) reduces red blood cell (RBC) transfusion requirements
No full textEssai de typologie des symptomes de deperissement dans les massifs dauphinois externes (Vercors-Chartreuse-Belledonne)
No full textCNRS RP 185 (2331) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc
Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells
No full textTR3 Nuclear Orphan Receptor Prevents Cyclic Stretch-Induced Proliferation of Venous Smooth Muscle Cells
No full textIn coronary artery bypass surgery, the patency of arterial grafts is higher than that of venous grafts because of vein-graft disease, which involves excessive proliferation of venous smooth muscle cells (SMCs) and subsequent accelerated atherosclerosis. We studied the function of TR3 nuclear orphan receptor (TR3) in the early response of SMCs to mechanical strain, a major initiator of vein-graft disease. We demonstrate that TR3 expression is induced in human saphenous vein segments exposed ex vivo to whole-blood perfusion under arterial pressure. Cultured venous SMCs challenged by cyclic stretch displayed TR3 induction and enhanced DNA synthesis, whereas SMCs derived from the internal mammary artery remained quiescent. Small-interfering RNA-mediated knockdown of TR3 and adenovirus-mediated overexpression of TR3 in venous SMCs enhanced and abolished stretch-induced DNA synthesis, respectively. Accordingly, in organ cultures of wild-type murine vessel segments exposed to cyclic stretch, p27(Kip1) was down-regulated, whereas expression of this cell cycle inhibitor was unaffected by cyclic stretch in TR3-transgenic vessels, concordant with a lower proliferative response. Finally, stretch-mediated proliferation was inhibited by 6-mercaptopurine, an agonist of TR3. In conclusion, TR3 represents inhibitory mechanisms to restrict venous SMC proliferation and may contribute to prevention of vein-graft disease
